PL358103A1 - Hydrofilowe molekularne roztwory dyspersyjne karwedilolu - Google Patents

Hydrofilowe molekularne roztwory dyspersyjne karwedilolu

Info

Publication number: PL358103A1
Authority: PL; Poland
Prior art keywords: carvedilol; molecular dispersion; hydrophilic molecular; dispersion solutions; pharmaceutically acceptable
Prior art date: 2000-04-03

Application number

PL01358103A

Other languages

English (en)

Inventor

Rolf-Dieter Gabel

Alexander Wirl

Walter Preis

Guenter Neugebauer

Original Assignee

F.Hoffmann-La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-03

Filing date

2001-03-28

Publication date

2004-08-09

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8168348&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL358103(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-03-28 Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag

2004-08-09 Publication of PL358103A1 publication Critical patent/PL358103A1/pl

Links

NPAKNKYSJIDKMW-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=NC3=CC=C[CH]C3=C12 NPAKNKYSJIDKMW-UHFFFAOYSA-N 0.000 title abstract 2
229960004195 carvedilol Drugs 0.000 title abstract 2
239000006185 dispersion Substances 0.000 title abstract 2
239000000203 mixture Substances 0.000 abstract 2
206010002383 Angina Pectoris Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

PL01358103A 2000-04-03 2001-03-28 Hydrofilowe molekularne roztwory dyspersyjne karwedilolu PL358103A1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00107093		2000-04-03
PCT/EP2001/003502 WO2001074357A1 (en)	2000-04-03	2001-03-28	Hydrophilic molecular disperse solutions of carvedilol

Publications (1)

Publication Number	Publication Date
PL358103A1 true PL358103A1 (pl)	2004-08-09

Family

ID=8168348

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL01358103A PL358103A1 (pl)	2000-04-03	2001-03-28	Hydrofilowe molekularne roztwory dyspersyjne karwedilolu

Country Status (24)

Country	Link
US (3)	US20010036959A1 (pl)
EP (1)	EP1272179B1 (pl)
JP (1)	JP2003528915A (pl)
KR (1)	KR100478793B1 (pl)
CN (1)	CN1189171C (pl)
AR (1)	AR029825A1 (pl)
AT (1)	ATE450257T1 (pl)
AU (2)	AU5622701A (pl)
BR (1)	BR0109779A (pl)
CA (1)	CA2401910C (pl)
CZ (1)	CZ20023625A3 (pl)
DE (1)	DE60140662D1 (pl)
HR (1)	HRP20020777A2 (pl)
HU (1)	HUP0300342A3 (pl)
IL (1)	IL151642A0 (pl)
MA (1)	MA26888A1 (pl)
MX (1)	MXPA02009725A (pl)
NO (1)	NO20024733D0 (pl)
NZ (1)	NZ521232A (pl)
PL (1)	PL358103A1 (pl)
RU (1)	RU2248204C2 (pl)
WO (1)	WO2001074357A1 (pl)
YU (1)	YU72602A (pl)
ZA (1)	ZA200207304B (pl)

Families Citing this family (38)

