|
WO2012129373A2
(en)
|
2011-03-23 |
2012-09-27 |
Pioneer Hi-Bred International, Inc. |
Methods for producing a complex transgenic trait locus
|
|
JP6261500B2
(ja)
|
2011-07-22 |
2018-01-17 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ヌクレアーゼ切断特異性の評価および改善
|
|
US10501791B2
(en)
|
2011-10-14 |
2019-12-10 |
President And Fellows Of Harvard College |
Sequencing by structure assembly
|
|
ES2991004T3
(es)
|
2011-12-22 |
2024-12-02 |
Harvard College |
Métodos para la detección de analitos
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
US9637739B2
(en)
*
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
IN2014DN09261A
(pl)
|
2012-04-25 |
2015-07-10 |
Regeneron Pharma |
|
|
EP3597741A1
(en)
|
2012-04-27 |
2020-01-22 |
Duke University |
Genetic correction of mutated genes
|
|
SG10201809817UA
(en)
|
2012-05-25 |
2018-12-28 |
Univ California |
Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
|
|
US20150225734A1
(en)
|
2012-06-19 |
2015-08-13 |
Regents Of The University Of Minnesota |
Gene targeting in plants using dna viruses
|
|
PT3494997T
(pt)
*
|
2012-07-25 |
2019-12-05 |
Massachusetts Inst Technology |
Proteínas de ligação a adn indutíveis e ferramentas de perturbação do genoma e aplicações destas
|
|
CN110643600A
(zh)
|
2012-10-23 |
2020-01-03 |
基因工具股份有限公司 |
用于切割靶dna的系统及其用途
|
|
CA2977152C
(en)
|
2012-12-06 |
2019-04-09 |
Sigma-Aldrich Co. Llc |
Crispr-based genome modification and regulation
|
|
PT2771468E
(pt)
*
|
2012-12-12 |
2015-06-02 |
Harvard College |
Engenharia de sistemas, métodos e composições-guia otimizadas para manipulação de sequências
|
|
US8993233B2
(en)
|
2012-12-12 |
2015-03-31 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
EP3434776A1
(en)
|
2012-12-12 |
2019-01-30 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
DK2921557T3
(en)
|
2012-12-12 |
2016-11-07 |
Broad Inst Inc |
Design of systems, methods and optimized sequence manipulation guide compositions
|
|
US20140310830A1
(en)
|
2012-12-12 |
2014-10-16 |
Feng Zhang |
CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
EP4286403A3
(en)
*
|
2012-12-12 |
2024-02-14 |
The Broad Institute Inc. |
Crispr-cas component systems, methods and compositions for sequence manipulation
|
|
DK3327127T3
(da)
*
|
2012-12-12 |
2021-06-28 |
Broad Inst Inc |
Fremføring, modificering og optimering af systemer, fremgangsmåder og sammensætninger til sekvensmanipulation og terapeutiske anvendelser
|
|
IL300461A
(en)
*
|
2012-12-12 |
2023-04-01 |
Harvard College |
Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
|
|
WO2014093701A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
RU2699523C2
(ru)
|
2012-12-17 |
2019-09-05 |
Президент Энд Фэллоуз Оф Харвард Коллидж |
Рнк-направляемая инженерия генома человека
|
|
US10138509B2
(en)
|
2013-03-12 |
2018-11-27 |
President And Fellows Of Harvard College |
Method for generating a three-dimensional nucleic acid containing matrix
|
|
ES2901396T3
(es)
|
2013-03-14 |
2022-03-22 |
Caribou Biosciences Inc |
Composiciones y métodos de ácidos nucleicos dirigidos a ácido nucleico
|
|
HK1214306A1
(zh)
*
|
2013-03-15 |
2016-07-22 |
Regents Of The University Of Minnesota |
采用crispr/cas系统的植物基因组的工程改造
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
EP2981617B1
(en)
*
|
2013-04-04 |
2023-07-05 |
President and Fellows of Harvard College |
Therapeutic uses of genome editing with crispr/cas systems
|
|
SI2986729T1
(sl)
|
2013-04-16 |
2019-02-28 |
Regeneron Pharmaceuticals, Inc. |
Ciljana sprememba genoma podgane
|
|
WO2014172470A2
(en)
*
|
2013-04-16 |
2014-10-23 |
Whitehead Institute For Biomedical Research |
Methods of mutating, modifying or modulating nucleic acid in a cell or nonhuman mammal
|
|
WO2014186686A2
(en)
*
|
2013-05-17 |
2014-11-20 |
Two Blades Foundation |
Targeted mutagenesis and genome engineering in plants using rna-guided cas nucleases
|
|
ES2670531T3
(es)
*
|
2013-05-29 |
2018-05-30 |
Cellectis S.A. |
Un método para producir una escisión de ADN precisa utilizando la actividad nickasa de Cas9
|
|
CN113846096B
(zh)
*
|
2013-06-04 |
2025-05-09 |
哈佛大学校长及研究员协会 |
Rna-导向的转录调控
|
|
US20140356956A1
(en)
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
|
EP3008186B1
(en)
|
2013-06-14 |
2018-11-28 |
Cellectis |
Methods for non-transgenic genome editing in plants
|
|
JP6665088B2
(ja)
|
2013-06-17 |
2020-03-13 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
配列操作のための最適化されたCRISPR−Cas二重ニッカーゼ系、方法および組成物
|
|
AU2014281028B2
(en)
|
2013-06-17 |
2020-09-10 |
Massachusetts Institute Of Technology |
Delivery and use of the CRISPR-Cas systems, vectors and compositions for hepatic targeting and therapy
|
|
CA2915795C
(en)
|
2013-06-17 |
2021-07-13 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
|
|
WO2014204724A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
WO2014204727A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
WO2015006498A2
(en)
|
2013-07-09 |
2015-01-15 |
President And Fellows Of Harvard College |
Therapeutic uses of genome editing with crispr/cas systems
|
|
US11459585B2
(en)
*
|
2013-07-09 |
2022-10-04 |
President And Fellows Of Harvard College |
Multiplex RNA-guided genome engineering
|
|
US10563225B2
(en)
|
2013-07-26 |
2020-02-18 |
President And Fellows Of Harvard College |
Genome engineering
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
EP3848695A1
(en)
|
2013-08-16 |
2021-07-14 |
Massachusetts Institute Of Technology |
Selective delivery of material to cells
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
CN105829536A
(zh)
|
2013-08-22 |
2016-08-03 |
纳幕尔杜邦公司 |
用于在不掺入选择性转基因标记的情况下,在植物基因组中产生基因修饰的方法,以及用于这种方法的组合物
|
|
US9737604B2
(en)
|
2013-09-06 |
2017-08-22 |
President And Fellows Of Harvard College |
Use of cationic lipids to deliver CAS9
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
WO2015040402A1
(en)
|
2013-09-18 |
2015-03-26 |
Kymab Limited |
Methods. cells & organisms
|
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
|
WO2015066119A1
(en)
|
2013-10-30 |
2015-05-07 |
North Carolina State University |
Compositions and methods related to a type-ii crispr-cas system in lactobacillus buchneri
|
|
EP4372090A3
(en)
|
2013-11-07 |
2024-08-07 |
Editas Medicine, Inc. |
Crispr-related methods and compositions with governing grnas
|
|
US10787684B2
(en)
*
|
2013-11-19 |
2020-09-29 |
President And Fellows Of Harvard College |
Large gene excision and insertion
|
|
KR102170502B1
(ko)
|
2013-12-11 |
2020-10-28 |
리제너론 파마슈티칼스 인코포레이티드 |
게놈의 표적화된 변형을 위한 방법 및 조성물
|
|
DK3080279T3
(en)
|
2013-12-11 |
2018-11-05 |
Regeneron Pharma |
METHODS AND COMPOSITIONS FOR TARGETED MODIFICATION OF A GENOM
|
|
JP6793547B2
(ja)
|
2013-12-12 |
2020-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
最適化機能CRISPR−Cas系による配列操作のための系、方法および組成物
|
|
SG10201804974RA
(en)
|
2013-12-12 |
2018-07-30 |
Broad Inst Inc |
Compositions and Methods of Use of Crispr-Cas Systems in Nucleotide Repeat Disorders
|
|
IL289736B2
(en)
|
2013-12-12 |
2025-09-01 |
Massachusetts Inst Technology |
