PL355331A1 - Nowa kompozycja i zastosowanie - Google Patents

Nowa kompozycja i zastosowanie

Info

Publication number: PL355331A1
Authority: PL; Poland
Prior art keywords: novel composition; thiazolidinedione; pharmaceutically acceptable; acceptable carrier; pharmaceutical composition
Prior art date: 1999-11-16

Application number

PL00355331A

Other languages

English (en)

Other versions

PL200943B1 (pl

Inventor

Karen Lewis

Nicola Jayne Lilliott

Donald Colin Mackenzie

Original Assignee

Smithkline Beecham P.L.C.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-16

Filing date

2000-11-16

Publication date

2004-04-19

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27447849&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL355331(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-11-16 Priority claimed from GBGB9927120.7A external-priority patent/GB9927120D0/en

1999-11-16 Priority claimed from GBGB9927119.9A external-priority patent/GB9927119D0/en

2000-05-31 Priority claimed from GB0013236A external-priority patent/GB0013236D0/en

2000-05-31 Priority claimed from GB0013240A external-priority patent/GB0013240D0/en

2000-11-16 Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.

2004-04-19 Publication of PL355331A1 publication Critical patent/PL355331A1/pl

2009-02-27 Publication of PL200943B1 publication Critical patent/PL200943B1/pl

Links

239000000203 mixture Substances 0.000 title abstract 2
ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 abstract 2
229940123464 Thiazolidinedione Drugs 0.000 abstract 2
239000003937 drug carrier Substances 0.000 abstract 2
OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 abstract 2
229960004329 metformin hydrochloride Drugs 0.000 abstract 2
XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin hydrochloride Natural products CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
-1 Compound (I) Chemical compound 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

PL355331A 1999-11-16 2000-11-16 Kompozycja farmaceutyczna zawierająca kombinację substancji aktywnych - tiazolidynodionu i chlorowodorku metforminy i sposób jej wytwarzania PL200943B1 (pl)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GBGB9927120.7A GB9927120D0 (en)	1999-11-16	1999-11-16	Novel composition and use
GBGB9927119.9A GB9927119D0 (en)	1999-11-16	1999-11-16	Novel composition and use
GB0013236A GB0013236D0 (en)	2000-05-31	2000-05-31	Novel composition and use
GB0013240A GB0013240D0 (en)	2000-05-31	2000-05-31	Novel composition and use
PCT/GB2000/004368 WO2001035941A2 (en)	1999-11-16	2000-11-16	Novel composition based on a thiazolidinedione and metformin and use

Publications (2)

Publication Number	Publication Date
PL355331A1 true PL355331A1 (pl)	2004-04-19
PL200943B1 PL200943B1 (pl)	2009-02-27

Family

ID=27447849

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL355331A PL200943B1 (pl)	1999-11-16	2000-11-16	Kompozycja farmaceutyczna zawierająca kombinację substancji aktywnych - tiazolidynodionu i chlorowodorku metforminy i sposób jej wytwarzania

Country Status (40)

