PL358155A1 - Bis-(N,N'-bis-(2-fluorowcoetylo) amino) fosforoamidy jako środki przeciw-nowotworowe - Google Patents

Bis-(N,N'-bis-(2-fluorowcoetylo) amino) fosforoamidy jako środki przeciw-nowotworowe

Info

Publication number: PL358155A1
Authority: PL; Poland
Prior art keywords: bis; haloethyl; phosphoramidates; amino; antitumor agents
Prior art date: 2000-05-02

Application number

PL01358155A

Other languages

English (en)

Other versions

PL207005B1 (pl

Inventor

R.Jason Herr

Robert T. Lum

Steven R. Schow

Fanying Meng

Michael R. Kozlowski

Pavel Zhichkin

Original Assignee

Telik, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-02

Filing date

2001-05-02

Publication date

2004-08-09

2001-05-02 Application filed by Telik, Inc. filed Critical Telik, Inc.

2004-08-09 Publication of PL358155A1 publication Critical patent/PL358155A1/pl

2010-10-29 Publication of PL207005B1 publication Critical patent/PL207005B1/pl

Links

239000002246 antineoplastic agent Substances 0.000 title 1
150000008298 phosphoramidates Chemical class 0.000 title 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PL358155A 2000-05-02 2001-05-02 Bis- (N,N'-bis-(2-fluorowcoetylo) amino) fosforoamidy, kompozycje farmaceutyczne zawierające te związki, sposoby wytwarzania tych związków, oraz ich zastosowanie do wytwarzania leku do leczenia nowotworów, zwłaszcza raka PL207005B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US56318100A	2000-05-02	2000-05-02
PCT/US2001/014290 WO2001083496A1 (en)	2000-05-02	2001-05-02	Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents

Publications (2)

Publication Number	Publication Date
PL358155A1 true PL358155A1 (pl)	2004-08-09
PL207005B1 PL207005B1 (pl)	2010-10-29

Family

ID=24249433

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL358155A PL207005B1 (pl)	2000-05-02	2001-05-02	Bis- (N,N'-bis-(2-fluorowcoetylo) amino) fosforoamidy, kompozycje farmaceutyczne zawierające te związki, sposoby wytwarzania tych związków, oraz ich zastosowanie do wytwarzania leku do leczenia nowotworów, zwłaszcza raka

Country Status (25)

Country	Link
EP (2)	EP1278759B1 (pl)
JP (1)	JP4249928B2 (pl)
KR (1)	KR100729980B1 (pl)
CN (1)	CN1182143C (pl)
AR (1)	AR029072A1 (pl)
AT (2)	ATE313549T1 (pl)
AU (2)	AU6115301A (pl)
BR (1)	BR0110553A (pl)
CA (1)	CA2407606C (pl)
CZ (1)	CZ20023615A3 (pl)
DE (2)	DE60116081T2 (pl)
DK (2)	DK1607399T3 (pl)
EA (1)	EA006852B1 (pl)
ES (2)	ES2337154T3 (pl)
HU (1)	HUP0300688A3 (pl)
IL (2)	IL152325A0 (pl)
MX (1)	MXPA02010813A (pl)
NO (2)	NO328854B1 (pl)
NZ (1)	NZ522189A (pl)
PL (1)	PL207005B1 (pl)
PT (1)	PT1607399E (pl)
TW (1)	TWI308569B (pl)
UA (1)	UA74574C2 (pl)
WO (1)	WO2001083496A1 (pl)
ZA (1)	ZA200208591B (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200600091A (en)	2004-05-21	2006-01-01	Telik Inc	Sulfonylethyl phosphorodiamidates
US8198247B2 (en)	2004-12-21	2012-06-12	Telik, Inc.	Process for and intermediates in the preparation of canfosfamide and its salts
US7655799B2 (en)	2006-11-29	2010-02-02	Telik, Inc.	2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en)	2007-12-12	2011-01-18	Telik, Inc.	2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
US9879267B2 (en) *	2008-03-14	2018-01-30	Genentech, Inc.	Genetic variations associated with drug resistance
CN118834240A (zh)	2019-05-13	2024-10-25	深圳艾欣达伟医药科技有限公司	含氟化合物及抗癌医药用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5556942A (en) *	1991-04-29	1996-09-17	Terrapin Technologies, Inc.	Glutathione S-transferase-activated compounds