Administration, use and therapeutic applications of CRISPR–Cas gene editing systems and gene editing preparations
|
|
US20150166985A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting von willebrand factor point mutations
|
|
AU2014361784A1
(en)
|
2013-12-12 |
2016-06-23 |
Massachusetts Institute Of Technology |
Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for HBV and viral diseases and disorders
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
WO2015089473A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
CN105899657A
(zh)
|
2013-12-12 |
2016-08-24 |
布罗德研究所有限公司 |
用于改变基因产物表达的crispr-cas系统和方法、结构信息以及诱导型模块化cas酶
|
|
US10787654B2
(en)
|
2014-01-24 |
2020-09-29 |
North Carolina State University |
Methods and compositions for sequence guiding Cas9 targeting
|
|
LT3105328T
(lt)
|
2014-02-11 |
2020-07-10 |
The Regents Of The University Of Colorado, A Body Corporate |
Daugiakomponentis genomo konstravimas, sudarantis sąlygas crispr
|
|
US10286084B2
(en)
|
2014-02-18 |
2019-05-14 |
Duke University |
Compositions for the inactivation of virus replication and methods of making and using the same
|
|
WO2015131101A1
(en)
|
2014-02-27 |
2015-09-03 |
Monsanto Technology Llc |
Compositions and methods for site directed genomic modification
|
|
US11028388B2
(en)
|
2014-03-05 |
2021-06-08 |
Editas Medicine, Inc. |
CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa
|
|
SG11201609211VA
(en)
*
|
2014-03-05 |
2016-12-29 |
Nat Univ Corp Univ Kobe |
Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
|
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
WO2015138510A1
(en)
|
2014-03-10 |
2015-09-17 |
Editas Medicine., Inc. |
Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
|
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
EP3981876A1
(en)
|
2014-03-26 |
2022-04-13 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
|
EP3540061A1
(en)
|
2014-04-02 |
2019-09-18 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
|
EP3129490A4
(en)
|
2014-04-08 |
2017-10-04 |
North Carolina State University |
Methods and compositions for rna-directed repression of transcription using crispr-associated genes
|
|
WO2015179540A1
(en)
*
|
2014-05-20 |
2015-11-26 |
Regents Of The University Of Minnesota |
Method for editing a genetic sequence
|
|
KR101886381B1
(ko)
*
|
2014-05-28 |
2018-08-10 |
기초과학연구원 |
불활성화된 표적 특이적 뉴클레아제를 이용한 표적 dna의 분리 방법
|
|
EP3152319A4
(en)
*
|
2014-06-05 |
2017-12-27 |
Sangamo BioSciences, Inc. |
Methods and compositions for nuclease design
|
|
JP6688231B2
(ja)
|
2014-06-06 |
2020-04-28 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
標的遺伝子座を修飾するための方法及び組成物
|
|
CA2951707A1
(en)
|
2014-06-10 |
2015-12-17 |
Massachusetts Institute Of Technology |
Method for gene editing
|
|
CA2952121A1
(en)
|
2014-06-13 |
2015-12-17 |
Childrens' Medical Center Corporation |
Products and methods to isolate mitochondria
|
|
CN106715694B
(zh)
|
2014-06-23 |
2020-10-20 |
瑞泽恩制药公司 |
核酸酶介导的dna组装
|
|
US20150376587A1
(en)
*
|
2014-06-25 |
2015-12-31 |
Caribou Biosciences, Inc. |
RNA Modification to Engineer Cas9 Activity
|
|
WO2015200555A2
(en)
*
|
2014-06-25 |
2015-12-30 |
Caribou Biosciences, Inc. |
Rna modification to engineer cas9 activity
|
|
SG10201911411YA
(en)
|
2014-06-26 |
2020-02-27 |
Regeneron Pharma |
Methods and compositions for targeted genetic modifications and methods of use
|
|
EP3166391A1
(en)
|
2014-07-11 |
2017-05-17 |
E. I. du Pont de Nemours and Company |
Compositions and methods for producing plants resistant to glyphosate herbicide
|
|
WO2016007839A1
(en)
|
2014-07-11 |
2016-01-14 |
President And Fellows Of Harvard College |
Methods for high-throughput labelling and detection of biological features in situ using microscopy
|
|
EP3169776B1
(en)
*
|
2014-07-14 |
2025-09-03 |
The Regents of The University of California |
Crispr/cas transcriptional modulation
|
|
SG11201702066UA
(en)
*
|
2014-07-21 |
2017-04-27 |
Illumina Inc |
Polynucleotide enrichment using crispr-cas systems
|
|
CA2956224A1
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
EP3194578B1
(en)
*
|
2014-08-06 |
2021-03-10 |
College of Medicine Pochon Cha University Industry-Academic Cooperation Foundation |
Immune-compatible cells created by nuclease-mediated editing of genes encoding hla
|
|
CN106922154B
(zh)
*
|
2014-08-06 |
2022-01-07 |
基因工具股份有限公司 |
使用空肠弯曲杆菌crispr/cas系统衍生的rna引导的工程化核酸酶的基因编辑
|
|
US11071289B2
(en)
|
2014-08-14 |
2021-07-27 |
Biocytogen Boston Corp |
DNA knock-in system
|
|
US9970030B2
(en)
|
2014-08-27 |
2018-05-15 |
Caribou Biosciences, Inc. |
Methods for increasing CAS9-mediated engineering efficiency
|
|
EP3186375A4
(en)
|
2014-08-28 |
2019-03-13 |
North Carolina State University |
Novel CAS9 PROTEINS AND CHARACTERISTICS FOR DNA TARGETING AND GENOME EDITING
|
|
US10570418B2
(en)
|
2014-09-02 |
2020-02-25 |
The Regents Of The University Of California |
Methods and compositions for RNA-directed target DNA modification
|
|
AU2015315651A1
(en)
|
2014-09-12 |
2017-02-16 |
E. I. Du Pont De Nemours And Company |
Generation of site-specific-integration sites for complex trait loci in corn and soybean, and methods of use
|
|
CN104212836A
(zh)
*
|
2014-09-18 |
2014-12-17 |
东华大学 |
一种在哺乳动物细胞系中敲除mir-505的方法
|
|
EP3204496A1
(en)
|
2014-10-10 |
2017-08-16 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
WO2016061374A1
(en)
|
2014-10-15 |
2016-04-21 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for generating or maintaining pluripotent cells
|
|
JP6612340B2
(ja)
|
2014-10-15 |
2019-11-27 |
セージ サイエンス, インコーポレイテッド |
核酸の自動化された加工処理および電気泳動による試料調製のための装置、方法およびシステム
|
|
GB201418965D0
(pl)
|
2014-10-24 |
2014-12-10 |
Ospedale San Raffaele And Fond Telethon |
|
|
EP3212772A4
(en)
|
2014-10-31 |
2018-10-03 |
Massachusetts Institute of Technology |
Delivery of biomolecules to immune cells
|
|
WO2016073955A2
(en)
|
2014-11-06 |
2016-05-12 |
President And Fellows Of Harvard College |
Cells lacking b2m surface expression and methods for allogeneic administration of such cells
|
|
EA038321B1
(ru)
*
|
2014-11-06 |
2021-08-09 |
Е.И. Дюпон Де Немур Энд Компани |
Опосредуемая пептидом доставка направляемой рнк эндонуклеазы в клетки
|
|
CA2963820A1
(en)
*
|
2014-11-07 |
2016-05-12 |
Editas Medicine, Inc. |
Methods for improving crispr/cas-mediated genome-editing
|
|
CN107109486B
(zh)
*
|
2014-11-14 |
2021-08-13 |
基础科学研究院 |
用于检测基因组中遗传剪刀的脱靶位点的方法
|
|
US11352666B2
(en)
|
2014-11-14 |
2022-06-07 |
Institute For Basic Science |
Method for detecting off-target sites of programmable nucleases in a genome
|
|
KR102531016B1
(ko)
|
2014-11-21 |
2023-05-10 |
리제너론 파마슈티칼스 인코포레이티드 |
쌍 형성된 가이드 rna를 사용하는 표적화된 유전자 변형을 위한 방법 및 조성물
|
|
CA2969619A1
(en)
|
2014-12-03 |
2016-06-09 |
Agilent Technologies, Inc. |
Guide rna with chemical modifications
|
|
HK1245010A1
(zh)
|
2014-12-10 |
2018-08-24 |
明尼苏达大学董事会 |
用於治疗疾病的遗传修饰的细胞、组织和器官
|
|
WO2016094867A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Protected guide rnas (pgrnas)
|
|
CA2971187C
