PL362924A1 - Peptydy i/lub białka i ich zastosowanie do wytwarzania leku terapeutycznego i/lub profilaktycznego - Google Patents

Peptydy i/lub białka i ich zastosowanie do wytwarzania leku terapeutycznego i/lub profilaktycznego

Info

Publication number: PL362924A1
Authority: PL; Poland
Prior art keywords: pro; gly; arg; fibrin; residue
Prior art date: 2000-12-12

Application number

PL01362924A

Other languages

English (en)

Other versions

PL209419B1 (pl

Inventor

Peter Petzelbauer

Original Assignee

Fibrex Medical Research & Development Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-12

Filing date

2001-12-07

Publication date

2004-11-02

2001-12-07 Application filed by Fibrex Medical Research & Development Gmbh filed Critical Fibrex Medical Research & Development Gmbh

2004-11-02 Publication of PL362924A1 publication Critical patent/PL362924A1/pl

2011-08-31 Publication of PL209419B1 publication Critical patent/PL209419B1/pl

Links

239000003814 drug Substances 0.000 title abstract 4
108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
102000004169 proteins and genes Human genes 0.000 title abstract 4
108090000623 proteins and genes Proteins 0.000 title abstract 4
102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
230000001225 therapeutic effect Effects 0.000 title abstract 3
230000000069 prophylactic effect Effects 0.000 title 1
102000009123 Fibrin Human genes 0.000 abstract 4
108010073385 Fibrin Proteins 0.000 abstract 4
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 4
229950003499 fibrin Drugs 0.000 abstract 4
230000005764 inhibitory process Effects 0.000 abstract 3
235000018102 proteins Nutrition 0.000 abstract 3
150000001408 amides Chemical class 0.000 abstract 2
239000003146 anticoagulant agent Substances 0.000 abstract 2
239000000463 material Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
230000003449 preventive effect Effects 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
210000001519 tissue Anatomy 0.000 abstract 2
102000008946 Fibrinogen Human genes 0.000 abstract 1
108010049003 Fibrinogen Proteins 0.000 abstract 1
206010063837 Reperfusion injury Diseases 0.000 abstract 1
235000001014 amino acid Nutrition 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000002682 anti-psoriatic effect Effects 0.000 abstract 1
230000003356 anti-rheumatic effect Effects 0.000 abstract 1
229940127219 anticoagulant drug Drugs 0.000 abstract 1
239000003435 antirheumatic agent Substances 0.000 abstract 1
125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 1
238000003776 cleavage reaction Methods 0.000 abstract 1
239000000824 cytostatic agent Substances 0.000 abstract 1
230000001085 cytostatic effect Effects 0.000 abstract 1
230000008021 deposition Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
210000003989 endothelium vascular Anatomy 0.000 abstract 1
229940012952 fibrinogen Drugs 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
210000005003 heart tissue Anatomy 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
238000001990 intravenous administration Methods 0.000 abstract 1
208000028867 ischemia Diseases 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
230000005012 migration Effects 0.000 abstract 1
238000013508 migration Methods 0.000 abstract 1
125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1
230000002537 thrombolytic effect Effects 0.000 abstract 1
230000002792 vascular Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/363—Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Epidemiology (AREA)
Toxicology (AREA)
Cardiology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Transplantation (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Materials For Medical Uses (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

PL362924A 2000-12-12 2001-12-07 Zastosowanie peptydów lub białek do wytwarzania leku do terapeutycznego i/lub profilaktycznego stosowania w przypadku zapaleń w medycynie i/lub weterynarii PL209419B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AT20632000		2000-12-12
PCT/AT2001/000387 WO2002048180A2 (de)	2000-12-12	2001-12-07	Peptide und/oder proteine sowie verwendung desselben zur herstellung eines therapeutischen und/oder präventiven arzneimittels

Publications (2)

Publication Number	Publication Date
PL362924A1 true PL362924A1 (pl)	2004-11-02
PL209419B1 PL209419B1 (pl)	2011-08-31

