PT100801A - Processo para a preparacao de aril-poliaminas sinteticas uteis como antagonistas de neurotransmissores aminoacidos excitadores e compostos assim obtidos - Google Patents
Processo para a preparacao de aril-poliaminas sinteticas uteis como antagonistas de neurotransmissores aminoacidos excitadores e compostos assim obtidos Download PDFInfo
- Publication number
- PT100801A PT100801A PT100801A PT10080192A PT100801A PT 100801 A PT100801 A PT 100801A PT 100801 A PT100801 A PT 100801A PT 10080192 A PT10080192 A PT 10080192A PT 100801 A PT100801 A PT 100801A
- Authority
- PT
- Portugal
- Prior art keywords
- equal
- boc
- compound
- amino
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/40—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F17/00—Metallocenes
- C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74901491A | 1991-08-23 | 1991-08-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT100801A true PT100801A (pt) | 1993-09-30 |
Family
ID=25011863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT100801A PT100801A (pt) | 1991-08-23 | 1992-08-21 | Processo para a preparacao de aril-poliaminas sinteticas uteis como antagonistas de neurotransmissores aminoacidos excitadores e compostos assim obtidos |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0641312A1 (cs) |
| JP (1) | JPH06505996A (cs) |
| CN (1) | CN1069969A (cs) |
| AU (1) | AU2426392A (cs) |
| BR (1) | BR9206403A (cs) |
| CA (1) | CA2114798A1 (cs) |
| CZ (1) | CZ39994A3 (cs) |
| FI (1) | FI940833A7 (cs) |
| HU (1) | HU9400503D0 (cs) |
| IL (1) | IL102835A0 (cs) |
| MX (1) | MX9204866A (cs) |
| PT (1) | PT100801A (cs) |
| WO (1) | WO1993004036A1 (cs) |
| ZA (1) | ZA926314B (cs) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6071970A (en) * | 1993-02-08 | 2000-06-06 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US7087765B2 (en) | 1995-06-07 | 2006-08-08 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US6211245B1 (en) | 1993-02-08 | 2001-04-03 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US6750244B2 (en) | 1993-02-08 | 2004-06-15 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US6017965A (en) * | 1993-02-08 | 2000-01-25 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| DE69434889D1 (de) | 1994-02-08 | 2007-01-11 | Nps Pharma Inc | An einer neuen Stelle von Rezeptorabhängigen Kalziumkanälen wirkende Verbindungen zur Behandlung von neurologischen Erkrankungen |
| US20010004460A1 (en) * | 1995-06-08 | 2001-06-21 | Carla Rasmussen Klittich | Process for the preparation of rice seed for sowing |
| US8198334B2 (en) | 1997-10-27 | 2012-06-12 | Pathologica Llc | Methods for modulating macrophage proliferation in ocular disease using polyamine analogs |
| AU2003231670B2 (en) * | 1997-10-27 | 2006-06-08 | Slil Biomedical Corporation | Methods for modulating macrophage proliferation using polyamine analogs |
| US7087648B1 (en) | 1997-10-27 | 2006-08-08 | The Regents Of The University Of California | Methods for modulating macrophage proliferation using polyamine analogs |
| IL146126A0 (en) | 1999-04-30 | 2002-07-25 | Slil Biomedical Corp | Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases |
| US20030130356A1 (en) | 2001-10-16 | 2003-07-10 | Slil Biomedical Corporation | Oligoamine compounds and derivatives thereof for cancer therapy |
| JP2007505044A (ja) * | 2003-09-09 | 2007-03-08 | ユニバーシティ オブ フロリダ リサーチ ファウンデイション、インコーポレイテッド | ポリアミン−金属キレーター接合体 |