(en)
*
|
2014-12-16 |
2023-10-24 |
Danisco Us Inc. |
Fungal genome modification systems and methods of use
|
|
EP3234133B1
(en)
|
2014-12-18 |
2020-11-11 |
Integrated DNA Technologies, Inc. |
Crispr-based compositions and methods of use
|
|
EP3234111A1
(en)
|
2014-12-19 |
2017-10-25 |
Regeneron Pharmaceuticals, Inc. |
Stem cells for modeling type 2 diabetes
|
|
NZ732895A
(en)
|
2014-12-19 |
2022-05-27 |
Regeneron Pharma |
Methods and compositions for targeted genetic modification through single-step multiple targeting
|
|
AU2015369725A1
(en)
|
2014-12-24 |
2017-06-29 |
Massachusetts Institute Of Technology |
CRISPR having or associated with destabilization domains
|
|
CN107250373A
(zh)
*
|
2015-01-12 |
2017-10-13 |
麻省理工学院 |
通过微流体递送实现的基因编辑
|
|
EP3256487A4
(en)
|
2015-02-09 |
2018-07-18 |
Duke University |
Compositions and methods for epigenome editing
|
|
KR102194612B1
(ko)
*
|
2015-03-16 |
2020-12-23 |
인스티튜트 오브 제네틱스 앤드 디벨롭멘털 바이오롤지, 차이니즈 아카데미 오브 사이언시스 |
비-유전성 물질을 이용한 식물 게놈의 부위-특이적인 변형 방법
|
|
WO2016150855A1
(en)
*
|
2015-03-20 |
2016-09-29 |
Danmarks Tekniske Universitet |
Crispr/cas9 based engineering of actinomycetal genomes
|
|
EP3851530A1
(en)
*
|
2015-03-26 |
2021-07-21 |
Editas Medicine, Inc. |
Crispr/cas-mediated gene conversion
|
|
CN107567499A
(zh)
|
2015-03-27 |
2018-01-09 |
纳幕尔杜邦公司 |
大豆u6核小rna基因启动子及其在植物小rna基因的组成型表达中的用途
|
|
CA2981715A1
(en)
|
2015-04-06 |
2016-10-13 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chemically modified guide rnas for crispr/cas-mediated gene regulation
|
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
|
EP3286571B1
(en)
|
2015-04-24 |
2021-08-18 |
Editas Medicine, Inc. |
Evaluation of cas9 molecule/guide rna molecule complexes
|
|
AU2016261600B2
(en)
|
2015-05-08 |
2021-09-23 |
President And Fellows Of Harvard College |
Universal donor stem cells and related methods
|
|
WO2016182959A1
(en)
|
2015-05-11 |
2016-11-17 |
Editas Medicine, Inc. |
Optimized crispr/cas9 systems and methods for gene editing in stem cells
|
|
KR101785847B1
(ko)
|
2015-05-12 |
2017-10-17 |
연세대학교 산학협력단 |
선형 이중가닥 DNA를 활용한 CRISPR/Cas9 시스템을 이용한 표적 유전체 교정
|
|
EP3095870A1
(en)
|
2015-05-19 |
2016-11-23 |
Kws Saat Se |
Methods for the in planta transformation of plants and manufacturing processes and products based and obtainable therefrom
|
|
US10136649B2
(en)
|
2015-05-29 |
2018-11-27 |
North Carolina State University |
Methods for screening bacteria, archaea, algae, and yeast using CRISPR nucleic acids
|
|
CN108368502B
(zh)
|
2015-06-03 |
2022-03-18 |
内布拉斯加大学董事委员会 |
使用单链dna的dna编辑
|
|
CN116334142A
(zh)
|
2015-06-09 |
2023-06-27 |
爱迪塔斯医药公司 |
用于改善移植的crispr/cas相关方法和组合物
|
|
CN107922918B
(zh)
|
2015-06-15 |
2022-10-21 |
北卡罗来纳州立大学 |
用于有效递送核酸和基于rna的抗微生物剂的方法和组合物
|
|
US9790490B2
(en)
*
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
IL293323B2
(en)
*
|
2015-06-18 |
2024-01-01 |
Massachusetts Inst Technology |
Crispr enzyme mutations reducing off-target effects
|
|
US10648020B2
(en)
|
2015-06-18 |
2020-05-12 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
EP4545544A3
(en)
|
2015-06-29 |
2025-10-08 |
Ionis Pharmaceuticals, Inc. |
Modified crispr rna and modified single crispr rna and uses thereof
|
|
SG10201912910PA
(en)
|
2015-07-09 |
2020-02-27 |
Massachusetts Inst Technology |
Delivery of materials to anucleate cells
|
|
DK3329001T3
(da)
*
|
2015-07-28 |
2021-12-20 |
Danisco Us Inc |
Genomredigeringssystemer og anvendelsesfremgangsmåder
|
|
US20170119820A1
(en)
|
2015-07-31 |
2017-05-04 |
Regents Of The University Of Minnesota |
Modified cells and methods of therapy
|
|
US9580727B1
(en)
|
2015-08-07 |
2017-02-28 |
Caribou Biosciences, Inc. |
Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
|
|
CA3033909A1
(en)
|
2015-08-14 |
2017-02-23 |
The University Of Sydney |
Connexin 45 inhibition for therapy
|
|
JP6905755B2
(ja)
|
2015-08-25 |
2021-07-21 |
デューク ユニバーシティ |
Rnaガイド型エンドヌクレアーゼを使用してゲノム工学における特異性を改善する組成物および方法
|
|
EP3344575B1
(en)
|
2015-09-04 |
2020-04-15 |
SQZ Biotechnologies Company |
Intracellular delivery of biomolecules to cells comprising a cell wall
|
|
WO2017053312A1
(en)
*
|
2015-09-21 |
2017-03-30 |
The Regents Of The University Of California |
Compositions and methods for target nucleic acid modification
|
|
EP3353296B1
(en)
|
2015-09-24 |
2020-11-04 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
|
WO2017058751A1
(en)
|
2015-09-28 |
2017-04-06 |
North Carolina State University |
Methods and compositions for sequence specific antimicrobials
|
|
MX390738B
(es)
*
|
2015-10-06 |
2025-03-21 |
Inst Basic Science |
Metodo para producir plantas de genoma modificado a partir de protoplastos de planta a alta eficiencia.
|
|
EP4089175A1
(en)
|
2015-10-13 |
2022-11-16 |
Duke University |
Genome engineering with type i crispr systems in eukaryotic cells
|
|
US20180282763A1
(en)
*
|
2015-10-20 |
2018-10-04 |
Pioneer Hi-Bred International, Inc. |
Restoring function to a non-functional gene product via guided cas systems and methods of use
|
|
EP3350327B1
(en)
|
2015-10-23 |
2018-09-26 |
Caribou Biosciences, Inc. |
Engineered crispr class 2 cross-type nucleic-acid targeting nucleic acids
|
|
IL294014B2
(en)
|
2015-10-23 |
2024-07-01 |
Harvard College |
Nucleobase editors and uses thereof
|
|
CN108474022A
(zh)
|
2015-11-03 |
2018-08-31 |
哈佛学院董事及会员团体 |
用于包含三维核酸的基质容积成像的设备和方法
|
|
KR101885901B1
(ko)
|
2015-11-13 |
2018-08-07 |
기초과학연구원 |
5' 말단의 인산기가 제거된 rna를 포함하는 리보핵산단백질 전달용 조성물
|
|
EP3414255B1
(en)
*
|
2015-11-20 |
2021-09-22 |
Washington University |
Preparative electrophoretic method for targeted purification of genomic dna fragments
|
|
EA201891317A3
(ru)
|
2015-11-30 |
2019-04-30 |
Дьюк Юниверсити |
Терапевтические мишени для коррекции гена дистрофина человека с помощью редактирования генов и способы их применения
|
|
CN106811479B
(zh)
*
|
2015-11-30 |
2019-10-25 |
中国农业科学院作物科学研究所 |
利用CRISPR/Cas9系统定点修饰ALS基因获得抗除草剂水稻的系统及其应用
|
|
US11903974B2
(en)
|
2015-11-30 |
2024-02-20 |
Flagship Pioneering Innovations V, Inc. |
Methods and compositions relating to chondrisomes from cultured cells
|
|
EP3564371B1
(en)
|
2015-12-04 |
2020-05-27 |
Caribou Biosciences, Inc. |
Engineered nucleic-acid targeting nucleic acids
|
|
CN106845151B
(zh)
*
|
2015-12-07 |
2019-03-26 |
中国农业大学 |
CRISPR-Cas9系统sgRNA作用靶点的筛选方法及装置
|
|
WO2017099494A1
(ko)
*
|
2015-12-08 |
2017-06-15 |
기초과학연구원 |
Cpf1을 포함하는 유전체 교정용 조성물 및 그 용도
|
|
US11542466B2
(en)
|
2015-12-22 |
2023-01-03 |
North Carolina State University |
Methods and compositions for delivery of CRISPR based antimicrobials
|
|
KR102917220B1
(ko)
|
2016-01-11 |
2026-01-22 |
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 |
키메라 단백질 및 유전자 발현을 조절하는 방법
|
|
EA201891614A1
(ru)
|
2016-01-11 |
2019-02-28 |
Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити |
Химерные белки и способы иммунотерапии
|
|
DK4272834T3
(da)
|
2016-01-15 |
2025-12-15 |
Childrens Medical Ct Corp |
Terapeutisk anvendelse af mitokondrier og kombinerede mitokondrielle midler
|
|
AU2017208086A1