Family

ID=3689750

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL362924A PL209419B1 (pl)	2000-12-12	2001-12-07	Zastosowanie peptydów lub białek do wytwarzania leku do terapeutycznego i/lub profilaktycznego stosowania w przypadku zapaleń w medycynie i/lub weterynarii
PL390342A PL209752B1 (pl)	2000-12-12	2001-12-07	Zastosowanie peptydów lub białek do wytwarzania leku do leczenia chorób zapalnych o podłożu zakaźnym

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL390342A PL209752B1 (pl)	2000-12-12	2001-12-07	Zastosowanie peptydów lub białek do wytwarzania leku do leczenia chorób zapalnych o podłożu zakaźnym

Country Status (30)

Country	Link
US (4)	US7271144B2 (pl)
EP (2)	EP1586586B1 (pl)
JP (1)	JP4181874B2 (pl)
KR (1)	KR100864069B1 (pl)
CN (2)	CN1518558B (pl)
AT (2)	ATE425184T1 (pl)
AU (1)	AU2002221316A1 (pl)
BG (1)	BG107891A (pl)
BR (1)	BR0116122A (pl)
CA (1)	CA2430972C (pl)
CY (2)	CY1106108T1 (pl)
CZ (1)	CZ20031630A3 (pl)
DE (2)	DE50110182D1 (pl)
DK (2)	DK1586586T3 (pl)
EA (1)	EA005576B1 (pl)
EE (1)	EE200300283A (pl)
ES (2)	ES2323963T3 (pl)
HR (1)	HRP20030564A2 (pl)
HU (1)	HUP0401536A3 (pl)
IL (2)	IL156360A0 (pl)
MX (1)	MXPA03005218A (pl)
NO (1)	NO330767B1 (pl)
NZ (1)	NZ550619A (pl)
PL (2)	PL209419B1 (pl)
PT (2)	PT1586586E (pl)
SI (2)	SI1586586T1 (pl)
SK (1)	SK7062003A3 (pl)
WO (1)	WO2002048180A2 (pl)
YU (1)	YU53803A (pl)
ZA (1)	ZA200304545B (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1518558B (zh)	2000-12-12	2010-06-16	菲布雷克斯医疗研究及开发有限责任公司	肽和/或蛋白质及其用于制备治疗性和/或预防性药物组合物的用途
PT1691827E (pt) *	2004-06-25	2009-11-23	Fibrex Medical Res & Dev Gmbh	Utilização de péptidos derivados da cadeia b beta de fibrinogénio humano para o tratamento do choque
FR2879604B1 (fr) *	2004-12-22	2010-08-13	Biomerieux Sa	Peptides citrullines derives de la fibrine reconnus par des auto-anticorps specifiques de la polyarthrite rhumatoide, et leurs utilisations
AT502987A1 (de)	2005-12-23	2007-07-15	Fibrex Medical Res & Dev Gmbh	Pharmazeutische zusammensetzung zur behandlung von hämorrhagischem schock und seinen folgeerscheinungen
US7799758B2 (en) *	2006-02-23	2010-09-21	Ikaria Development Subsidiary Two, LLC	Peptides and peptide derivatives as well as pharmaceutical compositions containing the same
DK1987063T3 (da) *	2006-02-23	2010-01-04	Fibrex Medical Res & Dev Gmbh	Peptider og peptidderivater, fremstilling deraf samt deres anvendelse til fremstilling af en terapeutisk og/eller præventivt aktiv farmaceutisk sammensætning
WO2007095659A1 (de) *	2006-02-23	2007-08-30	Fibrex Medical Research & Development Gmbh	Peptide und peptid-derivate, herstellun derselben sowie deren verwendung zur herstellung eines therapeutisch und/oder präventiv wirkenden arzneimittels
