PL3687996T3 - Sole pochodnych pirolotriazyny użyteczne jako inhibitory tam - Google Patents

Sole pochodnych pirolotriazyny użyteczne jako inhibitory tam

Info

Publication number
PL3687996T3
PL3687996T3 PL18783341T PL18783341T PL3687996T3 PL 3687996 T3 PL3687996 T3 PL 3687996T3 PL 18783341 T PL18783341 T PL 18783341T PL 18783341 T PL18783341 T PL 18783341T PL 3687996 T3 PL3687996 T3 PL 3687996T3
Authority
PL
Poland
Prior art keywords
pyrolotriazine
inhibitors
salts
derivatives useful
derivatives
Prior art date
Application number
PL18783341T
Other languages
English (en)
Inventor
Zhongjiang JIA
Yongzhong Wu
Yongchun Pan
Jiacheng Zhou
Qun Li
Original Assignee
Incyte Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corporation filed Critical Incyte Corporation
Publication of PL3687996T3 publication Critical patent/PL3687996T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL18783341T 2017-09-27 2018-09-26 Sole pochodnych pirolotriazyny użyteczne jako inhibitory tam PL3687996T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762564070P 2017-09-27 2017-09-27
US201862714196P 2018-08-03 2018-08-03
EP18783341.3A EP3687996B1 (en) 2017-09-27 2018-09-26 Salts of pyrrolotriazine derivatives useful as tam inhibitors
PCT/US2018/052925 WO2019067594A1 (en) 2017-09-27 2018-09-26 Salts of pyrrolotriazine derivatives useful as tam inhibitors

Publications (1)

Publication Number Publication Date
PL3687996T3 true PL3687996T3 (pl) 2022-02-21

Family

ID=63794769

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18783341T PL3687996T3 (pl) 2017-09-27 2018-09-26 Sole pochodnych pirolotriazyny użyteczne jako inhibitory tam

Country Status (34)

Country Link
US (4) US10633387B2 (pl)
EP (2) EP3988552A1 (pl)
JP (3) JP7504791B2 (pl)
KR (1) KR102739325B1 (pl)
CN (2) CN118930549A (pl)
AU (2) AU2018342471B2 (pl)
CA (1) CA3077308A1 (pl)
CL (2) CL2020000791A1 (pl)
CO (1) CO2020005009A2 (pl)
CR (1) CR20200179A (pl)
CY (1) CY1124952T1 (pl)
DK (1) DK3687996T3 (pl)
EC (1) ECSP20021655A (pl)
ES (1) ES2904458T3 (pl)
GE (2) GEAP202215322A (pl)
HU (1) HUE057190T2 (pl)
IL (1) IL273579B2 (pl)
JO (1) JOP20200081B1 (pl)
LT (1) LT3687996T (pl)
MA (1) MA50655B1 (pl)
MD (1) MD3687996T2 (pl)
MX (1) MX2020003375A (pl)
MY (1) MY208007A (pl)
PE (1) PE20210002A1 (pl)
PH (1) PH12020550143A1 (pl)
PL (1) PL3687996T3 (pl)
PT (1) PT3687996T (pl)
RS (1) RS62872B1 (pl)
SA (1) SA520411638B1 (pl)
SG (1) SG11202002821UA (pl)
SI (1) SI3687996T1 (pl)
SM (1) SMT202200011T1 (pl)
TW (1) TWI821200B (pl)
WO (1) WO2019067594A1 (pl)

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WO2017035366A1 (en) 2015-08-26 2017-03-02 Incyte Corporation Pyrrolopyrimidine derivatives as tam inhibitors
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TWI828027B (zh) 2016-03-28 2024-01-01 美商英塞特公司 作為tam抑制劑之吡咯并三嗪化合物
AU2017382339B2 (en) 2016-12-22 2024-02-15 Novartis Ag NMDA receptor modulators and uses thereof
US10633387B2 (en) 2017-09-27 2020-04-28 Incyte Corporation Salts of TAM inhibitors
ES3031110T3 (en) * 2018-06-29 2025-07-04 Incyte Corp Formulations of an axl/mer inhibitor
PT3830092T (pt) 2018-08-03 2023-07-25 Novartis Ag Moduladores do recetor nmda heteroaromáticos e suas utilizações
CR20250050A (es) 2018-09-05 2025-03-19 Incyte Corp Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165)
PH12022552347A1 (en) * 2020-03-06 2024-01-29 Incyte Corp Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors
US12534479B2 (en) 2020-07-10 2026-01-27 Findcure Biosciences (Zhongshan) Co., Ltd. Triazine compound and composition and use thereof
CN115028648B (zh) * 2021-03-03 2024-08-30 武汉誉祥医药科技有限公司 三并环化合物及其药物组合物和应用
WO2023286719A1 (ja) * 2021-07-13 2023-01-19 日本曹達株式会社 ウラシル化合物の製造方法

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