PL369256A1 - Podstawione pochodne alkiloaminopirydazynonu, proces ich otrzymywania i zawierająca te pochodne kompozycja farmaceutyczna - Google Patents

Podstawione pochodne alkiloaminopirydazynonu, proces ich otrzymywania i zawierająca te pochodne kompozycja farmaceutyczna

Info

Publication number: PL369256A1
Authority: PL; Poland
Prior art keywords: sub; hydrogen; stands; alkyl; carbon atoms
Prior art date: 2001-09-27

Application number

PL02369256A

Other languages

English (en)

Inventor

Jozsef Barkoczy

Gyula Simig

Nagy Peter Kotay

György Levay

Istvan Gacsalyi

Marko Bernadett Martonne

Eva Schmidt

Andras Egyed

Hajnalka Kompagne

Csilla Leveleki

Kovacs Aniko Miklosne

Gabor Szenasi

Janos Wellmann

Laszlo Gabor Harsing

Original Assignee

Egis Gyogyszergyar Rt.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-09-27

Filing date

2002-09-26

Publication date

2005-04-18

2002-09-26 Application filed by Egis Gyogyszergyar Rt. filed Critical Egis Gyogyszergyar Rt.

2005-04-18 Publication of PL369256A1 publication Critical patent/PL369256A1/pl

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 4
125000004432 carbon atom Chemical group C* 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
208000010877 cognitive disease Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000004193 piperazinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

PL02369256A 2001-09-27 2002-09-26 Podstawione pochodne alkiloaminopirydazynonu, proces ich otrzymywania i zawierająca te pochodne kompozycja farmaceutyczna PL369256A1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU0103912A HU227237B1 (en)	2001-09-27	2001-09-27	Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them

Publications (1)

Publication Number	Publication Date
PL369256A1 true PL369256A1 (pl)	2005-04-18

Family

ID=89979721

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL02369256A PL369256A1 (pl)	2001-09-27	2002-09-26	Podstawione pochodne alkiloaminopirydazynonu, proces ich otrzymywania i zawierająca te pochodne kompozycja farmaceutyczna
PL02369107A PL369107A1 (pl)	2001-09-27	2002-09-26	Podstawione pochodne alkiloaminopirydazynonu, proces ich otrzymywania i zawierajace te pochodne kompozycja farmaceutyczna

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL02369107A PL369107A1 (pl)	2001-09-27	2002-09-26	Podstawione pochodne alkiloaminopirydazynonu, proces ich otrzymywania i zawierajace te pochodne kompozycja farmaceutyczna

Country Status (25)

