PL3582853T3 - Związki cyklicznych di-nukleotydów do leczenia nowotworu złośliwego - Google Patents
Związki cyklicznych di-nukleotydów do leczenia nowotworu złośliwegoInfo
- Publication number
- PL3582853T3 PL3582853T3 PL18708032T PL18708032T PL3582853T3 PL 3582853 T3 PL3582853 T3 PL 3582853T3 PL 18708032 T PL18708032 T PL 18708032T PL 18708032 T PL18708032 T PL 18708032T PL 3582853 T3 PL3582853 T3 PL 3582853T3
- Authority
- PL
- Poland
- Prior art keywords
- nucleotides
- cancer
- cyclic
- compounds
- treatment
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6587—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having two phosphorus atoms as ring hetero atoms in the same ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762460562P | 2017-02-17 | 2017-02-17 | |
| US201762479169P | 2017-03-30 | 2017-03-30 | |
| US201762551647P | 2017-08-29 | 2017-08-29 | |
| US201762551668P | 2017-08-29 | 2017-08-29 | |
| US201762551645P | 2017-08-29 | 2017-08-29 | |
| EP18708032.0A EP3582853B1 (en) | 2017-02-17 | 2018-02-17 | Cyclic di-nucleotides compounds for the treatment of cancer |
| PCT/US2018/018556 WO2018152450A1 (en) | 2017-02-17 | 2018-02-17 | Cyclic di-nucleotides compounds for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3582853T3 true PL3582853T3 (pl) | 2022-02-21 |
Family
ID=61521844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18708032T PL3582853T3 (pl) | 2017-02-17 | 2018-02-17 | Związki cyklicznych di-nukleotydów do leczenia nowotworu złośliwego |
Country Status (32)
| Country | Link |
|---|---|
| US (4) | US20200055883A1 (pl) |
| EP (3) | EP3582854A1 (pl) |
| JP (2) | JP2020510638A (pl) |
| KR (1) | KR102645790B1 (pl) |
| CN (3) | CN110461416B (pl) |
| AU (1) | AU2018221170B2 (pl) |
| CA (1) | CA3053932A1 (pl) |
| CL (1) | CL2019002304A1 (pl) |
| CO (1) | CO2019008783A2 (pl) |
| CY (1) | CY1126855T1 (pl) |
| DK (1) | DK3582853T3 (pl) |
| ES (1) | ES2906299T3 (pl) |
| HR (1) | HRP20220110T1 (pl) |
| HU (1) | HUE057665T2 (pl) |
| IL (1) | IL268721B (pl) |
| JO (1) | JOP20190194B1 (pl) |
| LT (1) | LT3582853T (pl) |
| MA (1) | MA47501A (pl) |
| MD (1) | MD3582853T2 (pl) |
| MX (1) | MX394380B (pl) |
| PE (1) | PE20191686A1 (pl) |
| PH (1) | PH12019501914B1 (pl) |
| PL (1) | PL3582853T3 (pl) |
| PT (1) | PT3582853T (pl) |
| RS (1) | RS62842B1 (pl) |
| SG (1) | SG11201907496RA (pl) |
| SI (1) | SI3582853T1 (pl) |
| SM (1) | SMT202200054T1 (pl) |
| TW (1) | TWI766948B (pl) |
| UA (1) | UA125310C2 (pl) |
| WO (2) | WO2018152450A1 (pl) |
| ZA (1) | ZA201906111B (pl) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018100558A2 (en) | 2016-12-01 | 2018-06-07 | Takeda Pharmaceutical Company Limited | Cyclic dinucleotide |
| CN110214012B (zh) | 2017-01-20 | 2023-05-09 | 艾库斯生物科学有限公司 | 用于治疗癌症相关疾病的唑嘧啶 |
| PL3601233T3 (pl) | 2017-03-27 | 2025-01-07 | HYDRO-QUéBEC | Sole do zastosowania w kompozycjach elektrolitowych lub jako dodatki do elektrod |
| WO2019084060A1 (en) | 2017-10-24 | 2019-05-02 | Silverback Therapeutics, Inc. | CONJUGATES AND METHODS OF USE FOR THE SELECTIVE DELIVERY OF IMMUNOMODULATORY AGENTS |
