MA26713A1 - Modulateurs de recepteurs de la prostaglandine i2 (ip), procede pour leur preparation, composition pharmaceutique les contenant et leur utilisation - Google Patents

Modulateurs de recepteurs de la prostaglandine i2 (ip), procede pour leur preparation, composition pharmaceutique les contenant et leur utilisation

Info

Publication number: MA26713A1
Authority: MA; Morocco
Prior art keywords: prostaglandin; preparation; pharmaceutical composition; composition containing; receptor modulators
Prior art date: 1998-12-23

Application number

MA25866A

Other languages

English (en)

Inventor

Javier Lopez-Tapia Francisco

O'yang Counde

Lee Severance Daniel

Victor Muehldorf Alexander

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-23

Filing date

1999-12-20

Publication date

2004-12-20

1999-12-20 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-12-20 Publication of MA26713A1 publication Critical patent/MA26713A1/fr

Links

KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 title 2
229960001123 epoprostenol Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Gynecology & Obstetrics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)

MA25866A 1998-12-23 1999-12-20 Modulateurs de recepteurs de la prostaglandine i2 (ip), procede pour leur preparation, composition pharmaceutique les contenant et leur utilisation MA26713A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US11344698P	1998-12-23	1998-12-23
US15181499P	1999-08-30	1999-08-30

Publications (1)

Publication Number	Publication Date
MA26713A1 true MA26713A1 (fr)	2004-12-20

Family

ID=26811078

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA25866A MA26713A1 (fr)	1998-12-23	1999-12-20	Modulateurs de recepteurs de la prostaglandine i2 (ip), procede pour leur preparation, composition pharmaceutique les contenant et leur utilisation

Country Status (29)

Country	Link
US (1)	US6335459B1 (fr)
EP (1)	EP1013639B1 (fr)
JP (1)	JP3415085B2 (fr)
KR (1)	KR100378335B1 (fr)
CN (1)	CN1167670C (fr)
AR (1)	AR029320A1 (fr)
AT (1)	ATE251125T1 (fr)
AU (1)	AU735640B2 (fr)
BR (1)	BR9905974A (fr)
CA (1)	CA2292921C (fr)
DE (1)	DE69911726T2 (fr)
DK (1)	DK1013639T3 (fr)
ES (1)	ES2207108T3 (fr)
HR (1)	HRP990394A2 (fr)
HU (1)	HUP9904659A3 (fr)
ID (1)	ID25983A (fr)
IL (1)	IL133578A (fr)
MA (1)	MA26713A1 (fr)
NO (1)	NO316171B1 (fr)
NZ (1)	NZ501891A (fr)
PE (1)	PE20001368A1 (fr)
PL (1)	PL337419A1 (fr)
PT (1)	PT1013639E (fr)
RU (1)	RU2179969C2 (fr)
SG (1)	SG90086A1 (fr)
TR (1)	TR199903310A3 (fr)
TW (1)	TWI221834B (fr)
UY (1)	UY25876A1 (fr)
YU (1)	YU69699A (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9828442D0 (en)	1998-12-24	1999-02-17	Karobio Ab	Novel thyroid receptor ligands and method II
SE0100158D0 (sv) *	2001-01-19	2001-01-19	Synphora Ab	Novel method and composition for local treatment of Meniere´s disease and tinnitus
EP1368345B1 (fr) *	2001-03-02	2006-03-22	F. Hoffmann-La Roche AG	Derives d'acide alcoxycarbonylaminoheteroaryle carboxylique en tant qu'antagonistes d'ip
ES2636943T3 (es)	2003-05-09	2017-10-10	Toray Industries, Inc.	Beraprost y un inhibidor del sistema renina-angiotensina para usar en el tratamiento de enfermedades renales
RU2268037C1 (ru) *	2004-04-22	2006-01-20	Германов Евгений Павлович	Лекарственное средство
UA93548C2 (uk)	2006-05-05	2011-02-25	Айерем Елелсі	Сполуки та композиції як модулятори хеджхогівського сигнального шляху
US9669381B2 (en)	2007-06-27	2017-06-06	Hrd Corporation	System and process for hydrocracking
JP5536752B2 (ja)	2008-03-18	2014-07-02	アリーナファーマシューティカルズ，インコーポレイテッド	プロスタサイクリン（ｐｇｉ２）受容体に関連する障害の処置に有用なｐｇｉ２受容体の調節因子
BRPI0916282B8 (pt) *	2008-07-23	2021-05-25	Toray Industries	uso de um agonista do receptor-pgi2 no tratamento de insuficiência renal crônica
EP2995614B8 (fr)	2010-06-11	2018-03-28	Rhodes Technologies Inc.	Processus catalysés par des métaux de transition pour la préparation de composés de n-allyle et leur utilisation
AU2011263416B2 (en)	2010-06-11	2014-04-10	Rhodes Technologies	Process for N-dealkylation of tertiary amines
CN110582271B (zh)	2017-03-01	2022-06-14	阿瑞那制药公司	包含pgi2受体激动剂的组合物及其制备方法
KR20240149924A (ko)	2022-02-15	2024-10-15	유나이티드 세러퓨틱스 코오포레이션	결정질 프로스타시클린 (ip) 수용체 효능제 및 그의 용도