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DK1067910T3 (da) *	1998-04-03	2004-10-04	Egalet As	Komposition med styret afgivelse
US20050019399A1 (en) *	2001-09-21	2005-01-27	Gina Fischer	Controlled release solid dispersions
US20040253310A1 (en)	2001-09-21	2004-12-16	Gina Fischer	Morphine polymer release system
WO2003024429A1 (en) *	2001-09-21	2003-03-27	Egalet A/S	Polymer release system
PL370412A1 (pl) *	2001-09-28	2005-05-30	F.Hoffmann-La Roche Ag	Pseudopolimorficzne postacie karwedilolu
US8101209B2 (en)	2001-10-09	2012-01-24	Flamel Technologies	Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
AR038681A1 (es) *	2002-02-14	2005-01-26	Solvay Pharm Bv	Formulacion oral de solucion solida de una sustancia activa pobremente soluble en agua
JP2006500320A (ja) *	2002-04-30	2006-01-05	エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド	カルベジロール一クエン酸塩一水和物
JP2005524701A (ja) *	2002-05-03	2005-08-18	エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド	カルベジロール処方
CA2492084A1 (en) *	2002-06-27	2004-01-08	Sb Pharmco Puerto Rico Inc.	Carvedilol hydobromide
BR0312102A (pt) *	2002-06-27	2007-05-29	Sb Pharmco Inc	sais de fosfato de carvedilol e/ou seus solvatos, composições correspondentes, e/ou métodos de tratamento
WO2004041252A1 (en) *	2002-11-08	2004-05-21	Egalet A/S	Controlled release carvedilol compositions
JP2006518380A (ja)	2003-01-31	2006-08-10	スミスクライン・ビーチャム・コーポレイション	固体分散体組成物
US8877241B2 (en) *	2003-03-26	2014-11-04	Egalet Ltd.	Morphine controlled release system
DE602004014747D1 (de) *	2003-03-26	2008-08-14	Egalet As	Matrixzubereitungen für die kontrollierte darreichung von arzneistoffen
BRPI0412329A (pt) *	2003-07-09	2006-09-05	Chong Kun Dang Pharm Corp	dispersão sólida de tacrolimus e método de processar a mesma
ES2376238T3 (es) *	2003-08-29	2012-03-12	Veloxis Pharmaceuticals A/S	Composiciones de liberación modificada comprendiendo tacrolimus.
US7994214B2 (en) *	2003-08-29	2011-08-09	Lifecycle Pharma A/S	Solid dispersions comprising tacrolimus
EP1686967A4 (en) *	2003-11-25	2012-08-08	Smithkline Beecham Cork Ltd	CARVEDILOL-FREE BASE, SALTS, WATER-FREE FORMS OR SOLVATES THEREOF, CORRESPONDING PHARMACEUTICAL COMPOSITIONS, CONTROLLED RELEASE FORMULAS AND TREATMENT OR DISPOSAL PROCEDURES
JP2007512372A (ja) *	2003-11-25	2007-05-17	エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド	カルベジロール塩、対応する組成物、送達および／または治療方法
JP5072364B2 (ja) *	2003-11-25	2012-11-14	スミスクラインビーチャム（コーク）リミテッド	カルベジロール遊離塩基、カルベジロール塩、無水形態またはその溶媒和物、対応する医薬組成物、制御放出処方および治療またはデリバリー方法
EP1701704A2 (en) *	2003-12-31	2006-09-20	Pfizer Products Inc.	Solid compositions of low-solubility drugs and poloxamers
US20070148232A1 (en) *	2003-12-31	2007-06-28	Pfizer Inc.	Stabilized pharmaceutical solid compositions of low-solubility drugs and poloxamers, and stabilizing polymers
NZ563846A (en) *	2005-06-03	2010-03-26	Egalet As	A drug delivery system for delivering active substances dispersed in a dispersion medium
US8367112B2 (en) *	2006-02-28	2013-02-05	Alkermes Pharma Ireland Limited	Nanoparticulate carverdilol formulations
US20090028935A1 (en) *	2006-12-01	2009-01-29	Kristin Arnold	Carvedilol forms, compositions, and methods of preparation thereof
WO2008070072A2 (en) *	2006-12-01	2008-06-12	Mutual Pharmaceutical Company, Inc.	Carvedilol forms, compositions, and methods of preparation thereof
US20080138404A1 (en) *	2006-12-06	2008-06-12	Biovail Laboratories International S.R.L.	Extended release formulations of carvedilol
EP2104493A2 (en) *	2007-01-16	2009-09-30	Egalet A/S	Use of i) a polyglycol and n) an active drug substance for the preparation of a pharmaceutical composition for i) mitigating the risk of alcohol induced dose dumping and/or ii) reducing the risk of drug abuse
BRPI0701904A2 (pt) *	2007-04-27	2008-12-09	Libbs Farmaceutica Ltda	forma farmacÊutica de liberaÇço controlada de princÍpios ativos com solubilidade dependente do baixo ph do meio e processo para preparar a forma farmacÊutica
US8821928B2 (en)	2007-06-04	2014-09-02	Egalet Ltd.	Controlled release pharmaceutical compositions for prolonged effect
EP2259801B1 (en)	2008-03-04	2012-01-04	Lupin Limited	Stable pharmaceutical compositions of carvedilol
ES2330404B1 (es) *	2008-05-19	2010-09-22	Universidad De Barcelona	Solucion acuosa para la preservacion de tejidos y organos.
NZ594207A (en)	2009-02-06	2013-03-28	Egalet Ltd	Immediate release composition resistant to abuse by intake of alcohol
AU2010265213B2 (en)	2009-06-24	2012-08-23	Egalet Ltd.	Controlled release formulations
WO2011154009A1 (en) *	2010-06-10	2011-12-15	Lifecycle Pharma A/S	Composition comprising an active principle in an amorphous form and a porous adsorbent material
JP2015521988A (ja)	2012-07-06	2015-08-03	イガレット・リミテッド	制御放出用乱用防止性医薬組成物
KR102158339B1 (ko)	2016-02-05	2020-09-21	삼진제약주식회사	인습성이 개선된 카르베딜롤 속방성 제제