FR2900657B1 (fr)	2006-05-03	2009-04-17	Univ Toulouse	Identification de modulateurs de l'activation des macrophages, utilisables pour le traitement de la polyarthrite rhumatoide
WO2009038729A2 (en)	2007-09-17	2009-03-26	Regenerx Biopharmaceuticals, Inc.	Compositions and methods utilizing fibrin beta chain fragments of the bbeta chain of fibrinogen
FR2908134B1 (fr) *	2007-12-04	2012-10-12	Univ Toulouse 3 Paul Sabatier	Identification de modulateurs de l'activation des macrophages, utilisables pour le traitement de la polyarthrite rhumatoide
JP5410997B2 (ja) *	2008-01-31	2014-02-05	則行川村	うつ病およびうつ状態のマーカーおよびそれを用いた検出・診断
US20090286725A1 (en) *	2008-05-15	2009-11-19	Fibrex Medical Research & Development Gmbh	Peptides and derivatives thereof, the manufacturing thereof as well as their use for preparing a therapeutically and/or preventively active pharmaceutical composition
US8088890B2 (en)	2008-09-26	2012-01-03	Fibrex Medical Research & Development Gmbh	Peptides and peptidomimetic compounds, the manufacturing thereof as well as their use for preparing a therapeutically and/or preventively active pharmaceutical composition
WO2010043444A2 (en) *	2008-10-15	2010-04-22	Fibrex Medical Research & Development Gmbh	Pharmaceutical preparation for the treatment and/or prevention of ischemia/reperfusion injury and the sequels thereof
US20100152832A1 (en) *	2008-12-12	2010-06-17	Medtronic Vascular, Inc.	Apparatus and Methods for Treatment of Aneurysms With Fibrin Derived Peptide B-Beta
US10531655B2 (en)	2011-12-02	2020-01-14	The Regents Of The University Of California	Reperfusion protection solution and uses thereof
WO2017210539A1 (en)	2016-06-02	2017-12-07	University Of Maryland, Baltimore	Compositions for inhibiting fibrin-vldl receptor-dependent inflammation and methods of treatment
EP3912679A1 (en) *	2020-05-19	2021-11-24	Johann Wolfgang Goethe-Universität Frankfurt am Main	Bbeta-15-42 for the treatment of viral endothelitis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4927916A (en) *	1984-04-23	1990-05-22	The General Hospital Corporation	Method of producing fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity using fibrin-specific peptides
US5965107A (en) *	1992-03-13	1999-10-12	Diatide, Inc.	Technetium-99m labeled peptides for imaging
DE19729591A1 (de) *	1997-07-10	1999-02-11	Therasorb Medizinische Systeme	Mittel zur Behandlung und/oder Prophylaxe von Mikrozirkulationsstörungen
FR2795735B1 (fr) *	1999-07-01	2001-09-07	Univ Toulouse	Derives citrullines de la fibrine et leur utilisation pour le diagnostic ou le traitement de la polyarthrite rhumatoide
CN1518558B (zh)	2000-12-12	2010-06-16	菲布雷克斯医疗研究及开发有限责任公司	肽和/或蛋白质及其用于制备治疗性和/或预防性药物组合物的用途
US7201763B2 (en) *	2001-10-24	2007-04-10	Boston Scientific Scimed, Inc.	Distal balloon waist material relief and method of manufacture