Country	Link
US (2)	US20050043314A1 (pl)
EP (2)	EP1430034B1 (pl)
JP (2)	JP4472337B2 (pl)
KR (2)	KR100911069B1 (pl)
CN (3)	CN1325489C (pl)
AT (2)	ATE288910T1 (pl)
AU (2)	AU2002330656B9 (pl)
BR (2)	BR0212932A (pl)
CA (2)	CA2461467A1 (pl)
CZ (2)	CZ2004528A3 (pl)
DE (2)	DE60202969T2 (pl)
DK (2)	DK1430034T3 (pl)
EA (2)	EA006942B1 (pl)
ES (2)	ES2237696T3 (pl)
HU (1)	HU227237B1 (pl)
MA (2)	MA27137A1 (pl)
MX (2)	MXPA04002836A (pl)
NO (2)	NO326370B1 (pl)
NZ (2)	NZ532104A (pl)
PL (2)	PL369256A1 (pl)
PT (2)	PT1430047E (pl)
SI (2)	SI1430034T1 (pl)
SK (2)	SK1892004A3 (pl)
WO (2)	WO2003027078A1 (pl)
ZA (2)	ZA200402545B (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7504395B2 (en) *	2001-07-20	2009-03-17	Psychogenics, Inc.	Treatment for attention-deficit hyperactivity disorder
HU227592B1 (en) *	2002-11-13	2011-09-28	Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag	Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions
JP5147866B2 (ja) *	2007-03-15	2013-02-20	メルク・シャープ・アンド・ドーム・コーポレーション	グルカン合成酵素阻害剤として有用であるピリダジノン誘導体
BR112020022006A2 (pt) *	2018-04-30	2021-01-26	Ribon Therapeutics Inc.	piridazinonas como inibidores de parp7
CN109053693B (zh)	2018-09-20	2021-02-05	顺毅股份有限公司	哒嗪胺类化合物的制备及其应用
WO2020223229A1 (en)	2019-04-29	2020-11-05	Ribon Therapeutics, Inc.	Solid forms of a parp7 inhibitor
TWI902715B (zh)	2019-10-30	2025-11-01	美商律幫治療股份有限公司	作為ｐａｒｐ７抑制劑的嗒酮
WO2022188889A1 (zh) *	2021-03-12	2022-09-15	杭州英创医药科技有限公司	作为parp7抑制剂的化合物
CN115490671B (zh) *	2022-10-21	2024-05-14	水木未来(北京)科技有限公司	Parp7抑制剂及其制备方法
CN118388414A (zh) *	2023-01-17	2024-07-26	中国药科大学	哒嗪酮类化合物及其制备方法、药物组合物和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH557820A (de) *	1970-11-12	1975-01-15	Sandoz Ag	Verfahren zur herstellung von neuen 2-(2-hydroxyalkyl)4,5-dihydro-pyridazin (2h)-3-onen.
IE62890B1 (en) *	1988-12-06	1995-03-08	Hafslund Nycomed Pharma	New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure
PL164079B1 (pl)	1990-06-15	1994-06-30	Akad Medyczna	posób wytwarzania nowych 2-amlnoalkilopochodnych 5-aminometyleno-6-/p-chlorofenylo /-4,5-dihydro-2H- plrydazyn -3-onu
HU209388B (en) *	1990-12-27	1994-05-30	Richter Gedeon Vegyeszet	Process for producing new 3/2h/-pyridazinones and pharmaceutical compositions comprising same
HU214320B (hu)	1991-12-20	1998-03-02	EGIS Gyógyszergyár Rt.	Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására
HU224067B1 (hu)	1995-05-29	2005-05-30	Gyógyszerkutató Intézet Kft.	3(2H)-Piridazinon-származékok és e vegyületeket tartalmazó gyógyszerkészítmények
JP2004500314A (ja)	1998-06-05	2004-01-08	エギシュ　ヂョヂセルヂャール　エルテー	３（２ｈ）−ピリダジノン−４−置換アミノ−５−クロロ−誘導体の製法

