PL358103A1 - Hydrofilowe molekularne roztwory dyspersyjne karwedilolu - Google Patents

Hydrofilowe molekularne roztwory dyspersyjne karwedilolu

Info

Publication number: PL358103A1
Authority: PL; Poland
Prior art keywords: carvedilol; molecular dispersion; hydrophilic molecular; dispersion solutions; pharmaceutically acceptable
Prior art date: 2000-04-03

Application number

PL01358103A

Other languages

English (en)

Inventor

Rolf-Dieter Gabel

Alexander Wirl

Walter Preis

Guenter Neugebauer

Original Assignee

F.Hoffmann-La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-03

Filing date

2001-03-28

Publication date

2004-08-09

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8168348&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL358103(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-03-28 Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag

2004-08-09 Publication of PL358103A1 publication Critical patent/PL358103A1/pl

Links

NPAKNKYSJIDKMW-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=NC3=CC=C[CH]C3=C12 NPAKNKYSJIDKMW-UHFFFAOYSA-N 0.000 title abstract 2
229960004195 carvedilol Drugs 0.000 title abstract 2
239000006185 dispersion Substances 0.000 title abstract 2
239000000203 mixture Substances 0.000 abstract 2
206010002383 Angina Pectoris Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Organic Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

PL01358103A 2000-04-03 2001-03-28 Hydrofilowe molekularne roztwory dyspersyjne karwedilolu PL358103A1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00107093		2000-04-03
PCT/EP2001/003502 WO2001074357A1 (en)	2000-04-03	2001-03-28	Hydrophilic molecular disperse solutions of carvedilol

Publications (1)

Publication Number	Publication Date
PL358103A1 true PL358103A1 (pl)	2004-08-09

Family

ID=8168348

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL01358103A PL358103A1 (pl)	2000-04-03	2001-03-28	Hydrofilowe molekularne roztwory dyspersyjne karwedilolu

Country Status (24)

