PL367868A1 - C-2' metylowane pochodne paklitakselu do stosowania jako środki przeciwnowotworowe - Google Patents

C-2' metylowane pochodne paklitakselu do stosowania jako środki przeciwnowotworowe

Info

Publication number: PL367868A1
Authority: PL; Poland
Prior art keywords: sub; paclitaxel; methylated derivatives; antitumour agents; formula
Prior art date: 2001-08-07

Application number

PL02367868A

Other languages

English (en)

Other versions

PL194975B1 (pl

Inventor

Ezio Bombardelli

Gabriele Fontana

Arturo Battaglia

Samanta Cimitan

Original Assignee

Indena S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-07

Filing date

2002-07-23

Publication date

2005-03-07

2002-07-23 Application filed by Indena S.P.A. filed Critical Indena S.P.A.

2005-03-07 Publication of PL367868A1 publication Critical patent/PL367868A1/pl

2007-07-31 Publication of PL194975B1 publication Critical patent/PL194975B1/pl

Links

230000000259 anti-tumor effect Effects 0.000 title abstract 2
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical class O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000005676 cyclic carbonates Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
-1 t-butoxycarbonyl Chemical group 0.000 abstract 1
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Epoxy Compounds (AREA)

PL367868A 2001-08-07 2002-07-23 C-2' metylowane pochodne paklitakselu, kompozycja farmaceutyczna oraz ich zastosowanie PL194975B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2001MI001734A ITMI20011734A1 (it)	2001-08-07	2001-08-07	Derivanti tassanici e procedimenti per la loro preparazione
PCT/EP2002/008185 WO2003013503A1 (en)	2001-08-07	2002-07-23	C-2' methylated derivatives of paclitaxel for use as antitumour agents

Publications (2)

Publication Number	Publication Date
PL367868A1 true PL367868A1 (pl)	2005-03-07
PL194975B1 PL194975B1 (pl)	2007-07-31

Family

ID=11448252

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL367868A PL194975B1 (pl)	2001-08-07	2002-07-23	C-2' metylowane pochodne paklitakselu, kompozycja farmaceutyczna oraz ich zastosowanie

Country Status (20)

Country	Link
US (1)	US7153884B2 (pl)
EP (1)	EP1423108B1 (pl)
KR (1)	KR100894580B1 (pl)
CN (1)	CN100370980C (pl)
AT (1)	ATE363901T1 (pl)
AU (1)	AU2002328942B2 (pl)
BR (1)	BR0211770A (pl)
CA (1)	CA2456523A1 (pl)
DE (1)	DE60220524T2 (pl)
DK (1)	DK1423108T3 (pl)
ES (1)	ES2287310T3 (pl)
HU (1)	HUP0401275A3 (pl)
IL (1)	IL160233A0 (pl)
IT (1)	ITMI20011734A1 (pl)
MX (1)	MXPA04001234A (pl)
NO (1)	NO20040535L (pl)
PL (1)	PL194975B1 (pl)
PT (1)	PT1423108E (pl)
RU (1)	RU2287528C2 (pl)
WO (1)	WO2003013503A1 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101932938B (zh) *	2007-11-30	2014-08-27	克雷特诊疗服务公司	作为标记物用于化学疗法的tle3
CN101851231A (zh) *	2010-05-27	2010-10-06	东北林业大学	一种多西紫杉醇新衍生物的合成方法及其在制备抗肿瘤药物中的应用
CN104650012A (zh) *	2013-11-22	2015-05-27	天士力控股集团有限公司	一种紫杉烷类化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2059631C1 (ru) *	1991-11-29	1996-05-10	Дзе Юниверсити оф Канзас	Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью
FR2721024B1 (fr) *	1994-06-09	1996-07-12	Rhone Poulenc Rorer Sa	Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.

