PL435011A1 - Method of preparing 1-(5'-bromo-2'-hydroxyphenyl)-3-phenylpropan-1-one - Google Patents

Method of preparing 1-(5'-bromo-2'-hydroxyphenyl)-3-phenylpropan-1-one

Info

Publication number
PL435011A1
PL435011A1 PL435011A PL43501120A PL435011A1 PL 435011 A1 PL435011 A1 PL 435011A1 PL 435011 A PL435011 A PL 435011A PL 43501120 A PL43501120 A PL 43501120A PL 435011 A1 PL435011 A1 PL 435011A1
Authority
PL
Poland
Prior art keywords
hydroxyphenyl
bromo
phenylpropan
preparing
kch
Prior art date
Application number
PL435011A
Other languages
Polish (pl)
Other versions
PL245627B1 (en
Inventor
Mateusz Łużny
Dagmara Kaczanowska
Barbara GAWDZIK
Alicja Wzorek
Aleksandra Pawlak
Bożena Obmińska-Mrukowicz
Ewa Kozłowska
Edyta Kostrzewa-Susłow
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Uniwersytet Jana Kochanowskiego W Kielcach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu, Uniwersytet Jana Kochanowskiego W Kielcach filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL435011A priority Critical patent/PL245627B1/en
Publication of PL435011A1 publication Critical patent/PL435011A1/en
Publication of PL245627B1 publication Critical patent/PL245627B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Wynalazek dotyczy sposobu wytwarzania 1-(5'-bromo-2'-hydroksyfenylo)-3-fenylo-propan-1-onu o wzorze 2. Postępując zgodnie z wynalazkiem, w wyniku działania układu enzymatycznego zawartego w komórkach szczepu Yarrowia lipolytica KCh 71, następuje regioselektywna redukcji podwójnego wiązania w substracie. Uzyskany w ten sposób produkt wydziela się z wodnej kultury mikroorganizmu, znanym sposobem, przez ekstrakcję rozpuszczalnikiem organicznym niemieszającym się z wodą (chloroform).The invention relates to a process for the production of 1- (5'-bromo-2'-hydroxyphenyl) -3-phenyl-propan-1-one of formula 2. By following the invention, as a result of the action of the enzyme system contained in the cells of the Yarrowia lipolytica KCh 71 strain, there is a regioselective reduction of the double bond in the substrate. The product obtained in this way is separated from the aqueous culture of the microorganism in a known manner by extraction with a water-immiscible organic solvent (chloroform).

PL435011A 2020-08-19 2020-08-19 Method of preparing 1-(5'-bromo-2'-hydroxyphenyl)-3-phenylpropan-1-one PL245627B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL435011A PL245627B1 (en) 2020-08-19 2020-08-19 Method of preparing 1-(5'-bromo-2'-hydroxyphenyl)-3-phenylpropan-1-one

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL435011A PL245627B1 (en) 2020-08-19 2020-08-19 Method of preparing 1-(5'-bromo-2'-hydroxyphenyl)-3-phenylpropan-1-one

Publications (2)

Publication Number Publication Date
PL435011A1 true PL435011A1 (en) 2022-02-21
PL245627B1 PL245627B1 (en) 2024-09-09

Family

ID=80492623

Family Applications (1)

Application Number Title Priority Date Filing Date
PL435011A PL245627B1 (en) 2020-08-19 2020-08-19 Method of preparing 1-(5'-bromo-2'-hydroxyphenyl)-3-phenylpropan-1-one

Country Status (1)

Country Link
PL (1) PL245627B1 (en)

Also Published As

Publication number Publication date
PL245627B1 (en) 2024-09-09

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