PL373465A1 - Kompozycje oparte na podstawionych pochodnych 1,3-difenyloprop-2-en-1-onu - Google Patents

Kompozycje oparte na podstawionych pochodnych 1,3-difenyloprop-2-en-1-onu

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Publication number
PL373465A1
PL373465A1 PL03373465A PL37346503A PL373465A1 PL 373465 A1 PL373465 A1 PL 373465A1 PL 03373465 A PL03373465 A PL 03373465A PL 37346503 A PL37346503 A PL 37346503A PL 373465 A1 PL373465 A1 PL 373465A1
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Poland
Prior art keywords
diphenylprop
derivatives
substituted
compositions based
diseases
Prior art date
Application number
PL03373465A
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English (en)
Other versions
PL207707B1 (pl
Inventor
Jamila Najib
Karine Caumont-Bertrand
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Genfit
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Publication date
Application filed by Genfit filed Critical Genfit
Publication of PL373465A1 publication Critical patent/PL373465A1/pl
Publication of PL207707B1 publication Critical patent/PL207707B1/pl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/055—Phenols the aromatic ring being substituted by halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
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    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
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    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Wynalazek dotyczy kompozycji zawierających pochodne 1,3-difenyloprop-2-en-1-onu przeznaczonych do zastosowania farmaceutycznego. Kompozycje według wynalazku są użyteczne szczególnie do zapobiegania albo leczenia chorób sercowo-naczyniowych, zespołu X, restenozy, cukrzycy, otyłości, nadciśnienia, chorób zapalnych, raków albo nowotworów (nowotworów łagodnych i guzów złośliwych), chorób neurodegeneracyjnych i dermatologicznych, oraz zaburzeń związanych ze stresem oksydacyjnym i na przykład starzeniem się skóry, w szczególności w kosmetyce (występowanie zmarszczek i podobnych).
PL373465A 2002-07-08 2003-07-08 Kompozycja do leczenia lub zapobiegania stanom patologicznym związanym ze stanami zapalnymi, neurodegeneracją, deregulacją metabolizmu lipidów i/lub glukozy, rozrostem komórek i/lub różnicowaniem komórek i/lub ze starzeniem się skóry lub ośrodkowego układu nerwowego PL207707B1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0208570A FR2841784B1 (fr) 2002-07-08 2002-07-08 Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations
PCT/FR2003/002128 WO2004005243A2 (fr) 2002-07-08 2003-07-08 Composition a base de derives de 1,3-diphenylprop-2-en-one substitues

Publications (2)

Publication Number Publication Date
PL373465A1 true PL373465A1 (pl) 2005-09-05
PL207707B1 PL207707B1 (pl) 2011-01-31

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PL373465A PL207707B1 (pl) 2002-07-08 2003-07-08 Kompozycja do leczenia lub zapobiegania stanom patologicznym związanym ze stanami zapalnymi, neurodegeneracją, deregulacją metabolizmu lipidów i/lub glukozy, rozrostem komórek i/lub różnicowaniem komórek i/lub ze starzeniem się skóry lub ośrodkowego układu nerwowego

Country Status (24)

Country Link
US (3) US7632870B2 (pl)
EP (1) EP1519908B1 (pl)
JP (1) JP4907083B2 (pl)
KR (1) KR100947907B1 (pl)
CN (1) CN1688532B (pl)
AT (1) ATE364588T1 (pl)
AU (1) AU2003264699B2 (pl)
BR (1) BRPI0312399B8 (pl)
CA (1) CA2490993C (pl)
CY (1) CY1108051T1 (pl)
DE (1) DE60314420T2 (pl)
DK (1) DK1519908T3 (pl)
EA (1) EA012699B1 (pl)
ES (1) ES2287529T3 (pl)
FR (1) FR2841784B1 (pl)
IL (1) IL165454A (pl)
MX (1) MXPA05000425A (pl)
NO (1) NO334650B1 (pl)
NZ (1) NZ538052A (pl)
PL (1) PL207707B1 (pl)
PT (1) PT1519908E (pl)
SI (1) SI1519908T1 (pl)
WO (1) WO2004005243A2 (pl)
ZA (1) ZA200501081B (pl)

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FR2841900B1 (fr) 2002-07-08 2007-03-02 Genfit S A Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
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FR2841784B1 (fr) 2002-07-08 2007-03-02 Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations
FR2841900B1 (fr) 2002-07-08 2007-03-02 Genfit S A Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
FR2857361B1 (fr) * 2003-07-08 2005-09-09 Genfit S A PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one

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BRPI0312399B1 (pt) 2020-03-31
PT1519908E (pt) 2007-09-04
NO20045082L (no) 2004-12-27
ES2287529T3 (es) 2007-12-16
BRPI0312399B8 (pt) 2021-05-25
FR2841784B1 (fr) 2007-03-02
JP4907083B2 (ja) 2012-03-28
BR0312399A (pt) 2005-04-12
ZA200501081B (en) 2007-04-25
KR20050019818A (ko) 2005-03-03
IL165454A0 (en) 2006-01-15
EA012699B1 (ru) 2009-12-30
DK1519908T3 (da) 2007-10-15
WO2004005243A2 (fr) 2004-01-15
AU2003264699A1 (en) 2004-01-23
US7632870B2 (en) 2009-12-15
ATE364588T1 (de) 2007-07-15
DE60314420T2 (de) 2008-02-28
CN1688532A (zh) 2005-10-26
FR2841784A1 (fr) 2004-01-09
US20120129932A1 (en) 2012-05-24
EP1519908A2 (fr) 2005-04-06
MXPA05000425A (es) 2005-07-22
NZ538052A (en) 2007-09-28
CA2490993C (fr) 2012-09-18
WO2004005243A3 (fr) 2004-04-22
US8106097B2 (en) 2012-01-31
AU2003264699B2 (en) 2009-09-24
JP2005532386A (ja) 2005-10-27
SI1519908T1 (sl) 2007-08-31
US8461212B2 (en) 2013-06-11
KR100947907B1 (ko) 2010-03-17
DE60314420D1 (de) 2007-07-26
CY1108051T1 (el) 2013-09-04
PL207707B1 (pl) 2011-01-31
NO334650B1 (no) 2014-05-05
EA200500170A1 (ru) 2005-10-27
CN1688532B (zh) 2012-07-11
US20100120909A1 (en) 2010-05-13
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IL165454A (en) 2012-12-31
EP1519908B1 (fr) 2007-06-13

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