PL370711A1 - Pochodne indoliloalkiloaminy jako ligandy receptora 5-hydroksytryptaminy-6 - Google Patents

Pochodne indoliloalkiloaminy jako ligandy receptora 5-hydroksytryptaminy-6

Info

Publication number
PL370711A1
PL370711A1 PL02370711A PL37071102A PL370711A1 PL 370711 A1 PL370711 A1 PL 370711A1 PL 02370711 A PL02370711 A PL 02370711A PL 37071102 A PL37071102 A PL 37071102A PL 370711 A1 PL370711 A1 PL 370711A1
Authority
PL
Poland
Prior art keywords
hydroxytryptamine
ligands
indolylalkylamine
derivatives
indolylalkylamine derivatives
Prior art date
Application number
PL02370711A
Other languages
English (en)
Other versions
PL210413B1 (pl
Inventor
Derek Cecil Cole
Joseph Raymond Stock
William Joseph Lennox
Ping Zhou
Original Assignee
Wyeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth filed Critical Wyeth
Publication of PL370711A1 publication Critical patent/PL370711A1/pl
Publication of PL210413B1 publication Critical patent/PL210413B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL370711A 2001-12-20 2002-12-17 Pochodne indoliloalkiloaminy PL210413B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34290701P 2001-12-20 2001-12-20

Publications (2)

Publication Number Publication Date
PL370711A1 true PL370711A1 (pl) 2005-05-30
PL210413B1 PL210413B1 (pl) 2012-01-31

Family

ID=23343804

Family Applications (1)

Application Number Title Priority Date Filing Date
PL370711A PL210413B1 (pl) 2001-12-20 2002-12-17 Pochodne indoliloalkiloaminy

Country Status (29)

