PL371722A1 - Związki karbonylobenzoksazyny do nasilania glutaminergicznych reakcji synaptycznych - Google Patents

Związki karbonylobenzoksazyny do nasilania glutaminergicznych reakcji synaptycznych

Info

Publication number: PL371722A1
Authority: PL; Poland
Prior art keywords: synaptic responses; glutamatergic synaptic; carbonylbenzoxazine; compounds; enhancing glutamatergic
Prior art date: 2001-11-26

Application number

PL02371722A

Other languages

English (en)

Inventor

Gary A. Rogers

Matthew Allan

Clayton Harris

Jianjie Huang

Christopher M. Marrs

Rudolf Mueller

Stanislaw Rachwal

Original Assignee

Cortex Pharmaceuticals, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-26

Filing date

2002-11-25

Publication date

2005-06-27

2002-11-25 Application filed by Cortex Pharmaceuticals, Inc. filed Critical Cortex Pharmaceuticals, Inc.

2005-06-27 Publication of PL371722A1 publication Critical patent/PL371722A1/pl

Links

FEFCQDINBPEMNU-UHFFFAOYSA-N 4h-1,2-benzoxazin-3-ylidenemethanone Chemical class C1=CC=C2ONC(=C=O)CC2=C1 FEFCQDINBPEMNU-UHFFFAOYSA-N 0.000 title 1
230000002708 enhancing effect Effects 0.000 title 1
230000000848 glutamatergic effect Effects 0.000 title 1
230000009782 synaptic response Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
- C07D265/22—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Gynecology & Obstetrics (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

PL02371722A 2001-11-26 2002-11-25 Związki karbonylobenzoksazyny do nasilania glutaminergicznych reakcji synaptycznych PL371722A1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US33333401P	2001-11-26	2001-11-26

Publications (1)

Publication Number	Publication Date
PL371722A1 true PL371722A1 (pl)	2005-06-27

Family

ID=23302344

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL02371722A PL371722A1 (pl)	2001-11-26	2002-11-25	Związki karbonylobenzoksazyny do nasilania glutaminergicznych reakcji synaptycznych

Country Status (23)

