PL369447A1 - Sposób wytwarzania związków insuliny - Google Patents

Sposób wytwarzania związków insuliny

Info

Publication number: PL369447A1
Authority: PL; Poland
Prior art keywords: insulin compounds; preparing insulin; compounds; insulin; ester
Prior art date: 2001-11-19

Application number

PL02369447A

Other languages

English (en)

Other versions

PL210437B1 (pl

Inventor

Are Bogsnes

Ingun Christiansen

Per Balschmidt

Original Assignee

Novo Nordisk A/S

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-19

Filing date

2002-11-15

Publication date

2005-04-18

2002-11-15 Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S

2005-04-18 Publication of PL369447A1 publication Critical patent/PL369447A1/pl

2012-01-31 Publication of PL210437B1 publication Critical patent/PL210437B1/pl

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
-1 amino acid ester Chemical class 0.000 abstract 1
239000012736 aqueous medium Substances 0.000 abstract 1
230000008878 coupling Effects 0.000 abstract 1
238000010168 coupling process Methods 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
230000007030 peptide scission Effects 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Public Health (AREA)
Hematology (AREA)
Obesity (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Toxicology (AREA)
General Engineering & Computer Science (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

PL369447A 2001-11-19 2002-11-15 Sposób wytwarzania związków insuliny PL210437B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DKPA200101716		2001-11-19

Publications (2)

Publication Number	Publication Date
PL369447A1 true PL369447A1 (pl)	2005-04-18
PL210437B1 PL210437B1 (pl)	2012-01-31

Family

ID=8160841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL369447A PL210437B1 (pl)	2001-11-19	2002-11-15	Sposób wytwarzania związków insuliny

Country Status (15)

Country	Link
EP (1)	EP1448786B1 (pl)
JP (1)	JP4404631B2 (pl)
KR (1)	KR100925381B1 (pl)
CN (1)	CN100424179C (pl)
AT (1)	ATE464390T1 (pl)
AU (1)	AU2002342597A1 (pl)
BR (1)	BR0213583A (pl)
CA (1)	CA2464616C (pl)
DE (1)	DE60236014D1 (pl)
ES (1)	ES2344448T3 (pl)
HU (1)	HU228934B1 (pl)
IL (2)	IL161358A0 (pl)
PL (1)	PL210437B1 (pl)
RU (1)	RU2376379C2 (pl)
WO (1)	WO2003044210A2 (pl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102006031962A1 (de)	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Amidiertes Insulin Glargin
DE102006031955A1 (de) *	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
TW200902708A (en) *	2007-04-23	2009-01-16	Wyeth Corp	Methods of protein production using anti-senescence compounds
CN102256618A (zh)	2008-10-17	2011-11-23	赛诺菲-安万特德国有限公司	胰岛素和glp-1激动剂的组合
PL2451437T3 (pl)	2009-07-06	2017-05-31	Sanofi-Aventis Deutschland Gmbh	Wodne preparaty insuliny zawierające metioninę
EP2464655B1 (en) *	2009-08-11	2017-02-15	Biocon Limited	Chromatographic processes
NZ599847A (en)	2009-11-13	2013-09-27	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a glp-1 agonist and methionine
TR201809460T4 (tr)	2009-11-13	2018-07-23	Sanofi Aventis Deutschland	Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim.
WO2012028172A1 (en)	2010-08-30	2012-03-08	Sanofi-Aventis Deutschland Gmbh	Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087693A1 (es)	2011-08-29	2014-04-09	Sanofi Aventis Deutschland	Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
CN102703552B (zh) *	2012-05-15	2014-10-29	山东阿华生物药业有限公司	重组人胰岛素的制备方法及其产品
CN102816819B (zh) *	2012-08-13	2014-10-29	山东阿华生物药业有限公司	提高人胰岛素前体融合蛋白酶切转换成b30缺苏氨酸人胰岛素产率的方法
CN103305581B (zh) *	2013-07-04	2015-05-27	珠海联邦制药股份有限公司	一种重组人胰岛素的制备方法
UA119762C2 (uk) *	2013-12-23	2019-08-12	Біокон Ресерч Лімітед	Спосіб отримання метилового ефіру інсуліну людини
PE20171622A1 (es)	2014-12-12	2017-11-02	Sanofi Aventis Deutschland	Formulacion de relacion fija de insulina glargina/lixisenatida
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
WO2017052305A1 (en) *	2015-09-24	2017-03-30	Hanmi Pharm. Co., Ltd.	Method of insulin production

