PL355331A1 - Nowa kompozycja i zastosowanie - Google Patents

Nowa kompozycja i zastosowanie

Info

Publication number: PL355331A1
Authority: PL; Poland
Prior art keywords: novel composition; thiazolidinedione; pharmaceutically acceptable; acceptable carrier; pharmaceutical composition
Prior art date: 1999-11-16

Application number

PL00355331A

Other languages

English (en)

Other versions

PL200943B1 (pl

Inventor

Karen Lewis

Nicola Jayne Lilliott

Donald Colin Mackenzie

Original Assignee

Smithkline Beecham P.L.C.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-16

Filing date

2000-11-16

Publication date

2004-04-19

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27447849&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL355331(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-11-16 Priority claimed from GBGB9927119.9A external-priority patent/GB9927119D0/en

1999-11-16 Priority claimed from GBGB9927120.7A external-priority patent/GB9927120D0/en

2000-05-31 Priority claimed from GB0013236A external-priority patent/GB0013236D0/en

2000-05-31 Priority claimed from GB0013240A external-priority patent/GB0013240D0/en

2000-11-16 Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.

2004-04-19 Publication of PL355331A1 publication Critical patent/PL355331A1/pl

2009-02-27 Publication of PL200943B1 publication Critical patent/PL200943B1/pl

Links

239000000203 mixture Substances 0.000 title abstract 2
ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 abstract 2
229940123464 Thiazolidinedione Drugs 0.000 abstract 2
239000003937 drug carrier Substances 0.000 abstract 2
OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 abstract 2
229960004329 metformin hydrochloride Drugs 0.000 abstract 2
XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin hydrochloride Natural products CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
-1 Compound (I) Chemical compound 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

PL355331A 1999-11-16 2000-11-16 Kompozycja farmaceutyczna zawierająca kombinację substancji aktywnych - tiazolidynodionu i chlorowodorku metforminy i sposób jej wytwarzania PL200943B1 (pl)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GBGB9927119.9A GB9927119D0 (en)	1999-11-16	1999-11-16	Novel composition and use
GBGB9927120.7A GB9927120D0 (en)	1999-11-16	1999-11-16	Novel composition and use
GB0013236A GB0013236D0 (en)	2000-05-31	2000-05-31	Novel composition and use
GB0013240A GB0013240D0 (en)	2000-05-31	2000-05-31	Novel composition and use
PCT/GB2000/004368 WO2001035941A2 (en)	1999-11-16	2000-11-16	Novel composition based on a thiazolidinedione and metformin and use

Publications (2)

Publication Number	Publication Date
PL355331A1 true PL355331A1 (pl)	2004-04-19
PL200943B1 PL200943B1 (pl)	2009-02-27

Family

ID=27447849

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL355331A PL200943B1 (pl)	1999-11-16	2000-11-16	Kompozycja farmaceutyczna zawierająca kombinację substancji aktywnych - tiazolidynodionu i chlorowodorku metforminy i sposób jej wytwarzania

Country Status (40)

Country	Link
US (1)	US8236345B2 (pl)
EP (3)	EP1913945A3 (pl)
JP (2)	JP4865975B2 (pl)
KR (1)	KR100760063B1 (pl)
CN (1)	CN1222290C (pl)
AP (1)	AP1389A (pl)
AR (2)	AR030920A1 (pl)
AT (1)	ATE292466T1 (pl)
AU (3)	AU775654B2 (pl)
BG (1)	BG65616B1 (pl)
BR (1)	BR0015605A (pl)
CA (1)	CA2388846A1 (pl)
CO (1)	CO5300392A1 (pl)
CZ (1)	CZ302500B6 (pl)
DE (1)	DE60019329T2 (pl)
DK (1)	DK1231918T3 (pl)
DZ (1)	DZ3251A1 (pl)
EA (1)	EA004878B1 (pl)
ES (1)	ES2240199T3 (pl)
HK (1)	HK1049788B (pl)
HR (1)	HRP20020416B1 (pl)
HU (1)	HU229960B1 (pl)
IL (3)	IL149618A0 (pl)
MA (1)	MA25567A1 (pl)
ME (1)	ME00318B (pl)
MX (1)	MXPA02005005A (pl)
MY (1)	MY125516A (pl)
NO (1)	NO329926B1 (pl)
NZ (1)	NZ518946A (pl)
OA (1)	OA12513A (pl)
PE (1)	PE20011011A1 (pl)
PL (1)	PL200943B1 (pl)
PT (1)	PT1231918E (pl)
RS (1)	RS51343B (pl)
SI (1)	SI1231918T1 (pl)
SK (1)	SK286985B6 (pl)
TW (1)	TWI240626B (pl)
UA (1)	UA73150C2 (pl)
UY (1)	UY26439A1 (pl)
WO (1)	WO2001035941A2 (pl)