| JP7195317B2 (ja) | 2017-11-10 | 2022-12-23 | 武田薬品工業株式会社 | Ｓｔｉｎｇ調節剤化合物、ならびに製造及び使用する方法 |
| US10966999B2 (en) | 2017-12-20 | 2021-04-06 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| CN111511754B (zh) | 2017-12-20 | 2023-09-12 | 捷克共和国有机化学与生物化学研究所 | 活化sting转接蛋白的具有膦酸酯键的2’3’环状二核苷酸 |
| CA3090922A1 (en) | 2018-02-16 | 2019-08-22 | Arcus Biosciences, Inc. | Dosing with an azolopyrimidine compound |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| MX2020012964A (es) * | 2018-06-01 | 2021-02-16 | Eisai R&D Man Co Ltd | Metodos para el tratamiento de cancer de vejiga. |
| MX2020013322A (es) * | 2018-08-16 | 2021-02-22 | Eisai R&D Man Co Ltd | Sales de compuestos y cristales de los mismos. |
| US20200113912A1 (en) | 2018-09-12 | 2020-04-16 | Silverback Therapeutics, Inc. | Methods and Compositions for the Treatment of Disease with Immune Stimulatory Conjugates |
| CN111655712B (zh) * | 2018-12-29 | 2021-02-05 | 上海济煜医药科技有限公司 | 作为肿瘤免疫类的化合物及其应用 |
| JP7621974B2 (ja) | 2019-05-09 | 2025-01-27 | アリゴス セラピューティクス インコーポレイテッド | Ｓｔｉｎｇモジュレータとしての修飾環状ジヌクレオシド化合物 |
| US11453681B2 (en) * | 2019-05-23 | 2022-09-27 | Gilead Sciences, Inc. | Substituted eneoxindoles and uses thereof |
| CN114599374A (zh) * | 2019-07-01 | 2022-06-07 | 卫材R&D管理有限公司 | 用于增强抗癌化合物e7766的治疗依从性的系统 |
| CA3151322A1 (en) | 2019-10-01 | 2021-04-08 | Silverback Therapeutics, Inc. | Combination therapy with immune stimulatory conjugates |
| JP2022177332A (ja) * | 2019-10-24 | 2022-12-01 | 日東電工株式会社 | オリゴヌクレオチドを製造する方法 |
| JP7735291B2 (ja) | 2020-02-21 | 2025-09-08 | エーアールエス ファーマシューティカルズ、インコーポレイテッド | ネクチン－４抗体コンジュゲートおよびその使用 |
| WO2021206158A1 (ja) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | がん治療方法 |
| WO2021252904A1 (en) | 2020-06-11 | 2021-12-16 | Massachusetts Institute Of Technology | Ribonucleoprotein approach to boost the sting signaling for cancer immunotherapy |
| JP2023532304A (ja) | 2020-07-01 | 2023-07-27 | エーアールエス ファーマシューティカルズ オペレーションズ，インク． | 抗ａｓｇｒ１抗体コンジュゲートおよびその使用 |
| CN111909223A (zh) * | 2020-07-17 | 2020-11-10 | 清华大学 | 环二核苷酸共价修饰物及其制备方法和应用 |
| EP4228681A1 (en) | 2020-10-14 | 2023-08-23 | Boehringer Ingelheim International GmbH | Combination of a sting agonist and a complex comprising a cell penetrating peptide, a cargo and a tlr peptide agonist |
| JP7397996B2 (ja) | 2020-11-09 | 2023-12-13 | 武田薬品工業株式会社 | 抗体薬物コンジュゲート |
| CN120737157A (zh) * | 2022-09-16 | 2025-10-03 | 上海大学 | 一种具有抗炎活性的多肽类化合物及其制备方法与应用 |
| WO2024182569A2 (en) | 2023-02-28 | 2024-09-06 | Eisai R&D Management Co., Ltd. | Anti-psma antibodies, conjugates, and methods of use |
| WO2026044039A2 (en) | 2024-08-21 | 2026-02-26 | Eisai R&D Management Co., Ltd. | Anti-cd73 antibodies, conjugates, and methods of use |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2257704B (en) | 1991-07-18 | 1995-03-01 | Erba Carlo Spa | Cyclic oligonucleotides phosphorothioates |
| EP1729781B1 (en) | 2004-03-15 | 2012-10-24 | Karaolis, David K. R. | A method for inhibiting cancer cell proliferation or increasing cancer cell apoptosis |
