PL3766522T3 - Zautomatyzowany sposób wytwarzania kompozycji 18f-flucyklowiny - Google Patents

Zautomatyzowany sposób wytwarzania kompozycji 18f-flucyklowiny

Info

Publication number
PL3766522T3
PL3766522T3 PL20196030T PL20196030T PL3766522T3 PL 3766522 T3 PL3766522 T3 PL 3766522T3 PL 20196030 T PL20196030 T PL 20196030T PL 20196030 T PL20196030 T PL 20196030T PL 3766522 T3 PL3766522 T3 PL 3766522T3
Authority
PL
Poland
Prior art keywords
fluciclovine
compositions
preparation
automated method
automated
Prior art date
Application number
PL20196030T
Other languages
English (en)
Inventor
Kristine ROMOREN
Olav Ryan
Original Assignee
Ge Healthcare Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Limited filed Critical Ge Healthcare Limited
Priority claimed from EP12806500.0A external-priority patent/EP2793954B1/en
Publication of PL3766522T3 publication Critical patent/PL3766522T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B9/00—General methods of preparing halides
    • C01B9/08—Fluorides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
PL20196030T 2010-12-29 2012-12-21 Zautomatyzowany sposób wytwarzania kompozycji 18f-flucyklowiny PL3766522T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201061427839P 2010-12-29 2010-12-29
PCT/EP2011/073670 WO2012089594A1 (en) 2010-12-29 2011-12-21 Eluent solution
EP12806500.0A EP2793954B1 (en) 2011-12-21 2012-12-21 18f-fluciclovine compositions in citrate buffers
PCT/EP2012/076689 WO2013093025A1 (en) 2011-12-21 2012-12-21 18f - fluciclovine compositions in citrate buffers
EP20196030.9A EP3766522B1 (en) 2010-12-29 2012-12-21 Automated method for the preparation of 18f-fluciclovine compositions

Publications (1)

Publication Number Publication Date
PL3766522T3 true PL3766522T3 (pl) 2022-07-04

Family

ID=45495902

Family Applications (2)

Application Number Title Priority Date Filing Date
PL11808853T PL2658831T3 (pl) 2010-12-29 2011-12-21 Roztwór eluentu
PL20196030T PL3766522T3 (pl) 2010-12-29 2012-12-21 Zautomatyzowany sposób wytwarzania kompozycji 18f-flucyklowiny

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL11808853T PL2658831T3 (pl) 2010-12-29 2011-12-21 Roztwór eluentu

Country Status (16)

Country Link
US (3) US11504430B2 (pl)
EP (2) EP2658831B1 (pl)
JP (1) JP6018581B2 (pl)
KR (3) KR20130132892A (pl)
CN (2) CN108218650A (pl)
AU (1) AU2011351550B2 (pl)
BR (2) BR112013015396B1 (pl)
CA (1) CA2823063C (pl)
DK (3) DK2658831T3 (pl)
ES (2) ES2621950T3 (pl)
MX (1) MX363538B (pl)
PL (2) PL2658831T3 (pl)
PT (2) PT3766522T (pl)
RU (1) RU2608932C2 (pl)
SG (1) SG10201805198TA (pl)
WO (1) WO2012089594A1 (pl)