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UA80991C2 (en) *	2002-10-07	2007-11-26		Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes
BRPI0407074A (pt)	2003-01-29	2006-01-24	Takeda Pharmaceutical	Método para produção de uma preparação revestida, preparação revestida, e, método para melhorar a dissolução do cloridreto de pioglitazona de uma preparação revestida com cloridreto de pioglitazona
FR2858556B1 (fr) *	2003-08-06	2006-03-10	Galenix Innovations	Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation
EP1738754B1 (en) *	2004-04-14	2015-07-15	Takeda Pharmaceutical Company Limited	Solid pharmaceutical preparation
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PL1878426T3 (pl)	2005-04-26	2010-11-30	Sumitomo Dainippon Pharma Co Ltd	Preparat w formie granulatu zawierający związek biguanidu
ZA200805147B (en) *	2005-12-22	2010-05-26	Takeda Pharmaceutical	Solid preparation
FR2896159B1 (fr)	2006-01-13	2008-09-12	Merck Sante Soc Par Actions Si	Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline.
WO2008078390A1 (ja)	2006-12-26	2008-07-03	Fujitsu Limited	データ圧縮装置およびデータ復元装置
RS51592B (sr)	2007-02-01	2011-08-31	Takeda Pharmaceutical Company Limited	Čvrsti preparat koji sadrži alogliptin i pioglitazon
CA2677623C (en)	2007-02-09	2015-04-07	Alphapharm Pty Ltd	A dosage form containing two or more active pharmaceutical ingredients in different physical forms
TR200803177A2 (tr) *	2008-05-06	2009-11-23	Bi̇li̇m İlaç Sanayi̇ Ti̇caret A.Ş.	Antihiperglisemik etkili metformîn - pioglitazon formülasyonu.
US8846315B2 (en)	2008-08-12	2014-09-30	Zinfandel Pharmaceuticals, Inc.	Disease risk factors and methods of use
DK2324126T3 (da)	2008-08-12	2014-06-16	Zinfandel Pharmaceuticals Inc	FREMGANGSMÅDE TIL IDENTIFICERING AF Alzheimers SYGDOMSRISIKOFAKTORER
FR2951945B1 (fr) *	2009-11-05	2013-08-09	Sanofi Aventis	Composition pharmaceutique
CN105193761B (zh) *	2009-11-13	2019-12-06	阿斯利康(瑞典)有限公司	双层片剂
EP2441442A1 (en)	2010-10-08	2012-04-18	LEK Pharmaceuticals d.d.	A pharmaceutical composition comprising a thiazolidinedione
US9480663B2 (en)	2011-01-07	2016-11-01	Elcelyx Therapeutics, Inc.	Biguanide compositions and methods of treating metabolic disorders
US11974971B2 (en)	2011-01-07	2024-05-07	Anji Pharmaceuticals Inc.	Compositions and methods for treating metabolic disorders
US9211263B2 (en)	2012-01-06	2015-12-15	Elcelyx Therapeutics, Inc.	Compositions and methods of treating metabolic disorders
LT2661266T (lt)	2011-01-07	2020-12-10	Anji Pharma (Us) Llc	Gydimo būdai chemosensorinio receptoriaus ligando pagrindu
US9572784B2 (en)	2011-01-07	2017-02-21	Elcelyx Therapeutics, Inc.	Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
US8796338B2 (en)	2011-01-07	2014-08-05	Elcelyx Therapeutics, Inc	Biguanide compositions and methods of treating metabolic disorders
US11759441B2 (en)	2011-01-07	2023-09-19	Anji Pharmaceuticals Inc.	Biguanide compositions and methods of treating metabolic disorders
