PL374053A1 - Nowe związki jako modulatory receptora opioidowego - Google Patents

Nowe związki jako modulatory receptora opioidowego

Info

Publication number
PL374053A1
PL374053A1 PL03374053A PL37405303A PL374053A1 PL 374053 A1 PL374053 A1 PL 374053A1 PL 03374053 A PL03374053 A PL 03374053A PL 37405303 A PL37405303 A PL 37405303A PL 374053 A1 PL374053 A1 PL 374053A1
Authority
PL
Poland
Prior art keywords
receptor modulators
opioid receptor
novel compounds
opioid
disorders
Prior art date
Application number
PL03374053A
Other languages
English (en)
Other versions
PL211163B1 (pl
Inventor
Henry J. Breslin
Wei He
Robert W. Kavash
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of PL374053A1 publication Critical patent/PL374053A1/pl
Publication of PL211163B1 publication Critical patent/PL211163B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL374053A 2002-04-29 2003-04-17 Pochodna heterocykliczna i związek pośredni PL211163B1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37640602P 2002-04-29 2002-04-29
US10/400,006 US7041681B2 (en) 2002-04-29 2003-03-26 Compounds as opioid receptor modulators

Publications (2)

Publication Number Publication Date
PL374053A1 true PL374053A1 (pl) 2005-09-19
PL211163B1 PL211163B1 (pl) 2012-04-30

Family

ID=29406753

Family Applications (2)

Application Number Title Priority Date Filing Date
PL396160A PL219912B1 (pl) 2002-04-29 2003-04-17 Pochodna heterocykliczna i jej zastosowanie
PL374053A PL211163B1 (pl) 2002-04-29 2003-04-17 Pochodna heterocykliczna i związek pośredni

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL396160A PL219912B1 (pl) 2002-04-29 2003-04-17 Pochodna heterocykliczna i jej zastosowanie

Country Status (23)

Country Link
US (3) US7041681B2 (pl)
EP (2) EP1499313B1 (pl)
JP (1) JP4969039B2 (pl)
KR (2) KR101287409B1 (pl)
CN (2) CN101255131B (pl)
AT (1) ATE514425T1 (pl)
AU (3) AU2003223664A1 (pl)
BR (1) BRPI0309708B1 (pl)
CA (3) CA2753371C (pl)
CY (1) CY1111858T1 (pl)
DK (1) DK1499313T3 (pl)
ES (2) ES2366471T3 (pl)
HR (2) HRP20130893A2 (pl)
HU (1) HUE031331T2 (pl)
IL (2) IL164910A (pl)
MX (1) MXPA04011947A (pl)
NO (3) NO332722B1 (pl)
NZ (2) NZ561795A (pl)
PL (2) PL219912B1 (pl)
PT (1) PT1499313E (pl)
RU (1) RU2332411C2 (pl)
SI (1) SI1499313T1 (pl)
WO (1) WO2003092688A2 (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7041681B2 (en) * 2002-04-29 2006-05-09 Janssen Pharmaceutica N.V. Compounds as opioid receptor modulators
KR101166342B1 (ko) 2004-03-15 2012-07-18 얀센 파마슈티카 엔.브이. 아편계 약물 수용체 조절자로서의 신규의 화합물
ES2535048T3 (es) * 2005-03-14 2015-05-04 Janssen Pharmaceutica Nv Proceso para la preparación de moduladores de opioides
DE102005050497A1 (de) * 2005-10-21 2007-04-26 Bayer Healthcare Ag Difluorphenol-Derivate und ihre Verwendung
US7601844B2 (en) 2006-01-27 2009-10-13 Bristol-Myers Squibb Company Piperidinyl derivatives as modulators of chemokine receptor activity
US7615556B2 (en) 2006-01-27 2009-11-10 Bristol-Myers Squibb Company Piperazinyl derivatives as modulators of chemokine receptor activity
JP2010500372A (ja) * 2006-08-09 2010-01-07 スミスクライン ビーチャム コーポレーション オピオイド受容体に対するアンタゴニストまたはインバースアゴニストとしての新規化合物
TWI433838B (zh) 2008-06-25 2014-04-11 必治妥美雅史谷比公司 作為趨化因子受體活性調節劑之六氫吡啶衍生物
AU2010313392B2 (en) * 2009-10-30 2015-07-09 Janssen Pharmaceutica Nv Pyrazines as delta opioid receptor modulators
US8642622B2 (en) 2010-06-16 2014-02-04 Bristol-Myers Squibb Company Piperidinyl compound as a modulator of chemokine receptor activity
US9675587B2 (en) 2013-03-14 2017-06-13 Allergan Holdings Unlimited Company Opioid receptor modulator dosage formulations
CA2996281C (en) * 2015-08-31 2022-03-08 Regents Of The University Of Minnesota Opioid receptor modulators and use thereof
CN109563133B (zh) * 2016-09-27 2020-09-11 四川科伦博泰生物医药股份有限公司 多酰胺化合物及其用途
CN106866463B (zh) * 2017-01-24 2018-08-28 富乐马鸿凯(大连)医药有限公司 艾沙度林中间体的制备方法
CA3018321A1 (en) 2017-09-25 2019-03-25 Apotex Inc. Novel crystalline form of eluxadoline