Country	Link
US (1)	US8236345B2 (pl)
EP (3)	EP1913945A3 (pl)
JP (2)	JP4865975B2 (pl)
KR (1)	KR100760063B1 (pl)
CN (1)	CN1222290C (pl)
AP (1)	AP1389A (pl)
AR (2)	AR030920A1 (pl)
AT (1)	ATE292466T1 (pl)
AU (3)	AU775654B2 (pl)
BG (1)	BG65616B1 (pl)
BR (1)	BR0015605A (pl)
CA (1)	CA2388846A1 (pl)
CO (1)	CO5300392A1 (pl)
CZ (1)	CZ302500B6 (pl)
DE (1)	DE60019329T2 (pl)
DK (1)	DK1231918T3 (pl)
DZ (1)	DZ3251A1 (pl)
EA (1)	EA004878B1 (pl)
ES (1)	ES2240199T3 (pl)
HK (1)	HK1049788B (pl)
HR (1)	HRP20020416B1 (pl)
HU (1)	HU229960B1 (pl)
IL (3)	IL149618A0 (pl)
MA (1)	MA25567A1 (pl)
ME (1)	ME00318B (pl)
MX (1)	MXPA02005005A (pl)
MY (1)	MY125516A (pl)
NO (1)	NO329926B1 (pl)
NZ (1)	NZ518946A (pl)
OA (1)	OA12513A (pl)
PE (1)	PE20011011A1 (pl)
PL (1)	PL200943B1 (pl)
PT (1)	PT1231918E (pl)
RS (1)	RS51343B (pl)
SI (1)	SI1231918T1 (pl)
SK (1)	SK286985B6 (pl)
TW (1)	TWI240626B (pl)
UA (1)	UA73150C2 (pl)
UY (1)	UY26439A1 (pl)
WO (1)	WO2001035941A2 (pl)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU5745601A (en) *	2000-05-01	2001-11-12	Aeropharm Technology Inc	A core formulation
AU2001273290B2 (en) *	2001-07-10	2004-10-07	Kos Life Sciences, Inc.	Core formulation comprising troglitazone and a biguanide
GB0203296D0 (en) *	2002-02-12	2002-03-27	Glaxo Group Ltd	Novel composition
PL376577A1 (pl) *	2002-06-17	2006-01-09	Themis Laboratories Private Limited	Wielowarstwowe tabletki zawierające tiazolidinedion i biguanidy oraz metody ich wytwarzania
AU2003281181A1 (en) *	2002-07-11	2004-02-02	Takeda Pharmaceutical Company Limited	Process for producing coated preparation
US8637512B2 (en) *	2002-07-29	2014-01-28	Glaxo Group Limited	Formulations and method of treatment
ES2529180T3 (es) *	2002-09-20	2015-02-17	Andrx Labs Llc	Formulación multietapa que contiene una biguanida y un derivado de tiazolidinodiona
US7785627B2 (en) *	2002-09-20	2010-08-31	Watson Pharmaceuticals, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US8084058B2 (en)	2002-09-20	2011-12-27	Watson Pharmaceuticals, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US9060941B2 (en)	2002-09-20	2015-06-23	Actavis, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7959946B2 (en)	2002-09-20	2011-06-14	Watson Pharmaceuticals, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
UA80991C2 (en) *	2002-10-07	2007-11-26		Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes
WO2004067001A1 (ja)	2003-01-29	2004-08-12	Takeda Pharmaceutical Company Limited	被覆製剤の製造法
FR2858556B1 (fr) *	2003-08-06	2006-03-10	Galenix Innovations	Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation
US8263121B2 (en)	2004-04-14	2012-09-11	Takeda Pharmaceutical Company Limited	Solid pharmaceutical preparation
EP1772149A1 (en) *	2004-07-27	2007-04-11	Kowa Company. Ltd.	Drug for prevention or treatment of diabetes
CN101198319B (zh)	2005-04-26	2012-08-01	大日本住友制药株式会社	含有双胍化合物的颗粒制剂
WO2007072992A2 (en) *	2005-12-22	2007-06-28	Takeda Pharmaceutical Company Limited	Solid preparation containing an insulin sensitizer
FR2896159B1 (fr)	2006-01-13	2008-09-12	Merck Sante Soc Par Actions Si	Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline.
GB2456996B (en)	2006-12-26	2011-09-21	Fujitsu Ltd	Data compression apparatus and data decompression apparatus
TW201350143A (zh)	2007-02-01	2013-12-16	Takeda Pharmaceutical	固體型製劑
CA2677623C (en)	2007-02-09	2015-04-07	Alphapharm Pty Ltd	A dosage form containing two or more active pharmaceutical ingredients in different physical forms
TR200803177A2 (tr) *	2008-05-06	2009-11-23	Bi̇li̇m İlaç Sanayi̇ Ti̇caret A.Ş.	Antihiperglisemik etkili metformîn - pioglitazon formülasyonu.
US8846315B2 (en)	2008-08-12	2014-09-30	Zinfandel Pharmaceuticals, Inc.	Disease risk factors and methods of use
KR20160127181A (ko)	2008-08-12	2016-11-02	진판델 파마슈티컬스 인코포레이티드	질환 위험 인자의 식별 방법
FR2951945B1 (fr) *	2009-11-05	2013-08-09	Sanofi Aventis	Composition pharmaceutique
CN102711739B (zh) *	2009-11-13	2015-12-16	阿斯利康(瑞典)有限公司	双层片剂
EP2441442A1 (en)	2010-10-08	2012-04-18	LEK Pharmaceuticals d.d.	A pharmaceutical composition comprising a thiazolidinedione
US9480663B2 (en)	2011-01-07	2016-11-01	Elcelyx Therapeutics, Inc.	Biguanide compositions and methods of treating metabolic disorders
US9572784B2 (en)	2011-01-07	2017-02-21	Elcelyx Therapeutics, Inc.	Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
US11974971B2 (en)	2011-01-07	2024-05-07	Anji Pharmaceuticals Inc.	Compositions and methods for treating metabolic disorders
US11759441B2 (en)	2011-01-07	2023-09-19	Anji Pharmaceuticals Inc.	Biguanide compositions and methods of treating metabolic disorders
US8796338B2 (en)	2011-01-07	2014-08-05	Elcelyx Therapeutics, Inc	Biguanide compositions and methods of treating metabolic disorders
US9211263B2 (en)	2012-01-06	2015-12-15	Elcelyx Therapeutics, Inc.	Compositions and methods of treating metabolic disorders
WO2012094636A2 (en)	2011-01-07	2012-07-12	Elcelyx Therapeutics, Inc.	Chemosensory receptor ligand-based therapies
CN107362165A (zh)	2011-01-10	2017-11-21	金帆德尔制药股份有限公司	用于治疗阿尔茨海默病的方法和药物产品
CN104349773A (zh)	2012-01-06	2015-02-11	埃尔舍利克斯治疗公司	用于治疗代谢性病症的组合物和方法
BR112014016808B1 (pt)	2012-01-06	2022-01-11	Anji Pharma (Us) Llc	Uso de um composto de biguanida para a fabricação de um medicamento para baixar os níveis de glicose no sangue e para o tratamento de um distúrbio do metabolismo de glicose
CN108451923B (zh) *	2018-05-31	2025-05-06	常州兰陵制药有限公司	盐酸二甲双胍速释胶囊及其制备方法
EP4130005A4 (en)	2020-04-01	2024-04-24	Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd.	CRYSTALLINE FORM A OF A GLP-1 RECEPTOR AGONIST AND METHOD OF MANUFACTURING THEREOF
CN115315426B (zh)	2020-04-01	2023-12-12	杭州中美华东制药有限公司	Glp-1受体激动剂游离碱的药学上可接受的酸式盐及其制备方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4613596Y1 (pl) *	1969-06-02	1971-05-14
DE2347531A1 (de) *	1973-09-21	1975-04-30	Hoechst Ag	Arzneizubereitungen zur oralen diabetes-behandlung
ATE186724T1 (de) *	1987-09-04	1999-12-15	Beecham Group Plc	Substituierte thiazolidindionderivate
US4999226A (en)	1988-06-01	1991-03-12	Merrell Dow Pharmaceuticals Inc.	Pharmaceutical compositions for piperidinoalkanol-ibuprofen combination
JPH0553521A (ja)	1991-08-28	1993-03-05	Mitsubishi Electric Corp	オートトラツキング型ｃｒｔデイスプレイモニタ
GB9218830D0 (en) *	1992-09-05	1992-10-21	Smithkline Beecham Plc	Novel compounds
IT1255522B (it)	1992-09-24	1995-11-09	Ubaldo Conte	Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita'
US6183778B1 (en)	1993-09-21	2001-02-06	Jagotec Ag	Pharmaceutical tablet capable of liberating one or more drugs at different release rates
TW438587B (en)	1995-06-20	2001-06-07	Takeda Chemical Industries Ltd	A pharmaceutical composition for prophylaxis and treatment of diabetes
DE19539361A1 (de)	1995-10-23	1997-04-24	Basf Ag	Verfahren zur Herstellung von mehrschichtigen, festen Arzneiformen zur oralen oder rektalen Verabreichung
GB9612496D0 (en)	1996-06-14	1996-08-14	De La Rue Thomas & Co Ltd	Security device
TW522014B (en)	1997-02-07	2003-03-01	Sepracor Inc	Lactose-free, non-hygroscopic and anhydrous pharmaceutical unit dosage form containing descarboethoxyloratadine
TR199903057T2 (xx) *	1997-06-18	2000-04-21	Smithkline Beecham Plc	Diabetin tiazolidinedion ve metformin ile tedavisi.
US20020004515A1 (en)	1997-06-18	2002-01-10	Smith Stephen Alistair	Treatment of diabetes with thiazolidinedione and metformin
GB9715295D0 (en) *	1997-07-18	1997-09-24	Smithkline Beecham Plc	Novel method of treatment
WO1999047128A1 (en)	1998-03-19	1999-09-23	Bristol-Myers Squibb Company	Biphasic controlled release delivery system for high solubility pharmaceuticals and method
US6099859A (en)	1998-03-20	2000-08-08	Andrx Pharmaceuticals, Inc.	Controlled release oral tablet having a unitary core
US6117451A (en) *	1998-08-25	2000-09-12	Pharmalogix, Inc.	Direct compression metformin hydrochloride tablets
WO2000028989A1 (en)	1998-11-12	2000-05-25	Smithkline Beecham P.L.C.	Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
GB9824893D0 (en)	1998-11-12	1999-01-06	Smithkline Beckman Corp	Novel method of treatment
US20040081697A1 (en)	1998-11-12	2004-04-29	Smithkline Beecham P.L.C.	Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
DZ2937A1 (fr)	1998-11-12	2004-03-15	Smithkline Beecham Plc	Compositions nouvelles de sensibilidants à l'insuline.
US20040102486A1 (en)	1998-11-12	2004-05-27	Smithkline Beecham Corporation	Novel method of treatment
JP2003514011A (ja)	1999-11-16	2003-04-15	スミスクラインビーチャムパブリックリミテッドカンパニー	チアゾリジンジオン−塩酸メトホルミンを含む医薬組成物
US6403121B1 (en)	2000-05-01	2002-06-11	Aeropharm Technology Incorporated	Core formulation
US6451342B2 (en)	2000-05-01	2002-09-17	Aeropharm Technology Incorporated	Core formulation comprised of troglitazone and a biguanide
US6296874B1 (en)	2000-05-01	2001-10-02	Aeropharm Technology Incorporated	Core formulation comprising troglitazone and abiguanide
US6524621B2 (en)	2000-05-01	2003-02-25	Aeropharm Technology Inc.	Core formulation
US6780432B1 (en)	2000-05-01	2004-08-24	Aeropharm Technology, Inc.	Core formulation
US6461639B2 (en)	2000-05-01	2002-10-08	Aeropharm Technology, Inc.	Core formulation
GB0318824D0 (en)	2003-08-11	2003-09-10	Glaxo Group Ltd	Novel composition