2001
- 2001-12-07 CN CN018225993A patent/CN1518558B/zh not_active Expired - Fee Related
- 2001-12-07 YU YU53803A patent/YU53803A/sh unknown
- 2001-12-07 MX MXPA03005218A patent/MXPA03005218A/es active IP Right Grant
- 2001-12-07 DK DK05012488T patent/DK1586586T3/da active
- 2001-12-07 WO PCT/AT2001/000387 patent/WO2002048180A2/de not_active Ceased
- 2001-12-07 NZ NZ550619A patent/NZ550619A/en unknown
- 2001-12-07 BR BR0116122-9A patent/BR0116122A/pt not_active Application Discontinuation
- 2001-12-07 DE DE50110182T patent/DE50110182D1/de not_active Expired - Lifetime
- 2001-12-07 DE DE50114771T patent/DE50114771D1/de not_active Expired - Lifetime
- 2001-12-07 PT PT05012488T patent/PT1586586E/pt unknown
- 2001-12-07 ES ES05012488T patent/ES2323963T3/es not_active Expired - Lifetime
- 2001-12-07 CA CA2430972A patent/CA2430972C/en not_active Expired - Fee Related
- 2001-12-07 PL PL362924A patent/PL209419B1/pl not_active IP Right Cessation
- 2001-12-07 SI SI200130917T patent/SI1586586T1/sl unknown
- 2001-12-07 EA EA200300678A patent/EA005576B1/ru not_active IP Right Cessation
- 2001-12-07 CZ CZ20031630A patent/CZ20031630A3/cs unknown
- 2001-12-07 SK SK706-2003A patent/SK7062003A3/sk unknown
- 2001-12-07 DK DK01270546T patent/DK1341819T3/da active
- 2001-12-07 IL IL15636001A patent/IL156360A0/xx unknown
- 2001-12-07 CN CN200910163553A patent/CN101676299A/zh active Pending
- 2001-12-07 EE EEP200300283A patent/EE200300283A/xx unknown
- 2001-12-07 PT PT01270546T patent/PT1341819E/pt unknown
- 2001-12-07 AT AT05012488T patent/ATE425184T1/de active
- 2001-12-07 EP EP05012488A patent/EP1586586B1/de not_active Expired - Lifetime
- 2001-12-07 AU AU2002221316A patent/AU2002221316A1/en not_active Abandoned
- 2001-12-07 AT AT01270546T patent/ATE329614T1/de active
- 2001-12-07 PL PL390342A patent/PL209752B1/pl not_active IP Right Cessation
- 2001-12-07 ES ES01270546T patent/ES2266093T3/es not_active Expired - Lifetime
- 2001-12-07 JP JP2002549711A patent/JP4181874B2/ja not_active Expired - Fee Related
- 2001-12-07 SI SI200130609T patent/SI1341819T1/sl unknown
- 2001-12-07 HU HU0401536A patent/HUP0401536A3/hu unknown
- 2001-12-07 KR KR1020037007799A patent/KR100864069B1/ko not_active Expired - Fee Related
- 2001-12-07 HR HR20030564A patent/HRP20030564A2/hr not_active Application Discontinuation
- 2001-12-07 EP EP01270546A patent/EP1341819B1/de not_active Expired - Lifetime
2003
- 2003-06-09 BG BG107891A patent/BG107891A/bg unknown
- 2003-06-09 IL IL156360A patent/IL156360A/en not_active IP Right Cessation
- 2003-06-11 US US10/459,030 patent/US7271144B2/en not_active Expired - Fee Related
- 2003-06-12 NO NO20032656A patent/NO330767B1/no not_active IP Right Cessation
2004
- 2004-06-11 ZA ZA200304545A patent/ZA200304545B/en unknown
2006
- 2006-06-27 CY CY20061100876T patent/CY1106108T1/el unknown
- 2006-10-03 US US11/542,050 patent/US7494973B2/en not_active Expired - Lifetime
2007
- 2007-09-06 US US11/899,611 patent/US7811985B2/en not_active Expired - Fee Related
2008
- 2008-10-09 US US12/248,656 patent/US8067373B2/en not_active Expired - Fee Related
2009
- 2009-05-29 CY CY20091100574T patent/CY1109107T1/el unknown

