PL410357A1 - Gamma 2-[(5-nitro-2-furanyl)-methylene]-hydraziecarboxamide form and method for producing it - Google Patents
Gamma 2-[(5-nitro-2-furanyl)-methylene]-hydraziecarboxamide form and method for producing itInfo
- Publication number
- PL410357A1 PL410357A1 PL410357A PL41035714A PL410357A1 PL 410357 A1 PL410357 A1 PL 410357A1 PL 410357 A PL410357 A PL 410357A PL 41035714 A PL41035714 A PL 41035714A PL 410357 A1 PL410357 A1 PL 410357A1
- Authority
- PL
- Poland
- Prior art keywords
- furanyl
- nitro
- methylene
- carboxamide
- hydrazine
- Prior art date
Links
- -1 5-nitro-2-furanyl)-methylene]-hydraziecarboxamide form Chemical group 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 abstract 3
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 abstract 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
Wynalazek dotyczy odmiany ? 2-[(5-nitro-2-furanylo)-metyleno]-hydrazyno-karboksyamidu o wzorze 1, która znajduje zastosowanie w przemyśle farmaceutycznym. Ujawniono również sposób wytwarzania formy ? 2-[(5-nitro-2-furanylo)-metyleno]-hydrazyno-karboksyamidu o wzorze 1, który polega na tym, że do 0,100 mmol 2-[(5-nitro-2-furanylo)-metyleno]-hydrazyno-karboksyamidu dodaje się 4-6 ml rozpuszczalnika polarnego wybranego z grupy: metanol, etanol, propan-1-ol, propan-2-ol, butan-2-ol lub acetonitryl i miesza się na mieszadle magnetycznym z szybkością 100 - 300 rpm w temperaturze 60-80°C przez 10-20 minut, po czym klarowny roztwór ochładza się do temperatury 25-30°C i pozostawia do powolnego odparowania rozpuszczalnika w warunkach temperatury pokojowej, w wyniku czego po 2 do 5 dni uzyskuje się gotowy produkt w postaci żółtych kryształów.The invention relates to a variation? 2 - [(5-nitro-2-furanyl) methylene] hydrazine carboxamide of formula 1, which is used in the pharmaceutical industry. Also disclosed is a method for making the mold? 2 - [(5-nitro-2-furanyl) -methylene] -hydrazine-carboxamide of formula 1, which consists in that up to 0.100 mmol of 2 - [(5-nitro-2-furanyl) -methylene] -hydrazine carboxamide 4-6 ml of polar solvent selected from the group: methanol, ethanol, propan-1-ol, propan-2-ol, butan-2-ol or acetonitrile are added and mixed on a magnetic stirrer at a speed of 100 - 300 rpm at temperature 60-80 ° C for 10-20 minutes, after which the clear solution is cooled to 25-30 ° C and allowed to evaporate slowly at room temperature, resulting in a finished product in the form of yellow after 2 to 5 days crystals.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL410357A PL224685B1 (en) | 2014-12-04 | 2014-12-04 | Gamma 2-[(5-nitro-2-furanyl)-methylene]-hydraziecarboxamide form and method for producing it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL410357A PL224685B1 (en) | 2014-12-04 | 2014-12-04 | Gamma 2-[(5-nitro-2-furanyl)-methylene]-hydraziecarboxamide form and method for producing it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL410357A1 true PL410357A1 (en) | 2016-01-18 |
| PL224685B1 PL224685B1 (en) | 2017-01-31 |
Family
ID=55072343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL410357A PL224685B1 (en) | 2014-12-04 | 2014-12-04 | Gamma 2-[(5-nitro-2-furanyl)-methylene]-hydraziecarboxamide form and method for producing it |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL224685B1 (en) |
-
2014
- 2014-12-04 PL PL410357A patent/PL224685B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL224685B1 (en) | 2017-01-31 |
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