Country Link
US (2) US6770642B2 (pl)
EP (1) EP1455779B1 (pl)
JP (1) JP4335684B2 (pl)
KR (1) KR100985140B1 (pl)
CN (1) CN1309385C (pl)
AR (1) AR037906A1 (pl)
AT (1) ATE335477T1 (pl)
AU (1) AU2002357270B2 (pl)
BR (1) BR0215222A (pl)
CA (1) CA2470863C (pl)
CO (1) CO5590924A2 (pl)
CY (1) CY1105705T1 (pl)
DE (1) DE60213856T2 (pl)
DK (1) DK1455779T3 (pl)
EC (1) ECSP045156A (pl)
ES (1) ES2269827T3 (pl)
HU (1) HUP0402640A3 (pl)
IL (1) IL162243A0 (pl)
MX (1) MXPA04005889A (pl)
NO (1) NO330338B1 (pl)
NZ (1) NZ533666A (pl)
PL (1) PL210413B1 (pl)
PT (1) PT1455779E (pl)
RU (1) RU2309157C2 (pl)
SI (1) SI1455779T1 (pl)
TW (1) TWI254705B (pl)
UA (1) UA78536C2 (pl)
WO (1) WO2003053433A1 (pl)
ZA (1) ZA200405731B (pl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002212749A1 (en) * 2000-11-09 2002-05-21 Mitsui Chemicals, Inc. Optically active amine derivative and method of synthesis
TW200301251A (en) * 2001-12-20 2003-07-01 Wyeth Corp Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
CA2532071A1 (en) * 2003-07-23 2005-02-03 Wyeth Sulfonyldihydro- benzimidazolone compounds as 5-hydroxytryptamine-6 ligands
US20050032873A1 (en) * 2003-07-30 2005-02-10 Wyeth 3-Amino chroman and 2-amino tetralin derivatives
WO2005012311A1 (en) * 2003-07-31 2005-02-10 Wyeth N-sulfonylheterocyclopyrrolylalkylamine compounds as 5-hydroxytryptamine-6 ligands
BRPI0413234A (pt) * 2003-08-01 2006-10-03 Genelabs Tech Inc derivados de imidazola bicìclica contra flaviviridae
ATE430752T1 (de) 2004-01-02 2009-05-15 Suven Life Sciences Ltd Neue indenoä2,1-aüindene und isoindolä2,1-aüindol
PE20060303A1 (es) * 2004-06-23 2006-05-19 Wyeth Corp Metabolitos de indolilalquilamina como ligandos de 5-hidroxitriptamina-6
BRPI0519036A2 (pt) * 2004-12-14 2008-12-23 Wyeth Corp mÉtodo para o tratamento de um paciente acometido por uma doenÇa neuro-degenerativa; composiÇço farmacÊutica para tratar uma doenÇa neuro-degenerativa; e uso de um agonista 5-ht6 ou de um agonista 5-ht6
CN101103026A (zh) * 2005-01-14 2008-01-09 健亚生物科技公司 用于治疗病毒感染的吲哚衍生物
EP1953153A1 (en) * 2007-01-31 2008-08-06 Laboratorios del Dr. Esteve S.A. Heterocyclyl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders
KR20100031578A (ko) * 2007-05-24 2010-03-23 메모리 파마슈티칼스 코포레이션 5-ｈｔ6 수용체 친화성을 갖는 4'-치환된 화합물
DE602007012683D1 (de) * 2007-07-19 2011-04-07 Esteve Labor Dr Substituierte Tetrahydro-Chinolinsulfonamidverbindungen, ihre Herstellung und ihre Verwendung als Medikamente
EP2053052A1 (en) * 2007-10-23 2009-04-29 Laboratorios del Dr. Esteve S.A. Process for the preparation of 6-substituted imidazo[2,1-b]thiazole-5-sulfonyl halide
JP2011505418A (ja) * 2007-12-04 2011-02-24 メルク・シャープ・エンド・ドーム・コーポレイション ５−ｈｔ６アンタゴニストとしてのトリプタミンスルホンアミド
EP2236511A4 (en) 2007-12-21 2011-04-13 Alla Chem Llc LIGANDS OF ALPHA ADRENOCEPTORS AND OF DOPAMINE, HISTAMIN, IMIDAZOLIN AND SEROTONIN RECEPTORS AND THEIR APPLICATION THEREOF
US20100016297A1 (en) * 2008-06-24 2010-01-21 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
US20100022581A1 (en) * 2008-07-02 2010-01-28 Memory Pharmaceuticals Corporation Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity
US20100029629A1 (en) * 2008-07-25 2010-02-04 Memory Pharmaceuticals Corporation Acyclic compounds having 5-ht6 receptor affinity
US20100056531A1 (en) * 2008-08-22 2010-03-04 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
CN104725295B (zh) 2013-12-20 2019-05-24 广东东阳光药业有限公司 芳杂环类衍生物及其在药物上的应用
SG11201701580XA (en) 2014-08-29 2017-03-30 Chdi Foundation Inc Probes for imaging huntingtin protein
HRP20211778T1 (hr) 2014-08-29 2022-03-18 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina
EP4396162A4 (en) 2021-09-03 2025-11-12 Alexander Shulgin Res Institute Inc ASYMMETRIC ALLYL TRYPTAMINES

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
AU670579B2 (en) * 1992-04-07 1996-07-25 Pfizer Inc. Indole derivatives as 5-HT1 agonists
US6194410B1 (en) * 1998-03-11 2001-02-27 Hoffman-La Roche Inc. Pyrazolopyrimidine and pyrazolines and process for preparation thereof
US6133287A (en) * 1998-03-24 2000-10-17 Allelix Biopharmaceuticals Inc. Piperidine-indole compounds having 5-HT6 affinity
GB9820113D0 (en) * 1998-09-15 1998-11-11 Merck Sharp & Dohme Therapeutic agents
US6403808B1 (en) * 1999-12-10 2002-06-11 Virginia Commonwealth University Selective 5-HT6 receptor ligands
AU779832B2 (en) * 1999-08-12 2005-02-10 Nps Pharmaceuticals, Inc. Azaindoles having serotonin receptor affinity
WO2001032660A1 (en) * 1999-11-05 2001-05-10 Nps Allelix Corp. Compounds having 5-ht6 receptor antagonist activity
WO2001034146A1 (en) * 1999-11-08 2001-05-17 Smithkline Beecham Corporation Novel anti-infectives