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GB201411569D0 (en) 2014-06-30 2014-08-13 Ge Healthcare Ltd Novel formulation and method of synthesis
GB2509476B (en) * 2011-12-21 2018-08-08 Ge Healthcare Ltd Ip 18F - Fluciclovine compositions in citrate buffers
US11534494B2 (en) 2011-12-21 2022-12-27 Ge Healthcare Limited Formulation and method of synthesis
GB201214220D0 (en) * 2012-08-09 2012-09-19 Ge Healthcare Ltd Radiosynthesis
GB201221266D0 (en) 2012-11-27 2013-01-09 Ge Healthcare Ltd Aldehyde compositions
GB201305687D0 (en) * 2013-03-28 2013-05-15 Ge Healthcare Ltd Radiolabelling process
IL235650B (en) 2013-11-13 2019-10-31 Ge Healthcare Ltd Dual play tape
US9988336B2 (en) * 2014-03-18 2018-06-05 Mayo Foundation For Medical Education And Research Gaseous F-18 technologies
NL2014828B1 (en) 2015-05-20 2017-01-31 Out And Out Chemistry S P R L Method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, a device and cassette for performing this method.
JP6827709B2 (ja) * 2016-04-25 2021-02-10 日本メジフィジックス株式会社 2−[18f]フルオロ−2−デオキシ−d−グルコースの製造方法
US10695450B2 (en) 2016-07-26 2020-06-30 Laboratoires Cyclopharma Synthesis of a radioactive agent composition
JP7148121B2 (ja) * 2018-08-31 2022-10-05 国立大学法人北海道大学 放射性核種18fの精製方法
GB202005282D0 (en) 2020-04-09 2020-05-27 Blue Earth Diagnostics Ltd Pharmaceutical Formulations
MX2023004715A (es) * 2020-10-22 2023-05-10 Nihon Mediphysics Co Ltd Metodo para producir un complejo de circonio radioactivo.
JP7127164B2 (ja) * 2021-01-19 2022-08-29 日本メジフィジックス株式会社 2-[18f]フルオロ-2-デオキシ-d-グルコースの製造方法
CN113372399A (zh) * 2021-06-04 2021-09-10 江苏华益科技有限公司 一种氟[18f]脱氧葡糖注射液的合成方法
CN119591463B (zh) * 2024-11-27 2025-12-09 遵义医科大学 一种 [18f] 三氟甲基末端烯烃的放射性标记方法

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ZA978758B (en) * 1996-10-02 1999-03-30 Du Pont Merck Pharma Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents
RU2165266C1 (ru) 2000-06-28 2001-04-20 Центральный научно-исследовательский рентгенорадиологический институт Способ получения [2-18f]-2-дезоксиглюкозы
EP1356827A1 (en) 2002-04-24 2003-10-29 Mallinckrodt Inc. Method for obtaining a 2-18F-fluor-2-deoxy-D-glucose (18F-FDG)-solution
ATE473019T1 (de) 2002-11-05 2010-07-15 Ion Beam Applic Sa Stabilisierung von wässerigen zusammensetzungen von 18f-markiertem 2-fluoro-2-deoxy-d-glukose mit ethanol
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Also Published As

Publication number Publication date
US20190192660A1 (en) 2019-06-27
CN108218650A (zh) 2018-06-29
KR20190008994A (ko) 2019-01-25
RU2608932C2 (ru) 2017-01-26
EP3766522A1 (en) 2021-01-20
KR102137348B1 (ko) 2020-07-23
JP2014508731A (ja) 2014-04-10
DK3766522T3 (da) 2022-06-13
PT2793954T (pt) 2021-01-06
EP2658831B1 (en) 2017-02-15
PT3766522T (pt) 2022-06-14
CA2823063A1 (en) 2012-07-05
CA2823063C (en) 2020-08-11
EP3766522B1 (en) 2022-03-23
EP2658831A1 (en) 2013-11-06
DK2793954T3 (da) 2021-01-04
ES2917875T3 (es) 2022-07-12
MX2013007699A (es) 2013-08-15
BR112013015396B1 (pt) 2021-11-03
RU2013126979A (ru) 2015-03-20
AU2011351550A1 (en) 2013-07-25
SG10201805198TA (en) 2018-07-30
KR102218263B1 (ko) 2021-02-22
KR20190119673A (ko) 2019-10-22
MX363538B (es) 2019-03-27
DK2658831T3 (en) 2017-04-24
US20130324715A1 (en) 2013-12-05
BR112014015042B1 (pt) 2021-10-26
WO2012089594A1 (en) 2012-07-05
CN103270004A (zh) 2013-08-28
PL2658831T3 (pl) 2017-07-31
JP6018581B2 (ja) 2016-11-02
US11504430B2 (en) 2022-11-22
AU2011351550B2 (en) 2017-02-02
BR112014015042A2 (pt) 2017-06-13
US20230068052A1 (en) 2023-03-02
ES2621950T3 (es) 2017-07-05
KR20130132892A (ko) 2013-12-05
BR112014015042A8 (pt) 2017-07-04
BR112013015396A2 (pt) 2016-09-20

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