| US7592326B2 (en) | 2004-03-15 | 2009-09-22 | Karaolis David K R | Method for stimulating the immune, inflammatory or neuroprotective response |
| US8076303B2 (en) | 2005-12-13 | 2011-12-13 | Spring Bank Pharmaceuticals, Inc. | Nucleotide and oligonucleotide prodrugs |
| GB0607950D0 (en) | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
| WO2009133560A1 (en) | 2008-04-29 | 2009-11-05 | Smart Assays | Non-hydrolyzable and permeable cyclic bis-[nucleotide monophosphate] derivatives and uses thereof |
| CN102199183B (zh) | 2010-03-26 | 2013-12-18 | 北京大学 | 环二鸟苷酸及其类似物和制备方法 |
| CN104507538B (zh) * | 2012-06-08 | 2018-04-06 | 艾杜罗生物科技公司 | 癌症免疫疗法的组合物和方法 |
| PL2931738T3 (pl) | 2012-12-13 | 2019-07-31 | Aduro Biotech, Inc. | Kompozycje zawierające cykliczne dinukleotydy purynowe o zdefiniowanej stereochemii i sposoby ich otrzymywania i zastosowania |
| WO2014179335A1 (en) * | 2013-04-29 | 2014-11-06 | Memorial Sloan Kettering Cancer Center | Compositions and methods for altering second messenger signaling |
| WO2014179760A1 (en) | 2013-05-03 | 2014-11-06 | The Regents Of The University Of California | Cyclic di-nucleotide induction of type i interferon |
| US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
| RS59500B1 (sr) | 2013-05-18 | 2019-12-31 | Aduro Biotech Inc | Sastavi i metode za aktiviranje signaliziranja koje je zavisno od „stimulatora gena za interferon“ |
| JP2016538344A (ja) | 2013-11-19 | 2016-12-08 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | 癌処置としてのｓｔｉｎｇアゴニストの使用 |
| US10092644B2 (en) | 2013-11-22 | 2018-10-09 | Brock University | Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants |
| PE20170198A1 (es) | 2014-06-04 | 2017-04-08 | Glaxosmithkline Ip Dev Ltd | Dinucleotidos ciclicos como moduladores de sting |
| WO2016079899A1 (ja) * | 2014-11-20 | 2016-05-26 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 異なる核酸アジュバントの組み合わせによる、新規Ｔｈ１誘導性アジュバントおよびその用途 |
| EP3546473B1 (en) | 2014-12-16 | 2025-12-10 | Kayla Therapeutics | Fluorinated cyclic [(2',5')p(3',5')p]-dinucleotides for cytokine induction |
| WO2016096577A1 (en) * | 2014-12-16 | 2016-06-23 | Invivogen | Combined use of a chemotherapeutic agent and a cyclic dinucleotide for cancer treatment |
| WO2016100261A2 (en) | 2014-12-17 | 2016-06-23 | Lipogen Llc | Method of treating cancer with cgamp or cgasmp |
| GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| HK1248603A1 (zh) * | 2015-03-10 | 2018-10-19 | Aduro Biotech, Inc. | 用於活化"干扰素基因的刺激剂"依懒性信号传导的组合物和方法 |
| TW201717968A (zh) | 2015-07-14 | 2017-06-01 | 春季銀行製藥公司 | 誘導ｒｉｇ－ｉ和其他模式辨識受體之化合物及組成物 |
| US10844051B2 (en) | 2015-07-22 | 2020-11-24 | The Royal Institution For The Advancement Of Learning/Mcgill University | Substituted oxazoles for the treatment of cancer |
| CR20180101A (es) | 2015-08-13 | 2018-04-12 | Merck Sharp & Dohme | Compuestos di-nucleóticos cíclicos como agonistas de sting |
| US9809597B2 (en) | 2015-08-20 | 2017-11-07 | The Board Of Trustees Of The Leland Stanford Junior University | Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy |
| KR20180040706A (ko) | 2015-09-01 | 2018-04-20 | 인네이트 튜머 이뮤니티, 인코포레이티드 | 면역억제 시토카인에 대해 증가된 면역 또는 저항성을 갖는 면역 세포 및 그의 용도 |
| CA3002236A1 (en) | 2015-10-28 | 2017-05-04 | Aduro Biotech, Inc. | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling |
| TWI704154B (zh) | 2015-12-03 | 2020-09-11 | 英商葛蘭素史克智慧財產發展有限公司 | 新穎化合物 |
| JP6801956B2 (ja) | 2015-12-04 | 2020-12-16 | 株式会社エクセディ | モータサイクル用クラッチ装置 |
| WO2017123657A1 (en) | 2016-01-11 | 2017-07-20 | Gary Glick | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
| RS67188B1 (sr) | 2016-01-11 | 2025-10-31 | Innate Tumor Immunity Inc | Ciklični dinukleotidi za lečenje stanja povezanih sa aktivnošću sting kao što je kancer |
| SG10201912074PA (en) | 2016-03-18 | 2020-02-27 | Immune Sensor Llc | Cyclic di-nucleotide compounds and methods of use |
| JP2019510802A (ja) | 2016-04-07 | 2019-04-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | タンパク質調節物質として有用な複素環アミド |
| US10537590B2 (en) | 2016-09-30 | 2020-01-21 | Boehringer Ingelheim International Gmbh | Cyclic dinucleotide compounds |
| JOP20170188A1 (ar) | 2016-11-25 | 2019-01-30 | Janssen Biotech Inc | ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting) |
| WO2018140831A2 (en) | 2017-01-27 | 2018-08-02 | Silverback Therapeutics, Inc. | Tumor targeting conjugates and methods of use thereof |
| WO2018198084A1 (en) | 2017-04-27 | 2018-11-01 | Lupin Limited | Cyclic di-nucleotide compounds with tricyclic nucleobases |
| UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
-
2018
- 2018-02-16 US US16/486,954 patent/US20200055883A1/en not_active Abandoned
- 2018-02-17 MX MX2019009796A patent/MX394380B/es unknown
- 2018-02-17 JP JP2019544725A patent/JP2020510638A/ja active Pending
- 2018-02-17 SI SI201830553T patent/SI3582853T1/sl unknown
- 2018-02-17 CN CN201880021349.XA patent/CN110461416B/zh active Active
- 2018-02-17 WO PCT/US2018/018556 patent/WO2018152450A1/en not_active Ceased
- 2018-02-17 CN CN202410024195.7A patent/CN117866030A/zh active Pending
- 2018-02-17 EP EP18709835.5A patent/EP3582854A1/en not_active Withdrawn
- 2018-02-17 JP JP2019544817A patent/JP6672532B2/ja active Active
- 2018-02-17 PH PH1/2019/501914A patent/PH12019501914B1/en unknown
- 2018-02-17 AU AU2018221170A patent/AU2018221170B2/en active Active
- 2018-02-17 WO PCT/US2018/018561 patent/WO2018152453A1/en not_active Ceased
- 2018-02-17 LT LTEPPCT/US2018/018556T patent/LT3582853T/lt unknown
- 2018-02-17 SM SM20220054T patent/SMT202200054T1/it unknown
- 2018-02-17 UA UAA201909860A patent/UA125310C2/uk unknown
- 2018-02-17 KR KR1020197027073A patent/KR102645790B1/ko active Active
- 2018-02-17 DK DK18708032.0T patent/DK3582853T3/da active
- 2018-02-17 EP EP18708032.0A patent/EP3582853B1/en active Active
- 2018-02-17 JO JOP/2019/0194A patent/JOP20190194B1/ar active
- 2018-02-17 HR HRP20220110TT patent/HRP20220110T1/hr unknown
- 2018-02-17 MD MDE20200009T patent/MD3582853T2/ro unknown
- 2018-02-17 PE PE2019001715A patent/PE20191686A1/es unknown