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE584914A (pl) 1958-11-24
CH543479A (de) 1970-05-06 1973-10-31 Hoffmann La Roche Verfahren zur Herstellung von Phenyläthylaminderivaten
GB2146026A (en) 1983-09-07 1985-04-11 Tanabe Seiyaku Co Peptides and process for preparing the same
US5159081A (en) 1991-03-29 1992-10-27 Eli Lilly And Company Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
JPH05339240A (ja) 1992-06-04 1993-12-21 Yamanouchi Pharmaceut Co Ltd テトラヒドロイソキノリンアミド誘導体
SE9402880D0 (sv) 1994-08-30 1994-08-30 Astra Ab New peptide derivatives
FR2735776B1 (fr) 1995-06-22 1997-07-18 Synthelabo Derives de 2,3-dihydro-1h-indole, leur preparation et leur application en therapeutique
GB9609976D0 (en) * 1996-05-13 1996-07-17 Lilly Industries Ltd Pharmaceutical compounds
US6451806B2 (en) * 1999-09-29 2002-09-17 Adolor Corporation Methods and compositions involving opioids and antagonists thereof
US6916905B2 (en) 2000-03-24 2005-07-12 The United States Of America As Represented By The Department Of Health And Human Services Dmt-Tic di-and tri-peptidic derivatives and related compositions and methods of use
AU2479702A (en) * 2000-10-30 2002-05-15 Janssen Pharmaceutica Nv Tripeptidyl peptidase inhibitors
US7041681B2 (en) * 2002-04-29 2006-05-09 Janssen Pharmaceutica N.V. Compounds as opioid receptor modulators
ES2535048T3 (es) * 2005-03-14 2015-05-04 Janssen Pharmaceutica Nv Proceso para la preparación de moduladores de opioides

Also Published As

Publication number Publication date
PT1499313E (pt) 2011-08-24
NO20045159L (no) 2004-11-25
CA2483662C (en) 2011-12-06
AU2011202364B2 (en) 2012-09-20
NO332722B1 (no) 2012-12-27
KR101377078B1 (ko) 2014-03-25
MXPA04011947A (es) 2005-07-26
NO335607B1 (no) 2015-01-12
AU2011202364A1 (en) 2011-06-09
JP2005530749A (ja) 2005-10-13
HRP20041014A2 (en) 2005-06-30
DK1499313T3 (da) 2011-10-03
ES2608840T3 (es) 2017-04-17
NO20120788L (no) 2004-11-25
IL197642A (en) 2015-04-30
IL197642A0 (en) 2009-12-24
PL219912B1 (pl) 2015-07-31
NO20140530L (no) 2004-11-25
HRP20130893A2 (hr) 2014-02-28
CN101255131A (zh) 2008-09-03
ES2366471T3 (es) 2011-10-20
ATE514425T1 (de) 2011-07-15
KR20040104663A (ko) 2004-12-10
KR20130041301A (ko) 2013-04-24
RU2332411C2 (ru) 2008-08-27
IL164910A0 (en) 2005-12-18
CN1665501B (zh) 2010-10-06
HRP20041014B1 (hr) 2013-10-11
US20060030558A1 (en) 2006-02-09
RU2004131829A (ru) 2005-05-27
PL211163B1 (pl) 2012-04-30
KR101287409B1 (ko) 2013-07-19
CA2883629A1 (en) 2003-11-13
WO2003092688A2 (en) 2003-11-13
AU2009233679A1 (en) 2009-11-26
EP1499313A2 (en) 2005-01-26
CA2753371C (en) 2015-06-30
HUE031331T2 (hu) 2017-07-28
US7202381B2 (en) 2007-04-10
WO2003092688A3 (en) 2004-08-19
NZ561795A (en) 2009-04-30
JP4969039B2 (ja) 2012-07-04
US20050187252A1 (en) 2005-08-25
CA2483662A1 (en) 2003-11-13
BR0309708A (pt) 2005-02-15
AU2003223664A1 (en) 2003-11-17
US7041681B2 (en) 2006-05-09
US20040010014A1 (en) 2004-01-15
IL164910A (en) 2011-07-31
EP1499313B1 (en) 2011-06-29
EP2275105A1 (en) 2011-01-19
SI1499313T1 (sl) 2011-10-28
CY1111858T1 (el) 2015-11-04
PL396160A1 (pl) 2012-01-16
BRPI0309708B1 (pt) 2017-03-21
AU2009233679B2 (en) 2011-05-26
US7659402B2 (en) 2010-02-09
CN101255131B (zh) 2012-12-05
CN1665501A (zh) 2005-09-07
EP2275105B1 (en) 2016-10-05
CA2753371A1 (en) 2003-11-13
NZ575640A (en) 2010-10-29

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Legal Events

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