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE50892B1 (en)	1980-02-11	1986-08-06	Novo Industri As	Process for preparing insulin esters
WO1983000504A1 (en)	1981-08-10	1983-02-17	Andresen, Finn, Hede	Enzymatic preparation of human insulin
US4601979A (en)	1981-09-15	1986-07-22	Nordisk Insulinlaboratorium	Process for preparing human insulin or B-30 esters thereof
DK149824C (da)	1982-01-22	1987-03-16	Carlsberg Biotechnology Ltd	Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner
EP0087238A1 (en)	1982-02-08	1983-08-31	Biogen N.V.	Am improved method for preparing human insulin from non-human insulin
DK347086D0 (da)	1986-07-21	1986-07-21	Novo Industri As	Novel peptides
PH25772A (en)	1985-08-30	1991-10-18	Novo Industri As	Insulin analogues, process for their preparation
IL84110A (en) *	1986-10-14	1992-11-15	Lilly Co Eli	Process for transforming a human insulin precursor to a human insulin
FI884914A0 (fi)	1987-02-25	1988-10-24	Novo Industri As	Nya insulinderivat.
US6011007A (en)	1993-09-17	2000-01-04	Novo Nordisk A/S	Acylated insulin
CZ287945B6 (cs)	1993-09-17	2001-03-14	Novo Nordisk A/S	Inzulinový derivát a farmaceutický prostředek s jeho obsahem pro léčení diabetu
RU2141531C1 (ru) *	1999-05-26	1999-11-20	Российское акционерное общество открытого типа "Биопрепарат"	Способ получения рекомбинантного инсулина человека
EP1246933B1 (en)	1999-12-29	2010-07-21	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
KR20030004317A (ko)	1999-12-29	2003-01-14	노보 노르디스크 에이/에스	인슐린 선구물질 및 인슐린 선구물질 유사체의 제조 방법
AU2001255400A1 (en)	2000-04-14	2001-10-30	University Of Maryland Biotechnology Institute	Enhanced protein thermostability and temperature resistance
US20040198960A1 (en)	2001-03-29	2004-10-07	Janoff Edward N	Human monoclonal antibodies against capsular polysaccharides of streptococcus pneumoniae

2002
- 2002-11-15 DE DE60236014T patent/DE60236014D1/de not_active Expired - Lifetime
- 2002-11-15 CN CNB028229622A patent/CN100424179C/zh not_active Expired - Lifetime
- 2002-11-15 AT AT02779247T patent/ATE464390T1/de not_active IP Right Cessation
- 2002-11-15 CA CA2464616A patent/CA2464616C/en not_active Expired - Fee Related
- 2002-11-15 EP EP02779247A patent/EP1448786B1/en not_active Expired - Lifetime
- 2002-11-15 HU HU0500037A patent/HU228934B1/hu not_active IP Right Cessation
- 2002-11-15 WO PCT/DK2002/000765 patent/WO2003044210A2/en not_active Ceased
- 2002-11-15 PL PL369447A patent/PL210437B1/pl unknown
- 2002-11-15 KR KR1020047007129A patent/KR100925381B1/ko not_active Expired - Fee Related
- 2002-11-15 JP JP2003545831A patent/JP4404631B2/ja not_active Expired - Lifetime
- 2002-11-15 BR BR0213583-3A patent/BR0213583A/pt not_active Application Discontinuation
- 2002-11-15 AU AU2002342597A patent/AU2002342597A1/en not_active Abandoned
- 2002-11-15 ES ES02779247T patent/ES2344448T3/es not_active Expired - Lifetime
- 2002-11-15 RU RU2004118503/13A patent/RU2376379C2/ru not_active IP Right Cessation
- 2002-11-15 IL IL16135802A patent/IL161358A0/xx unknown
2004
- 2004-04-14 IL IL161358A patent/IL161358A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL161358A0 (en)	2004-09-27
RU2004118503A (ru)	2005-06-10
EP1448786B1 (en)	2010-04-14
BR0213583A (pt)	2004-08-24
HU228934B1 (hu)	2013-06-28
DE60236014D1 (de)	2010-05-27
JP2005509687A (ja)	2005-04-14
WO2003044210A3 (en)	2004-03-25
CN1589328A (zh)	2005-03-02
KR20050044855A (ko)	2005-05-13
AU2002342597A1 (en)	2003-06-10
EP1448786A2 (en)	2004-08-25
ATE464390T1 (de)	2010-04-15
CN100424179C (zh)	2008-10-08
RU2376379C2 (ru)	2009-12-20
JP4404631B2 (ja)	2010-01-27
PL210437B1 (pl)	2012-01-31
CA2464616C (en)	2012-07-24
WO2003044210A2 (en)	2003-05-30
CA2464616A1 (en)	2003-05-30
HUP0500037A2 (hu)	2005-03-29
ES2344448T3 (es)	2010-08-27
HUP0500037A3 (en)	2010-01-28
KR100925381B1 (ko)	2009-11-09
AU2002342597A8 (en)	2003-06-10
IL161358A (en)	2011-05-31

Legal Events

Date	Code	Title	Description
2012-05-31	RECP	Rectifications of patent specification

Publication	Publication Date	Title
AU2002342597A8 (en)	2003-06-10	Process for preparing insulin compounds
EG23843A (en)	2007-10-17	Modified pictet-spengler reaction and products prepared therefrom
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SI1109782T1 (sl)	2005-12-31	Postopek za pripravo N-zascitenih azeditin-2-karboksilnih kislin (AzeOH)
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AU2002356427A1 (en)	2004-06-15	An improved process for the preparation of gabalactam
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AU7677798A (en)	1998-12-30	Process for the preparation of ampicillin
WO2003048161A8 (en)	2004-04-22	A process for preparing 2,6-dichloropurine
EP1568693A4 (en)	2007-09-05	PROCESS FOR PRODUCING QUINOLINECARBALDEHYDE
HK1050672A1 (zh)	2003-07-04	制备环己腈中间体和方法
WO2005017171A3 (en)	2005-06-23	Process for the production of d-amino acids