(en)
*
|
2016-01-15 |
2018-08-09 |
The Jackson Laboratory |
Genetically modified non-human mammals by multi-cycle electroporation of Cas9 protein
|
|
WO2017165826A1
(en)
|
2016-03-25 |
2017-09-28 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
EP3433364A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
SI3436077T1
(sl)
*
|
2016-03-30 |
2025-07-31 |
Intellia Therapeutics, Inc. |
Formulacije lipidnih nanodelcev za komponente crispr/cas
|
|
WO2017180694A1
(en)
|
2016-04-13 |
2017-10-19 |
Editas Medicine, Inc. |
Cas9 fusion molecules gene editing systems, and methods of use thereof
|
|
US20190127713A1
(en)
|
2016-04-13 |
2019-05-02 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
AU2017253089B2
(en)
|
2016-04-19 |
2023-07-20 |
Massachusetts Institute Of Technology |
Novel CRISPR enzymes and systems
|
|
EP3445853A1
(en)
|
2016-04-19 |
2019-02-27 |
The Broad Institute, Inc. |
Cpf1 complexes with reduced indel activity
|
|
CA3022290A1
(en)
|
2016-04-25 |
2017-11-02 |
President And Fellows Of Harvard College |
Hybridization chain reaction methods for in situ molecular detection
|
|
CN107326046A
(zh)
*
|
2016-04-28 |
2017-11-07 |
上海邦耀生物科技有限公司 |
一种提高外源基因同源重组效率的方法
|
|
US20170332610A1
(en)
|
2016-05-20 |
2017-11-23 |
Regeneron Pharmaceuticals, Inc. |
Methods for breaking immunological tolerance using multiple guide rnas
|
|
WO2017205846A1
(en)
*
|
2016-05-27 |
2017-11-30 |
Aadigen, Llc |
Peptides and nanoparticles for intracellular delivery of genome-editing molecules
|
|
US10266851B2
(en)
|
2016-06-02 |
2019-04-23 |
Sigma-Aldrich Co. Llc |
Using programmable DNA binding proteins to enhance targeted genome modification
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
JP6940117B2
(ja)
*
|
2016-06-15 |
2021-09-22 |
ツールゲン インコーポレイテッドToolgen Incorporated |
オンターゲットおよびオフターゲットの多標的システムを用いた標的特異的ヌクレアーゼをスクリーニングするための方法およびその利用
|
|
EP3472321A2
(en)
*
|
2016-06-17 |
2019-04-24 |
Genesis Technologies Limited |
Crispr-cas system, materials and methods
|
|
KR20190019168A
(ko)
*
|
2016-06-17 |
2019-02-26 |
더 브로드 인스티튜트, 인코퍼레이티드 |
제vi형 crispr 오솔로그 및 시스템
|
|
IL263595B2
(en)
*
|
2016-06-20 |
2023-11-01 |
Keygene Nv |
A method for targeted modification of DNA in plant cells
|
|
CN109688820B
(zh)
|
2016-06-24 |
2023-01-10 |
科罗拉多州立大学董事会(法人团体) |
用于生成条形码化组合文库的方法
|
|
US20200069818A1
(en)
*
|
2016-07-05 |
2020-03-05 |
The Johns Hopkins University |
Crispr/cas9-based compositions and methods for treating cancer
|
|
KR102319845B1
(ko)
|
2016-07-13 |
2021-11-01 |
디에스엠 아이피 어셋츠 비.브이. |
조류 숙주 세포에 대한 crispr-cas 시스템
|
|
WO2018017754A1
(en)
|
2016-07-19 |
2018-01-25 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
|
US20190309283A1
(en)
*
|
2016-07-19 |
2019-10-10 |
Biodynamics Laboratory, Inc. |
Method for preparing long-chain single-stranded dna
|
|
JP6875500B2
(ja)
|
2016-07-28 |
2021-05-26 |
インスティテュート フォー ベーシック サイエンスInstitute For Basic Science |
Cas9タンパク質およびガイドRNAを含む眼疾患治療用薬学組成物
|
|
EP3490373B1
(en)
|
2016-07-29 |
2023-10-25 |
Regeneron Pharmaceuticals, Inc. |
Mice comprising mutations resulting in expression of c-truncated fibrillin-1
|
|
CA3032822A1
(en)
|
2016-08-02 |
2018-02-08 |
Editas Medicine, Inc. |
Compositions and methods for treating cep290 associated disease
|
|
SG11201900907YA
(en)
|
2016-08-03 |
2019-02-27 |
Harvard College |
Adenosine nucleobase editors and uses thereof
|
|
US11078481B1
(en)
|
2016-08-03 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for screening for cancer targets
|
|
US11661590B2
(en)
|
2016-08-09 |
2023-05-30 |
President And Fellows Of Harvard College |
Programmable CAS9-recombinase fusion proteins and uses thereof
|
|
KR101710026B1
(ko)
|
2016-08-10 |
2017-02-27 |
주식회사 무진메디 |
Cas9 단백질 및 가이드 RNA의 혼성체를 함유하는 나노 리포좀 전달체 조성물
|
|
KR101856345B1
(ko)
*
|
2016-08-24 |
2018-06-20 |
경상대학교산학협력단 |
CRISPR/Cas9 시스템을 이용하여 APOBEC3H 및 APOBEC3CH 이중-넉아웃 고양이를 제조하는 방법
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
EP3507385A4
(en)
|
2016-08-31 |
2020-04-29 |
President and Fellows of Harvard College |
METHOD FOR COMBINING THE DETECTION OF BIOMOLECULES IN A SINGLE TEST WITH FLUORESCENT IN SITU SEQUENCING
|
|
US11078483B1
(en)
|
2016-09-02 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for measuring and improving CRISPR reagent function
|
|
US20190225974A1
(en)
*
|
2016-09-23 |
2019-07-25 |
BASF Agricultural Solutions Seed US LLC |
Targeted genome optimization in plants
|
|
EP3532089A4
(en)
|
2016-09-30 |
2020-05-13 |
The Regents of The University of California |
RNA-GUIDED NUCLEIC ACID MODIFYING ENZYMES AND METHOD FOR USE THEREOF
|
|
US11242542B2
(en)
|
2016-10-07 |
2022-02-08 |
Integrated Dna Technologies, Inc. |
S. pyogenes Cas9 mutant genes and polypeptides encoded by same
|
|
CA3039409A1
(en)
|
2016-10-07 |
2018-04-12 |
Integrated Dna Technologies, Inc. |
S. pyogenes cas9 mutant genes and polypeptides encoded by same
|
|
KR101997116B1
(ko)
|
2016-10-14 |
2019-07-05 |
연세대학교 산학협력단 |
Kras 유전자에 상보적인 가이드 rna 및 이의 용도
|
|
KR20240007715A
(ko)
|
2016-10-14 |
2024-01-16 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵염기 에디터의 aav 전달
|
|
EP4338799A3
(en)
|
2016-10-18 |
2024-06-05 |
Regents of the University of Minnesota |
Tumor infiltrating lymphocytes and methods of therapy
|
|
WO2018085693A1
(en)
|
2016-11-04 |
2018-05-11 |
Inari Agriculture, Inc. |
Novel plant cells, plants, and seeds
|
|
CN109906030B
(zh)
|
2016-11-04 |
2022-03-18 |
安健基因公司 |
用于产生仅重链抗体的经基因修饰的非人动物和方法
|
|
AU2017358122B2
(en)
*
|
2016-11-14 |
2022-12-22 |
Toolgen Incorporated |
Artificially engineered SC function control system
|
|
CA3044101A1
(en)
|
2016-11-22 |
2018-05-31 |
Integrated Dna Technologies, Inc. |
Crispr/cpf1 systems and methods
|
|
WO2018111947A1
(en)
|
2016-12-12 |
2018-06-21 |
Integrated Dna Technologies, Inc. |
Genome editing enhancement
|
|
KR101748575B1
(ko)
*
|
2016-12-16 |
2017-06-20 |
주식회사 엠젠플러스 |
Ins 유전자 녹아웃 당뇨병 또는 당뇨병 합병증 동물모델 및 이의 제조방법
|
|
EP3555297A1
(en)
|
2016-12-19 |
2019-10-23 |
Editas Medicine, Inc. |
Assessing nuclease cleavage
|
|
AU2017379402B2
(en)
*
|
2016-12-22 |
2022-03-10 |
Toolgen Incorporated |
Oleic acid-enriched plant body having genetically modified FAD2 and production method therefor
|
|
CN110300802A
(zh)
*
|
2016-12-23 |
2019-10-01 |
基础科学研究院 |
用于动物胚胎碱基编辑的组合物和碱基编辑方法
|
|
US10745677B2
(en)
|
2016-12-23 |
2020-08-18 |
President And Fellows Of Harvard College |
Editing of CCR5 receptor gene to protect against HIV infection
|
|
JP6994730B2
(ja)
*
|
2016-12-26 |
2022-02-04 |
独立行政法人酒類総合研究所 |
ゲノム編集タンパク質の直接導入による糸状菌ゲノム編集方法
|
|
US11859219B1
(en)
|
2016-12-30 |
2024-01-02 |
Flagship Pioneering Innovations V, Inc. |
Methods of altering a target nucleotide sequence with an RNA-guided nuclease and a single guide RNA
|
|
US12110545B2
(en)
|
2017-01-06 |
2024-10-08 |
Editas Medicine, Inc. |
Methods of assessing nuclease cleavage
|
|
KR102515727B1
(ko)
*
|
2017-01-11 |
2023-03-30 |
주식회사 툴젠 |
중첩된 가이드핵산을 이용한 표적 핵산에 특정 핵산 서열을 삽입하기 위한 조성물 및 방법
|
|
JP7458785B2
(ja)
|
2017-01-23 |
