PT1013639E - Derivados de acido aril-carboxilico e tetrazol que compreendem um radical carbamoiloxi - Google Patents

Derivados de acido aril-carboxilico e tetrazol que compreendem um radical carbamoiloxi

Info

Publication number
PT1013639E
PT1013639E PT99125027T PT99125027T PT1013639E PT 1013639 E PT1013639 E PT 1013639E PT 99125027 T PT99125027 T PT 99125027T PT 99125027 T PT99125027 T PT 99125027T PT 1013639 E PT1013639 E PT 1013639E
Authority
PT
Portugal
Prior art keywords
aril
carbamoyloxy
radical
understand
carboxylic acid
Prior art date
Application number
PT99125027T
Other languages
English (en)
Inventor
Alexander V Muehldorf
Francisco Javier Lopez-Tapia
Counde O'yang
Daniel Lee Severance
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PT1013639E publication Critical patent/PT1013639E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
PT99125027T 1998-12-23 1999-12-15 Derivados de acido aril-carboxilico e tetrazol que compreendem um radical carbamoiloxi PT1013639E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11344698P 1998-12-23 1998-12-23
US15181499P 1999-08-30 1999-08-30

Publications (1)

Publication Number Publication Date
PT1013639E true PT1013639E (pt) 2004-02-27

Family

ID=26811078

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99125027T PT1013639E (pt) 1998-12-23 1999-12-15 Derivados de acido aril-carboxilico e tetrazol que compreendem um radical carbamoiloxi

Country Status (29)

Country Link
US (1) US6335459B1 (pt)
EP (1) EP1013639B1 (pt)
JP (1) JP3415085B2 (pt)
KR (1) KR100378335B1 (pt)
CN (1) CN1167670C (pt)
AR (1) AR029320A1 (pt)
AT (1) ATE251125T1 (pt)
AU (1) AU735640B2 (pt)
BR (1) BR9905974A (pt)
CA (1) CA2292921C (pt)
DE (1) DE69911726T2 (pt)
DK (1) DK1013639T3 (pt)
ES (1) ES2207108T3 (pt)
HR (1) HRP990394A2 (pt)
HU (1) HUP9904659A3 (pt)
ID (1) ID25983A (pt)
IL (1) IL133578A (pt)
MA (1) MA26713A1 (pt)
NO (1) NO316171B1 (pt)
NZ (1) NZ501891A (pt)
PE (1) PE20001368A1 (pt)
PL (1) PL337419A1 (pt)
PT (1) PT1013639E (pt)
RU (1) RU2179969C2 (pt)
SG (1) SG90086A1 (pt)
TR (1) TR199903310A3 (pt)
TW (1) TWI221834B (pt)
UY (1) UY25876A1 (pt)
YU (1) YU69699A (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9828442D0 (en) 1998-12-24 1999-02-17 Karobio Ab Novel thyroid receptor ligands and method II
SE0100158D0 (sv) * 2001-01-19 2001-01-19 Synphora Ab Novel method and composition for local treatment of Meniere´s disease and tinnitus
DE60210058T2 (de) * 2001-03-02 2006-11-09 F. Hoffmann-La Roche Ag Alkoxycarbonylamino-heteroaryl-carbonsäurederivate als ip-antagonisten
CN101439039B (zh) 2003-05-09 2012-06-13 东丽株式会社 增强剂
RU2268037C1 (ru) * 2004-04-22 2006-01-20 Германов Евгений Павлович Лекарственное средство
UA93548C2 (uk) 2006-05-05 2011-02-25 Айерем Елелсі Сполуки та композиції як модулятори хеджхогівського сигнального шляху
US9669381B2 (en) 2007-06-27 2017-06-06 Hrd Corporation System and process for hydrocracking
WO2009117095A1 (en) 2008-03-18 2009-09-24 Arena Pharmaceuticals, Inc. Modulators of the prostacyclin (pgi2) receptor useful for the treatment of disorders related thereto
US8575175B2 (en) 2008-07-23 2013-11-05 Toray Industries, Inc. Therapeutic agent for chronic renal failure
CA2802294C (en) 2010-06-11 2016-05-10 Rhodes Technologies Process for n-dealkylation of tertiary amines
EP2580201B1 (en) 2010-06-11 2017-08-02 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
IL268997B2 (en) 2017-03-01 2023-09-01 Arena Pharm Inc Preparations containing pgi2 receptor agonists and processes for their preparation
WO2023158634A1 (en) 2022-02-15 2023-08-24 United Therapeutics Corporation Crystalline prostacyclin (ip) receptor agonist and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1079414A (en) 1965-06-30 1967-08-16 Smith & Nephew Derivatives of acetic acid and a process for their preparation
GB1185539A (en) 1967-11-03 1970-03-25 Smith & Nephew Substituted Tetrazoles
DE2432560A1 (de) 1974-07-06 1976-01-22 Boehringer Mannheim Gmbh Neue phenoxyalkylcarbonsaeurederivate und verfahren zur herstellung derselben
JPS5832859A (ja) 1981-08-20 1983-02-25 Dainippon Pharmaceut Co Ltd N,n−ジメチルカルバミン酸ベンジルエステル誘導体
JPH0725725B2 (ja) 1987-07-23 1995-03-22 保土谷化学工業株式会社 ベンズアミド誘導体
US5084466A (en) 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
CA2090283A1 (en) 1992-02-28 1993-08-29 Nobuyuki Hamanaka Phenoxyacetic acid derivatives
JP3692536B2 (ja) 1994-02-10 2005-09-07 小野薬品工業株式会社 プロスタグランジンi2受容体
TW282456B (pt) 1994-03-10 1996-08-01 Fujisawa Yakusin Kogyo Kk
US5753700A (en) 1994-12-28 1998-05-19 Ono Pharmaceutical Co., Ltd. Naphthyloxyacetic acid derivatives
TW401408B (en) 1995-07-21 2000-08-11 Fujisawa Pharmaceutical Co Heterocyclic compounds having prostaglandin I2 agonism
EP0845451A4 (en) 1995-07-26 1999-10-13 Ono Pharmaceutical Co NAPHTHYLOXYACETIC ACID DERIVATIVES AND MEDICINAL PRODUCTS INTEGRATING THESE DERIVATIVES AS ACTIVE INGREDIENTS
DE19619445C1 (de) * 1996-05-14 1997-09-25 Bayer Ag Verfahren zur Herstellung von optisch aktiver N-Phenylcarbamat-milchsäure
AUPP029197A0 (en) 1997-11-10 1997-12-04 Fujisawa Pharmaceutical Co., Ltd. Benzocycloheptene derivatives
AUPP109097A0 (en) 1997-12-22 1998-01-22 Fujisawa Pharmaceutical Co., Ltd. Napthalene derivatives