2001
- 2001-09-27 HU HU0103912A patent/HU227237B1/hu not_active IP Right Cessation
2002
- 2002-09-26 EP EP02767729A patent/EP1430034B1/en not_active Expired - Lifetime
- 2002-09-26 WO PCT/HU2002/000097 patent/WO2003027078A1/en not_active Ceased
- 2002-09-26 US US10/490,959 patent/US20050043314A1/en not_active Abandoned
- 2002-09-26 BR BR0212932-9A patent/BR0212932A/pt not_active IP Right Cessation
- 2002-09-26 EA EA200400470A patent/EA006942B1/ru not_active IP Right Cessation
- 2002-09-26 DE DE60202969T patent/DE60202969T2/de not_active Expired - Lifetime
- 2002-09-26 EA EA200400469A patent/EA006392B1/ru not_active IP Right Cessation
- 2002-09-26 JP JP2003530685A patent/JP4472337B2/ja not_active Expired - Lifetime
- 2002-09-26 DE DE60202970T patent/DE60202970T2/de not_active Expired - Lifetime
- 2002-09-26 NZ NZ532104A patent/NZ532104A/en unknown
- 2002-09-26 AU AU2002330656A patent/AU2002330656B9/en not_active Ceased
- 2002-09-26 EP EP02762620A patent/EP1430047B1/en not_active Expired - Lifetime
- 2002-09-26 SK SK1892004A patent/SK1892004A3/sk unknown
- 2002-09-26 PL PL02369256A patent/PL369256A1/pl unknown
- 2002-09-26 CA CA002461467A patent/CA2461467A1/en not_active Abandoned
- 2002-09-26 CN CNB028204425A patent/CN1325489C/zh not_active Expired - Fee Related
- 2002-09-26 BR BR0212839-0A patent/BR0212839A/pt not_active IP Right Cessation
- 2002-09-26 US US10/491,151 patent/US6930110B2/en not_active Expired - Fee Related
- 2002-09-26 WO PCT/HU2002/000096 patent/WO2003027097A1/en not_active Ceased
- 2002-09-26 CN CNB028189752A patent/CN100368404C/zh not_active Expired - Fee Related
- 2002-09-26 PT PT02762620T patent/PT1430047E/pt unknown
- 2002-09-26 MX MXPA04002836A patent/MXPA04002836A/es active IP Right Grant
- 2002-09-26 SI SI200230107T patent/SI1430034T1/xx unknown
- 2002-09-26 JP JP2003530669A patent/JP2005508914A/ja active Pending
- 2002-09-26 MX MXPA04002838A patent/MXPA04002838A/es active IP Right Grant
- 2002-09-26 CZ CZ2004528A patent/CZ2004528A3/cs unknown
- 2002-09-26 PT PT02767729T patent/PT1430034E/pt unknown
- 2002-09-26 DK DK02767729T patent/DK1430034T3/da active
- 2002-09-26 AU AU2002328166A patent/AU2002328166B2/en not_active Ceased
- 2002-09-26 ES ES02767729T patent/ES2237696T3/es not_active Expired - Lifetime
- 2002-09-26 AT AT02762620T patent/ATE288910T1/de not_active IP Right Cessation
- 2002-09-26 CN CN200710104934XA patent/CN101099740B/zh not_active Expired - Fee Related
- 2002-09-26 CZ CZ2004532A patent/CZ2004532A3/cs unknown
- 2002-09-26 SK SK1902004A patent/SK1902004A3/sk unknown
- 2002-09-26 CA CA002461510A patent/CA2461510C/en not_active Expired - Fee Related
- 2002-09-26 NZ NZ532103A patent/NZ532103A/en unknown
- 2002-09-26 PL PL02369107A patent/PL369107A1/pl not_active IP Right Cessation
- 2002-09-26 ES ES02762620T patent/ES2237690T3/es not_active Expired - Lifetime
- 2002-09-26 DK DK02762620T patent/DK1430047T3/da active
- 2002-09-26 SI SI200230109T patent/SI1430047T1/xx unknown
- 2002-09-26 AT AT02767729T patent/ATE288899T1/de not_active IP Right Cessation
- 2002-09-26 KR KR1020047004607A patent/KR100911069B1/ko not_active Expired - Fee Related
- 2002-09-26 KR KR1020047004606A patent/KR100890667B1/ko not_active Expired - Fee Related
2004
- 2004-03-24 MA MA27588A patent/MA27137A1/fr unknown
- 2004-03-24 MA MA27589A patent/MA27068A1/fr unknown
- 2004-03-31 ZA ZA200402545A patent/ZA200402545B/en unknown
- 2004-03-31 ZA ZA200402544A patent/ZA200402544B/en unknown
- 2004-04-16 NO NO20041551A patent/NO326370B1/no not_active IP Right Cessation
- 2004-04-26 NO NO20041704A patent/NO325080B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
HU0103912D0 (en)	2001-12-28
JP2005508914A (ja)	2005-04-07
HU227237B1 (en)	2010-12-28
AU2002330656A2 (en)	2003-04-07
AU2002330656B2 (en)	2009-04-09
HK1069817A1 (en)	2005-06-03
PT1430034E (pt)	2005-06-30
BR0212839A (pt)	2004-10-13
KR100890667B1 (ko)	2009-03-26
NO20041704L (no)	2004-04-26
JP2005503437A (ja)	2005-02-03
AU2002328166A2 (en)	2003-04-07
CN1558904A (zh)	2004-12-29
ZA200402544B (en)	2005-04-26
SK1902004A3 (en)	2004-10-05
EP1430047A1 (en)	2004-06-23
NZ532104A (en)	2005-10-28
EP1430034A1 (en)	2004-06-23
ZA200402545B (en)	2005-04-26
CA2461510C (en)	2009-07-07
ATE288899T1 (de)	2005-02-15
CN1325489C (zh)	2007-07-11
CN101099740A (zh)	2008-01-09
EP1430047B1 (en)	2005-02-09
MA27068A1 (fr)	2004-12-20
US20040242873A1 (en)	2004-12-02
WO2003027097A1 (en)	2003-04-03
SK1892004A3 (en)	2004-10-05
CA2461467A1 (en)	2003-04-03
SI1430034T1 (en)	2005-08-31
ATE288910T1 (de)	2005-02-15
DE60202969T2 (de)	2006-01-19
NZ532103A (en)	2005-08-26
WO2003027078A1 (en)	2003-04-03
SI1430047T1 (en)	2005-08-31
CZ2004528A3 (cs)	2004-08-18
ES2237690T3 (es)	2005-08-01
HK1115728A1 (en)	2008-12-05
PL369107A1 (pl)	2005-04-18
ES2237696T3 (es)	2005-08-01
BR0212932A (pt)	2004-10-13
EA200400469A1 (ru)	2004-08-26
NO326370B1 (no)	2008-11-17
JP4472337B2 (ja)	2010-06-02
US20050043314A1 (en)	2005-02-24
CN1571783A (zh)	2005-01-26
DK1430034T3 (da)	2005-05-30
DE60202970D1 (de)	2005-03-17
HUP0103912A3 (en)	2004-03-01
DE60202969D1 (de)	2005-03-17
KR100911069B1 (ko)	2009-08-06
NO20041551L (no)	2004-06-10
CN100368404C (zh)	2008-02-13
KR20040039446A (ko)	2004-05-10
US6930110B2 (en)	2005-08-16
HK1069816A1 (en)	2005-06-03
CZ2004532A3 (cs)	2004-08-18
CA2461510A1 (en)	2003-04-03
NO325080B1 (no)	2008-01-28
AU2002328166B2 (en)	2008-04-17
MA27137A1 (fr)	2005-01-03
MXPA04002836A (es)	2004-07-05
DE60202970T2 (de)	2006-02-16
EA200400470A1 (ru)	2004-08-26
EA006392B1 (ru)	2005-12-29
MXPA04002838A (es)	2004-07-05
HUP0103912A2 (hu)	2003-07-28
EP1430034B1 (en)	2005-02-09
PT1430047E (pt)	2005-06-30
KR20040039445A (ko)	2004-05-10
DK1430047T3 (da)	2005-06-06
CN101099740B (zh)	2010-09-08
EA006942B1 (ru)	2006-06-30
AU2002330656B9 (en)	2009-09-03