2024-04-01 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用
|
|
EP3573448A4
(en)
|
2017-01-28 |
2020-09-02 |
Inari Agriculture, Inc. |
NEW PLANT CELLS, PLANTS AND SEEDS
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
WO2018164457A1
(ko)
*
|
2017-03-06 |
2018-09-13 |
기초과학연구원 |
C2cL 엔도뉴클레아제를 포함하는 유전체 교정용 조성물 및 이를 이용한 유전체 교정 방법
|
|
US11898179B2
(en)
|
2017-03-09 |
2024-02-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
CN110662556A
(zh)
|
2017-03-09 |
2020-01-07 |
哈佛大学的校长及成员们 |
癌症疫苗
|
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
|
WO2018170184A1
(en)
|
2017-03-14 |
2018-09-20 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
IL269458B2
(en)
|
2017-03-23 |
2024-02-01 |
Harvard College |
Nucleic base editors that include nucleic acid programmable DNA binding proteins
|
|
WO2018187779A1
(en)
|
2017-04-07 |
2018-10-11 |
Sage Science, Inc. |
Systems and methods for detection of genetic structural variation using integrated electrophoretic dna purification
|
|
US11767512B2
(en)
|
2017-04-13 |
2023-09-26 |
Cellectis |
Sequence specific reagents targeting CCR5 in primary hematopoietic cells
|
|
WO2018195129A1
(en)
|
2017-04-17 |
2018-10-25 |
University Of Maryland, College Park |
Embryonic cell cultures and methods of using the same
|
|
BR112019021977A2
(pt)
|
2017-04-20 |
2020-06-16 |
Egenesis, Inc. |
Métodos para a geração de animais geneticamente modificados
|
|
US11499151B2
(en)
|
2017-04-28 |
2022-11-15 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide RNA molecules
|
|
EP3635118A4
(en)
*
|
2017-05-05 |
2021-01-27 |
Institute Of Genetics And Developmental Biology Chinese Academy of Sciences |
PROCESSES FOR ISOLATING CELLS WITHOUT USING TRANSGENIC MARKER SEQUENCES
|
|
EP3622070A2
(en)
|
2017-05-10 |
2020-03-18 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
CN108977442B
(zh)
*
|
2017-06-05 |
2023-01-06 |
广州市锐博生物科技有限公司 |
用于dna编辑的系统及其应用
|
|
FI3635102T3
(fi)
|
2017-06-05 |
2025-10-28 |
Regeneron Pharma |
B4GALT1-variantteja ja niiden käyttöjä
|
|
KR102746733B1
(ko)
|
2017-06-09 |
2024-12-24 |
에디타스 메디신, 인코포레이티드 |
조작된 cas9 뉴클레아제
|
|
EP3638797A1
(en)
|
2017-06-13 |
2020-04-22 |
Flagship Pioneering Innovations V, Inc. |
Compositions comprising curons and uses thereof
|
|
AU2018283405B2
(en)
|
2017-06-15 |
2025-06-26 |
The Regents Of The University Of California |
Targeted non-viral DNA insertions
|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
EP3645021A4
(en)
|
2017-06-30 |
2021-04-21 |
Intima Bioscience, Inc. |
ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY
|
|
WO2019014564A1
(en)
|
2017-07-14 |
2019-01-17 |
Editas Medicine, Inc. |
SYSTEMS AND METHODS OF TARGETED INTEGRATION AND GENOME EDITING AND DETECTION THEREOF WITH INTEGRATED PRIMING SITES
|
|
CN107488710B
(zh)
*
|
2017-07-14 |
2020-09-22 |
上海吐露港生物科技有限公司 |
一种Cas蛋白的用途及靶标核酸分子的检测方法和试剂盒
|
|
EP3655961A4
(en)
*
|
2017-07-17 |
2021-09-01 |
Massachusetts Institute of Technology |
HEALTHY AND SICK BARRIER TISSUE CELL ATLAS
|
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
|
SG11201912236YA
(en)
|
2017-07-31 |
2020-01-30 |
Regeneron Pharma |
Crispr reporter non-human animals and uses thereof
|
|
CA3067872A1
(en)
|
2017-07-31 |
2019-02-07 |
Regeneron Pharmaceuticals, Inc. |
Cas-transgenic mouse embryonic stem cells and mice and uses thereof
|
|
WO2019028029A1
(en)
|
2017-07-31 |
2019-02-07 |
Regeneron Pharmaceuticals, Inc. |
EVALUATION OF CRISPR / CAS INDUCED RECOMBINATION WITH IN VIVO EXOGENIC DONOR NUCLEIC ACID
|
|
US11897920B2
(en)
|
2017-08-04 |
2024-02-13 |
Peking University |
Tale RVD specifically recognizing DNA base modified by methylation and application thereof
|
|
EP3666898A4
(en)
|
2017-08-08 |
2021-03-24 |
Peking University |
GENE INACTIVATION PROCESS
|
|
US11319532B2
(en)
|
2017-08-30 |
2022-05-03 |
President And Fellows Of Harvard College |
High efficiency base editors comprising Gam
|
|
US11713452B2
(en)
|
2017-09-08 |
2023-08-01 |
University Of North Texas Health Science Center |
Engineered CAS9 variants
|
|
CN111194350A
(zh)
|
2017-09-18 |
2020-05-22 |
博雅辑因(北京)生物科技有限公司 |
一种基因编辑t细胞及其用途
|
|
RU2022103641A
(ru)
*
|
2017-09-28 |
2022-03-18 |
Тулджен Инкорпорейтед |
Искусственная модификация генома для регуляции экспрессии гена
|
|
US11572574B2
(en)
|
2017-09-28 |
2023-02-07 |
Toolgen Incorporated |
Artificial genome manipulation for gene expression regulation
|
|
IL311278B1
(en)
*
|
2017-09-29 |
2026-01-01 |
Intellia Therapeutics Inc |
Polynucleotides, compositions, and methods for genome editing
|
|
KR102207352B1
(ko)
*
|
2017-09-29 |
2021-01-26 |
서울대학교산학협력단 |
Klotho 유전자 넉아웃 질환모델 동물 및 이의 용도
|
|
SG11202000771UA
(en)
|
2017-09-29 |
2020-04-29 |
Regeneron Pharma |
Non-human animals comprising a humanized ttr locus and methods of use
|
|
AU2018352592C1
(en)
|
2017-10-16 |
2025-09-25 |
Beam Therapeutics, Inc. |
Uses of adenosine base editors
|
|
EA202091056A1
(ru)
|
2017-10-27 |
2020-09-17 |
Те Риджентс Оф Те Юниверсити Оф Калифорния |
Направленная замена эндогенных т-клеточных рецепторов
|
|
CN109722415B
(zh)
|
2017-10-27 |
2021-01-26 |
博雅辑因(北京)生物科技有限公司 |
一种造血干细胞的培养组合物、培养基以及造血干细胞的培养方法
|
|
WO2019089804A1
(en)
|
2017-11-01 |
2019-05-09 |
The Regents Of The University Of California |
Casy compositions and methods of use
|
|
CN108192956B
(zh)
*
|
2017-11-17 |
2021-06-01 |
东南大学 |
一种基于Cas9核酸酶的DNA检测分析方法及其应用
|
|
US11667917B2
(en)
|
2017-11-21 |
2023-06-06 |
Genkore Co. Ltd. |
Composition for genome editing using CRISPR/CPF1 system and use thereof
|
|
EP3724214A4
(en)
|
2017-12-15 |
2021-09-01 |
The Broad Institute Inc. |
SYSTEMS AND PROCEDURES FOR PREDICTING REPAIR RESULTS IN GENE ENGINEERING
|
|
MX2020007466A
(es)
|
2018-01-12 |
2020-11-12 |
Basf Se |
Gen subyacente al qtl de la cantidad de espiguillas por espiga en trigo en el cromosoma 7a.
|
|
EP3740580A4
(en)
|
2018-01-19 |
2021-10-20 |
Duke University |
GENOME ENGINEERING WITH CRISPR-CAS SYSTEMS IN EUKARYONTS
|
|
EP3744844A4
(en)
|
2018-01-23 |
2021-10-20 |
Institute for Basic Science |
EXTENDED SIMPLE RNA GUIDE AND ASSOCIATED USE
|
|
US11926835B1
(en)
|
2018-01-29 |
2024-03-12 |
Inari Agriculture Technology, Inc. |
Methods for efficient tomato genome editing
|
|
KR102086689B1
(ko)
|
2018-02-06 |
2020-03-09 |
주식회사 진씨커 |
돌연변이 세포 유리 유전자 분리 키트 및 이를 이용한 돌연변이 세포 유리 유전자 분리 방법
|
|
WO2019156475A1
(ko)
*
|
2018-02-06 |
2019-08-15 |
주식회사 진씨커 |
돌연변이 세포 유리 유전자 분리 키트 및 이를 이용한 돌연변이 세포 유리 유전자 분리 방법
|
|
CN112020554B
(zh)
|
2018-02-23 |
2024-10-22 |
先锋国际良种公司 |
新颖cas9直系同源物
|
|
WO2019178426A1
(en)
|
2018-03-14 |
2019-09-19 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
CN111885915B
(zh)
|
2018-03-19 |
2023-04-28 |
瑞泽恩制药公司 |
使用crispr/cas系统对动物进行转录调制
|
|
JP7555822B2
(ja)
|
2018-04-19 |
2024-09-25 |
ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア |
ゲノム編集のための組成物および方法
|
|
CN112020560B
(zh)
*
|
2018-04-25 |
2024-02-23 |
中国农业大学 |
一种RNA编辑的CRISPR/Cas效应蛋白及系统
|
|
GB2589246A
(en)
|
2018-05-16 |
2021-05-26 |
Synthego Corp |
Methods and systems for guide RNA design and use
|
|
EP3797160A1
(en)
|