2001
- 2001-02-05 UA UA2002119554A patent/UA74574C2/uk unknown
- 2001-05-01 TW TW090110381A patent/TWI308569B/zh not_active IP Right Cessation
- 2001-05-02 AT AT01935025T patent/ATE313549T1/de active
- 2001-05-02 CA CA002407606A patent/CA2407606C/en not_active Expired - Fee Related
- 2001-05-02 AR ARP010102067A patent/AR029072A1/es active IP Right Grant
- 2001-05-02 EP EP01935025A patent/EP1278759B1/en not_active Expired - Lifetime
- 2001-05-02 WO PCT/US2001/014290 patent/WO2001083496A1/en not_active Ceased
- 2001-05-02 KR KR1020027014577A patent/KR100729980B1/ko not_active Expired - Fee Related
- 2001-05-02 CZ CZ20023615A patent/CZ20023615A3/cs unknown
- 2001-05-02 ES ES05020467T patent/ES2337154T3/es not_active Expired - Lifetime
- 2001-05-02 DE DE60116081T patent/DE60116081T2/de not_active Expired - Lifetime
- 2001-05-02 AU AU6115301A patent/AU6115301A/xx active Pending
- 2001-05-02 MX MXPA02010813A patent/MXPA02010813A/es active IP Right Grant
- 2001-05-02 IL IL15232501A patent/IL152325A0/xx unknown
- 2001-05-02 JP JP2001580921A patent/JP4249928B2/ja not_active Expired - Fee Related
- 2001-05-02 PT PT05020467T patent/PT1607399E/pt unknown
- 2001-05-02 HU HU0300688A patent/HUP0300688A3/hu unknown
- 2001-05-02 AU AU2001261153A patent/AU2001261153B2/en not_active Ceased
- 2001-05-02 NZ NZ522189A patent/NZ522189A/en not_active IP Right Cessation
- 2001-05-02 EP EP05020467A patent/EP1607399B1/en not_active Expired - Lifetime
- 2001-05-02 DK DK05020467.6T patent/DK1607399T3/da active
- 2001-05-02 DK DK01935025T patent/DK1278759T3/da active
- 2001-05-02 DE DE60141181T patent/DE60141181D1/de not_active Expired - Lifetime
- 2001-05-02 ES ES01935025T patent/ES2253380T3/es not_active Expired - Lifetime
- 2001-05-02 BR BR0110553-1A patent/BR0110553A/pt active Search and Examination
- 2001-05-02 PL PL358155A patent/PL207005B1/pl not_active IP Right Cessation
- 2001-05-02 CN CNB018089623A patent/CN1182143C/zh not_active Expired - Fee Related
- 2001-05-02 AT AT05020467T patent/ATE455779T1/de active
- 2001-05-02 EA EA200201154A patent/EA006852B1/ru not_active IP Right Cessation
2002
- 2002-10-16 IL IL152325A patent/IL152325A/en not_active IP Right Cessation
- 2002-10-23 ZA ZA200208591A patent/ZA200208591B/en unknown
- 2002-11-01 NO NO20025240A patent/NO328854B1/no not_active IP Right Cessation
2009
- 2009-11-18 NO NO20093371A patent/NO331833B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2407606C (en)	2008-07-15
DE60116081D1 (en)	2006-01-26
HUP0300688A3 (en)	2005-02-28
DK1278759T3 (da)	2006-02-13
ZA200208591B (en)	2004-03-04
JP4249928B2 (ja)	2009-04-08
NO331833B1 (no)	2012-04-16
EP1607399A3 (en)	2006-01-04
CN1182143C (zh)	2004-12-29
EP1607399B1 (en)	2010-01-20
PL207005B1 (pl)	2010-10-29
PT1607399E (pt)	2010-02-02
AR029072A1 (es)	2003-06-04
HK1050368A1 (en)	2003-06-20
EA006852B1 (ru)	2006-04-28
NO20025240L (no)	2002-12-04
AU6115301A (en)	2001-11-12
HK1084119A1 (en)	2006-07-21
NO20025240D0 (no)	2002-11-01
HUP0300688A2 (hu)	2003-07-28
WO2001083496A1 (en)	2001-11-08
DE60116081T2 (de)	2006-08-03
NO20093371L (no)	2002-12-04
IL152325A (en)	2011-04-28
DK1607399T3 (da)	2010-05-10
KR100729980B1 (ko)	2007-06-20
CA2407606A1 (en)	2001-11-08
IL152325A0 (en)	2003-05-29
NZ522189A (en)	2004-04-30
ATE455779T1 (de)	2010-02-15
ES2253380T3 (es)	2006-06-01
AU2001261153B2 (en)	2005-04-07
MXPA02010813A (es)	2004-02-26
BR0110553A (pt)	2003-04-01
EP1607399A2 (en)	2005-12-21
ES2337154T3 (es)	2010-04-21
JP2003531913A (ja)	2003-10-28
EP1278759A1 (en)	2003-01-29
TWI308569B (en)	2009-04-11
UA74574C2 (en)	2006-01-16
ATE313549T1 (de)	2006-01-15
KR20020094000A (ko)	2002-12-16
CN1427844A (zh)	2003-07-02
NO328854B1 (no)	2010-05-31
EA200201154A1 (ru)	2003-04-24
CZ20023615A3 (cs)	2003-04-16
EP1278759B1 (en)	2005-12-21
DE60141181D1 (de)	2010-03-11

