PL393385A1 - Sposób modyfikacji i rekrystalizacji pokroju kryształów substancji leczniczej, kryształy mykofenolanu sodu i ich zastosowanie oraz kompozycja farmaceutyczna - Google Patents

Sposób modyfikacji i rekrystalizacji pokroju kryształów substancji leczniczej, kryształy mykofenolanu sodu i ich zastosowanie oraz kompozycja farmaceutyczna

Info

Publication number: PL393385A1
Authority: PL; Poland
Prior art keywords: habit; recrystallization; modification; pharmaceutical composition; drug substance
Prior art date: 2003-01-20

Application number

PL393385A

Other languages

English (en)

Other versions

PL213192B1 (pl

Inventor

Sabine Pfeffer

Dierk Wieckhusen

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-01-20

Filing date

2004-01-19

Publication date

2011-03-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9951448&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL393385(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-01-19 Application filed by Novartis Ag filed Critical Novartis Ag

2011-03-14 Publication of PL393385A1 publication Critical patent/PL393385A1/pl

2013-01-31 Publication of PL213192B1 publication Critical patent/PL213192B1/pl

Links

239000008186 active pharmaceutical agent Substances 0.000 title 1
239000013078 crystal Substances 0.000 title 1
229940088679 drug related substance Drugs 0.000 title 1
238000000034 method Methods 0.000 title 1
238000012986 modification Methods 0.000 title 1
230000004048 modification Effects 0.000 title 1
229960000951 mycophenolic acid Drugs 0.000 title 1
HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
238000001953 recrystallisation Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Furan Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

PL393385A 2003-01-20 2004-01-19 Sposób modyfikacji pokroju krysztalów substancji leczniczej, krysztaly mykofenolanu sodu i ich zastosowanie oraz kompozycja farmaceutyczna PL213192B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0301259.8A GB0301259D0 (en)	2003-01-20	2003-01-20	Organic compounds

Publications (2)

Publication Number	Publication Date
PL393385A1 true PL393385A1 (pl)	2011-03-14
PL213192B1 PL213192B1 (pl)	2013-01-31

Family

ID=9951448

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL376525A PL376525A1 (pl)	2003-01-20	2004-01-19	Sposób modyfikacji pokroju kryształów substancji leczniczej
PL393385A PL213192B1 (pl)	2003-01-20	2004-01-19	Sposób modyfikacji pokroju krysztalów substancji leczniczej, krysztaly mykofenolanu sodu i ich zastosowanie oraz kompozycja farmaceutyczna

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PL376525A PL376525A1 (pl)	2003-01-20	2004-01-19	Sposób modyfikacji pokroju kryształów substancji leczniczej

Country Status (31)