Country	Link
US (3)	US20010036959A1 (pl)
EP (1)	EP1272179B1 (pl)
JP (1)	JP2003528915A (pl)
KR (1)	KR100478793B1 (pl)
CN (1)	CN1189171C (pl)
AR (1)	AR029825A1 (pl)
AT (1)	ATE450257T1 (pl)
AU (2)	AU2001256227B2 (pl)
BR (1)	BR0109779A (pl)
CA (1)	CA2401910C (pl)
CZ (1)	CZ20023625A3 (pl)
DE (1)	DE60140662D1 (pl)
HR (1)	HRP20020777A2 (pl)
HU (1)	HUP0300342A3 (pl)
IL (1)	IL151642A0 (pl)
MA (1)	MA26888A1 (pl)
MX (1)	MXPA02009725A (pl)
NO (1)	NO20024733L (pl)
NZ (1)	NZ521232A (pl)
PL (1)	PL358103A1 (pl)
RU (1)	RU2248204C2 (pl)
WO (1)	WO2001074357A1 (pl)
YU (1)	YU72602A (pl)
ZA (1)	ZA200207304B (pl)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4533531B2 (ja) *	1998-04-03	2010-09-01	ビーエムリサーチエイ／エス	制御放出組成物
US20040234602A1 (en)	2001-09-21	2004-11-25	Gina Fischer	Polymer release system
EP1429744A1 (en) *	2001-09-21	2004-06-23	Egalet A/S	Morphine polymer release system
WO2003024426A1 (en) *	2001-09-21	2003-03-27	Egalet A/S	Controlled release solid dispersions
KR100752549B1 (ko) *	2001-09-28	2007-08-30	에프. 호프만-라 로슈 아게	카르베딜올의 유사다형태
US8101209B2 (en)	2001-10-09	2012-01-24	Flamel Technologies	Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
AR038681A1 (es) *	2002-02-14	2005-01-26	Solvay Pharm Bv	Formulacion oral de solucion solida de una sustancia activa pobremente soluble en agua
EP1499310A4 (en) *	2002-04-30	2005-12-07	Sb Pharmco Inc	MONOCITRATE MONOHYDRATE OF CARVEDILOL
WO2003092625A2 (en) *	2002-05-03	2003-11-13	Smithkline Beecham Pharmco Puerto Rico, Inc.	Carvedilol formulations
JP2005533822A (ja) *	2002-06-27	2005-11-10	エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド	臭化水素酸カルベジロール
MXPA04012923A (es) *	2002-06-27	2005-03-31	Sb Pharmco Inc	Sales de fosfato de carvedilol y/o solvatos de las mismas, composiciones correspondientes y/o metodos de tratamiento.
EP1562552A1 (en) *	2002-11-08	2005-08-17	Egalet A/S	Controlled release carvedilol compositions
US7423004B2 (en)	2003-01-31	2008-09-09	Smithkline Beecham Corporation	Solid dispersion compositions
WO2004084868A1 (en) *	2003-03-26	2004-10-07	Egalet A/S	Morphine controlled release system
ATE454886T1 (de) *	2003-03-26	2010-01-15	Egalet As	Matrixzubereitungen für die kontrollierte darreichung von arzneistoffen
EP1641437A4 (en) *	2003-07-09	2009-06-03	Chong Kun Dang Pharm Corp	SOLID DISPERSION OF TACROLIMUS
WO2005020993A1 (en)	2003-08-29	2005-03-10	Lifecycle Pharma A/S	Modified release compositions comprising tacrolimus
US8591946B2 (en) *	2003-08-29	2013-11-26	Veloxis Pharmaceuticals A/S	Modified release compositions comprising tacrolimus
CA2547137A1 (en) *	2003-11-25	2005-06-09	Sb Pharmco Puerto Rico Inc.	Carvedilol free base, salts, anhydrous forms or solvates thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods
JP2007512372A (ja) *	2003-11-25	2007-05-17	エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド	カルベジロール塩、対応する組成物、送達および／または治療方法
EP1686967A4 (en) *	2003-11-25	2012-08-08	Smithkline Beecham Cork Ltd	CARVEDILOL-FREE BASE, SALTS, WATER-FREE FORMS OR SOLVATES THEREOF, CORRESPONDING PHARMACEUTICAL COMPOSITIONS, CONTROLLED RELEASE FORMULAS AND TREATMENT OR DISPOSAL PROCEDURES
JP2007517016A (ja) *	2003-12-31	2007-06-28	ファイザー・プロダクツ・インク	低溶解性薬剤及びポロキサマーの固体組成物
ATE500819T1 (de) *	2003-12-31	2011-03-15	Bend Res Inc	Stabilisierte pharmazeutische feste zusammensetzungen von arzneimitteln mit geringer löslichkeit, poloxameren und stabilisierenden polymeren
CA2611081C (en) *	2005-06-03	2016-05-31	Egalet A/S	A drug delivery system for delivering active substances dispersed in a dispersion medium
US8367112B2 (en) *	2006-02-28	2013-02-05	Alkermes Pharma Ireland Limited	Nanoparticulate carverdilol formulations
US20090028935A1 (en) *	2006-12-01	2009-01-29	Kristin Arnold	Carvedilol forms, compositions, and methods of preparation thereof
US20080292695A1 (en) *	2006-12-01	2008-11-27	Kristin Arnold	Carvedilol forms, compositions, and methods of preparation thereof
US20080138404A1 (en) *	2006-12-06	2008-06-12	Biovail Laboratories International S.R.L.	Extended release formulations of carvedilol
NZ577560A (en) *	2007-01-16	2012-01-12	Egalet Ltd	Use of i) a polyglycol and ii) an active drug substance for the preparation of a pharmaceutical composition for i) mitigating the risk of alcohol induced dose dumping and/or ii) reducing the risk of drug abuse
BRPI0701904A2 (pt) *	2007-04-27	2008-12-09	Libbs Farmaceutica Ltda	forma farmacÊutica de liberaÇço controlada de princÍpios ativos com solubilidade dependente do baixo ph do meio e processo para preparar a forma farmacÊutica
EP2155167A2 (en)	2007-06-04	2010-02-24	Egalet A/S	Controlled release pharmaceutical compositions for prolonged effect
ATE539769T1 (de) *	2008-03-04	2012-01-15	Lupin Ltd	Stabile pharmazeutische zusammensetzungen mit carvedilol
ES2330404B1 (es) *	2008-05-19	2010-09-22	Universidad De Barcelona	Solucion acuosa para la preservacion de tejidos y organos.
NZ594207A (en)	2009-02-06	2013-03-28	Egalet Ltd	Immediate release composition resistant to abuse by intake of alcohol
NZ597283A (en)	2009-06-24	2013-07-26	Egalet Ltd	Controlled release formulations
WO2011154009A1 (en) *	2010-06-10	2011-12-15	Lifecycle Pharma A/S	Composition comprising an active principle in an amorphous form and a porous adsorbent material
BR112015000150A2 (pt)	2012-07-06	2017-06-27	Egalet Ltd	composições farmacêuticas dissuasoras de abuso de liberação controlada
KR102158339B1 (ko)	2016-02-05	2020-09-21	삼진제약주식회사	인습성이 개선된 카르베딜롤 속방성 제제