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US5760069A (en) *	1995-02-08	1998-06-02	Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1	Method of treatment for decreasing mortality resulting from congestive heart failure
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DE19809242A1 (de) *	1998-03-05	1999-09-09	Basf Ag	Verfahren zur Herstellung von festen, sphärischen Formkörpern, enthaltend pharmazeutische Wirkstoffe in einer Bindemittelmatrix
DE19816036A1 (de) *	1998-04-09	1999-10-14	Roche Diagnostics Gmbh	Verfahren zur Herstellung schnellauflösender pharmazeutischer Zubereitungen von schwerlöslichen Wirkstoffen
US6852337B2 (en) *	1998-04-09	2005-02-08	Roche Diagnostics Gmbh	Carvedilol-galenics
US6664284B2 (en) *	1998-07-23	2003-12-16	Roche Diagnostics Gmbh	Stabilized carvedilol injection solution
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2001
- 2001-03-26 US US09/817,308 patent/US20010036959A1/en not_active Abandoned
- 2001-03-28 CN CNB018074278A patent/CN1189171C/zh not_active Expired - Fee Related
- 2001-03-28 KR KR10-2002-7013230A patent/KR100478793B1/ko not_active Expired - Fee Related
- 2001-03-28 AT AT01929462T patent/ATE450257T1/de not_active IP Right Cessation
- 2001-03-28 DE DE60140662T patent/DE60140662D1/de not_active Expired - Fee Related
- 2001-03-28 RU RU2002129571/15A patent/RU2248204C2/ru not_active IP Right Cessation
- 2001-03-28 HR HRP20020777 patent/HRP20020777A2/hr not_active Application Discontinuation
- 2001-03-28 CA CA002401910A patent/CA2401910C/en not_active Expired - Fee Related
- 2001-03-28 NZ NZ521232A patent/NZ521232A/en unknown
- 2001-03-28 WO PCT/EP2001/003502 patent/WO2001074357A1/en not_active Ceased
- 2001-03-28 AU AU5622701A patent/AU5622701A/xx active Pending
- 2001-03-28 BR BR0109779-2A patent/BR0109779A/pt not_active Application Discontinuation
- 2001-03-28 AU AU2001256227A patent/AU2001256227B2/en not_active Ceased
- 2001-03-28 PL PL01358103A patent/PL358103A1/pl not_active Application Discontinuation
- 2001-03-28 HU HU0300342A patent/HUP0300342A3/hu unknown
- 2001-03-28 EP EP01929462A patent/EP1272179B1/en not_active Revoked
- 2001-03-28 JP JP2001572101A patent/JP2003528915A/ja not_active Ceased
- 2001-03-28 YU YU72602A patent/YU72602A/sh unknown
- 2001-03-28 IL IL15164201A patent/IL151642A0/xx unknown
- 2001-03-28 MX MXPA02009725A patent/MXPA02009725A/es active IP Right Grant
- 2001-03-28 CZ CZ20023625A patent/CZ20023625A3/cs unknown
- 2001-03-30 AR ARP010101538A patent/AR029825A1/es not_active Application Discontinuation
2002
- 2002-08-08 US US10/214,697 patent/US20030004205A1/en not_active Abandoned
- 2002-09-11 ZA ZA200207304A patent/ZA200207304B/en unknown
- 2002-10-01 MA MA26845A patent/MA26888A1/fr unknown
- 2002-10-02 NO NO20024733A patent/NO20024733D0/no unknown
2005
- 2005-08-16 US US11/204,614 patent/US20050271721A1/en not_active Abandoned

Also Published As

Publication number	Publication date
KR100478793B1 (ko)	2005-03-24
EP1272179A1 (en)	2003-01-08
NO20024733L (no)	2002-10-02
HUP0300342A3 (en)	2005-07-28
HUP0300342A2 (hu)	2003-06-28
CN1420771A (zh)	2003-05-28
WO2001074357A1 (en)	2001-10-11
RU2248204C2 (ru)	2005-03-20
AU2001256227B2 (en)	2005-09-01
CA2401910A1 (en)	2001-10-11
US20050271721A1 (en)	2005-12-08
CN1189171C (zh)	2005-02-16
BR0109779A (pt)	2003-01-21
ZA200207304B (en)	2003-12-11
RU2002129571A (ru)	2004-03-27
MXPA02009725A (es)	2003-03-27
EP1272179B1 (en)	2009-12-02
HRP20020777A2 (en)	2004-12-31
CZ20023625A3 (cs)	2003-04-16
IL151642A0 (en)	2003-04-10
KR20030019339A (ko)	2003-03-06
JP2003528915A (ja)	2003-09-30
YU72602A (sh)	2005-03-15
NO20024733D0 (no)	2002-10-02
US20030004205A1 (en)	2003-01-02
NZ521232A (en)	2004-05-28
US20010036959A1 (en)	2001-11-01
ATE450257T1 (de)	2009-12-15
DE60140662D1 (de)	2010-01-14
AU5622701A (en)	2001-10-15
MA26888A1 (fr)	2004-12-20
CA2401910C (en)	2008-04-15
AR029825A1 (es)	2003-07-16

Legal Events

Date	Code	Title	Description
2009-01-30	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
NO20024733D0 (no)	2002-10-02	Hydrofile molekyl¶rdisperse lösninger av karvedilol
CA2402336A1 (en)	2001-10-11	Concentrated solutions of carvedilol
DE69713148D1 (de)	2002-07-11	Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen
DE69713152D1 (de)	2002-07-11	Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen
EA200401009A1 (ru)	2004-12-30	Предварительно желатинированный крахмал в композиции с контролируемым высвобождением
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