PL420946A1 - Method for producing 6β-hydroxyandrost-4-en-3,17-dione - Google Patents
Method for producing 6β-hydroxyandrost-4-en-3,17-dioneInfo
- Publication number
- PL420946A1 PL420946A1 PL420946A PL42094617A PL420946A1 PL 420946 A1 PL420946 A1 PL 420946A1 PL 420946 A PL420946 A PL 420946A PL 42094617 A PL42094617 A PL 42094617A PL 420946 A1 PL420946 A1 PL 420946A1
- Authority
- PL
- Poland
- Prior art keywords
- hydroxyandrost
- dione
- producing
- ene
- hydroxyl group
- Prior art date
Links
- WVAMBAWFDOYFOD-DQXCSHPPSA-N 6beta-hydroxyandrost-4-ene-3,17-dione Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3C[C@@H](O)C2=C1 WVAMBAWFDOYFOD-DQXCSHPPSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241000894120 Trichoderma atroviride Species 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000006317 isomerization reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
Landscapes
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Zgłoszenie dotyczy sposobu wytwarzania 6ß-hydroksyandrost-4-en-3,17-dionu o wzorze 2. Przedmiotowy sposób polega na tym, że w wyniku działania układu enzymatycznego zawartego w komórkach szczepu Trichoderma atroviride KCh SB6, następuje regio- i stereoselektywne wprowadzenie grupy hydroksylowej przy szóstym atomie węgla (C-6) poprzedzone utlenieniem grupy hydroksylowej przy trzecim atomie węgla i izomeryzacją wiązania podwójnego z 5-en do 4-en. Uzyskany w ten sposób produkt wydziela się z wodnej kultury mikroorganizmu, znanym sposobem, przez ekstrakcję rozpuszczalnikiem organicznym niemieszającym się z wodą (chloroform).The application relates to a method for producing 6ß-hydroxyandrost-4-en-3,17-dione of formula 2. The subject method consists in the fact that as a result of the enzyme system contained in the cells of the Trichoderma atroviride KCh SB6 strain, a regio- and stereoselective introduction of the hydroxyl group occurs on the sixth carbon atom (C-6) preceded by oxidation of the hydroxyl group on the third carbon atom and isomerization of the double bond from 5-ene to 4-ene. The product thus obtained is separated from the aqueous culture of the microorganism in a known manner by extraction with a water-immiscible organic solvent (chloroform).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL420946A PL235022B1 (en) | 2017-03-22 | 2017-03-22 | Method for producing 6β-hydroxyandrost-4-en-3,17-dione |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL420946A PL235022B1 (en) | 2017-03-22 | 2017-03-22 | Method for producing 6β-hydroxyandrost-4-en-3,17-dione |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL420946A1 true PL420946A1 (en) | 2018-09-24 |
| PL235022B1 PL235022B1 (en) | 2020-05-18 |
Family
ID=63578777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL420946A PL235022B1 (en) | 2017-03-22 | 2017-03-22 | Method for producing 6β-hydroxyandrost-4-en-3,17-dione |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL235022B1 (en) |
-
2017
- 2017-03-22 PL PL420946A patent/PL235022B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL235022B1 (en) | 2020-05-18 |
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