UA78536C2 - Indolylalkylamine derivatives as ligands of 5-hydroxytryptamine-6, method of production (variants), pharmaceutical composition - Google Patents
Indolylalkylamine derivatives as ligands of 5-hydroxytryptamine-6, method of production (variants), pharmaceutical composition Download PDFInfo
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- UA78536C2 UA78536C2 UA20040705919A UA20040705919A UA78536C2 UA 78536 C2 UA78536 C2 UA 78536C2 UA 20040705919 A UA20040705919 A UA 20040705919A UA 20040705919 A UA20040705919 A UA 20040705919A UA 78536 C2 UA78536 C2 UA 78536C2
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- Ukraine
- Prior art keywords
- sulfonyl
- indol
- optionally substituted
- formula
- chloroimidazo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34290701P | 2001-12-20 | 2001-12-20 | |
| PCT/US2002/040217 WO2003053433A1 (en) | 2001-12-20 | 2002-12-17 | Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA78536C2 true UA78536C2 (en) | 2007-04-10 |
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|---|---|---|---|
| UA20040705919A UA78536C2 (en) | 2001-12-20 | 2002-12-17 | Indolylalkylamine derivatives as ligands of 5-hydroxytryptamine-6, method of production (variants), pharmaceutical composition |
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| US (2) | US6770642B2 (pl) |
| EP (1) | EP1455779B1 (pl) |
| JP (1) | JP4335684B2 (pl) |
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| CN (1) | CN1309385C (pl) |
| AR (1) | AR037906A1 (pl) |
| AT (1) | ATE335477T1 (pl) |
| AU (1) | AU2002357270B2 (pl) |
| BR (1) | BR0215222A (pl) |
| CA (1) | CA2470863C (pl) |
| CO (1) | CO5590924A2 (pl) |
| CY (1) | CY1105705T1 (pl) |
| DE (1) | DE60213856T2 (pl) |
| DK (1) | DK1455779T3 (pl) |
| EC (1) | ECSP045156A (pl) |
| ES (1) | ES2269827T3 (pl) |
| HU (1) | HUP0402640A3 (pl) |
| IL (1) | IL162243A0 (pl) |
| MX (1) | MXPA04005889A (pl) |
| NO (1) | NO330338B1 (pl) |
| NZ (1) | NZ533666A (pl) |
| PL (1) | PL210413B1 (pl) |
| PT (1) | PT1455779E (pl) |
| RU (1) | RU2309157C2 (pl) |
| SI (1) | SI1455779T1 (pl) |
| TW (1) | TWI254705B (pl) |
| UA (1) | UA78536C2 (pl) |
| WO (1) | WO2003053433A1 (pl) |
| ZA (1) | ZA200405731B (pl) |
Families Citing this family (24)
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| AU2002212749A1 (en) * | 2000-11-09 | 2002-05-21 | Mitsui Chemicals, Inc. | Optically active amine derivative and method of synthesis |
| TW200301251A (en) * | 2001-12-20 | 2003-07-01 | Wyeth Corp | Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands |
| CA2532071A1 (en) * | 2003-07-23 | 2005-02-03 | Wyeth | Sulfonyldihydro- benzimidazolone compounds as 5-hydroxytryptamine-6 ligands |
| US20050032873A1 (en) * | 2003-07-30 | 2005-02-10 | Wyeth | 3-Amino chroman and 2-amino tetralin derivatives |
| WO2005012311A1 (en) * | 2003-07-31 | 2005-02-10 | Wyeth | N-sulfonylheterocyclopyrrolylalkylamine compounds as 5-hydroxytryptamine-6 ligands |
| BRPI0413234A (pt) * | 2003-08-01 | 2006-10-03 | Genelabs Tech Inc | derivados de imidazola bicìclica contra flaviviridae |
| ATE430752T1 (de) | 2004-01-02 | 2009-05-15 | Suven Life Sciences Ltd | Neue indenoä2,1-aüindene und isoindolä2,1-aüindol |
| PE20060303A1 (es) * | 2004-06-23 | 2006-05-19 | Wyeth Corp | Metabolitos de indolilalquilamina como ligandos de 5-hidroxitriptamina-6 |
| BRPI0519036A2 (pt) * | 2004-12-14 | 2008-12-23 | Wyeth Corp | mÉtodo para o tratamento de um paciente acometido por uma doenÇa neuro-degenerativa; composiÇço farmacÊutica para tratar uma doenÇa neuro-degenerativa; e uso de um agonista 5-ht6 ou de um agonista 5-ht6 |
| CN101103026A (zh) * | 2005-01-14 | 2008-01-09 | 健亚生物科技公司 | 用于治疗病毒感染的吲哚衍生物 |
| EP1953153A1 (en) * | 2007-01-31 | 2008-08-06 | Laboratorios del Dr. Esteve S.A. | Heterocyclyl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders |
| KR20100031578A (ko) * | 2007-05-24 | 2010-03-23 | 메모리 파마슈티칼스 코포레이션 | 5-ｈｔ6 수용체 친화성을 갖는 4'-치환된 화합물 |
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| EP2053052A1 (en) * | 2007-10-23 | 2009-04-29 | Laboratorios del Dr. Esteve S.A. | Process for the preparation of 6-substituted imidazo[2,1-b]thiazole-5-sulfonyl halide |
| JP2011505418A (ja) * | 2007-12-04 | 2011-02-24 | メルク・シャープ・エンド・ドーム・コーポレイション | ５−ｈｔ６アンタゴニストとしてのトリプタミンスルホンアミド |
| EP2236511A4 (en) | 2007-12-21 | 2011-04-13 | Alla Chem Llc | LIGANDS OF ALPHA ADRENOCEPTORS AND OF DOPAMINE, HISTAMIN, IMIDAZOLIN AND SEROTONIN RECEPTORS AND THEIR APPLICATION THEREOF |
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| US5545644A (en) * | 1990-10-15 | 1996-08-13 | Pfizer Inc. | Indole derivatives |
| AU670579B2 (en) * | 1992-04-07 | 1996-07-25 | Pfizer Inc. | Indole derivatives as 5-HT1 agonists |
| US6194410B1 (en) * | 1998-03-11 | 2001-02-27 | Hoffman-La Roche Inc. | Pyrazolopyrimidine and pyrazolines and process for preparation thereof |
| US6133287A (en) * | 1998-03-24 | 2000-10-17 | Allelix Biopharmaceuticals Inc. | Piperidine-indole compounds having 5-HT6 affinity |
| GB9820113D0 (en) * | 1998-09-15 | 1998-11-11 | Merck Sharp & Dohme | Therapeutic agents |
| US6403808B1 (en) * | 1999-12-10 | 2002-06-11 | Virginia Commonwealth University | Selective 5-HT6 receptor ligands |
| AU779832B2 (en) * | 1999-08-12 | 2005-02-10 | Nps Pharmaceuticals, Inc. | Azaindoles having serotonin receptor affinity |
| WO2001032660A1 (en) * | 1999-11-05 | 2001-05-10 | Nps Allelix Corp. | Compounds having 5-ht6 receptor antagonist activity |
| WO2001034146A1 (en) * | 1999-11-08 | 2001-05-17 | Smithkline Beecham Corporation | Novel anti-infectives |
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