Also Published As

Publication number Publication date
HUP9904659A3 (en) 2000-12-28
DE69911726T2 (de) 2004-07-29
DK1013639T3 (da) 2004-02-09
UY25876A1 (es) 2001-07-31
PL337419A1 (en) 2000-07-03
AR029320A1 (es) 2003-06-25
RU2179969C2 (ru) 2002-02-27
CN1266054A (zh) 2000-09-13
CA2292921C (en) 2004-08-17
PE20001368A1 (es) 2000-12-14
AU735640B2 (en) 2001-07-12
NO996366D0 (no) 1999-12-21
CN1167670C (zh) 2004-09-22
HU9904659D0 (en) 2000-02-28
ES2207108T3 (es) 2004-05-16
EP1013639B1 (en) 2003-10-01
KR100378335B1 (ko) 2003-03-29
KR20000048322A (ko) 2000-07-25
ATE251125T1 (de) 2003-10-15
TR199903310A2 (xx) 2000-10-23
BR9905974A (pt) 2000-09-12
HRP990394A2 (en) 2000-08-31
TWI221834B (en) 2004-10-11
MA26713A1 (fr) 2004-12-20
IL133578A (en) 2004-07-25
TR199903310A3 (tr) 2000-10-23
NZ501891A (en) 2001-10-26
NO996366L (no) 2000-06-26
CA2292921A1 (en) 2000-06-23
JP3415085B2 (ja) 2003-06-09
ID25983A (id) 2000-11-16
DE69911726D1 (de) 2003-11-06
YU69699A (sh) 2001-12-26
AU6534099A (en) 2000-07-06
IL133578A0 (en) 2001-04-30
NO316171B1 (no) 2003-12-22
SG90086A1 (en) 2002-07-23
HUP9904659A2 (hu) 2000-11-28
EP1013639A1 (en) 2000-06-28
US6335459B1 (en) 2002-01-01
JP2000191523A (ja) 2000-07-11

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