PL378867A1 - 2-alkinylo- i 2-alkenylo-pirazolo- [4,3-e] -1,2,4-triazolo- [1,5-c]-pirymidynowi antagoniści receptora adenozynowego A <v>2a<D> - Google Patents

2-alkinylo- i 2-alkenylo-pirazolo- [4,3-e] -1,2,4-triazolo- [1,5-c]-pirymidynowi antagoniści receptora adenozynowego A <v>2a<D>

Info

Publication number
PL378867A1
PL378867A1 PL378867A PL37886704A PL378867A1 PL 378867 A1 PL378867 A1 PL 378867A1 PL 378867 A PL378867 A PL 378867A PL 37886704 A PL37886704 A PL 37886704A PL 378867 A1 PL378867 A1 PL 378867A1
Authority
PL
Poland
Prior art keywords
triazolo
pyrazolo
alkynyl
alkenyl
receptor
Prior art date
Application number
PL378867A
Other languages
English (en)
Inventor
Bernard R. Neustadt
Jinsong Hao
Hong Liu
Craig D. Boyle
Samuel Chackalamannil
Unmesh G. Shah
Andrew Stamford
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of PL378867A1 publication Critical patent/PL378867A1/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL378867A 2003-04-23 2004-04-21 2-alkinylo- i 2-alkenylo-pirazolo- [4,3-e] -1,2,4-triazolo- [1,5-c]-pirymidynowi antagoniści receptora adenozynowego A <v>2a<D> PL378867A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46484003P 2003-04-23 2003-04-23

Publications (1)

Publication Number Publication Date
PL378867A1 true PL378867A1 (pl) 2006-05-29

Family

ID=33310963

Family Applications (2)

Application Number Title Priority Date Filing Date
PL04760128T PL1622912T3 (pl) 2003-04-23 2004-04-21 2-ALKINYLO i 2-ALKENYLO-PIRAZOLO-[4,3-E]-1,2,4-TRIAZOLO-[1,5-C]-PIRYMIDYNY JAKO ANTAGONIŚCI RECEPTORA ADENOZYNOWEGO A2A
PL378867A PL378867A1 (pl) 2003-04-23 2004-04-21 2-alkinylo- i 2-alkenylo-pirazolo- [4,3-e] -1,2,4-triazolo- [1,5-c]-pirymidynowi antagoniści receptora adenozynowego A <v>2a<D>

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL04760128T PL1622912T3 (pl) 2003-04-23 2004-04-21 2-ALKINYLO i 2-ALKENYLO-PIRAZOLO-[4,3-E]-1,2,4-TRIAZOLO-[1,5-C]-PIRYMIDYNY JAKO ANTAGONIŚCI RECEPTORA ADENOZYNOWEGO A2A

Country Status (31)

Country Link
US (2) US6897217B2 (pl)
EP (1) EP1622912B1 (pl)
JP (2) JP4527712B2 (pl)
KR (1) KR100831107B1 (pl)
CN (1) CN100503609C (pl)
AR (1) AR044041A1 (pl)
AT (1) ATE432282T1 (pl)
AU (1) AU2004233334B2 (pl)
BR (1) BRPI0409787B8 (pl)
CA (1) CA2522813C (pl)
CL (1) CL2004000847A1 (pl)
CO (1) CO5700766A2 (pl)
CY (1) CY1109263T1 (pl)
DE (1) DE602004021250D1 (pl)
DK (1) DK1622912T3 (pl)
EC (1) ECSP056115A (pl)
ES (1) ES2326270T3 (pl)
HR (1) HRP20090394T1 (pl)
IL (1) IL171567A (pl)
MX (1) MXPA05011366A (pl)
MY (1) MY139344A (pl)
NO (1) NO332182B1 (pl)
NZ (1) NZ542823A (pl)
PE (1) PE20050141A1 (pl)
PL (2) PL1622912T3 (pl)
PT (1) PT1622912E (pl)
RU (1) RU2373210C2 (pl)
SI (1) SI1622912T1 (pl)
TW (2) TWI355381B (pl)
WO (1) WO2004094431A2 (pl)
ZA (1) ZA200508489B (pl)