Country	Link
US (3)	US20060122265A1 (pl)
EP (2)	EP2308471A1 (pl)
JP (1)	JP4549976B2 (pl)
KR (5)	KR100855149B1 (pl)
CN (2)	CN101333201A (pl)
AR (2)	AR043343A1 (pl)
AT (1)	ATE546132T1 (pl)
AU (1)	AU2004206731B2 (pl)
BR (1)	BRPI0406827A (pl)
CA (2)	CA2509796C (pl)
CL (1)	CL2004000073A1 (pl)
CO (1)	CO5580738A2 (pl)
CY (1)	CY1112772T1 (pl)
DK (1)	DK1592401T3 (pl)
EC (1)	ECSP055918A (pl)
ES (1)	ES2382035T3 (pl)
GB (1)	GB0301259D0 (pl)
IL (1)	IL169484A (pl)
MX (1)	MXPA05007691A (pl)
MY (1)	MY148297A (pl)
NO (1)	NO20053846L (pl)
NZ (1)	NZ541073A (pl)
PE (2)	PE20040826A1 (pl)
PL (2)	PL376525A1 (pl)
PT (1)	PT1592401E (pl)
RU (1)	RU2388757C2 (pl)
SG (1)	SG155046A1 (pl)
SI (1)	SI1592401T1 (pl)
TW (1)	TWI325785B (pl)
WO (1)	WO2004064806A2 (pl)
ZA (1)	ZA200504442B (pl)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0124953D0 (en)	2001-10-17	2001-12-05	Novartis Ag	Organic Compounds
GB0301259D0 (en)	2003-01-20	2003-02-19	Novartis Ag	Organic compounds
AR045957A1 (es) *	2003-10-03	2005-11-16	Novartis Ag	Composicion farmaceutica y combinacion
MXPA06005659A (es)	2004-04-26	2007-04-10	Teva Gyogyszergyar Zartkoruen	Proceso para preparacion de acido micofenolico y derivados de ester del mismo.
EP1740563A2 (en)	2004-04-27	2007-01-10	Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság	Mycophenolate mofetil impurity
US7439373B2 (en)	2004-07-20	2008-10-21	TEVA Gyógyszergyár Zártkörúen Múködö Részvénytársaság	Crystalline mycophenolate sodium
GB0419355D0 (en) *	2004-08-31	2004-09-29	Novartis Ag	Organic compounds
US20080176937A1 (en) *	2007-01-23	2008-07-24	Apotex Fermentation Inc.	Novel crystalline mycophenolate sodium polymorph and processes to manufacture same
ES2391132T3 (es) *	2008-10-09	2012-11-21	Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi	Uso de disolventes orgánicos en la granulación húmeda de moxifloxacino
CN101756958B (zh) *	2008-11-10	2011-07-20	鲁南制药集团股份有限公司	一种治疗关节炎的药物组合物及其制备方法
US20110009347A1 (en)	2009-07-08	2011-01-13	Yin Liang	Combination therapy for the treatment of diabetes
EP2451797B1 (en) *	2009-07-10	2013-04-03	Janssen Pharmaceutica, N.V.	CRYSTALLISATION PROCESS FOR 1-(ß-D-GLUCOPYRANOSYL)-4-METHYL-3-[5-(4-FLUOROPHENYL)-2-THIENYLMETHYL]BENZENE
EA201270544A1 (ru) *	2009-10-13	2012-09-28	Тева Фармасьютикал Индастриз Лтд.	Композиции с отсроченным высвобождением
JP5856980B2 (ja)	2010-01-27	2016-02-10	アリーナファーマシューティカルズ，インコーポレイテッド	（Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸およびその塩の調製のためのプロセス
SG10201506114UA (en)	2010-05-11	2015-09-29	Janssen Pharmaceutica Nv	Pharmaceutical formulations comprising 1 - (beta-d-glucopyranosyl) - 2 -thienylmethylbenzene derivatives as inhibitors of sglt
CN103880800A (zh) *	2010-11-16	2014-06-25	北京京卫信康医药科技发展有限公司	麦考酚酸钠的新晶型及其制备方法
CN103880799A (zh) *	2010-11-16	2014-06-25	北京京卫信康医药科技发展有限公司	麦考酚酸钠的新晶型及其制备方法
EP2697218B1 (en)	2011-04-13	2016-05-25	Janssen Pharmaceutica NV	Process for the preparation of compounds useful as inhibitors of sglt2
TWI582078B (zh) *	2013-01-23	2017-05-11	北京貝美拓新藥研發有限公司	抑制脯氨酸羥化酶活性的化合物的晶型及其應用
BR112017027656B1 (pt)	2015-06-22	2023-12-05	Arena Pharmaceuticals, Inc.	Hábito cristalino de placa livre de sal de l-arginina de ácido (r)-2-(7-(4- ciclopentil-3-(trifluorometil)benzilóxi)- 1,2,3,4-tetra-hidrociclo-penta[b]indol-3- il)acético, composição farmacêutica que o compreende, seus usos e método de preparação do mesmo
US20170071970A1 (en)	2015-09-15	2017-03-16	Janssen Pharmaceutica Nv	Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
HUE049895T2 (hu) *	2015-12-21	2020-11-30	Janssen Pharmaceutica Nv	Kristályosítási eljárás kanagliflozin hemihidrát kristályok elõállítására
MX2019009843A (es)	2017-02-16	2020-01-30	Arena Pharm Inc	Compuestos y metodos para el tratamiento de la enfermedad inflamatoria intestinal con manifestaciones extraintestinales.
MX2019009841A (es)	2017-02-16	2020-01-30	Arena Pharm Inc	Compuestos y metodos para el tratamiento de la colangitis biliar primaria.
CN108727318A (zh) *	2017-04-25	2018-11-02	鲁南制药集团股份有限公司	麦考酚酸的晶型物
CN108727317A (zh) *	2017-04-25	2018-11-02	鲁南制药集团股份有限公司	一种麦考酚酸的晶型物
CA3102136A1 (en)	2018-06-06	2019-12-12	Arena Pharmaceuticals, Inc.	Methods of treating conditions related to the s1p1 receptor
CN110922371B (zh) *	2019-12-27	2020-08-11	广东蓝宝制药有限公司	一种m2晶型麦考酚钠的制备方法
CN120208923A (zh)	2020-05-18	2025-06-27	诺华股份有限公司	Lnp023的结晶形式
KR20250013155A (ko) *	2022-05-31	2025-01-31	혼슈우 카가쿠고교 가부시키가이샤	4,4'－비스(1,1－비스(4－히드록시－3－메틸페닐)에틸)비페닐의 결정 및 그의 제조방법