CN103501783A (zh)	2011-01-10	2014-01-08	金帆德尔制药股份有限公司	用于治疗阿尔茨海默病的方法和药物产品
CN104254325A (zh)	2012-01-06	2014-12-31	埃尔舍利克斯治疗公司	双胍组合物和治疗代谢性病症的方法
CN110693867A (zh)	2012-01-06	2020-01-17	埃尔舍利克斯治疗公司	用于治疗代谢性病症的组合物和方法
CN108451923B (zh) *	2018-05-31	2025-05-06	常州兰陵制药有限公司	盐酸二甲双胍速释胶囊及其制备方法
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2000
- 2000-11-15 MY MYPI20005360A patent/MY125516A/en unknown
- 2000-11-15 AR ARP000106019A patent/AR030920A1/es active IP Right Grant
- 2000-11-16 UA UA2002064826A patent/UA73150C2/uk unknown
- 2000-11-16 BR BR0015605-1A patent/BR0015605A/pt not_active Application Discontinuation
- 2000-11-16 AU AU14040/01A patent/AU775654B2/en not_active Expired
- 2000-11-16 DE DE60019329T patent/DE60019329T2/de not_active Expired - Lifetime
- 2000-11-16 WO PCT/GB2000/004368 patent/WO2001035941A2/en not_active Ceased
- 2000-11-16 AT AT00976156T patent/ATE292466T1/de active
- 2000-11-16 OA OA1200200145A patent/OA12513A/en unknown
- 2000-11-16 CA CA002388846A patent/CA2388846A1/en not_active Abandoned
- 2000-11-16 DK DK00976156T patent/DK1231918T3/da active
- 2000-11-16 KR KR1020027006271A patent/KR100760063B1/ko not_active Expired - Lifetime
- 2000-11-16 CZ CZ20021679A patent/CZ302500B6/cs not_active IP Right Cessation
- 2000-11-16 MX MXPA02005005A patent/MXPA02005005A/es active IP Right Grant
- 2000-11-16 PT PT00976156T patent/PT1231918E/pt unknown
- 2000-11-16 UY UY26439A patent/UY26439A1/es not_active IP Right Cessation
- 2000-11-16 DZ DZ003251A patent/DZ3251A1/fr active
- 2000-11-16 EP EP07120386A patent/EP1913945A3/en not_active Withdrawn
- 2000-11-16 PL PL355331A patent/PL200943B1/pl unknown
- 2000-11-16 CN CNB008178224A patent/CN1222290C/zh not_active Expired - Lifetime
- 2000-11-16 NZ NZ518946A patent/NZ518946A/en not_active IP Right Cessation
- 2000-11-16 HK HK03100745.5A patent/HK1049788B/en not_active IP Right Cessation
- 2000-11-16 AP APAP/P/2002/002505A patent/AP1389A/en active
- 2000-11-16 JP JP2001537934A patent/JP4865975B2/ja not_active Expired - Lifetime
- 2000-11-16 HU HU0204122A patent/HU229960B1/hu unknown
- 2000-11-16 EP EP00976156A patent/EP1231918B1/en not_active Expired - Lifetime
- 2000-11-16 SI SI200030697T patent/SI1231918T1/xx unknown
- 2000-11-16 ES ES00976156T patent/ES2240199T3/es not_active Expired - Lifetime
- 2000-11-16 EA EA200200571A patent/EA004878B1/ru not_active IP Right Cessation
- 2000-11-16 HR HR20020416A patent/HRP20020416B1/xx not_active IP Right Cessation
- 2000-11-16 ME MEP-2008-340A patent/ME00318B/me unknown
- 2000-11-16 SK SK679-2002A patent/SK286985B6/sk not_active IP Right Cessation
- 2000-11-16 PE PE2000001226A patent/PE20011011A1/es not_active Application Discontinuation
- 2000-11-16 IL IL14961800A patent/IL149618A0/xx unknown
- 2000-11-16 EP EP04078538A patent/EP1520581A1/en not_active Withdrawn
- 2000-11-16 RS YUP-388/02A patent/RS51343B/sr unknown