2018-05-23 |
2021-03-31 |
The Broad Institute Inc. |
Base editors and uses thereof
|
|
US11866719B1
(en)
|
2018-06-04 |
2024-01-09 |
Inari Agriculture Technology, Inc. |
Heterologous integration of regulatory elements to alter gene expression in wheat cells and wheat plants
|
|
US12338436B2
(en)
|
2018-06-29 |
2025-06-24 |
Editas Medicine, Inc. |
Synthetic guide molecules, compositions and methods relating thereto
|
|
US12522807B2
(en)
|
2018-07-09 |
2026-01-13 |
The Broad Institute, Inc. |
RNA programmable epigenetic RNA modifiers and uses thereof
|
|
KR102035654B1
(ko)
*
|
2018-07-23 |
2019-10-24 |
대한민국 |
항균 펩타이드를 생산하는 돌연변이 곤충 세포주 또는 이의 제조방법
|
|
US11479762B1
(en)
|
2018-08-31 |
2022-10-25 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
US12545910B2
(en)
|
2018-08-31 |
2026-02-10 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
US12534743B2
(en)
|
2018-08-31 |
2026-01-27 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
US20220049274A1
(en)
*
|
2018-09-12 |
2022-02-17 |
Institute For Basic Science |
Composition for inducing death of cells having mutated gene, and method for inducing death of cells having mutated gene by using composition
|
|
US12264330B2
(en)
|
2018-10-01 |
2025-04-01 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for killing target cells
|
|
WO2020072248A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system
|
|
WO2020072253A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system and uses thereof for screening for variant cells
|
|
WO2020072250A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system and uses thereof for genome modification and alteration of expression
|
|
WO2020076976A1
(en)
|
2018-10-10 |
2020-04-16 |
Readcoor, Inc. |
Three-dimensional spatial molecular indexing
|
|
KR102081962B1
(ko)
*
|
2018-10-11 |
2020-02-26 |
충남대학교 산학협력단 |
아밀로이드 전구 단백질 유전자를 절단하기 위한 조성물
|
|
CA3116918A1
(en)
|
2018-10-18 |
2020-04-23 |
Intellia Therapeutics, Inc. |
Compositions and methods for transgene expression from an albumin locus
|
|
AU2019361204A1
(en)
|
2018-10-18 |
2021-05-27 |
Intellia Therapeutics, Inc. |
Compositions and methods for treating alpha-1 antitrypsin deficiencey
|
|
CA3116580A1
(en)
|
2018-10-18 |
2020-04-23 |
Intellia Therapeutics, Inc. |
Nucleic acid constructs and methods of use
|
|
JP7578590B2
(ja)
|
2018-10-18 |
2024-11-06 |
インテリア セラピューティクス,インコーポレーテッド |
第ix因子を発現するための組成物及び方法
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
EP3875469A4
(en)
*
|
2018-10-29 |
2022-08-17 |
China Agricultural University |
NOVEL CRISPR/CAS12F ENZYME AND SYSTEM
|
|
EP3874048A1
(en)
*
|
2018-11-01 |
2021-09-08 |
Keygene N.V. |
Dual guide rna for crispr/cas genome editing in plants cells
|
|
EP3650557B1
(en)
*
|
2018-11-07 |
2021-10-20 |
Justus-Liebig-Universität Gießen |
Method for determination of restriction efficiency of endonucleases mediating double-strand breaks in dna target sequences
|
|
WO2020100361A1
(ja)
|
2018-11-16 |
2020-05-22 |
国立大学法人大阪大学 |
ゲノム編集された細胞を製造する方法
|
|
KR20200071198A
(ko)
|
2018-12-10 |
2020-06-19 |
네오이뮨텍, 인코퍼레이티드 |
Nrf2 발현 조절 기반 T 세포 항암면역치료법
|
|
US11166996B2
(en)
|
2018-12-12 |
2021-11-09 |
Flagship Pioneering Innovations V, Inc. |
Anellovirus compositions and methods of use
|
|
EP3896155A4
(en)
*
|
2018-12-12 |
2022-08-17 |
Kyushu University, National University Corporation |
Production method for genome-edited cells
|
|
US12365888B2
(en)
|
2018-12-14 |
2025-07-22 |
Pioneer Hi-Bred International, Inc. |
CRISPR-Cas systems for genome editing
|
|
CN116064550A
(zh)
|
2018-12-20 |
2023-05-05 |
瑞泽恩制药公司 |
核酸酶介导的重复扩增
|
|
WO2020146290A1
(en)
*
|
2019-01-07 |
2020-07-16 |
Crisp-Hr Therapeutics, Inc. |
A non-toxic cas9 enzyme and application thereof
|
|
WO2020154500A1
(en)
|
2019-01-23 |
2020-07-30 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
CN109868275A
(zh)
*
|
2019-03-12 |
2019-06-11 |
中国农业大学 |
CRISPR/Cas9介导的羊FGF5基因敲除和定点整合MTNR1A基因的方法
|
|
US11845931B2
(en)
|
2019-03-18 |
2023-12-19 |
Regeneron Pharmaceuticals, Inc. |
CRISPR/Cas screening platform to identify genetic modifiers of tau seeding or aggregation
|
|
CN113711046B
(zh)
|
2019-03-18 |
2023-08-29 |
瑞泽恩制药公司 |
用于揭示与Tau聚集相关的基因脆弱性的CRISPR/Cas脱落筛选平台
|
|
GB2601618B
(en)
|
2019-03-19 |
2024-11-06 |
Broad Inst Inc |
Methods and compositions for editing nucleotide sequences
|
|
BR112021019512A2
(pt)
|
2019-04-03 |
2022-02-15 |
Regeneron Pharma |
Métodos para inserir uma sequência de codificação de proteína de ligação ao antígeno e para tratar ou efetuar a profilaxia de uma doença em um animal, animal, célula, genoma, ácido nucleico doador exógeno, gene de porto seguro, e, agente de nuclease ou um ou mais ácidos nucleicos
|
|
WO2020206134A1
(en)
|
2019-04-04 |
2020-10-08 |
Regeneron Pharmaceuticals, Inc. |
Methods for scarless introduction of targeted modifications into targeting vectors
|
|
ES2966625T3
(es)
|
2019-04-04 |
2024-04-23 |
Regeneron Pharma |
Roedores que comprenden un locus del factor de coagulación 12 humanizado
|
|
WO2020214842A1
(en)
|
2019-04-17 |
2020-10-22 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
PH12021552732A1
(en)
|
2019-04-30 |
2023-01-16 |
Edigene Guangzhou Inc |
Method for predicting effectiveness of treatment of hemoglobinopathy
|
|
US11692197B2
(en)
|
2019-05-06 |
2023-07-04 |
Inari Agriculture Technology, Inc. |
Delivery of biological molecules to plant cells
|
|
CN111304180B
(zh)
*
|
2019-06-04 |
2023-05-26 |
山东舜丰生物科技有限公司 |
一种新的dna核酸切割酶及其应用
|
|
AU2020286382B2
(en)
|
2019-06-04 |
2026-03-26 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized TTR locus with a beta-slip mutation and methods of use
|
|
JP7698587B2
(ja)
|
2019-06-07 |
2025-06-25 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
ヒト化アルブミン遺伝子座を含む非ヒト動物
|
|
WO2020252340A1
(en)
|
2019-06-14 |
2020-12-17 |
Regeneron Pharmaceuticals, Inc. |
Models of tauopathy
|
|
CN114630910A
(zh)
|
2019-06-25 |
2022-06-14 |
伊纳瑞农业技术有限公司 |
改善的同源依赖修复基因组编辑
|
|
EP3999103A4
(en)
|
2019-07-19 |
2023-11-22 |
Inari Agriculture Technology, Inc. |
GENOMIC EDITING FOR ENHANCED HOMOLOGY-DIRECTED REPAIR
|
|
CN115244176A
(zh)
*
|
2019-08-19 |
2022-10-25 |
钟明宏 |
向导rna-cas蛋白复合物的缀合物
|
|
JP2022547105A
(ja)
|
2019-09-04 |
2022-11-10 |
博雅▲輯▼因(北京)生物科技有限公司 |
オフターゲット評価に基づく遺伝子編集治療の評価方法
|
|
JP2022548031A
(ja)
|
2019-09-13 |
2022-11-16 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
脂質ナノ粒子によって送達されるcrispr/casシステムを使用する動物における転写調節
|
|
CN114391040A
(zh)
|
2019-09-23 |
2022-04-22 |
欧米茄治疗公司 |
用于调节载脂蛋白b(apob)基因表达的组合物和方法
|
|
US11987791B2
(en)
|
2019-09-23 |
2024-05-21 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating hepatocyte nuclear factor 4-alpha (HNF4α) gene expression
|
|
JP7689949B2
(ja)
|
2019-10-03 |
2025-06-09 |
アーティサン ディベロップメント ラブズ インコーポレイテッド |
操作されたデュアルガイド核酸を有するcrisprシステム
|
|
WO2021072328A1
(en)
|
2019-10-10 |
2021-04-15 |
The Broad Institute, Inc. |
Methods and compositions for prime editing rna
|
|
AU2020369599A1
(en)
|
2019-10-23 |
2022-05-12 |
Monsanto Technology Llc |
Compositions and methods for RNA-templated editing in plants