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US158835A (en) *		1875-01-19		Improvement in mortising-tools
GB935432A (en) *	1958-05-29	1963-08-28	Secr Aviation	Improvements in the manufacture of crystalline substances
US3187039A (en) *	1962-10-19	1965-06-01	Commercial Solvents Corp	Method for changing the crystal habit of monosodium glutamate
US3183263A (en) *	1962-10-19	1965-05-11	Commercial Solvents Corp	Method for changing the crystal habit of mono-sodium glutamate
US3352906A (en) *	1963-02-04	1967-11-14	Charles R Parkerson	Habit modification and preparation of single crystal triglycine sulfate
GB1157100A (en) *	1966-09-27	1969-07-02	Ici Ltd	Pharmaceutical Compositions
GB1157099A (en) *	1966-09-27	1969-07-02	Ici Ltd	Fermentation Process
US3770390A (en) *	1971-02-26	1973-11-06	Dow Chemical Co	Crystal habit modification of inorganic salts using polymeric sulfonates or sulfates
US4259239A (en) *	1980-04-21	1981-03-31	Allied Chemical Corporation	Resolution of enantiomeric complexes of nickelous chloride and alpha-aminocaprolactam
IL60254A (en)	1980-06-08	1983-11-30	Yeda Res & Dev	Resolution of amino acids
JPS5875194A (ja) *	1981-10-30	1983-05-06	株式会社日立製作所	マトリクス表示装置及び駆動方法
JPS59232916A (ja) *	1983-06-16	1984-12-27	Shiraishi Chuo Kenkyusho:Kk	針柱状炭酸カルシウム結束体、その製造法及び該結束体を含有する感熱紙用塗被組成物
IL77031A (en)	1985-11-12	1995-12-08	Yeda Res & Dev	Kinetic resolution of racemic mixtures by polymer-bound crystallization inhibitors
JPH0745359B2 (ja)	1987-12-25	1995-05-17	東レ株式会社	有機化合物結晶の製造方法
EP0582452B1 (en) *	1992-08-04	1998-10-14	Toda Kogyo Corp.	Granulated particles for magnetic particles for magnetic recording and process for producing the same
JP3411038B2 (ja)	1993-09-15	2003-05-26	シンテックス（ユー・エス・エイ）・インコーポレイテッド	ミコフェノール酸モフェチルの結晶質無水物およびその静注用製剤
JPH09209297A (ja) *	1996-01-26	1997-08-12	Nippon Paper Ind Co Ltd	艶消し軽量塗工紙及びその製造方法
KR100491274B1 (ko) *	1996-04-12	2005-09-05	노파르티스 아게	미코페놀레이트의장용코팅된약제조성물
ID18663A (id)	1996-04-12	1998-04-30	Novartis Ag	Komposisi farmasi berlapis enterik
FR2780403B3 (fr) *	1998-06-24	2000-07-21	Sanofi Sa	Nouvelle forme de l'irbesartan, procedes pour obtenir ladite forme et compositions pharmaceutiques en contenant
GB0301259D0 (en) *	2003-01-20	2003-02-19	Novartis Ag	Organic compounds