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IL161716A0 (en) * 2001-11-30 2004-09-27 Schering Corp ADENOSINE A2a RECEPTOR ANTAGONISTS
US20060128694A1 (en) * 2002-12-19 2006-06-15 Michael Grzelak Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
TWI331036B (en) * 2002-12-19 2010-10-01 Schering Corp Adenosine a2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
EP1622912B1 (en) * 2003-04-23 2009-05-27 Schering Corporation 2-alkynyl-and 2-alkenyl-pyrazolo- [4,3-e ] -1,2,4-triazolo- [1,5-c] -pyrimidine adenosine a2a receptor antagonists
ATE461932T1 (de) * 2004-04-21 2010-04-15 Schering Corp Pyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidine als antagonisten des adenosin-a2a-rezeptors
EP2258372B8 (en) * 2005-06-07 2012-12-19 Kyowa Hakko Kirin Co., Ltd. A2A antagonists for use in the treatment of motor disorders
EP1934227B1 (en) 2005-09-19 2011-12-21 Schering Corporation 2-HETEROARYL-PYRAZOLO-[4, 3-e]-1, 2, 4-TRIAZOLO-[1,5-c]-PYRIMIDINE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
PE20070521A1 (es) 2005-09-23 2007-07-13 Schering Corp 7-[2-[4-(6-FLUORO-3-METIL-1,2-BENCISOXAZOL-5-IL)-1-PIPERAZINIL]ETIL]-2-(1-PROPINIL)-7H-PIRAZOL-[4,3-E]-[1,2,4]-TRIAZOL-[1,5-C]-PIRIMIDIN-5-AMINA COMO ANTAGONISTA DEL RECEPTOR DE ADENOSINA A2a
ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
US7723343B2 (en) * 2007-03-30 2010-05-25 King Pharmaceuticals Research And Development, Inc. Adenosine A2A receptor antagonists
JP2011513417A (ja) * 2008-03-04 2011-04-28 シェーリング コーポレイション アデノシンＡ２ａ受容体アンタゴニストとして使用するための１，２，４−トリアゾロ［４，３−ｃ］ピリミジン−３−オンおよびピラゾロ［４，３−ｅ］−１，２，４−トリアゾロ［４，３−ｃ］ピリミジン−３−オン化合物
US8501997B2 (en) * 2008-08-25 2013-08-06 Air Products And Chemicals, Inc. Curing agent for low temperature cure applications
US8512594B2 (en) * 2008-08-25 2013-08-20 Air Products And Chemicals, Inc. Curing agent of N,N′-dimethyl-meta-xylylenediamine and multifunctional amin(s)
EP2406243B1 (en) 2009-03-10 2014-05-07 Takeda Pharmaceutical Company Limited Benzofuran derivatives
US8598343B2 (en) 2009-08-07 2013-12-03 Merck Sharp & Dohme Corp. Process for preparing a 2-alkynyl substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
US8420661B2 (en) * 2010-04-13 2013-04-16 Hoffmann-La Roche Inc. Arylethynyl derivatives
EP2797880B1 (en) * 2011-12-27 2017-03-01 Bio-Pharm Solutions Co., Ltd. Phenyl carbamate compounds for use in preventing or treating epilepsy
WO2014101120A1 (en) 2012-12-28 2014-07-03 Merck Sharp & Dohme Corp. Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
RU2675818C2 (ru) * 2013-03-14 2018-12-25 Галапаго Нв Новые соединения и фармацевтические композиции, их содержащие, для лечения воспалительных расстройств
US11498923B2 (en) 2017-12-13 2022-11-15 Merck Sharp & Dohme Llc Substituted imidazo[1,2-c]quinazolines as A2A antagonists
JP2022540583A (ja) * 2019-07-17 2022-09-16 テオン セラピューティクス，インク． アデノシンａ２ａ受容体アンタゴニスト及びその使用
CN115160120B (zh) * 2022-08-02 2024-08-27 乐威医药（江苏）股份有限公司 一种多烷氧基芳香酮的合成方法

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EP1622912B1 (en) * 2003-04-23 2009-05-27 Schering Corporation 2-alkynyl-and 2-alkenyl-pyrazolo- [4,3-e ] -1,2,4-triazolo- [1,5-c] -pyrimidine adenosine a2a receptor antagonists

Also Published As

Publication number Publication date
PL1622912T3 (pl) 2009-11-30
SI1622912T1 (sl) 2009-10-31
NO20055510D0 (no) 2005-11-22
DK1622912T3 (da) 2009-09-07
TW201144317A (en) 2011-12-16
KR20060005379A (ko) 2006-01-17
US7368449B2 (en) 2008-05-06
CA2522813C (en) 2009-09-08
KR100831107B1 (ko) 2008-05-20
IL171567A (en) 2013-01-31
TWI355381B (en) 2012-01-01
EP1622912A2 (en) 2006-02-08
PT1622912E (pt) 2009-08-17
NO332182B1 (no) 2012-07-23
BRPI0409787B8 (pt) 2021-05-25
AU2004233334B2 (en) 2010-08-12
ECSP056115A (es) 2006-03-01
WO2004094431A2 (en) 2004-11-04
ZA200508489B (en) 2007-04-25
JP4527712B2 (ja) 2010-08-18
US20050222164A1 (en) 2005-10-06
NZ542823A (en) 2009-03-31
RU2373210C2 (ru) 2009-11-20
US20040220194A1 (en) 2004-11-04
HRP20090394T1 (hr) 2009-08-31
AU2004233334A1 (en) 2004-11-04
US6897217B2 (en) 2005-05-24
RU2005136166A (ru) 2006-06-10
HK1085466A1 (en) 2006-08-25
MXPA05011366A (es) 2005-11-28
WO2004094431A3 (en) 2004-12-02
BRPI0409787A (pt) 2006-05-30
CO5700766A2 (es) 2006-11-30
ES2326270T3 (es) 2009-10-06
DE602004021250D1 (de) 2009-07-09
CA2522813A1 (en) 2004-11-04
BRPI0409787B1 (pt) 2018-08-21
JP2006523619A (ja) 2006-10-19
CY1109263T1 (el) 2014-07-02
CN100503609C (zh) 2009-06-24
PE20050141A1 (es) 2005-04-01
AR044041A1 (es) 2005-08-24
EP1622912B1 (en) 2009-05-27
ATE432282T1 (de) 2009-06-15
CN1777609A (zh) 2006-05-24
CL2004000847A1 (es) 2005-03-11
TWI375677B (en) 2012-11-01
JP2010059178A (ja) 2010-03-18
NO20055510L (no) 2006-01-20
MY139344A (en) 2009-09-30
TW200427689A (en) 2004-12-16

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