|
|
KR20220110748A
(ko)
*
|
2019-11-05 |
2022-08-09 |
페어와이즈 플랜츠 서비시즈, 인크. |
대립유전자의 rna-코딩된 dna-대체를 위한 조성물 및 방법
|
|
US12521451B2
(en)
|
2019-11-08 |
2026-01-13 |
Regeneron Pharmaceuticals, Inc. |
CRISPR and AAV strategies for x-linked juvenile retinoschisis therapy
|
|
JP7448120B2
(ja)
*
|
2019-11-14 |
2024-03-12 |
国立研究開発法人農業・食品産業技術総合研究機構 |
プラズマを用いてゲノム編集酵素を植物細胞内に導入する方法
|
|
WO2021108363A1
(en)
|
2019-11-25 |
2021-06-03 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-mediated upregulation of humanized ttr allele
|
|
WO2021108442A2
(en)
*
|
2019-11-27 |
2021-06-03 |
The Regents Of The University Of California |
Modulators of cas9 polypeptide activity and methods of use thereof
|
|
CN114867850A
(zh)
|
2019-12-30 |
2022-08-05 |
博雅缉因(北京)生物科技有限公司 |
一种纯化ucart细胞的方法与应用
|
|
WO2021136176A1
(zh)
|
2019-12-30 |
2021-07-08 |
博雅辑因(北京)生物科技有限公司 |
一种靶向t细胞淋巴瘤细胞的通用型car-t及其制备方法和应用
|
|
WO2021145700A1
(ko)
*
|
2020-01-14 |
2021-07-22 |
주식회사 툴젠 |
저산소 환경 하에서 높은 적응력을 가지는 세포 및 이의 용도
|
|
CN114945680A
(zh)
*
|
2020-01-14 |
2022-08-26 |
深圳华大智造科技股份有限公司 |
使用微流体隔室化快速多路复用基于crispr的诊断
|
|
EP4091635A4
(en)
|
2020-01-14 |
2024-02-21 |
Toolgen Incorporated |
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING ALZHEIMER'S DISEASE AND USE THEREOF
|
|
CN115362264A
(zh)
|
2020-01-29 |
2022-11-18 |
10X基因组学有限公司 |
用于分析物检测的组合物和方法
|
|
WO2021163515A1
(en)
*
|
2020-02-12 |
2021-08-19 |
Temple University - Of The Commonwealth System Of Higher Education |
Crispr-cas9 mediated disruption of alcam gene inhibits adhesion and trans-endothelial migration of myeloid cells
|
|
CN115485385A
(zh)
|
2020-03-04 |
2022-12-16 |
瑞泽恩制药公司 |
用于使肿瘤细胞对免疫疗法敏感的方法和组合物
|
|
AU2021234302A1
(en)
|
2020-03-11 |
2022-11-10 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating forkhead box p3 (foxp3) gene expression
|
|
EP4125348A1
(en)
|
2020-03-23 |
2023-02-08 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use
|
|
US12057197B2
(en)
|
2020-04-03 |
2024-08-06 |
Creyon Bio, Inc. |
Oligonucleotide-based machine learning
|
|
JP2023525304A
(ja)
|
2020-05-08 |
2023-06-15 |
ザ ブロード インスティテュート,インコーポレーテッド |
標的二本鎖ヌクレオチド配列の両鎖同時編集のための方法および組成物
|
|
CN111690720B
(zh)
*
|
2020-06-16 |
2021-06-15 |
山东舜丰生物科技有限公司 |
利用修饰的单链核酸进行靶核酸检测的方法
|
|
US20220049303A1
(en)
|
2020-08-17 |
2022-02-17 |
Readcoor, Llc |
Methods and systems for spatial mapping of genetic variants
|
|
KR102638799B1
(ko)
*
|
2020-10-08 |
2024-02-22 |
주식회사 진코어 |
CRISPR/Cas12f1(Cas14a1) system 효율화를 위한 engineered guide RNA 및 이의 용도
|
|
WO2022120022A1
(en)
|
2020-12-02 |
2022-06-09 |
Regeneron Pharmaceuticals, Inc. |
Crispr sam biosensor cell lines and methods of use thereof
|
|
WO2022124839A1
(ko)
*
|
2020-12-09 |
2022-06-16 |
재단법인 아산사회복지재단 |
온-타겟 활성이 유지되고 오프-타겟 활성이 감소된 가이드 rna 및 이의 용도
|
|
KR20230124682A
(ko)
|
2020-12-23 |
2023-08-25 |
플래그쉽 파이어니어링 이노베이션스 브이, 인크. |
Rna를 봉입하는 아넬로바이러스 캡시드의 시험관 내어셈블리
|
|
IL304069A
(en)
|
2020-12-30 |
2023-08-01 |
Intellia Therapeutics Inc |
Engineered T cells
|
|
KR102285906B1
(ko)
*
|
2021-02-18 |
2021-08-04 |
주식회사 엔에이피 |
수생태계 교란어종 관리를 위한 큰입배스 불임 유도용 조성물
|
|
AU2022227650A1
(en)
|
2021-02-25 |
2023-10-12 |
Celyntra Therapeutics Sa |
Compositions and methods for targeting, editing, or modifying genes
|
|
WO2022240846A1
(en)
|
2021-05-10 |
2022-11-17 |
Sqz Biotechnologies Company |
Methods for delivering genome editing molecules to the nucleus or cytosol of a cell and uses thereof
|
|
KR102616916B1
(ko)
*
|
2021-05-11 |
2023-12-21 |
주식회사 애이마 |
발암성 돌연변이 유전자 검출용 가이드 rna 내지 이의 용도
|
|
WO2022251644A1
(en)
|
2021-05-28 |
2022-12-01 |
Lyell Immunopharma, Inc. |
Nr4a3-deficient immune cells and uses thereof
|
|
EP4419672A2
(en)
|
2021-06-01 |
2024-08-28 |
Artisan Development Labs, Inc. |
Compositions and methods for targeting, editing, or modifying genes
|
|
KR20240027676A
(ko)
|
2021-06-02 |
2024-03-04 |
라이엘 이뮤노파마, 인크. |
Nr4a3-결핍 면역 세포 및 이의 용도
|
|
KR102618072B1
(ko)
|
2021-06-15 |
2023-12-28 |
대한민국 |
작물의 개화조절 관련 유전자 교정용 가이드 rna 및 이의 용도
|
|
US20250034558A1
(en)
|
2021-06-18 |
2025-01-30 |
Artisan Development Labs, Inc. |
Compositions and methods for targeting, editing or modifying human genes
|
|
WO2023283359A2
(en)
|
2021-07-07 |
2023-01-12 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating secreted frizzled receptor protein 1 (sfrp1) gene expression
|
|
KR20230010617A
(ko)
|
2021-07-09 |
2023-01-19 |
주식회사 툴젠 |
산화스트레스 저항성을 갖는 중간엽줄기세포, 이의 제조방법 및 용도
|
|
KR20230019791A
(ko)
|
2021-07-29 |
2023-02-09 |
주식회사 툴젠 |
혈액 적합성을 갖는 중간엽 줄기세포, 이의 제조방법 및 용도
|
|
CN113584134B
(zh)
*
|
2021-09-06 |
2024-01-30 |
青岛金斯达生物技术有限公司 |
一种基于CRISPR-Cas9的等温核酸检测系统及其方法和应用
|
|
CA3230927A1
(en)
|
2021-09-10 |
2023-03-16 |
Agilent Technologies, Inc. |
Guide rnas with chemical modification for prime editing
|
|
CN118119702A
(zh)
|
2021-10-14 |
2024-05-31 |
隆萨销售股份有限公司 |
用于细胞外囊泡产生的经修饰的生产者细胞
|
|
JP2024537991A
(ja)
|
2021-10-14 |
2024-10-18 |
アーセナル バイオサイエンシズ インコーポレイテッド |
共発現されるshRNAと論理ゲートシステムとを有する免疫細胞
|
|
CN118251491A
(zh)
|
2021-10-28 |
2024-06-25 |
瑞泽恩制药公司 |
用于敲除C5的CRISPR/Cas相关方法及组合物
|
|
US20260022386A1
(en)
|
2021-11-01 |
2026-01-22 |
Basecamp Research Ltd |
Single Construct Platform for Simultaneous Delivery of Gene Editing Machinery and Nucleic Acid Cargo
|
|
CA3238939A1
(en)
|
2021-12-08 |
2023-06-15 |
Gaurang Patel |
Mutant myocilin disease model and uses thereof
|
|
WO2023122764A1
(en)
|
2021-12-22 |
2023-06-29 |
Tome Biosciences, Inc. |
Co-delivery of a gene editor construct and a donor template
|
|
IL313726A
(en)
|
2021-12-23 |
2024-08-01 |
Univ Massachusetts |
Medical treatment of fragile X-linked disorder
|
|
JP2025501221A
(ja)
|
2021-12-29 |
2025-01-17 |
ブリストル-マイヤーズ スクイブ カンパニー |
ランディングパッド細胞株の生成
|
|
WO2023150181A1
(en)
|
2022-02-01 |
2023-08-10 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
|
US20250032642A1
(en)
|
2022-02-02 |
2025-01-30 |
Regeneron Pharmaceuticals, Inc. |
Crispr-mediated transgene insertion in neonatal cells
|
|
WO2023167882A1
(en)
|
2022-03-01 |
2023-09-07 |
Artisan Development Labs, Inc. |
Composition and methods for transgene insertion
|
|
CN118843688A
(zh)
|
2022-03-04 |
2024-10-25 |
株式会社图尔金 |
低免疫原性干细胞、由干细胞分化或衍生的低免疫原性细胞及其制备方法
|
|
CN114410609B
(zh)
*
|
2022-03-29 |
2022-07-12 |
舜丰生物科技(海南)有限公司 |
一种活性提高的Cas蛋白以及应用
|
|
WO2023205744A1
(en)
|
2022-04-20 |
2023-10-26 |
Tome Biosciences, Inc. |
Programmable gene insertion compositions
|
|
WO2023205844A1
(en)
*
|
2022-04-26 |
2023-11-02 |
Peter Maccallum Cancer Institute |
Nucleic acids and uses thereof
|
|
CN117004604A
(zh)
*
|
2022-04-28 |
2023-11-07 |
南京北恒生物科技有限公司 |
一种ciita基因被敲除的工程化免疫细胞及其用途
|
|
CN119487200A
(zh)
|
2022-04-29 |
2025-02-18 |
瑞泽恩制药公司 |
用于基因治疗方法的组织特异性基因外安全港的鉴定
|
|
WO2023215831A1
(en)
|
2022-05-04 |
2023-11-09 |
Tome Biosciences, Inc. |
Guide rna compositions for programmable gene insertion
|
|
CN119604610A
(zh)
|
2022-05-09 |
2025-03-11 |
瑞泽恩制药公司 |
用于体内抗体产生的载体和方法
|
|
WO2023219434A1
(ko)
|
2022-05-13 |
2023-11-16 |
주식회사 툴젠 |
혈액 적합성을 갖는 혈관 내 이식용 세포, 이의 제조방법 및 용도
|
|
CA3253951A1
(en)
|
2022-05-19 |
2023-11-23 |