Also Published As

Publication number	Publication date
CY1106108T1 (el)	2011-06-08
KR100864069B1 (ko)	2008-10-16
US20090137464A1 (en)	2009-05-28
CY1109107T1 (el)	2014-07-02
SI1341819T1 (sl)	2006-10-31
US7811985B2 (en)	2010-10-12
EA200300678A1 (ru)	2003-10-30
PL209419B1 (pl)	2011-08-31
CZ20031630A3 (cs)	2003-10-15
DE50114771D1 (de)	2009-04-23
EP1341819B1 (de)	2006-06-14
US20040192596A1 (en)	2004-09-30
MXPA03005218A (es)	2004-12-03
EP1341819A2 (de)	2003-09-10
HUP0401536A2 (hu)	2004-11-29
PT1341819E (pt)	2006-10-31
ATE425184T1 (de)	2009-03-15
CN1518558A (zh)	2004-08-04
ZA200304545B (en)	2004-09-13
ES2266093T3 (es)	2007-03-01
EP1586586A2 (de)	2005-10-19
DK1341819T3 (da)	2006-10-16
SI1586586T1 (sl)	2009-08-31
US20070037749A1 (en)	2007-02-15
AU2002221316A1 (en)	2002-06-24
NO330767B1 (no)	2011-07-11
KR20030060988A (ko)	2003-07-16
HRP20030564A2 (en)	2005-06-30
EE200300283A (et)	2003-10-15
CN1518558B (zh)	2010-06-16
CA2430972C (en)	2014-08-05
ES2323963T3 (es)	2009-07-28
WO2002048180A3 (de)	2003-01-30
BG107891A (bg)	2004-08-31
NZ550619A (en)	2008-06-30
YU53803A (sh)	2006-03-03
US8067373B2 (en)	2011-11-29
JP2004527469A (ja)	2004-09-09
BR0116122A (pt)	2003-10-14
PL209752B1 (pl)	2011-10-31
PT1586586E (pt)	2010-05-28
NO20032656D0 (no)	2003-06-12
EP1586586B1 (de)	2009-03-11
IL156360A0 (en)	2004-01-04
DE50110182D1 (de)	2006-07-27
EA005576B1 (ru)	2005-04-28
US7271144B2 (en)	2007-09-18
US7494973B2 (en)	2009-02-24
SK7062003A3 (en)	2003-11-04
HK1084400A1 (zh)	2006-07-28
US20090088384A1 (en)	2009-04-02
NO20032656L (no)	2003-06-12
IL156360A (en)	2012-12-31
EP1586586A3 (de)	2006-03-29
CN101676299A (zh)	2010-03-24
HUP0401536A3 (en)	2008-09-29
JP4181874B2 (ja)	2008-11-19
CA2430972A1 (en)	2002-06-20
DK1586586T3 (da)	2009-06-29
ATE329614T1 (de)	2006-07-15
WO2002048180A2 (de)	2002-06-20

Legal Events

Date	Code	Title	Description
2013-02-28	LAPS	Decisions on the lapse of the protection rights	Effective date: 20111207

Publication	Publication Date	Title
IL156360A0 (en)	2004-01-04	Peptides and/or proteins and use thereof for the production of a therapeutic and/or prophylactic medicament
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HU211634A9 (en)	1995-12-28	Tripeptide antithrombotic agents
JPH09512022A (ja)	1997-12-02	酵素阻害剤としてのメチオニンスルホンおよびｓ−置換システインスルホン誘導体
JPH03118330A (ja)	1991-05-20	フイブリノーゲンレセプター拮抗剤
US5498601A (en)	1996-03-12	Platelet aggregation-inhibiting peptides
JPH03118331A (ja)	1991-05-20	環状フイブリノーゲンレセプター拮抗薬
AU703256B2 (en)	1999-03-25	Bradykinin analogs as selective thrombin inhibitors
WO1992007870A1 (en)	1992-05-14	Platelet aggregation inhibitors
US5236903A (en)	1993-08-17	Polypeptide comprising repeated cell-adhesive core sequences
CA1341354C (en)	2002-04-02	Anticoagulant peptide alcohols
AU641215B2 (en)	1993-09-16	Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
AU630132B2 (en)	1992-10-22	Anticoagulant peptides
EP0702696B1 (en)	2003-07-30	Trifunctional antithrombin and antiplatelet peptides
US5789540A (en)	1998-08-04	Anticoagulant peptides
US5192745A (en)	1993-03-09	Cyclic anticoagulant peptides
US5574012A (en)	1996-11-12	Analogs of hirudin having anti-platelet activity
HK1016090B (en)	2004-02-06	Bradykinin analogs as selective thrombin inhibitors