Country	Link
US (1)	US7799913B2 (pl)
EP (1)	EP1448537A4 (pl)
JP (1)	JP4620349B2 (pl)
KR (1)	KR100915176B1 (pl)
CN (1)	CN1620440A (pl)
AU (1)	AU2002352886B2 (pl)
BR (1)	BR0214425A (pl)
CA (1)	CA2463592A1 (pl)
CZ (1)	CZ2004632A3 (pl)
EA (1)	EA011034B1 (pl)
GE (1)	GEP20063859B (pl)
HR (1)	HRP20040424A2 (pl)
HU (1)	HUP0402279A3 (pl)
IL (1)	IL161452A0 (pl)
MA (1)	MA26233A1 (pl)
MX (1)	MXPA04004815A (pl)
NO (1)	NO20041590L (pl)
NZ (1)	NZ532368A (pl)
PL (1)	PL371722A1 (pl)
SK (1)	SK2292004A3 (pl)
UA (1)	UA79940C2 (pl)
WO (1)	WO2003045315A2 (pl)
ZA (1)	ZA200403729B (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2007342364A1 (en) *	2007-01-03	2008-07-17	Cortex Pharmaceuticals, Inc.	3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses
MY154877A (en) *	2007-01-03	2015-08-14	Servier Lab	3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamateric synaptic responses
US20130058915A1 (en)	2010-03-02	2013-03-07	Children's Medica Center Corporation	Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
WO2012170845A2 (en) *	2011-06-08	2012-12-13	Heffernan Michele L R	Metabotropic glutamate receptor 5 modulators and methods of use thereof
BR112015031249A2 (pt)	2013-06-13	2017-07-25	Veroscience Llc	método de tratamento, método para tratar um distúrbio metabólico ou um elemento chave do mesmo, método para normalizar um ritmo diário de liberação de dopamina no sumn, método para estimular a liberação de dopamina de neurônios dopaminérgicos no sumn de um indivíduo e composição farmacêutica
KR20180019234A (ko)	2015-06-26	2018-02-23	다케다 야쿠힌 고교 가부시키가이샤	콜린성 무스카린 m1 수용체의 조절제로서의 2,3-디히드로-4h-1,3-벤족사진-4-온 유도체
JP6787913B2 (ja)	2015-10-20	2020-11-18	武田薬品工業株式会社	複素環化合物
US20190112300A1 (en)	2016-03-29	2019-04-18	Arnold Stan Lippa	Compositions And Methods For Treating Attention Deficit Disorders
JP7365332B2 (ja)	2017-08-07	2023-10-19	ジョイント・ストック・カンパニー “バイオキャド”	Ｃｄｋ８／１９阻害薬としての新規ヘテロ環式化合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2943087A (en) *		1960-06-28		n naoh
DE1122531B (de) *	1957-09-13	1962-01-25	Thomae Gmbh Dr K	Verfahren zur Herstellung von therapeutisch wertvollen 4-Oxo-2-(halogenalkyl)-2,3-dihydro-benzoxazinen-(1,3)
US4022139A (en) *	1975-10-28	1977-05-10	Blue Bell, Inc.	Tacker guide and method
EP0010348A1 (en) *	1978-09-12	1980-04-30	Imperial Chemical Industries Plc	Heterocyclic trichloromethyl derivatives, process for their preparation and their use
JPH0597824A (ja) *	1990-09-25	1993-04-20	Takeda Chem Ind Ltd	１，３−ベンゾオキサジン誘導体
EP1156043B1 (en)	1992-07-24	2003-11-12	The Regents Of The University Of California	Drugs that enhance synaptic responses mediated by ampa receptors
US5650409A (en)	1995-06-02	1997-07-22	Cortex Pharmaceuticals, Inc.	Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en)	1996-04-03	1998-04-07	The Regents Of The University Of California	Benzoxazines for enhancing synaptic response
GB9716962D0 (en) *	1997-08-12	1997-10-15	Univ Birmingham	Liver function test
WO1999016758A1 (en) *	1997-10-27	1999-04-08	Dr. Reddy's Research Foundation	Novel heterocyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
CA2320354A1 (en) *	1998-02-18	1999-08-26	Neurosearch A/S	Novel compounds and their use as positive ampa receptor modulators
US6124278A (en)	1998-04-03	2000-09-26	The Regents Of The University Of California	Acylbenzoxazines for enhancing synaptic response

2002
- 2002-11-25 PL PL02371722A patent/PL371722A1/pl not_active Application Discontinuation
- 2002-11-25 AU AU2002352886A patent/AU2002352886B2/en not_active Ceased
- 2002-11-25 CA CA002463592A patent/CA2463592A1/en not_active Abandoned
- 2002-11-25 BR BR0214425-5A patent/BR0214425A/pt not_active Application Discontinuation
- 2002-11-25 NZ NZ532368A patent/NZ532368A/en not_active IP Right Cessation
- 2002-11-25 KR KR1020047007502A patent/KR100915176B1/ko not_active Expired - Fee Related
- 2002-11-25 US US10/495,049 patent/US7799913B2/en not_active Expired - Fee Related
- 2002-11-25 EA EA200400584A patent/EA011034B1/ru not_active IP Right Cessation
- 2002-11-25 HR HR20040424A patent/HRP20040424A2/xx not_active Application Discontinuation
- 2002-11-25 WO PCT/US2002/037646 patent/WO2003045315A2/en not_active Ceased
- 2002-11-25 UA UA20040503965A patent/UA79940C2/uk unknown
- 2002-11-25 CZ CZ2004632A patent/CZ2004632A3/cs unknown
- 2002-11-25 SK SK229-2004A patent/SK2292004A3/sk not_active Application Discontinuation
- 2002-11-25 IL IL16145202A patent/IL161452A0/xx unknown
- 2002-11-25 MX MXPA04004815A patent/MXPA04004815A/es active IP Right Grant
- 2002-11-25 JP JP2003546820A patent/JP4620349B2/ja not_active Expired - Fee Related
- 2002-11-25 GE GE5593A patent/GEP20063859B/en unknown
- 2002-11-25 EP EP02789846A patent/EP1448537A4/en not_active Withdrawn
- 2002-11-25 HU HU0402279A patent/HUP0402279A3/hu unknown
- 2002-11-25 CN CNA028234502A patent/CN1620440A/zh active Pending
2004
- 2004-04-19 NO NO20041590A patent/NO20041590L/no not_active Application Discontinuation
- 2004-05-14 ZA ZA200403729A patent/ZA200403729B/en unknown
- 2004-05-21 MA MA27691A patent/MA26233A1/fr unknown