Lyell Immunopharma, Inc. |
NR4A3 Targeted Polynucleotides and Their Uses
|
|
WO2023225670A2
(en)
|
2022-05-20 |
2023-11-23 |
Tome Biosciences, Inc. |
Ex vivo programmable gene insertion
|
|
EP4526884A2
(en)
|
2022-05-20 |
2025-03-26 |
Artisan Development Labs, Inc. |
Systems and methods for assessing risk of genome editing events
|
|
EP4533088A2
(en)
|
2022-05-25 |
2025-04-09 |
Flagship Pioneering Innovations VII, LLC |
Compositions and methods for modulating genetic drivers
|
|
JP2025517967A
(ja)
|
2022-05-25 |
2025-06-12 |
フラッグシップ パイオニアリング イノベーションズ セブン,エルエルシー |
サイトカインを調節するための組成物及び方法
|
|
AU2023276714A1
(en)
|
2022-05-25 |
2024-11-21 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulation of immune responses
|
|
JP2025517969A
(ja)
|
2022-05-25 |
2025-06-12 |
フラッグシップ パイオニアリング イノベーションズ セブン,エルエルシー |
腫瘍抑制因子及び癌遺伝子の調節のための組成物及び方法
|
|
AU2023276715A1
(en)
|
2022-05-25 |
2025-01-09 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulating circulating factors
|
|
WO2023235725A2
(en)
|
2022-05-31 |
2023-12-07 |
Regeneron Pharmaceuticals, Inc. |
Crispr-based therapeutics for c9orf72 repeat expansion disease
|
|
CN119421951A
(zh)
|
2022-05-31 |
2025-02-11 |
瑞泽恩制药公司 |
用于c9orf72重复序列扩增疾病的crispr干扰疗法
|
|
KR20250044484A
(ko)
|
2022-06-24 |
2025-03-31 |
튠 쎄라퓨틱스, 인코포레이티드 |
표적 유전자 억제를 통해 저밀도 지단백질을 감소시키기 위한 조성물, 시스템, 및 방법
|
|
IL317790A
(en)
|
2022-06-29 |
2025-02-01 |
Intellia Therapeutics Inc |
Engineered T cells
|
|
EP4299733A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
EP4299739A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
WO2024005863A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
WO2024005864A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
WO2024020587A2
(en)
|
2022-07-22 |
2024-01-25 |
Tome Biosciences, Inc. |
Pleiopluripotent stem cell programmable gene insertion
|
|
WO2024026474A1
(en)
|
2022-07-29 |
2024-02-01 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
|
|
JP2025525745A
(ja)
|
2022-08-05 |
2025-08-07 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Tdp-43の凝集耐性バリアント
|
|
CN115386597B
(zh)
*
|
2022-09-19 |
2025-04-25 |
国家纳米科学中心 |
一种提高基因载体转染效率和/或转染精度的转染辅助试剂及其应用
|
|
WO2024064952A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells overexpressing c-jun
|
|
WO2024064958A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
|
WO2024073606A1
(en)
|
2022-09-28 |
2024-04-04 |
Regeneron Pharmaceuticals, Inc. |
Antibody resistant modified receptors to enhance cell-based therapies
|
|
WO2024077174A1
(en)
|
2022-10-05 |
2024-04-11 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
|
KR20250115463A
(ko)
|
2022-11-04 |
2025-07-30 |
리제너론 파아마슈티컬스, 인크. |
칼슘 전압 개폐 채널 보조 서브유닛 감마 1(cacng1) 결합 단백질 및 골격근으로의 cacng1-매개 전달
|
|
WO2024102434A1
(en)
|
2022-11-10 |
2024-05-16 |
Senda Biosciences, Inc. |
Rna compositions comprising lipid nanoparticles or lipid reconstructed natural messenger packs
|
|
EP4619438A2
(en)
|
2022-11-14 |
2025-09-24 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
|
|
WO2024138194A1
(en)
|
2022-12-22 |
2024-06-27 |
Tome Biosciences, Inc. |
Platforms, compositions, and methods for in vivo programmable gene insertion
|
|
US20250339384A1
(en)
|
2023-01-27 |
2025-11-06 |
Regeneron Pharmaceuticals, Inc. |
Modified rhabdovirus glycoproteins and uses thereof
|
|
WO2024211287A1
(en)
|
2023-04-03 |
2024-10-10 |
Seagen Inc. |
Production cell lines with targeted integration sites
|
|
EP4697940A1
(en)
|
2023-04-21 |
2026-02-25 |
Vib Vzw |
Allelic combinations in crops for yield increase
|
|
WO2024234006A1
(en)
|
2023-05-11 |
2024-11-14 |
Tome Biosciences, Inc. |
Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs)
|
|
WO2024243438A2
(en)
|
2023-05-23 |
2024-11-28 |
Omega Therapeutics, Inc. |
Compositions and methods for reducing cxcl9, cxcl10, and cxcl11 gene expression
|
|
AU2024305332A1
(en)
|
2023-06-15 |
2026-01-15 |
Regeneron Pharmaceuticals, Inc. |
Gene therapy for hearing disorders
|
|
AU2024309884A1
(en)
|
2023-06-30 |
2025-12-18 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for increasing homology-directed repair
|
|
WO2025029657A2
(en)
|
2023-07-28 |
2025-02-06 |
Regeneron Pharmaceuticals, Inc. |
Anti-tfr:gaa and anti-cd63:gaa insertion for treatment of pompe disease
|
|
AR133384A1
(es)
|
2023-07-28 |
2025-09-24 |
Regeneron Pharma |
Anti-tfr:esfingomielinasa ácida para el tratamiento de la deficiencia de esfingomielinasa ácida
|
|
WO2025029654A2
(en)
|
2023-07-28 |
2025-02-06 |
Regeneron Pharmaceuticals, Inc. |
Use of bgh-sv40l tandem polya to enhance transgene expression during unidirectional gene insertion
|
|
WO2025038750A2
(en)
|
2023-08-14 |
2025-02-20 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
|
WO2025038164A1
(en)
*
|
2023-08-15 |
2025-02-20 |
University Of Massachusetts |
Nick resection in cancer
|
|
WO2025049524A1
(en)
|
2023-08-28 |
2025-03-06 |
Regeneron Pharmaceuticals, Inc. |
Cxcr4 antibody-resistant modified receptors
|
|
WO2025050069A1
(en)
|
2023-09-01 |
2025-03-06 |
Tome Biosciences, Inc. |
Programmable gene insertion using engineered integration enzymes
|
|
WO2025056732A1
(en)
|
2023-09-13 |
2025-03-20 |
Medizinische Universität Graz |
Method for providing antigen-reactive lymphocytes
|
|
EP4554371A1
(en)
|
2023-10-03 |
2025-05-21 |
Inari Agriculture Technology, Inc. |
Viral delivery of grna to the scion
|
|
TW202542303A
(zh)
|
2023-12-20 |
2025-11-01 |
美商英特利亞醫療公司 |
經工程改造之t細胞
|
|
WO2025168705A1
(en)
|
2024-02-08 |
2025-08-14 |
Vib Vzw |
Means and methods for the production of saponins with endosomal escape-enhancing properties
|
|
US20250276092A1
(en)
|
2024-03-01 |
2025-09-04 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response
|
|
WO2025188676A1
(en)
*
|
2024-03-04 |
2025-09-12 |
The Board Of Trustees Of The Leland Stanford Junior University |
Genetic engineering of cells for secretion of therapeutic antibodies
|
|
WO2025217398A1
(en)
|
2024-04-10 |
2025-10-16 |
Lyell Immunopharma, Inc. |
Methods for culturing cells with improved culture medium
|
|
WO2025224107A1
(en)
|
2024-04-22 |
2025-10-30 |
Basecamp Research Ltd |
Method and compositions for detecting off-target editing
|
|
WO2025224182A2
(en)
|
2024-04-23 |
2025-10-30 |
Basecamp Research Ltd |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
WO2025235388A1
(en)
|
2024-05-06 |
2025-11-13 |
Regeneron Pharmaceuticals, Inc. |
Transgene genomic identification by nuclease-mediated long read sequencing
|
|
WO2025240947A1
(en)
|
2024-05-17 |
2025-11-20 |
University Of Massachusetts |
Therapeutic treatment for fragile x-associated disorder
|
|
WO2025259669A1
(en)
|
2024-06-10 |
2025-12-18 |
Regeneron Pharmaceuticals, Inc. |
Methods and systems for characterizing modified oligonucleotides
|
|
US20250388890A1
(en)
|
2024-06-20 |
2025-12-25 |
Regeneron Pharmaceuticals, Inc. |
ASS1 Gene Insertion For The Treatment Of Citrullinemia Type I
|
|
WO2026036000A1
(en)
|
2024-08-08 |
2026-02-12 |
Invaio Sciences, Inc. |
Nature-derived lipid particles for use in agriculture
|