PL3679025T3 - Podstawione imidazochinoliny jako agoniści tlr7 - Google Patents

Podstawione imidazochinoliny jako agoniści tlr7

Info

Publication number
PL3679025T3
PL3679025T3 PL18769603T PL18769603T PL3679025T3 PL 3679025 T3 PL3679025 T3 PL 3679025T3 PL 18769603 T PL18769603 T PL 18769603T PL 18769603 T PL18769603 T PL 18769603T PL 3679025 T3 PL3679025 T3 PL 3679025T3
Authority
PL
Poland
Prior art keywords
tlr7 agonists
substituted imidazoquinolines
imidazoquinolines
substituted
tlr7
Prior art date
Application number
PL18769603T
Other languages
English (en)
Inventor
Christophe Henry
Original Assignee
BioNTech SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BioNTech SE filed Critical BioNTech SE
Publication of PL3679025T3 publication Critical patent/PL3679025T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL18769603T 2017-09-06 2018-08-31 Podstawione imidazochinoliny jako agoniści tlr7 PL3679025T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2017072353 2017-09-06
EP18769603.4A EP3679025B8 (en) 2017-09-06 2018-08-31 Substituted imidazoquinolines as agonists of tlr7
PCT/EP2018/073485 WO2019048353A1 (en) 2017-09-06 2018-08-31 SUBSTITUTED IMIDAZOQUINOLINES AS TLR7 AGONISTS

Publications (1)

Publication Number Publication Date
PL3679025T3 true PL3679025T3 (pl) 2022-07-11

Family

ID=63586658

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18769603T PL3679025T3 (pl) 2017-09-06 2018-08-31 Podstawione imidazochinoliny jako agoniści tlr7

Country Status (24)

Country Link
US (2) US11279684B2 (pl)
EP (2) EP3679025B8 (pl)
JP (1) JP7304848B2 (pl)
KR (1) KR20200050964A (pl)
CN (1) CN111132969B (pl)
AU (1) AU2018329152B2 (pl)
BR (1) BR112020004505A2 (pl)
CA (1) CA3074611A1 (pl)
CY (1) CY1125206T1 (pl)
DK (1) DK3679025T3 (pl)
ES (1) ES2914800T3 (pl)
HR (1) HRP20220669T1 (pl)
HU (1) HUE058995T2 (pl)
IL (1) IL273039B2 (pl)
LT (1) LT3679025T (pl)
MX (1) MX2020002366A (pl)
PL (1) PL3679025T3 (pl)
PT (1) PT3679025T (pl)
RS (1) RS63265B1 (pl)
SG (1) SG11202001926QA (pl)
SI (1) SI3679025T1 (pl)
SM (1) SMT202200226T1 (pl)
WO (1) WO2019048353A1 (pl)
ZA (2) ZA202001267B (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4257198A3 (en) 2017-08-22 2023-10-18 Dynavax Technologies Corporation Alkyl chain modified imidazoquinoline derivatives as tlr7/8 agonists and uses thereof
WO2019048036A1 (en) * 2017-09-06 2019-03-14 Biontech Ag SUBSTITUTED IMIDAZOQUINOLINES
CA3132229A1 (en) * 2019-03-07 2020-09-10 BioNTech SE Process for the preparation of a substituted imidazoquinoline
WO2022011043A2 (en) * 2020-07-08 2022-01-13 Purdue Research Foundation Compounds, compositions, and methods for the treatment of fibrotic diseases and cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756382B2 (en) 1999-06-10 2004-06-29 3M Innovative Properties Company Amide substituted imidazoquinolines
US6451810B1 (en) 1999-06-10 2002-09-17 3M Innovative Properties Company Amide substituted imidazoquinolines
US6573273B1 (en) * 1999-06-10 2003-06-03 3M Innovative Properties Company Urea substituted imidazoquinolines
US6677349B1 (en) 2001-12-21 2004-01-13 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
MY157827A (en) 2003-06-27 2016-07-29 3M Innovative Properties Co Sulfonamide substituted imidazoquinolines
EP1686992A4 (en) 2003-11-25 2009-11-04 3M Innovative Properties Co HYDROXYLAMINE, AND IMIDAZOQUINOLEINS, AND IMIDAZOPYRIDINES AND IMIDAZONAPHTYRIDINE SUBSTITUTED WITH OXIME
MX344330B (es) * 2008-03-24 2016-12-13 4Sc Ag Imidazoquinolinas substituidas novedosas.
EP3344622B1 (en) 2015-08-31 2021-07-07 3M Innovative Properties Company Guanidine substituted, fused 1h-imidazo[4,5-c]pyridine compounds useful in the treatment of viral and neoplastic diseases
WO2019048036A1 (en) * 2017-09-06 2019-03-14 Biontech Ag SUBSTITUTED IMIDAZOQUINOLINES