2003
- 2003-01-20 GB GBGB0301259.8A patent/GB0301259D0/en not_active Ceased
2004
- 2004-01-19 BR BR0406827-0A patent/BRPI0406827A/pt not_active Application Discontinuation
- 2004-01-19 ES ES04703158T patent/ES2382035T3/es not_active Expired - Lifetime
- 2004-01-19 PL PL376525A patent/PL376525A1/pl not_active Application Discontinuation
- 2004-01-19 SI SI200431859T patent/SI1592401T1/sl unknown
- 2004-01-19 EP EP10177718A patent/EP2308471A1/en not_active Withdrawn
- 2004-01-19 RU RU2005126328/04A patent/RU2388757C2/ru active
- 2004-01-19 KR KR1020057013313A patent/KR100855149B1/ko not_active Expired - Lifetime
- 2004-01-19 MX MXPA05007691A patent/MXPA05007691A/es active IP Right Grant
- 2004-01-19 AR ARP040100142A patent/AR043343A1/es unknown
- 2004-01-19 NZ NZ541073A patent/NZ541073A/en not_active IP Right Cessation
- 2004-01-19 AT AT04703158T patent/ATE546132T1/de active
- 2004-01-19 JP JP2005518641A patent/JP4549976B2/ja not_active Expired - Fee Related
- 2004-01-19 SG SG200700660-4A patent/SG155046A1/en unknown
- 2004-01-19 PT PT04703158T patent/PT1592401E/pt unknown
- 2004-01-19 CN CNA2008101443548A patent/CN101333201A/zh active Pending
- 2004-01-19 KR KR1020097022061A patent/KR101129105B1/ko not_active Expired - Lifetime
- 2004-01-19 WO PCT/EP2004/000354 patent/WO2004064806A2/en not_active Ceased
- 2004-01-19 AU AU2004206731A patent/AU2004206731B2/en not_active Expired
- 2004-01-19 CA CA2509796A patent/CA2509796C/en not_active Expired - Lifetime
- 2004-01-19 CA CA2706900A patent/CA2706900A1/en not_active Abandoned
- 2004-01-19 US US10/541,504 patent/US20060122265A1/en not_active Abandoned
- 2004-01-19 TW TW093101302A patent/TWI325785B/zh not_active IP Right Cessation
- 2004-01-19 PE PE2004000074A patent/PE20040826A1/es not_active Application Discontinuation
- 2004-01-19 CN CN200480002455A patent/CN100595199C/zh not_active Expired - Lifetime
- 2004-01-19 PE PE2011000069A patent/PE20110276A1/es active IP Right Grant
- 2004-01-19 KR KR1020107024515A patent/KR20100120321A/ko not_active Ceased
- 2004-01-19 KR KR1020097022060A patent/KR20090115821A/ko not_active Ceased
- 2004-01-19 DK DK04703158.8T patent/DK1592401T3/da active
- 2004-01-19 MY MYPI20040142A patent/MY148297A/en unknown
- 2004-01-19 EP EP04703158A patent/EP1592401B1/en not_active Revoked
- 2004-01-19 PL PL393385A patent/PL213192B1/pl unknown
- 2004-01-19 KR KR1020077016703A patent/KR20070087181A/ko not_active Ceased