Legal Events

Date	Code	Title	Description
2014-04-30	DISC	Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
HUP0100615A2 (hu)	2001-10-28	Szubsztituált 2-(2,6-dioxo-3-fluoro-piperidin-3-il)-izoindolinok és ezek alkalmazása TNFalfa-szint csökkentésére
HUP0002112A2 (hu)	2000-09-28	Helyettesített 3-ciano-kinolinok, előállításuk és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények
MXPA02012033A (es)	2003-04-25	Derivados de 2-aminocarbonil-9h-purina.
MXPA03000161A (es)	2004-02-26	Compuestos novedosos los cuales tienen actividad antiinflamatoria, proceso para su preparacion y composiciones farmaceuticas que las contienen.
SI1430034T1 (en)	2005-08-31	Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same
AU4811396A (en)	1996-09-26	Substituted benzothienylpiperazines their use as medicaments, and processes for their preparation
AP1396A (en)	2005-04-19	1-Trifluoromethyl-4-hydroxy-7-piperidinylaminomethylchroman derivatives.
PL371520A1 (pl)	2005-06-27	Nowe pochodne piperydynylo-alkiloamino-pirydazynonu, proces ich otrzymywania oraz zawierające je kompozycje farmaceutyczne
IL158839A0 (en)	2004-05-12	DIHYDROIMIDAZO [5,1-A]-beta-CARBOLINE DERIVATIVES, METHOD FOR PREPARING SAME AND USE THEREOF AS MEDICINE
IL115085A (en)	1999-06-20	Piperazine bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them
HUP9800889A1 (hu)	2000-11-28	Új naftil-piperazin-származékok
CA2323315A1 (en)	2001-04-18	Process for the preparation of piperidinylaminomethyl trifluoromethyl cyclic ether compounds
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