Also Published As

Publication number Publication date
JP2005517661A (ja) 2005-06-16
US7022701B2 (en) 2006-04-04
HK1065949A1 (en) 2005-03-11
CA2470863A1 (en) 2003-07-03
EP1455779A1 (en) 2004-09-15
US20040209867A1 (en) 2004-10-21
ATE335477T1 (de) 2006-09-15
CO5590924A2 (es) 2005-12-30
TWI254705B (en) 2006-05-11
HUP0402640A3 (en) 2012-09-28
NO330338B1 (no) 2011-03-28
KR100985140B1 (ko) 2010-10-05
PL210413B1 (pl) 2012-01-31
ES2269827T3 (es) 2007-04-01
IL162243A0 (en) 2005-11-20
RU2004122129A (ru) 2005-05-10
EP1455779B1 (en) 2006-08-09
DE60213856D1 (de) 2006-09-21
MXPA04005889A (es) 2004-11-01
AU2002357270A1 (en) 2003-07-09
PT1455779E (pt) 2006-11-30
ZA200405731B (en) 2007-02-28
TW200301252A (en) 2003-07-01
NZ533666A (en) 2006-03-31
CN1620290A (zh) 2005-05-25
NO20043100L (no) 2004-08-26
AR037906A1 (es) 2004-12-22
US20030171353A1 (en) 2003-09-11
RU2309157C2 (ru) 2007-10-27
CY1105705T1 (el) 2010-12-22
UA78536C2 (en) 2007-04-10
CN1309385C (zh) 2007-04-11
US6770642B2 (en) 2004-08-03
KR20040075892A (ko) 2004-08-30
CA2470863C (en) 2012-05-15
HUP0402640A2 (hu) 2005-04-28
DK1455779T3 (da) 2006-10-30
AU2002357270B2 (en) 2007-06-14
WO2003053433A1 (en) 2003-07-03
ECSP045156A (es) 2004-07-23
BR0215222A (pt) 2005-05-24
SI1455779T1 (sl) 2006-12-31
DE60213856T2 (de) 2007-09-13
JP4335684B2 (ja) 2009-09-30

Similar Documents

Publication Publication Date Title
IL157059A0 (en) 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
PL370890A1 (pl) Pochodne azaindoliloalkiloaminy jako ligandy receptora 5-hydroksytryptaminy-6
IL158445A0 (en) Heterocyclyloxy-, -thioxy-and-aminobenzazole derivatives as 5-hydroxytryptamine-6 ligands
IL166139A0 (en) 1-heterocycylalkyl-3-sulfonylazaindole or- azaindazole derivatives as 5-hydroxytryptamine-6 ligands
IL155443A0 (en) 1- aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands
ZA200500435B (en) 1-heterocyclyalkyl-3-sulfonylindole or -indazole derivatves as 5-hydroxytryptamine-6 ligands
IL162243A0 (en) Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
IL160701A0 (en) 3-substituted-4-pyrimidone derivatives
ZA200506416B (en) Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands
IL156518A0 (en) Heteocyclylalkylindole or-azaindole compounds as 5-hydroxytryptamine-6 ligands
IL213984A0 (en) Spiroindolinepiperidine derivatives
IL158448A0 (en) Heterocyclylalkoxy- alkylthio-and-alkylaminobenzazole derivatives as 5-hydroxytryptamine-6 ligands
HUP0303186A3 (en) 4-aminobenzopyran derivatives
HUP0401949A3 (en) 4-imidazolin-2-one derivatives
HUP0500026A3 (en) N-heteroarylnicotinamide derivatives
IL159064A0 (en) New phenylalkyloxy- phenyl derivatives
AU2003209114A1 (en) Pyrrolylalkylidene-hydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands
EP1364954A4 (en) Dicarba closo DODECARBORANDERIVATE
HK1060880A (en) Heterocyclylalkoxy-, -alkylthio- and - alkylaminobenzazole derivatives as 5-hydroxytryptamine-6 ligands
HK1056561A (en) 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
HK1060128A (en) Heterocyclyloxy-, -thioxy-and-aminobenzazole derivatives as 5-hydroxytryptamine-6 ligands
HK1066002A (en) Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
HK1055969A (en) 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands
HK1076464A (en) 1-heterocyclylalkyl-3-sulfonylindole or -indazole derivatives as 5-hydroxytryptamine-6 ligands
HK1074619A (en) 1-heterocyclylalkyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands

Legal Events

Date Code Title Description
LAPS Decisions on the lapse of the protection rights

Effective date: 20111217