- 2004-01-20 CL CL200400073A patent/CL2004000073A1/es unknown
2005
- 2005-05-31 ZA ZA200504442A patent/ZA200504442B/en unknown
- 2005-06-30 IL IL169484A patent/IL169484A/en active IP Right Grant
- 2005-07-15 EC EC2005005918A patent/ECSP055918A/es unknown
- 2005-07-25 CO CO05072728A patent/CO5580738A2/es not_active Application Discontinuation
- 2005-08-16 NO NO20053846A patent/NO20053846L/no not_active Application Discontinuation
2008
- 2008-12-18 US US12/337,663 patent/US8008511B2/en not_active Expired - Lifetime
2011
- 2011-08-04 US US13/198,022 patent/US8124795B2/en not_active Expired - Lifetime
2012
- 2012-05-14 CY CY20121100450T patent/CY1112772T1/el unknown
2016
- 2016-02-15 AR ARP160100409A patent/AR103711A2/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP1592401A2 (en)	2005-11-09
MXPA05007691A (es)	2005-09-30
PE20040826A1 (es)	2004-12-23
SI1592401T1 (sl)	2012-05-31
IL169484A (en)	2016-03-31
PE20110276A1 (es)	2011-05-27
AU2004206731A1 (en)	2004-08-05
US8124795B2 (en)	2012-02-28
ES2382035T3 (es)	2012-06-04
AU2004206731A8 (en)	2004-08-05
JP2006515016A (ja)	2006-05-18
AR043343A1 (es)	2005-07-27
JP4549976B2 (ja)	2010-09-22
KR20090115821A (ko)	2009-11-06
GB0301259D0 (en)	2003-02-19
DK1592401T3 (da)	2012-05-21
KR20050096940A (ko)	2005-10-06
US20060122265A1 (en)	2006-06-08
NO20053846L (no)	2005-08-16
SG155046A1 (en)	2009-09-30
KR20070087181A (ko)	2007-08-27
CN1738605A (zh)	2006-02-22
PL376525A1 (pl)	2006-01-09
CL2004000073A1 (es)	2005-01-14
ATE546132T1 (de)	2012-03-15
ZA200504442B (en)	2006-02-22
EP1592401B1 (en)	2012-02-22
BRPI0406827A (pt)	2005-12-27
KR20090115898A (ko)	2009-11-09
MY148297A (en)	2013-03-29
WO2004064806A3 (en)	2004-10-28
CA2509796C (en)	2010-09-14
WO2004064806A2 (en)	2004-08-05
CO5580738A2 (es)	2005-11-30
RU2388757C2 (ru)	2010-05-10
KR101129105B1 (ko)	2012-04-12
IL169484A0 (en)	2007-07-04
PT1592401E (pt)	2012-05-10
ECSP055918A (es)	2005-11-22
US8008511B2 (en)	2011-08-30
HK1084874A1 (en)	2006-08-11
CA2509796A1 (en)	2004-08-05
AU2004206731B2 (en)	2008-03-20
PL213192B1 (pl)	2013-01-31
KR20100120321A (ko)	2010-11-15
CN100595199C (zh)	2010-03-24
KR100855149B1 (ko)	2008-08-28
CY1112772T1 (el)	2016-02-10
AR103711A2 (es)	2017-05-31
CN101333201A (zh)	2008-12-31
US20110288313A1 (en)	2011-11-24
US20090209639A1 (en)	2009-08-20
EP2308471A1 (en)	2011-04-13
RU2005126328A (ru)	2006-07-27
NZ541073A (en)	2008-12-24
CA2706900A1 (en)	2004-08-05
TWI325785B (en)	2010-06-11
TW200505505A (en)	2005-02-16

