PL411200A1 - Cocrystalline salt of 4-methylbenzenesulfonate-4-amino-n-(4,6-dimethylpyridin-2-ylo)-benzene-1-sulfonamide and method for producing it - Google Patents
Cocrystalline salt of 4-methylbenzenesulfonate-4-amino-n-(4,6-dimethylpyridin-2-ylo)-benzene-1-sulfonamide and method for producing itInfo
- Publication number
- PL411200A1 PL411200A1 PL411200A PL41120015A PL411200A1 PL 411200 A1 PL411200 A1 PL 411200A1 PL 411200 A PL411200 A PL 411200A PL 41120015 A PL41120015 A PL 41120015A PL 411200 A1 PL411200 A1 PL 411200A1
- Authority
- PL
- Poland
- Prior art keywords
- sulfonamide
- benzene
- amino
- dimethylpyrimidin
- salt
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 229940124530 sulfonamide Drugs 0.000 title abstract 2
- -1 4-methyl-benzenesulfonate-4-amino-N- (4,6-dimethylpyrimidin-2-yl) -benzene-1-sulfonamide Chemical compound 0.000 abstract 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000013078 crystal Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- ASWVTGNCAZCNNR-UHFFFAOYSA-N sulfamethazine Chemical compound CC1=CC(C)=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ASWVTGNCAZCNNR-UHFFFAOYSA-N 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Wynalazek dotyczy krystalicznej soli 4-metylobenzenosulfonian-4-amino-N-(4,6-dimetylopirymidyn-2-ylo)-benzeno-1-sulfonamidu o wzorze 1, która znajduje zastosowanie w przemyśle farmaceutycznym. Ujawniono również sposób wytwarzania soli 4-metylobenzenosulfonian-4-amino-N-(4,6-dimetylopirymidyn-2-ylo)-benzeno-1-sulfonamidu, charakteryzujący się tym, że 0,1 mmol 4-amino-N-(4,6-dimetylopirymidyn-2-ylo)-benzeno-1-sulfonamidu i 0,1 mmol kwasu 4-metylobenzenosulfonowego miesza się z 5 - 8 ml metanolu lub etanolu oraz 2 - 5 ml acetonitrylu, całość miesza się z szybkością 100 - 300 rpm przez około 10 do 20 minut w temperaturze 60 - 80°C. Następnie klarowny roztwór pozostawia w celu powolnego odparowania rozpuszczalnika w warunkach temperatury pokojowej, po czym po 3 do 6 dniach uzyskuje się sól 4-metylobenzenosulfonian-4-amino-N-(4,6-dimetylopirymidyn-2-ylo)-benzeno-1-sulfonamidu w postaci żółtych kryształów.The invention relates to the crystalline salt of 4-methyl-benzenesulfonate-4-amino-N- (4,6-dimethylpyrimidin-2-yl) -benzene-1-sulfonamide of formula 1, which is used in the pharmaceutical industry. Also disclosed is a method for producing 4-amino-N- (4,6-dimethylpyrimidin-2-yl) -benzene-1-sulfonamide 4-methylbenzenesulfonate salt, characterized in that 0.1 mmol of 4-amino-N- (4 , 6-dimethylpyrimidin-2-yl) -benzene-1-sulfonamide and 0.1 mmol of 4-methylbenzenesulfonic acid are mixed with 5-8 ml of methanol or ethanol and 2-5 ml of acetonitrile, mixed at 100-300 rpm for about 10 to 20 minutes at 60 - 80 ° C. The clear solution is then allowed to slowly evaporate the solvent at room temperature, after which after 3 to 6 days a 4-methyl-benzenesulfonate-4-amino-N- (4,6-dimethylpyrimidin-2-yl) -benzene-1- salt is obtained. sulfonamide in the form of yellow crystals.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL411200A PL411200A1 (en) | 2015-02-11 | 2015-02-11 | Cocrystalline salt of 4-methylbenzenesulfonate-4-amino-n-(4,6-dimethylpyridin-2-ylo)-benzene-1-sulfonamide and method for producing it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL411200A PL411200A1 (en) | 2015-02-11 | 2015-02-11 | Cocrystalline salt of 4-methylbenzenesulfonate-4-amino-n-(4,6-dimethylpyridin-2-ylo)-benzene-1-sulfonamide and method for producing it |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL411200A1 true PL411200A1 (en) | 2016-08-16 |
Family
ID=56617310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL411200A PL411200A1 (en) | 2015-02-11 | 2015-02-11 | Cocrystalline salt of 4-methylbenzenesulfonate-4-amino-n-(4,6-dimethylpyridin-2-ylo)-benzene-1-sulfonamide and method for producing it |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL411200A1 (en) |
-
2015
- 2015-02-11 PL PL411200A patent/PL411200A1/en unknown
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