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2815926A1 (de) *	1978-04-13	1979-10-18	Boehringer Mannheim Gmbh	Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3319027A1 (de) *	1983-05-26	1984-11-29	Boehringer Mannheim Gmbh, 6800 Mannheim	Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten
US5258185A (en) *	1989-08-23	1993-11-02	Bauer Kurt H	Highly active, rapidly absorbable formulations of glibenclamide, processes for the production thereof and their use
US5281420A (en) *	1992-05-19	1994-01-25	The Procter & Gamble Company	Solid dispersion compositions of tebufelone
US5760069A (en) *	1995-02-08	1998-06-02	Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1	Method of treatment for decreasing mortality resulting from congestive heart failure
GB9514473D0 (en) *	1995-07-14	1995-09-13	Glaxo Lab Sa	Chemical compounds
DE19637082A1 (de) *	1996-09-12	1998-03-19	Boehringer Mannheim Gmbh	Schnellzerfallende Pellets
IL131713A (en) *	1997-03-11	2004-08-31	Arakis Ltd	Dosage forms comprising separate portions of r- and s-enantiomers
DE19809242A1 (de) *	1998-03-05	1999-09-09	Basf Ag	Verfahren zur Herstellung von festen, sphärischen Formkörpern, enthaltend pharmazeutische Wirkstoffe in einer Bindemittelmatrix
US6852337B2 (en) *	1998-04-09	2005-02-08	Roche Diagnostics Gmbh	Carvedilol-galenics
DE19816036A1 (de) *	1998-04-09	1999-10-14	Roche Diagnostics Gmbh	Verfahren zur Herstellung schnellauflösender pharmazeutischer Zubereitungen von schwerlöslichen Wirkstoffen
US6664284B2 (en) *	1998-07-23	2003-12-16	Roche Diagnostics Gmbh	Stabilized carvedilol injection solution
US6395300B1 (en) *	1999-05-27	2002-05-28	Acusphere, Inc.	Porous drug matrices and methods of manufacture thereof
MXPA04006909A (es) *	2002-01-15	2005-04-19	Teva Pharma	Solidos cristalinos de carvedilol y procesos para su preparacion.

2001
- 2001-03-26 US US09/817,308 patent/US20010036959A1/en not_active Abandoned
- 2001-03-28 MX MXPA02009725A patent/MXPA02009725A/es active IP Right Grant
- 2001-03-28 DE DE60140662T patent/DE60140662D1/de not_active Expired - Fee Related
- 2001-03-28 PL PL01358103A patent/PL358103A1/pl not_active Application Discontinuation
- 2001-03-28 KR KR10-2002-7013230A patent/KR100478793B1/ko not_active Expired - Fee Related
- 2001-03-28 CN CNB018074278A patent/CN1189171C/zh not_active Expired - Fee Related
- 2001-03-28 AT AT01929462T patent/ATE450257T1/de not_active IP Right Cessation
- 2001-03-28 NZ NZ521232A patent/NZ521232A/en unknown
- 2001-03-28 HU HU0300342A patent/HUP0300342A3/hu unknown
- 2001-03-28 YU YU72602A patent/YU72602A/sh unknown
- 2001-03-28 CZ CZ20023625A patent/CZ20023625A3/cs unknown
- 2001-03-28 EP EP01929462A patent/EP1272179B1/en not_active Revoked
- 2001-03-28 CA CA002401910A patent/CA2401910C/en not_active Expired - Fee Related
- 2001-03-28 AU AU2001256227A patent/AU2001256227B2/en not_active Ceased
- 2001-03-28 HR HRP20020777 patent/HRP20020777A2/hr not_active Application Discontinuation
- 2001-03-28 IL IL15164201A patent/IL151642A0/xx unknown
- 2001-03-28 AU AU5622701A patent/AU5622701A/xx active Pending
- 2001-03-28 JP JP2001572101A patent/JP2003528915A/ja not_active Ceased
- 2001-03-28 RU RU2002129571/15A patent/RU2248204C2/ru not_active IP Right Cessation
- 2001-03-28 BR BR0109779-2A patent/BR0109779A/pt not_active Application Discontinuation
- 2001-03-28 WO PCT/EP2001/003502 patent/WO2001074357A1/en not_active Ceased
- 2001-03-30 AR ARP010101538A patent/AR029825A1/es not_active Application Discontinuation
2002
- 2002-08-08 US US10/214,697 patent/US20030004205A1/en not_active Abandoned
- 2002-09-11 ZA ZA200207304A patent/ZA200207304B/en unknown
- 2002-10-01 MA MA26845A patent/MA26888A1/fr unknown
- 2002-10-02 NO NO20024733A patent/NO20024733L/no unknown
2005
- 2005-08-16 US US11/204,614 patent/US20050271721A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN1189171C (zh)	2005-02-16
RU2248204C2 (ru)	2005-03-20
NO20024733D0 (no)	2002-10-02
CN1420771A (zh)	2003-05-28
AU5622701A (en)	2001-10-15
NO20024733L (no)	2002-10-02
EP1272179B1 (en)	2009-12-02
YU72602A (sh)	2005-03-15
CA2401910C (en)	2008-04-15
ZA200207304B (en)	2003-12-11
RU2002129571A (ru)	2004-03-27
WO2001074357A1 (en)	2001-10-11
AR029825A1 (es)	2003-07-16
US20050271721A1 (en)	2005-12-08
JP2003528915A (ja)	2003-09-30
HUP0300342A2 (hu)	2003-06-28
HUP0300342A3 (en)	2005-07-28
MA26888A1 (fr)	2004-12-20
EP1272179A1 (en)	2003-01-08
US20030004205A1 (en)	2003-01-02
IL151642A0 (en)	2003-04-10
CZ20023625A3 (cs)	2003-04-16
KR100478793B1 (ko)	2005-03-24
NZ521232A (en)	2004-05-28
HRP20020777A2 (en)	2004-12-31
US20010036959A1 (en)	2001-11-01
CA2401910A1 (en)	2001-10-11
MXPA02009725A (es)	2003-03-27
BR0109779A (pt)	2003-01-21
ATE450257T1 (de)	2009-12-15
DE60140662D1 (de)	2010-01-14
KR20030019339A (ko)	2003-03-06
AU2001256227B2 (en)	2005-09-01