Publication	Publication Date	Title
PL393385A1 (pl)	2011-03-14	Sposób modyfikacji i rekrystalizacji pokroju kryształów substancji leczniczej, kryształy mykofenolanu sodu i ich zastosowanie oraz kompozycja farmaceutyczna
IL163831A0 (en)	2005-12-18	Derivatives of aminoindazoles, method of preparation and intermediates of the method as drugs pharmaceutical compounds containing
IL176236A (en)	2015-10-29	Heterocyclic compounds, pharmaceuticals containing them and their use in the preparation of drugs
AP2004003184A0 (en)	2004-12-31	Benzofused heteroaryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same and methods for their use.
NO20033244D0 (no)	2003-07-17	Farmasöytisk sammensetning med redusert tendens for legemiddelkrystallisasjon
PL372084A1 (pl)	2005-07-11	Związek pochodnej 8-azaprostaglandyny i środek zawierający ten związek jako składnik aktywny
IL164798A0 (en)	2005-12-18	Benzothiadiazepine derivatives, processes for their preparation and pharmaceutical compositions containing them
PL375790A1 (pl)	2005-12-12	Nowe heterocykliczne pochodne fluoroglikozydu, leki zawierające te związki oraz ich zastosowanie
IL170690A0 (en)	2011-08-01	Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient
IL164699A0 (en)	2005-12-18	Diketohydrazine derivative compounds and drugs containing the compounds as the active ingredient
IL190218A0 (en)	2008-11-03	Novel compounds, pharmaceutical compositions containing same, and methods of use for same
NO20043733L (no)	2004-10-20	Aryl-5-tio-Β-D-glukopyranosid-derivater og legemidler for diabetes inneholdende de samme
IL166621A0 (en)	2006-01-15	Polymorph of n-methyl-n-(3-ä-3-Ä2-thienylcarbonylÜ-pyrazol-Ä1,5-alphaÜpyrimidin-7-ylüacetamide and pharmaceutical compositions containing the same
IL162765A (en)	2012-04-30	Diazabicycle derivatives, processes for their preparation, pharmaceutical compositions comprising them and their medical use
EP1557415A4 (en)	2011-02-23	Heterocyclic compounds and antitumor agents containing them as an active ingredient
FR2838648B1 (fr)	2004-05-21	Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent
ZA200506422B (en)	2007-02-28	Substituted 4-phenyltetrahydroisoquinolines, method for the production thereof, the use of the same as medicaments, and medicament containing such compounds
IL172733A0 (en)	2006-04-10	Diphenylpyridine derivatives, preparation and therapeutic application thereof
BRPI0312413A2 (pt)	2016-08-02	compostos, composições farmacêuticas contendo os mesmos, e método de utilização para os mesmos
IL163643A0 (en)	2005-12-18	Oxazolidinone derivatives, processes for their forpreparation, and pharmaceutical compositions containing them
AU2003218824A8 (en)	2003-10-20	Benzopyran derivatives substituted with secondary amines including tetrazole, method for the preparation thereof and pharmaceutical compositions containing them
ZA200602788B (en)	2008-01-30	Amidomethyl-substituted 2-(4-sulfonilamino)-3-hidroxy-3,4-dihydro-2H-chromen-6-YL-derivatives and drugs containing said compounds
HUP0500958A2 (en)	2006-01-30	2-arylimino-2,3-dihydrothiazole derivatives, methods for preparing them, therapeutic use thereof and pharmaceutical compositions containing them
PT2070914E (pt)	2011-10-12	Novos derivados antagonistas do receptor da vitronectina, procedimentos para a sua preparação, suas aplicações como medicamentos e as composições farmacêuticas que os contêm
EP1515960A4 (en)	2006-07-26	2-THIOXOTHIAZOL DERIVATIVE, METHOD FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF