PL377696A1 - Enancjomery pochodnych kwasu tiofenohydroksamowego i ich zastosowanie jako inhibitorów HDAC - Google Patents
Enancjomery pochodnych kwasu tiofenohydroksamowego i ich zastosowanie jako inhibitorów HDACInfo
- Publication number
- PL377696A1 PL377696A1 PL377696A PL37769603A PL377696A1 PL 377696 A1 PL377696 A1 PL 377696A1 PL 377696 A PL377696 A PL 377696A PL 37769603 A PL37769603 A PL 37769603A PL 377696 A1 PL377696 A1 PL 377696A1
- Authority
- PL
- Poland
- Prior art keywords
- enantiomers
- acid derivatives
- hydroxamic acid
- hdac inhibitors
- thiophene hydroxamic
- Prior art date
Links
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 title 1
- XNSXTZGRPNUMTQ-UHFFFAOYSA-N n-hydroxythiophene-2-carboxamide Chemical class ONC(=O)C1=CC=CS1 XNSXTZGRPNUMTQ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02028038 | 2002-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL377696A1 true PL377696A1 (pl) | 2006-02-06 |
Family
ID=32524005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL377696A PL377696A1 (pl) | 2002-12-16 | 2003-12-15 | Enancjomery pochodnych kwasu tiofenohydroksamowego i ich zastosowanie jako inhibitorów HDAC |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7098241B2 (pl) |
| EP (1) | EP1575933A1 (pl) |
| JP (1) | JP2006513181A (pl) |
| KR (1) | KR100781929B1 (pl) |
| CN (1) | CN100391954C (pl) |
| AR (1) | AR042459A1 (pl) |
| AU (1) | AU2003293882A1 (pl) |
| BR (1) | BR0317348A (pl) |
| CA (1) | CA2507629A1 (pl) |
| CL (1) | CL2003002611A1 (pl) |
| GT (1) | GT200300285A (pl) |
| PA (1) | PA8592101A1 (pl) |
| PE (1) | PE20040913A1 (pl) |
| PL (1) | PL377696A1 (pl) |
| RU (1) | RU2348625C2 (pl) |
| TW (1) | TW200418825A (pl) |
| UY (1) | UY28127A1 (pl) |
| WO (1) | WO2004054999A1 (pl) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002344854B2 (en) * | 2001-06-11 | 2008-11-06 | Vertex Pharmaceuticals (Canada) Incorporated | Thiophene derivatives as antiviral agents for flavivirus infection |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| CN100413861C (zh) | 2002-12-10 | 2008-08-27 | 维勒凯姆制药股份有限公司 | 用于治疗或预防黄病毒感染的化合物 |
| KR20050122210A (ko) | 2003-03-17 | 2005-12-28 | 다케다 샌디에고, 인코포레이티드 | 히스톤 탈아세틸화 효소 억제제 |
| US7435837B2 (en) * | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| US20050261347A1 (en) * | 2003-10-24 | 2005-11-24 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| CN1980920A (zh) * | 2004-06-14 | 2007-06-13 | 霍夫曼-拉罗奇有限公司 | 噻吩衍生物、它们的制备以及作为药剂的应用 |
| CN1964963A (zh) * | 2004-06-14 | 2007-05-16 | 霍夫曼-拉罗奇有限公司 | 异羟肟酸酯、它们的制备以及作为药剂的应用 |
| JP2008501665A (ja) * | 2004-06-14 | 2008-01-24 | エフ．ホフマン−ラ ロシュ アーゲー | チオフェンヒドロキサム酸誘導体及びｈｄａｃ阻害剤としてのこれらの使用 |
| JP2008524246A (ja) | 2004-12-16 | 2008-07-10 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| WO2006122319A2 (en) | 2005-05-11 | 2006-11-16 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| CN101218224B (zh) * | 2005-05-13 | 2013-05-08 | Viro化学制药公司 | 治疗或预防黄病毒感染的组合物和方法 |
| ZA200800901B (en) | 2005-07-14 | 2010-05-26 | Takeda San Diego Inc | Histone deacetylase inhibitors |
| GB0518237D0 (en) * | 2005-09-07 | 2005-10-19 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| GB0522130D0 (en) * | 2005-10-31 | 2005-12-07 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| GB0603041D0 (en) * | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| PT2104674E (pt) | 2006-11-15 | 2013-07-26 | Virochem Pharma Inc | Análogos de tiofeno para o tratamento ou prevenção de infeções por flavivírus |
| AR074797A1 (es) * | 2008-10-10 | 2011-02-16 | Japan Tobacco Inc | Compuesto de fluoreno , composiciones farmaceuticas , inhibidores de pdhk y pdhk2 , metodos de tratamiento , usos de los mismos y kit comercial |
| WO2011106632A1 (en) * | 2010-02-26 | 2011-09-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2011106627A1 (en) * | 2010-02-26 | 2011-09-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2012019772A1 (en) * | 2010-08-12 | 2012-02-16 | Institut De Recherche Pour Le Developpement (I.R.D) | Method for treating protozoan parasitic diseases |
| US20140107166A1 (en) * | 2011-02-14 | 2014-04-17 | Dana-Farber Cancer Institute, Inc. | Histone deacetylase inhibitors and methods of use thereof |
| CA2850757A1 (en) * | 2011-10-03 | 2013-04-11 | The Trustees Of Columbia University In The City Of New York | Novel molecules that selectively inhibit histone deacetylase 6 relative to histone deacetylase 1 |
| JP6208603B2 (ja) | 2013-03-15 | 2017-10-04 | 日本たばこ産業株式会社 | ピラゾール−アミド化合物およびその医薬用途 |
| CN103159646B (zh) * | 2013-03-19 | 2014-10-22 | 广东药学院 | 一种异羟肟酸类化合物及其制备方法和应用 |
| CA2933907A1 (en) | 2013-12-23 | 2015-07-02 | The Trustees Of Columbia University In The City Of New York | Selective hdac6 inhibitors |
| TWI773657B (zh) | 2015-12-18 | 2022-08-11 | 美商亞德利克斯公司 | 作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物 |
| US12084472B2 (en) | 2015-12-18 | 2024-09-10 | Ardelyx, Inc. | Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists |
| JP7036724B2 (ja) | 2016-07-29 | 2022-03-15 | 日本たばこ産業株式会社 | ピラゾール－アミド化合物の製造方法 |
| CN116120300B (zh) * | 2023-02-21 | 2024-10-15 | 贵州大学 | 一种含异羟肟酸片段的嘧啶类化合物其制备方法和应用 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE661226A (fr) | 1965-03-17 | 1965-09-17 | Acides arylacethydroxamiques, amides correspondants et procedes de preparation. | |
| NL6406688A (pl) | 1964-06-05 | 1965-12-06 | ||
| GB1200886A (en) | 1966-09-23 | 1970-08-05 | Allen & Hanburys Ltd | Phenylaminoethanol derivatives |
| NL7614113A (nl) | 1976-12-18 | 1978-06-20 | Akzo Nv | Hydroxamzuren. |
| US4173652A (en) | 1976-12-18 | 1979-11-06 | Akzona Incorporated | Pharmaceutical hydroxamic acid compositions and uses thereof |
| JPS5436229A (en) | 1977-08-25 | 1979-03-16 | Hokuriku Pharmaceutical | Substituted acetohydroxam derivative |
| JPS57145838A (en) | 1981-03-05 | 1982-09-09 | Hodogaya Chem Co Ltd | P-benzyloxybenzoic acid derivative and herbicide containing the same |
| JPS57149254A (en) | 1981-03-10 | 1982-09-14 | Hodogaya Chem Co Ltd | M-benzyloxybenzamide derivative and herbicide containing the same |
| GB8320702D0 (en) | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agents |
| US4769461A (en) | 1986-09-16 | 1988-09-06 | American Home Products Corporation | Quinolinyl benzene hydroxamic acids as anti-inflammatory/antiallergic agents |
| GB8728051D0 (en) | 1987-12-01 | 1988-01-06 | Leo Pharm Prod Ltd | Chemical compounds |
| JPH01216961A (ja) | 1988-02-25 | 1989-08-30 | Takeda Chem Ind Ltd | １２−リポキシゲネース阻害剤 |
| DE3903989A1 (de) | 1989-02-10 | 1990-09-20 | Basf Ag | Diphenylheteroalkylderivate, ihre herstellung und daraus hergestellte arzneimittel und kosmetika |
| US5091533A (en) | 1990-03-12 | 1992-02-25 | Merck Frosst Canada, Inc. | 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors |
| JPH04217950A (ja) | 1990-03-28 | 1992-08-07 | Asahi Chem Ind Co Ltd | ヒドロキサム酸誘導体および酵素阻害剤ならびに抗潰瘍剤 |
| JPH03291264A (ja) | 1990-04-06 | 1991-12-20 | Japan Tobacco Inc | ジメチルアニリン誘導体、その製造方法及びそれを有効成分として含有するガン細胞分化誘導検査試薬及び制癌剤 |
| JPH04187666A (ja) | 1990-11-20 | 1992-07-06 | Asahi Chem Ind Co Ltd | シクロヘキサンカルボン酸アミド誘導体及び酵素阻害剤ならびに抗潰瘍剤 |
| US5700811A (en) | 1991-10-04 | 1997-12-23 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and method of use thereof |
| US5369108A (en) | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| EP0544166A3 (en) | 1991-11-26 | 1993-11-03 | Hoffmann La Roche | Cephalosporinderivatives |
| CA2139325A1 (en) | 1992-07-16 | 1994-02-03 | Stephen E. Bales | Thiodiphenol copolycarbonates and their use as components of multilayered polymeric reflective bodies |
| US5783593A (en) | 1993-11-04 | 1998-07-21 | Abbott Laboratories | Inhibitors of squalene synthetase and protein farnesyltransferase |
| US5776983A (en) | 1993-12-21 | 1998-07-07 | Bristol-Myers Squibb Company | Catecholamine surrogates useful as β3 agonists |
| US6008257A (en) | 1994-01-28 | 1999-12-28 | Bayer Aktiengesellschaft | Hydroxamic-acid derivatives, method of preparing them and their use as fungicides |
| GB9420557D0 (en) | 1994-10-12 | 1994-11-30 | Zeneca Ltd | Aromatic compounds |
| KR100430059B1 (ko) | 1995-04-10 | 2004-09-24 | 후지사와 야꾸힝 고교 가부시키가이샤 | cGMP-PDE억제제로서의인돌유도체 |
| US5786358A (en) | 1995-09-08 | 1998-07-28 | The Trustees Of Princeton University | Pyridopyrimidines as nonclassical antifolates |
| WO1997012903A1 (en) | 1995-10-04 | 1997-04-10 | Warner-Lambert Company | Compounds, compositions and methods for inhibiting the binding of proteins containing an sh2 domain to cognate phosphorylated proteins |
| FR2746098B1 (fr) | 1996-03-14 | 1998-04-30 | Composes propynyl biaromatiques | |
| AUPO118896A0 (en) | 1996-07-23 | 1996-08-15 | Fujisawa Pharmaceutical Co., Ltd. | New use |
| RU2171250C2 (ru) | 1996-08-05 | 2001-07-27 | Пролинкс, Инк. | Производные 2,6-дигидрокси-4-аминометилбензоата |
| US6174905B1 (en) | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
| JPH10114654A (ja) | 1996-10-09 | 1998-05-06 | Fujisawa Pharmaceut Co Ltd | 新規用途 |
| AU743901B2 (en) | 1996-10-16 | 2002-02-07 | Wyeth Holdings Corporation | Ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloprote inase and tace inhibitors |
| US6392010B1 (en) | 1996-12-19 | 2002-05-21 | Aventis Pharmaceuticals Inc. | Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds |
| JPH10182583A (ja) | 1996-12-25 | 1998-07-07 | Mitsui Chem Inc | 新規ヒドロキサム酸誘導体 |
| ATE292622T1 (de) | 1997-01-22 | 2005-04-15 | Aventis Pharma Inc | Substituierte beta-thiocarbonsäuren |
| GEP20022626B (en) | 1997-02-27 | 2002-02-25 | American Cyanamid Company Us | N-Hydroxy-2-(Alkyl, Aryl, or Heteroaryl Sulfanyl, Sulfinil or Sulfonyl)-3-Substituted Alkyl, Aryl or Heteroarylamides as Matrix Metalloproteinase Inhibitors |
| US6696449B2 (en) | 1997-03-04 | 2004-02-24 | Pharmacia Corporation | Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors |
| JPH10259176A (ja) | 1997-03-17 | 1998-09-29 | Japan Tobacco Inc | 血管新生阻害作用を有する新規アミド誘導体及びその用途 |
| JPH10287634A (ja) | 1997-04-11 | 1998-10-27 | Otsuka Pharmaceut Co Ltd | ベンゼン誘導体 |
| CA2293433C (en) | 1997-06-17 | 2009-09-29 | Schering Corporation | Benzo(5,6)cyclohepta(1,2-b)pyridine derivatives as farnesyl protein transferase inhibitors |
| DE69824433D1 (en) | 1997-08-28 | 2004-07-15 | Biovitrum Ab | Proteintyrosinphosphatase inhibitoren |
| JP4125868B2 (ja) | 1997-09-09 | 2008-07-30 | 塩野義製薬株式会社 | ４−置換安息香酸誘導体およびそれを有効成分として含有する制癌剤 |
| DK1021413T3 (da) | 1997-10-06 | 2003-10-06 | Wyeth Corp | Fremstilling og anvendelse af ortho-sulfonamido-bicykliske heteroarylhydroxamsyrer som matrixmetalloproteinase- og TACE-inhibitorer |
| JP2001519410A (ja) | 1997-10-15 | 2001-10-23 | アメリカン・ホーム・プロダクツ・コーポレイション | 新規なアリールオキシ−アルキル−ジアルキルアミン |
| ID25639A (id) | 1998-02-19 | 2000-10-19 | American Cyanamid Co | Alkil, aril atau heteroarilamida tersubstitusi n-hidroksi-2-(alkil, aril, atau heteroaril sulfanil, sulfinil atau sulfonil)-3 sebagai inhibitor matriks mataloproteinase |
| EP0960882A1 (en) * | 1998-05-19 | 1999-12-01 | Hoechst Marion Roussel Deutschland GmbH | Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists |
| CA2391952C (en) | 1999-11-23 | 2012-01-31 | Methylgene Inc. | Inhibitors of histone deacetylase |
| AU2001248701A1 (en) | 2000-03-24 | 2001-10-03 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| US6784173B2 (en) * | 2001-06-15 | 2004-08-31 | Hoffmann-La Roche Inc. | Aromatic dicarboxylic acid derivatives |
| WO2003055479A1 (en) * | 2001-12-21 | 2003-07-10 | Consejo Superior De Investigaciones Cientificas | Compounds and their therapeutic use related to the phosphorylating activity of the enzyme gsk-3 |
-
2003
- 2003-12-10 TW TW092134881A patent/TW200418825A/zh unknown
- 2003-12-10 US US10/732,633 patent/US7098241B2/en not_active Expired - Fee Related
- 2003-12-11 PE PE2003001262A patent/PE20040913A1/es not_active Application Discontinuation
- 2003-12-11 PA PA20038592101A patent/PA8592101A1/es unknown
- 2003-12-12 AR ARP030104605A patent/AR042459A1/es unknown
- 2003-12-12 CL CL200302611A patent/CL2003002611A1/es unknown
- 2003-12-12 GT GT200300285A patent/GT200300285A/es unknown
- 2003-12-15 RU RU2005122447/04A patent/RU2348625C2/ru not_active IP Right Cessation
- 2003-12-15 UY UY28127A patent/UY28127A1/es not_active Application Discontinuation
- 2003-12-15 CA CA002507629A patent/CA2507629A1/en not_active Abandoned
- 2003-12-15 CN CNB2003801059568A patent/CN100391954C/zh not_active Expired - Fee Related
- 2003-12-15 KR KR1020057011170A patent/KR100781929B1/ko not_active Expired - Fee Related
- 2003-12-15 AU AU2003293882A patent/AU2003293882A1/en not_active Abandoned
- 2003-12-15 JP JP2004560408A patent/JP2006513181A/ja not_active Ceased
- 2003-12-15 EP EP03789278A patent/EP1575933A1/en not_active Withdrawn
- 2003-12-15 PL PL377696A patent/PL377696A1/pl not_active Application Discontinuation
- 2003-12-15 WO PCT/EP2003/014235 patent/WO2004054999A1/en not_active Ceased
- 2003-12-15 BR BR0317348-8A patent/BR0317348A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20050089157A (ko) | 2005-09-07 |
| RU2005122447A (ru) | 2006-05-27 |
| CA2507629A1 (en) | 2004-07-01 |
| BR0317348A (pt) | 2005-11-16 |
| AU2003293882A1 (en) | 2004-07-09 |
| CL2003002611A1 (es) | 2005-01-14 |
| UY28127A1 (es) | 2004-06-30 |
| CN1726204A (zh) | 2006-01-25 |
| JP2006513181A (ja) | 2006-04-20 |
| AR042459A1 (es) | 2005-06-22 |
| PE20040913A1 (es) | 2005-01-18 |
| CN100391954C (zh) | 2008-06-04 |
| US7098241B2 (en) | 2006-08-29 |
| US20040122079A1 (en) | 2004-06-24 |
| WO2004054999A1 (en) | 2004-07-01 |
| GT200300285A (es) | 2004-07-14 |
| KR100781929B1 (ko) | 2007-12-04 |
| EP1575933A1 (en) | 2005-09-21 |
| RU2348625C2 (ru) | 2009-03-10 |
| PA8592101A1 (es) | 2004-11-02 |
| TW200418825A (en) | 2004-10-01 |
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