Legal Events

Date	Code	Title	Description
2009-01-30	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
PL358103A1 (pl)	2004-08-09	Hydrofilowe molekularne roztwory dyspersyjne karwedilolu
CA2402336A1 (en)	2001-10-11	Concentrated solutions of carvedilol
NO20052739L (no)	2005-08-19	CCR5-antagonister som medikamenter
DE69713148D1 (de)	2002-07-11	Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen
DE69713152D1 (de)	2002-07-11	Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen
EA200401009A1 (ru)	2004-12-30	Предварительно желатинированный крахмал в композиции с контролируемым высвобождением
CY1109861T1 (el)	2014-09-10	Διαδερμικο θεραπευτικο συστημα για την ασθενεια του παρκινσον που προκαλει υψηλα επιπεδα πλασματος της ροτιγοτινης
CY1105648T1 (el)	2010-12-22	Filbanserin για την θεραπεια εξτραπυραμιδικων διαταραχων κινησης
EA200301165A1 (ru)	2004-06-24	Лекарственное средство на основе оксикодона
BR0008059A (pt)	2002-03-26	Composições de valdecoxib
HUP9802221A2 (hu)	1999-02-01	Parazitaellenes hatású markfortin- és paraherkvamidszármazékok
TR200101470T2 (tr)	2001-11-21	Farmasötik bileşim terkipleri.
ATE218581T1 (de)	2002-06-15	Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung
TR200401793T4 (tr)	2004-08-23	Perindopril tuzu ve bunu içeren farmasötik bileşimler.
BRPI0008228B8 (pt)	2021-05-25	composição farmacêutica contendo n-benzoil estaurosporina e agentes solubilizantes
ES2130081B1 (es)	2000-01-01	Comprimido de maleato de trimebutina con recubrimiento laminar.
SE0102440D0 (sv)	2001-07-05	New compound
DE60102590T2 (de)	2005-04-21	Darreichungsformen zur behandlung von oralen mykosen
BR0114395A (pt)	2005-08-16	Composição farmacêutica para administração por suprimento via oral
AU2002358819A1 (en)	2003-06-17	Aqueous base liquid pharmaceutical compositions in suspension form for the oral administration of ibuprofen
SE0001916D0 (sv)	2000-05-23	Novel formulation
RU96120655A (ru)	1998-12-10	Композиция для профилактики и лечения гриппа и орви
EP1411956B8 (en)	2005-10-05	Use of oversulfated polysaccharides as inhibitors of hiv
BR0116554A (pt)	2004-02-03	Composto, composição farmacêutica para o tratamento da angina ou hipertensão, processo, processo para o tratamento ou prevenção da angina ou hipertensão, composição do ingrediente farmaceuticamente ativo e composição farmacêutica para o tratamento ou prevenção da angina ou hipertensão
MXPA04005033A (es)	2004-08-11	Composicion farmaceutica que comprende una combinacion de metformina y acido 4-oxobutanoico y el uso de la misma para el tratamiento contra diabetes.