Also Published As

Publication number	Publication date
BR0214425A (pt)	2004-11-03
HRP20040424A2 (en)	2005-06-30
SK2292004A3 (en)	2004-09-08
ZA200403729B (en)	2005-05-19
IL161452A0 (en)	2004-09-27
CZ2004632A3 (cs)	2004-08-18
CN1620440A (zh)	2005-05-25
EP1448537A2 (en)	2004-08-25
EP1448537A4 (en)	2005-05-04
CA2463592A1 (en)	2003-06-05
UA79940C2 (en)	2007-08-10
EA011034B1 (ru)	2008-12-30
US7799913B2 (en)	2010-09-21
JP2005510532A (ja)	2005-04-21
MXPA04004815A (es)	2005-02-17
EA200400584A1 (ru)	2005-02-24
AU2002352886B2 (en)	2008-10-16
NZ532368A (en)	2006-10-27
NO20041590L (no)	2004-07-12
HUP0402279A3 (en)	2008-09-29
MA26233A1 (fr)	2004-07-01
US20040259871A1 (en)	2004-12-23
WO2003045315A2 (en)	2003-06-05
JP4620349B2 (ja)	2011-01-26
HUP0402279A2 (hu)	2005-02-28
KR20040054777A (ko)	2004-06-25
GEP20063859B (en)	2006-06-26
AU2002352886A1 (en)	2003-06-10
WO2003045315A3 (en)	2003-08-28
KR100915176B1 (ko)	2009-09-03

Legal Events

Date	Code	Title	Description
2012-09-28	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
AU2002322585A1 (en)	2003-03-03	Fat accumulation-modulating compounds
GB0124463D0 (en)	2001-12-05	Compounds
PL367273A1 (pl)	2005-02-21	Związki na bazie peptydów
GB0127430D0 (en)	2002-01-09	Compounds
IL158013A0 (en)	2004-03-28	Disease-associated protein
GB0127433D0 (en)	2002-01-09	Compounds
GB2381602B (en)	2004-04-14	Early resolving instructions
IL161452A0 (en)	2004-09-27	Carbonylbenzoxazine compounds for enhancing glutamatergic synaptic responses
PL369829A1 (pl)	2005-05-02	Podstawione związki 1H-chinolin-2-onowe
GB0118364D0 (en)	2001-09-19	Compounds
DE50115802D1 (de)	2011-04-07	Dafür
GB0114294D0 (en)	2001-08-01	Assay Apparatus
AU2002356540A1 (en)	2003-05-06	Methods for combating bio-terrorism
GB0120344D0 (en)	2001-10-17	Compounds
GB0101497D0 (en)	2001-03-07	Means for means for calibration
GB0100600D0 (en)	2001-02-21	Thereapeutic compounds
PL112013U1 (en)	2002-09-23	Apparatus for disinfecting eggs
GB0110462D0 (en)	2001-06-20	Egg Device
GB0110926D0 (en)	2001-06-27	Egg device
GB0117810D0 (en)	2001-09-12	Novel egg charectors
AU2264P (en)	2003-06-11	PA300 Pennisetum alopecuroides
AU3083P (en)	2006-06-27	PA400 Pennisetum alopecuroides
ZA200207052B (en)	2003-04-30	Recaptacle for drums.
HU0103282D0 (en)	2001-10-28	Round-sewing-machine for haemorrhoidectomy
AU2002326569A1 (en)	2003-02-24	Fat accumulation-modulating compounds