2000
- 2000-11-15 MY MYPI20005360A patent/MY125516A/en unknown
- 2000-11-15 AR ARP000106019A patent/AR030920A1/es active IP Right Grant
- 2000-11-16 EA EA200200571A patent/EA004878B1/ru not_active IP Right Cessation
- 2000-11-16 DE DE60019329T patent/DE60019329T2/de not_active Expired - Lifetime
- 2000-11-16 WO PCT/GB2000/004368 patent/WO2001035941A2/en not_active Ceased
- 2000-11-16 ME MEP-2008-340A patent/ME00318B/me unknown
- 2000-11-16 EP EP07120386A patent/EP1913945A3/en not_active Withdrawn
- 2000-11-16 NZ NZ518946A patent/NZ518946A/en not_active IP Right Cessation
- 2000-11-16 HU HU0204122A patent/HU229960B1/hu unknown
- 2000-11-16 EP EP00976156A patent/EP1231918B1/en not_active Expired - Lifetime
- 2000-11-16 AP APAP/P/2002/002505A patent/AP1389A/en active
- 2000-11-16 DZ DZ003251A patent/DZ3251A1/fr active
- 2000-11-16 UA UA2002064826A patent/UA73150C2/uk unknown
- 2000-11-16 HR HR20020416A patent/HRP20020416B1/xx not_active IP Right Cessation
- 2000-11-16 KR KR1020027006271A patent/KR100760063B1/ko not_active Expired - Lifetime
- 2000-11-16 PT PT00976156T patent/PT1231918E/pt unknown
- 2000-11-16 SK SK679-2002A patent/SK286985B6/sk not_active IP Right Cessation
- 2000-11-16 PE PE2000001226A patent/PE20011011A1/es not_active Application Discontinuation
- 2000-11-16 SI SI200030697T patent/SI1231918T1/xx unknown
- 2000-11-16 RS YUP-388/02A patent/RS51343B/sr unknown
- 2000-11-16 MX MXPA02005005A patent/MXPA02005005A/es active IP Right Grant
- 2000-11-16 AU AU14040/01A patent/AU775654B2/en not_active Expired
- 2000-11-16 CN CNB008178224A patent/CN1222290C/zh not_active Expired - Lifetime
- 2000-11-16 UY UY26439A patent/UY26439A1/es not_active IP Right Cessation
- 2000-11-16 CA CA002388846A patent/CA2388846A1/en not_active Abandoned
- 2000-11-16 OA OA1200200145A patent/OA12513A/en unknown
- 2000-11-16 EP EP04078538A patent/EP1520581A1/en not_active Withdrawn
- 2000-11-16 AT AT00976156T patent/ATE292466T1/de active
- 2000-11-16 PL PL355331A patent/PL200943B1/pl unknown
- 2000-11-16 BR BR0015605-1A patent/BR0015605A/pt not_active Application Discontinuation
- 2000-11-16 DK DK00976156T patent/DK1231918T3/da active
- 2000-11-16 CZ CZ20021679A patent/CZ302500B6/cs not_active IP Right Cessation
- 2000-11-16 IL IL14961800A patent/IL149618A0/xx unknown
- 2000-11-16 ES ES00976156T patent/ES2240199T3/es not_active Expired - Lifetime
- 2000-11-16 JP JP2001537934A patent/JP4865975B2/ja not_active Expired - Lifetime
- 2000-11-16 HK HK03100745.5A patent/HK1049788B/en not_active IP Right Cessation
- 2000-11-20 CO CO00088045A patent/CO5300392A1/es not_active Application Discontinuation
- 2000-12-04 TW TW089125730A patent/TWI240626B/zh not_active IP Right Cessation
2002