| CN103073448B (zh) * | 2012-12-29 | 2015-11-18 | 河南大学 | 含芳环结构的多胺衍生物及其制备方法和应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5037846A (en) * | 1990-01-02 | 1991-08-06 | Pfizer Inc. | Indolyl-3 polyamines and their use as antagonists of excitatory amino acid neurotransmitters |
-
1992
- 1992-08-10 BR BR9206403A patent/BR9206403A/pt not_active Application Discontinuation
- 1992-08-10 JP JP5504331A patent/JPH06505996A/ja active Pending
- 1992-08-10 CA CA002114798A patent/CA2114798A1/en not_active Abandoned
- 1992-08-10 HU HU9400503A patent/HU9400503D0/hu unknown
- 1992-08-10 AU AU24263/92A patent/AU2426392A/en not_active Abandoned
- 1992-08-10 EP EP92916921A patent/EP0641312A1/en not_active Withdrawn
- 1992-08-10 WO PCT/US1992/006482 patent/WO1993004036A1/en not_active Ceased
- 1992-08-10 CZ CS94399A patent/CZ39994A3/cs unknown
- 1992-08-10 FI FI940833A patent/FI940833A7/fi not_active Application Discontinuation
- 1992-08-17 IL IL102835A patent/IL102835A0/xx unknown
- 1992-08-21 ZA ZA926314A patent/ZA926314B/xx unknown
- 1992-08-21 MX MX9204866A patent/MX9204866A/es unknown
- 1992-08-21 PT PT100801A patent/PT100801A/pt not_active Application Discontinuation
- 1992-08-22 CN CN92109681A patent/CN1069969A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX9204866A (es) | 1993-04-01 |
| FI940833A0 (fi) | 1994-02-22 |
| EP0641312A1 (en) | 1995-03-08 |
| CA2114798A1 (en) | 1993-03-04 |
| CZ39994A3 (en) | 1994-11-16 |
| ZA926314B (en) | 1994-02-21 |
| WO1993004036A1 (en) | 1993-03-04 |
| FI940833L (fi) | 1994-02-22 |
| IL102835A0 (en) | 1993-01-31 |
| FI940833A7 (fi) | 1994-02-22 |
| CN1069969A (zh) | 1993-03-17 |
| JPH06505996A (ja) | 1994-07-07 |
| HU9400503D0 (en) | 1994-05-30 |
| BR9206403A (pt) | 1994-12-27 |
| AU2426392A (en) | 1993-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU658377B2 (en) | Alpha-substituted tryptophane dipeptoid derivatives | |
| PT100801A (pt) | Processo para a preparacao de aril-poliaminas sinteticas uteis como antagonistas de neurotransmissores aminoacidos excitadores e compostos assim obtidos | |
| AU603004B2 (en) | 1-((2-pyrimidinyl)aminoalkyl)piperidines, their preparation and their application in therapy | |
| IE55091B1 (en) | New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these derivatives and their use | |
| DK164557B (da) | Derivater af cis,endo-2-azabicyclo-oe5.3.0aa-decan-3-carboxylsyre samt laegemiddel indeholdende dem | |
| PT100802A (pt) | Processo para a preparacao de heteroaril-poliaminas sinteticas uteis como antagonistas de neurotransmissores aminoacidos excitadores e compostos assim obtidos | |
| PT96389A (pt) | Processo para a preparacao de poliaminas, contendo um anel indole, uteis como antagonistas de neurotransmissores de amino-acidos excitadores | |
| PT89779B (pt) | Processo para a preparacao de derivados da piperidina | |
| EP0546108B1 (en) | Pro-drugs for cck antagonists | |
| SK8752002A3 (en) | Substituted N-benzyl-indol-3-yl glyoxylic acid derivatives having an anti-tumoral effect | |
| US5264419A (en) | N-substituted cycloalkyl and polycycloalkyl α-substituted TRP derivatives | |
| JPH0780901B2 (ja) | Ｌ−５−ヒドロキシトリプトファンの新規なジペプチド類およびそれらを製造する方法並びにそれらジペプチド類を含む薬剤 | |
| US5340825A (en) | Pro drugs for CCK antagonists | |
| RU2173146C2 (ru) | Производные полициклических алкалоидов как антагонисты nmda-рецептора | |
| WO1994018171A1 (en) | Unsymmetrical bis-imides as anticancer agents |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19930506 |
|
| FC3A | Refusal |
Effective date: 19990312 |