- 2018-02-17 EP EP21208462.8A patent/EP4008403A1/en not_active Withdrawn
- 2018-02-17 RS RS20220079A patent/RS62842B1/sr unknown
- 2018-02-17 US US15/898,533 patent/US10246480B2/en active Active
- 2018-02-17 ES ES18708032T patent/ES2906299T3/es active Active
- 2018-02-17 SG SG11201907496RA patent/SG11201907496RA/en unknown
- 2018-02-17 PL PL18708032T patent/PL3582853T3/pl unknown
- 2018-02-17 CA CA3053932A patent/CA3053932A1/en active Pending
- 2018-02-17 PT PT187080320T patent/PT3582853T/pt unknown
- 2018-02-17 CN CN201880025317.7A patent/CN110536719A/zh active Pending
- 2018-02-17 HU HUE18708032A patent/HUE057665T2/hu unknown
- 2018-02-17 MA MA047501A patent/MA47501A/fr unknown
- 2018-02-21 TW TW107105846A patent/TWI766948B/zh active
-
2019
- 2019-02-15 US US16/277,522 patent/US10618930B2/en active Active
- 2019-08-13 CO CONC2019/0008783A patent/CO2019008783A2/es unknown
- 2019-08-14 CL CL2019002304A patent/CL2019002304A1/es unknown
- 2019-08-15 IL IL268721A patent/IL268721B/en unknown
- 2019-09-16 ZA ZA2019/06111A patent/ZA201906111B/en unknown
-
2020
- 2020-02-04 US US16/781,352 patent/US11339188B2/en active Active
-
2022
- 2022-01-26 CY CY20221100065T patent/CY1126855T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL268721B (en) | Cyclic dinucleotide compounds for cancer therapy | |
| ZA201905902B (en) | 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides for the treatment of cancer | |
| ZA201704732B (en) | Cyclic dinucleotides useful for the treatment of inter alia cancer | |
| PL3109223T3 (pl) | Mieszanina do obróbki nawozów zawierających mocznik | |
| IL259996A (en) | Combinations for cancer treatment | |
| IL263793A (en) | Compounds and preparations for the treatment of cancer | |
| IL263835A (en) | Exosome-guided treatment of cancer | |
| IL261278A (en) | Pharmaceutical compositions for the treatment of cancer | |
| IL275525A (en) | A pharmaceutical preparation for the treatment of cancer | |
| ZA201901578B (en) | Combinations including abx196 for the treatment of cancer | |
| PL3630754T3 (pl) | Związki izoindolinoacetylenowe do leczenia nowotworu | |
| IL274748A (en) | Improved cancer treatment | |
| EP3242681B8 (en) | Novel compounds for the treatment of cancer | |
| IL255167A0 (en) | Compounds for the treatment of cancer | |
| ZA201704589B (en) | Compounds for the treatment of cancer | |
| HK40016436A (en) | Cyclic di-nucleotides compounds for the treatment of cancer | |
| PT3580211T (pt) | 2-heteroaril-3-oxo-2,3-di-hidropiridazina-4-carboxamidas para o tratamento de cancro | |
| GB201713936D0 (en) | Pharmaceutical combinations for the treatment of cancer | |
| GB201719584D0 (en) | Pharmaceutical compositions for the treatment of cancer | |
| GB201704287D0 (en) | Treatment of cancer | |
| GB201703857D0 (en) | Treatment of cancer | |
| GB201702565D0 (en) | Treatment of cancer | |
| GB201622214D0 (en) | treatment of cancer | |
| GB201604621D0 (en) | Treatment of cancer | |
| GB201604293D0 (en) | Treatment of cancer |