- 2002-05-13 IL IL149618A patent/IL149618A/en unknown
- 2002-05-15 MA MA26640A patent/MA25567A1/fr unknown
- 2002-05-15 NO NO20022334A patent/NO329926B1/no not_active IP Right Cessation
- 2002-05-29 BG BG106747A patent/BG65616B1/bg unknown
2004
- 2004-11-04 AU AU2004226955A patent/AU2004226955B2/en not_active Expired
2006
- 2006-12-05 AR ARP060105370A patent/AR057970A2/es active IP Right Grant
2007
- 2007-07-18 US US11/779,546 patent/US8236345B2/en not_active Expired - Fee Related
2008
- 2008-03-17 IL IL190220A patent/IL190220A0/en unknown
- 2008-08-18 AU AU2008207375A patent/AU2008207375A1/en not_active Abandoned
2011
- 2011-08-11 JP JP2011175883A patent/JP5282130B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
NZ518946A (en)	2003-10-31
DK1231918T3 (da)	2005-08-01
BR0015605A (pt)	2002-07-09
NO20022334L (no)	2002-07-09
NO20022334D0 (no)	2002-05-15
US20070275054A1 (en)	2007-11-29
AR057970A2 (es)	2007-12-26
AP1389A (en)	2005-04-14
ATE292466T1 (de)	2005-04-15
AU2004226955B2 (en)	2008-08-28
HRP20020416B1 (hr)	2011-04-30
JP2003514012A (ja)	2003-04-15
MA25567A1 (fr)	2002-10-01
MXPA02005005A (es)	2003-10-14
ME00318B (me)	2011-05-10
UY26439A1 (es)	2001-07-31
SK6792002A3 (en)	2002-09-10
TWI240626B (en)	2005-10-01
EP1520581A1 (en)	2005-04-06
EP1913945A3 (en)	2008-04-30
MEP34008A (en)	2011-02-10
WO2001035941A2 (en)	2001-05-25
EA200200571A1 (ru)	2002-12-26
DZ3251A1 (fr)	2001-05-25
DE60019329T2 (de)	2006-03-09
JP2011252007A (ja)	2011-12-15
CN1222290C (zh)	2005-10-12
EP1231918B1 (en)	2005-04-06
EP1231918A2 (en)	2002-08-21
SI1231918T1 (en)	2005-08-31
OA12513A (en)	2006-05-29
CO5300392A1 (es)	2003-07-31
EP1913945A2 (en)	2008-04-23
ES2240199T3 (es)	2005-10-16
HK1049788B (en)	2005-11-04
YU38802A (sh)	2005-03-15
AU1404001A (en)	2001-05-30
KR100760063B1 (ko)	2007-09-18
WO2001035941A3 (en)	2002-05-23
AP2002002505A0 (en)	2002-06-30
US8236345B2 (en)	2012-08-07
MY125516A (en)	2006-08-30
JP4865975B2 (ja)	2012-02-01
AU2004226955A1 (en)	2004-12-02
PL200943B1 (pl)	2009-02-27
AR030920A1 (es)	2003-09-03
HUP0204122A3 (en)	2006-01-30
UA73150C2 (uk)	2005-06-15
CN1414852A (zh)	2003-04-30
PT1231918E (pt)	2005-08-31
AU2008207375A1 (en)	2008-09-11
RS51343B (sr)	2011-02-28
PE20011011A1 (es)	2001-10-28
WO2001035941A8 (en)	2002-08-29
CZ302500B6 (cs)	2011-06-22
IL149618A (en)	2008-07-08
JP5282130B2 (ja)	2013-09-04
DE60019329D1 (de)	2005-05-12
BG65616B1 (bg)	2009-03-31
HUP0204122A2 (hu)	2003-03-28
KR20030019300A (ko)	2003-03-06
CA2388846A1 (en)	2001-05-25
BG106747A (en)	2003-01-31
HK1049788A1 (en)	2003-05-30
IL149618A0 (en)	2002-12-01
SK286985B6 (sk)	2009-08-06
EA004878B1 (ru)	2004-08-26
AU775654B2 (en)	2004-08-12
IL190220A0 (en)	2008-11-03
NO329926B1 (no)	2011-01-24
HU229960B1 (hu)	2015-03-30
HRP20020416A2 (en)	2004-08-31