Legal Events

Date	Code	Title	Description
2014-06-30	LAPS	Decisions on the lapse of the protection rights	Effective date: 20130502

Publication	Publication Date	Title
IL161881A0 (en)	2005-11-20	N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives
PL337329A1 (en)	2000-08-14	Oxazolydinone based antibacterial agents comprising a thiocarbonyl functional group
IL153508A0 (en)	2003-07-06	4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity
IL157704A0 (en)	2004-03-28	4,5-dihydro-1h-pyrazole derivatives having potent cbi-antagonistic activity
IL160081A0 (en)	2004-06-20	Novel 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity
PL351611A1 (en)	2003-05-05	4,5,6,7-tetrahydroindazole derivatives as antitumor agents
IL160851A0 (en)	2004-08-31	Thiopene-and thiazolesulfonamides as antineoplastic agents
MXPA03000107A (es)	2003-08-19	Pirroloquinolonas como agentes antivirales.
AU6807501A (en)	2002-01-02	1-aryl-4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents
AU6115301A (en)	2001-11-12	Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents
IL162310A0 (en)	2005-11-20	3,4-Dihydro-1h-isoquinoloin-2-yl-derivatives
GB0222844D0 (en)	2002-11-06	Trouser waist adjuster
IL159965A0 (en)	2004-06-20	Novel 2,4-diaminothiazole derivatives
GB0127101D0 (en)	2002-01-02	Unicompartmental knee replacement
CA95903S (en)	2002-04-26	"belt"
AU148709S (en)	2002-08-02	Garment pocket
SI1470127T1 (sl)	2007-10-31	N,n-dimetilirani n-zamenjani porfirini
TW451639U (en)	2001-08-21	Positioning buckle for necktie
ZA200007433B (en)	2001-08-29	Waist belt holder.
GB0125857D0 (en)	2001-12-19	Pocket technical writer 21
PL371851A1 (pl)	2005-06-27	Pochodne 3,4-dihydro-1-H-izochinolin-2-ylu
DK1177185T3 (da)	2005-06-06	4,5,6,7-tetrahydroindazolderivater som antitumormidler
ZA200202698B (en)	2002-12-23	"A shoulder for a rail clip".
UA4997S (uk)	2001-07-16	Етикетка «княжна. печиво мигдальне»
ZA200206157B (en)	2003-04-03	"A smoking accessory".