Also Published As

Publication number Publication date
LT3679025T (lt) 2022-06-27
RU2020112231A3 (pl) 2021-10-06
IL273039B2 (en) 2023-10-01
US11987569B2 (en) 2024-05-21
IL273039A (en) 2020-04-30
CN111132969A (zh) 2020-05-08
HRP20220669T1 (hr) 2022-08-19
SMT202200226T1 (it) 2022-07-21
RU2020112231A (ru) 2021-10-06
SG11202001926QA (en) 2020-04-29
CY1125206T1 (el) 2025-03-28
JP7304848B2 (ja) 2023-07-07
CA3074611A1 (en) 2019-03-14
CN111132969B (zh) 2024-01-30
ZA202101323B (en) 2022-09-28
EP4098652A1 (en) 2022-12-07
AU2018329152A1 (en) 2020-03-19
IL273039B1 (en) 2023-06-01
KR20200050964A (ko) 2020-05-12
JP2020532571A (ja) 2020-11-12
EP3679025B8 (en) 2022-06-15
US11279684B2 (en) 2022-03-22
MX2020002366A (es) 2020-07-20
HUE058995T2 (hu) 2022-10-28
ZA202001267B (en) 2021-07-28
US20210002249A1 (en) 2021-01-07
AU2018329152B2 (en) 2024-02-15
ES2914800T3 (es) 2022-06-16
DK3679025T3 (da) 2022-06-07
EP3679025A1 (en) 2020-07-15
PT3679025T (pt) 2022-06-01
WO2019048353A1 (en) 2019-03-14
RS63265B1 (sr) 2022-06-30
US20220242845A1 (en) 2022-08-04
SI3679025T1 (sl) 2022-07-29
BR112020004505A2 (pt) 2020-09-15
EP3679025B1 (en) 2022-05-04

Similar Documents

Publication Publication Date Title
DK3319956T3 (da) Substituerede oxopyridinderivater
PT3687999T (pt) Derivados de rapamicina
LT3190113T (lt) Pirolopirimidino junginiai, naudotini kaip tlr7 agonistai
EP3337481A4 (en) HUMAN TLR8 SELECTIVE AGONISTS
DK3642202T3 (da) Dihydro-pyrrolo-pyridin-derivater
MA41976A (fr) Composition lubrifiante ultra-fluide
BR112017006622A2 (pt) derivados de ácido borônico
HUE067529T2 (hu) Berendezés tárgyak megvilágítására
EP3385358A4 (en) LUBRICANT COMPOSITION
HUE057043T2 (hu) Kinolin-2-on származékok
FR3034100B1 (fr) Composition lubrifiante
EP3409751A4 (en) LUBRICANT COMPOSITION
LT3371168T (lt) Indolin-2-ono dariniai
MA41790A (fr) Dérivé de morphinane
EP3309163A4 (en) SUBSTITUTED DIHYDROPYRROLO PYRAZOL DERIVATIVE
PT3131898T (pt) Derivados de fluoroalquilfluoreno
ZA202101323B (en) Substituted imidazoquinolines as agonists of tlr7
EP3492568A4 (en) LUBRICANT COMPOSITION
DK3679038T3 (da) Substituerede imidazoquinoliner
PT3801538T (pt) Agonistas de tlr7
DK3672977T3 (da) Boronsyrederivater
DK3645513T3 (da) Benzazepinderivater
EP3344737C0 (en) LUBRICATING COMPOSITION
PL3645539T3 (pl) Pochodne pirydoimidazoryfamycyny jako środek przeciwbakteryjny
EP3595647A4 (en) ARYL-PIPERIDINE DERIVATIVES