- 2000-11-20 CO CO00088045A patent/CO5300392A1/es not_active Application Discontinuation
- 2000-12-04 TW TW089125730A patent/TWI240626B/zh not_active IP Right Cessation
2002
- 2002-05-13 IL IL149618A patent/IL149618A/en unknown
- 2002-05-15 MA MA26640A patent/MA25567A1/fr unknown
- 2002-05-15 NO NO20022334A patent/NO329926B1/no not_active IP Right Cessation
- 2002-05-29 BG BG106747A patent/BG65616B1/bg unknown
2004
- 2004-11-04 AU AU2004226955A patent/AU2004226955B2/en not_active Expired
2006
- 2006-12-05 AR ARP060105370A patent/AR057970A2/es active IP Right Grant
2007
- 2007-07-18 US US11/779,546 patent/US8236345B2/en not_active Expired - Fee Related
2008
- 2008-03-17 IL IL190220A patent/IL190220A0/en unknown
- 2008-08-18 AU AU2008207375A patent/AU2008207375A1/en not_active Abandoned
2011
- 2011-08-11 JP JP2011175883A patent/JP5282130B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
MEP34008A (en)	2011-02-10
MXPA02005005A (es)	2003-10-14
WO2001035941A3 (en)	2002-05-23
EP1231918A2 (en)	2002-08-21
EP1520581A1 (en)	2005-04-06
NO20022334L (no)	2002-07-09
HU229960B1 (hu)	2015-03-30
PT1231918E (pt)	2005-08-31
CO5300392A1 (es)	2003-07-31
JP2003514012A (ja)	2003-04-15
DZ3251A1 (fr)	2001-05-25
BR0015605A (pt)	2002-07-09
CN1414852A (zh)	2003-04-30
RS51343B (sr)	2011-02-28
NZ518946A (en)	2003-10-31
IL149618A (en)	2008-07-08
AR057970A2 (es)	2007-12-26
US8236345B2 (en)	2012-08-07
NO20022334D0 (no)	2002-05-15
JP4865975B2 (ja)	2012-02-01
IL149618A0 (en)	2002-12-01
CA2388846A1 (en)	2001-05-25
AU2008207375A1 (en)	2008-09-11
OA12513A (en)	2006-05-29
MY125516A (en)	2006-08-30
BG65616B1 (bg)	2009-03-31
AU2004226955B2 (en)	2008-08-28
ES2240199T3 (es)	2005-10-16
IL190220A0 (en)	2008-11-03
HUP0204122A3 (en)	2006-01-30
MA25567A1 (fr)	2002-10-01
UA73150C2 (uk)	2005-06-15
PE20011011A1 (es)	2001-10-28
AP2002002505A0 (en)	2002-06-30
HRP20020416A2 (en)	2004-08-31
EA200200571A1 (ru)	2002-12-26
DE60019329D1 (de)	2005-05-12
CZ302500B6 (cs)	2011-06-22
BG106747A (en)	2003-01-31
AU1404001A (en)	2001-05-30
UY26439A1 (es)	2001-07-31
ATE292466T1 (de)	2005-04-15
KR20030019300A (ko)	2003-03-06
CN1222290C (zh)	2005-10-12
ME00318B (me)	2011-05-10
AU775654B2 (en)	2004-08-12
WO2001035941A8 (en)	2002-08-29
YU38802A (sh)	2005-03-15
AR030920A1 (es)	2003-09-03
HRP20020416B1 (hr)	2011-04-30
HK1049788A1 (en)	2003-05-30
EP1231918B1 (en)	2005-04-06
EP1913945A2 (en)	2008-04-23
AU2004226955A1 (en)	2004-12-02
SI1231918T1 (en)	2005-08-31
AP1389A (en)	2005-04-14
JP2011252007A (ja)	2011-12-15
WO2001035941A2 (en)	2001-05-25
NO329926B1 (no)	2011-01-24
US20070275054A1 (en)	2007-11-29
PL200943B1 (pl)	2009-02-27
KR100760063B1 (ko)	2007-09-18
SK286985B6 (sk)	2009-08-06
TWI240626B (en)	2005-10-01
EA004878B1 (ru)	2004-08-26
DE60019329T2 (de)	2006-03-09
HK1049788B (en)	2005-11-04
JP5282130B2 (ja)	2013-09-04
HUP0204122A2 (hu)	2003-03-28
DK1231918T3 (da)	2005-08-01
SK6792002A3 (en)	2002-09-10
EP1913945A3 (en)	2008-04-30

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