2001
- 2001-08-07 IT IT2001MI001734A patent/ITMI20011734A1/it unknown
2002
- 2002-07-23 US US10/485,982 patent/US7153884B2/en not_active Expired - Fee Related
- 2002-07-23 BR BR0211770-3A patent/BR0211770A/pt not_active IP Right Cessation
- 2002-07-23 KR KR1020047001736A patent/KR100894580B1/ko not_active Expired - Fee Related
- 2002-07-23 CN CNB028153529A patent/CN100370980C/zh not_active Expired - Fee Related
- 2002-07-23 DK DK02764753T patent/DK1423108T3/da active
- 2002-07-23 MX MXPA04001234A patent/MXPA04001234A/es active IP Right Grant
- 2002-07-23 WO PCT/EP2002/008185 patent/WO2003013503A1/en not_active Ceased
- 2002-07-23 EP EP02764753A patent/EP1423108B1/en not_active Expired - Lifetime
- 2002-07-23 IL IL16023302A patent/IL160233A0/xx unknown
- 2002-07-23 PL PL367868A patent/PL194975B1/pl not_active IP Right Cessation
- 2002-07-23 HU HU0401275A patent/HUP0401275A3/hu unknown
- 2002-07-23 CA CA002456523A patent/CA2456523A1/en not_active Abandoned
- 2002-07-23 PT PT02764753T patent/PT1423108E/pt unknown
- 2002-07-23 RU RU2004103481/04A patent/RU2287528C2/ru not_active IP Right Cessation
- 2002-07-23 DE DE60220524T patent/DE60220524T2/de not_active Expired - Fee Related
- 2002-07-23 ES ES02764753T patent/ES2287310T3/es not_active Expired - Lifetime
- 2002-07-23 AU AU2002328942A patent/AU2002328942B2/en not_active Ceased
- 2002-07-23 AT AT02764753T patent/ATE363901T1/de not_active IP Right Cessation
2004
- 2004-02-05 NO NO20040535A patent/NO20040535L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR20040030926A (ko)	2004-04-09
US20040242674A1 (en)	2004-12-02
NO20040535L (no)	2004-04-26
CA2456523A1 (en)	2003-02-20
WO2003013503A1 (en)	2003-02-20
ITMI20011734A1 (it)	2003-02-07
EP1423108A1 (en)	2004-06-02
PL194975B1 (pl)	2007-07-31
AU2002328942B2 (en)	2007-08-30
IL160233A0 (en)	2004-07-25
CN1538841A (zh)	2004-10-20
ATE363901T1 (de)	2007-06-15
MXPA04001234A (es)	2004-05-27
RU2004103481A (ru)	2005-06-10
BR0211770A (pt)	2004-07-27
ITMI20011734A0 (it)	2001-08-07
KR100894580B1 (ko)	2009-04-24
HUP0401275A2 (hu)	2004-10-28
DE60220524T2 (de)	2008-02-07
HK1066483A1 (en)	2005-03-24
US7153884B2 (en)	2006-12-26
EP1423108B1 (en)	2007-06-06
RU2287528C2 (ru)	2006-11-20
PT1423108E (pt)	2007-08-28
ES2287310T3 (es)	2007-12-16
CN100370980C (zh)	2008-02-27
DE60220524D1 (de)	2007-07-19
HUP0401275A3 (en)	2007-05-29
DK1423108T3 (da)	2007-10-01

Legal Events

Date	Code	Title	Description
2010-10-29	LAPS	Decisions on the lapse of the protection rights	Effective date: 20090723

Publication	Publication Date	Title
NZ514409A (en)	2004-03-26	C7 ester substituted taxanes as antitumor agents
AP1753A (en)	2007-07-18	Thiophene derivatives as antiviral agents for flavvivirus infection
SI1585739T1 (sl)	2011-07-29	Substituirani arilciklopropilacetamidi kot aktivatorji glukokinaze
MXPA03011197A (es)	2004-02-26	Benzoilsufonamidas y sulfonilbenzamidinas que se usan como agentes antitumorales.
MY139243A (en)	2009-09-30	Prodrugs of piperazine and substituted piperidine antiviral agents.
MXPA02000973A (es)	2002-07-30	Benzofurilpiperazinas y benzofurilhomopiperazinas: agonistas de serotonina.
DE602004008098D1 (de)	2007-09-20	Substituierte 2h-ä1,2,4ütriazoloä4,3-aüpyrazine als gsk-3-inhibitoren
BR0207302A (pt)	2004-02-10	Trifluorometilpurinas como inibidores da fosfodiesterase 4
MXPA04003886A (es)	2004-07-08	Tiofen- y tiazolsulfonamidas como agentes antineoplasticos.
YU82303A (sh)	2006-03-03	Analozi nociceptina
MY141255A (en)	2010-03-31	Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
MX2009006689A (es)	2009-06-30	Inhibidores viia de los factores macrociclicos utiles como anticoagulantes.
MX2009008756A (es)	2009-08-27	Compuesto macrociclico.
MX2009003713A (es)	2009-07-02	Inhibidor de progresion de enfermedad de alzheimer que contiene un compuesto heterociclico con estructura especifica.
MXPA03009602A (es)	2004-04-02	Analogos de nociceptina.
DE60336735D1 (de)	2011-05-26	Neue biologischaktive molekü le
MY138826A (en)	2009-07-31	2,7-substituted indoles
TW200505446A (en)	2005-02-16	Inhibitor of cox
DK1644389T3 (da)	2011-05-09	Pyrinidinforbindelser med phosphonatgrupper som antivirale nukleotidanaloger
ATE239722T1 (de)	2003-05-15	Benzofurylpiperazine als serotonin-agonisten
ZA200500436B (en)	2006-07-26	6-amino-1H-indazole and 4-aminobenzofuran compounds as phosphodiesterase 4 inhibitors
IL160233A0 (en)	2004-07-25	C-2' methylated derivatives of paclitaxel for use as antitumor agents
BG105964A (en)	2002-08-30	C(10) carbonate substituted taxanes and their use as antitumor agents
MXPA06003345A (es)	2006-06-08	Derivados de aminopiridina como inhibidores de la no-sintasa inducible.
WO2003093247A3 (en)	2003-12-24	Antibacterial agents