Publication	Publication Date	Title
MXPA02005005A (es)	2003-10-14	Nueva composicion y uso.
ATE312080T1 (de)	2005-12-15	2-chinolonen enthaltende arzneimittel
HUP0203973A3 (en)	2004-07-28	Heterocyclic compounds having sulfonamide groups, pharmaceutical compositions containing them and their use
GEP20074099B (en)	2007-05-10	3-β-D-RIBOFURANO-SYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF
IL172695A0 (en)	2006-04-10	Novel medicament compositions, based on anticholinergically effective compounds and beta-mimetics
SI1572707T1 (sl)	2006-08-31	Novi aromatski fluorglikozidni derivati, farmacevtski proizvodi, ki vsebujejo te spojine, in njihova uporaba
ZA200203368B (en)	2003-09-02	Pharmaceutical composition comprising a combination of metformin and glibenclamide.
EP1405859A4 (en)	2008-01-23	NITROGENIC HETEROCYCLIC DERIVATIVE, MEDICAL COMPOSITION, MEDICAL USE AND INTERMEDIATE PRODUCTS CONTAINING THEREOF
PL347471A1 (en)	2002-04-08	Novel n-(iminomethyl)amine derivatives, their preparation, their use as medicines and compositions containing them
EP1595543A3 (en)	2006-08-02	Antineoplastic pharmaceutical compositions comprising taurolidine or taurultam and 5-fluorouracil
WO2001035940A3 (en)	2002-03-21	Pharmaceutical composition comprising a thiazolidinedione-metformin hydrochloride
AU4796700A (en)	2000-12-05	Ureido-substituted cyclic amine derivatives and their use as drug
ZA985392B (en)	1999-01-20	New derivatives of 2-(iminomethyl) amino-phenyl, their preparation their use as medicaments and the pharmaceutical compositions containing them
HUP0200996A3 (en)	2003-01-28	Amine derivatives, pharmaceutical compositions containing them and their use
HRP20040171A2 (en)	2004-10-31	Combined preparations, containing 1,4-benzothiepine-1,1-dioxide derivatives and other active substances, and the use thereof
WO2002067865A3 (en)	2003-03-20	N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof
HUP0200121A3 (en)	2002-11-28	Calcilytic compounds, pharmaceutical compositions containing them and their use
IL137365A0 (en)	2001-07-24	Heteroaryl-substituted pyrrole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
HUP0204360A3 (en)	2005-04-28	Substituted norbornylamino derivatives, method for the production thereof, use thereof as a medicament and medicaments containing said compounds
HUP0300295A3 (en)	2006-01-30	Substituted benzamide derivatives, pharmaceutical compositions containing them and their use
AU1650501A (en)	2001-06-12	1,3,4-oxadiazoline derivatives and drugs containing these derivatives as the active ingredient
IL162385A (en)	2010-06-30	Benzothiazole - and benzoxazole - 4,7 - dione derivatives, uses thereof for the preparation of a medicament, medicaments containing them and pharmaceutical compositions containing them
ES2191908T3 (es)	2003-09-16	4-aminopirrol(3,2-d)pirimidinas como antagonistas del receptor del neuropeptido.
EP1234834A4 (en)	2003-01-29	1,3,4-OXADIAZOLINE-2-ONE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING SUCH DERIVATIVES USEFUL AS ACTIVE INGREDIENT
HUP0204149A3 (en)	2005-04-28	New sulfonyl oxazole amine derivatives, pharmaceutical compositions containing them and process for preparation the compounds