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1079414A (en)	1965-06-30	1967-08-16	Smith & Nephew	Derivatives of acetic acid and a process for their preparation
GB1185539A (en)	1967-11-03	1970-03-25	Smith & Nephew	Substituted Tetrazoles
DE2432560A1 (de)	1974-07-06	1976-01-22	Boehringer Mannheim Gmbh	Neue phenoxyalkylcarbonsaeurederivate und verfahren zur herstellung derselben
JPS5832859A (ja)	1981-08-20	1983-02-25	Dainippon Pharmaceut Co Ltd	Ｎ，ｎ−ジメチルカルバミン酸ベンジルエステル誘導体
JPH0725725B2 (ja)	1987-07-23	1995-03-22	保土谷化学工業株式会社	ベンズアミド誘導体
US5084466A (en)	1989-01-31	1992-01-28	Hoffmann-La Roche Inc.	Novel carboxamide pyridine compounds which have useful pharmaceutical utility
CA2090283A1 (fr)	1992-02-28	1993-08-29	Nobuyuki Hamanaka	Derives de l'acide phenoxyacetique
EP0753528A4 (fr)	1994-02-10	1999-03-10	Ono Pharmaceutical Co	Recepteur de la prostaglandine i 2?
ATE205479T1 (de)	1994-03-10	2001-09-15	Fujisawa Pharmaceutical Co	Naphtalen-derivate als prostaglandin i2 agonisten
US5753700A (en)	1994-12-28	1998-05-19	Ono Pharmaceutical Co., Ltd.	Naphthyloxyacetic acid derivatives
TW401408B (en)	1995-07-21	2000-08-11	Fujisawa Pharmaceutical Co	Heterocyclic compounds having prostaglandin I2 agonism
US6018068A (en)	1995-07-26	2000-01-25	Ono Pharmaceutical Co., Ltd.	Naphthyloxyacetic acid derivatives and drugs comprising the same as active ingredients
DE19619445C1 (de) *	1996-05-14	1997-09-25	Bayer Ag	Verfahren zur Herstellung von optisch aktiver N-Phenylcarbamat-milchsäure
AUPP029197A0 (en)	1997-11-10	1997-12-04	Fujisawa Pharmaceutical Co., Ltd.	Benzocycloheptene derivatives
AUPP109097A0 (en)	1997-12-22	1998-01-22	Fujisawa Pharmaceutical Co., Ltd.	Napthalene derivatives

1999
- 1999-12-07 US US09/456,167 patent/US6335459B1/en not_active Expired - Fee Related
- 1999-12-15 DE DE69911726T patent/DE69911726T2/de not_active Expired - Fee Related
- 1999-12-15 EP EP99125027A patent/EP1013639B1/fr not_active Expired - Lifetime
- 1999-12-15 PT PT99125027T patent/PT1013639E/pt unknown
- 1999-12-15 DK DK99125027T patent/DK1013639T3/da active
- 1999-12-15 ES ES99125027T patent/ES2207108T3/es not_active Expired - Lifetime
- 1999-12-15 AT AT99125027T patent/ATE251125T1/de not_active IP Right Cessation
- 1999-12-17 AU AU65340/99A patent/AU735640B2/en not_active Ceased
- 1999-12-17 NZ NZ501891A patent/NZ501891A/en unknown
- 1999-12-17 SG SG9906425A patent/SG90086A1/en unknown
- 1999-12-17 IL IL13357899A patent/IL133578A/en not_active IP Right Cessation
- 1999-12-20 HU HU9904659A patent/HUP9904659A3/hu unknown
- 1999-12-20 MA MA25866A patent/MA26713A1/fr unknown
- 1999-12-20 HR HR990394A patent/HRP990394A2/hr not_active Application Discontinuation
- 1999-12-21 AR ARP990106638A patent/AR029320A1/es not_active Application Discontinuation
- 1999-12-21 PE PE1999001307A patent/PE20001368A1/es not_active Application Discontinuation
- 1999-12-21 NO NO19996366A patent/NO316171B1/no unknown
- 1999-12-22 RU RU99127329/04A patent/RU2179969C2/ru not_active IP Right Cessation
- 1999-12-22 KR KR10-1999-0060163A patent/KR100378335B1/ko not_active Expired - Fee Related
- 1999-12-22 CA CA002292921A patent/CA2292921C/fr not_active Expired - Fee Related
- 1999-12-22 JP JP36452099A patent/JP3415085B2/ja not_active Expired - Fee Related
- 1999-12-22 UY UY25876A patent/UY25876A1/es unknown
- 1999-12-22 ID IDP991169D patent/ID25983A/id unknown
- 1999-12-23 TW TW088122774A patent/TWI221834B/zh not_active IP Right Cessation
- 1999-12-23 TR TR1999/03310A patent/TR199903310A3/tr unknown
- 1999-12-23 YU YU69699A patent/YU69699A/sh unknown
- 1999-12-23 CN CNB991277953A patent/CN1167670C/zh not_active Expired - Fee Related
- 1999-12-23 PL PL99337419A patent/PL337419A1/xx not_active Application Discontinuation
- 1999-12-23 BR BR9905974-6A patent/BR9905974A/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO996366D0 (no)	1999-12-21
BR9905974A (pt)	2000-09-12
NO996366L (no)	2000-06-26
DK1013639T3 (da)	2004-02-09
TR199903310A2 (xx)	2000-10-23
PL337419A1 (en)	2000-07-03
SG90086A1 (en)	2002-07-23
NO316171B1 (no)	2003-12-22
CA2292921A1 (fr)	2000-06-23
CN1266054A (zh)	2000-09-13
JP2000191523A (ja)	2000-07-11
CN1167670C (zh)	2004-09-22
DE69911726T2 (de)	2004-07-29
JP3415085B2 (ja)	2003-06-09
EP1013639A1 (fr)	2000-06-28
HUP9904659A3 (en)	2000-12-28
AU6534099A (en)	2000-07-06
ATE251125T1 (de)	2003-10-15
ES2207108T3 (es)	2004-05-16
HU9904659D0 (en)	2000-02-28
KR100378335B1 (ko)	2003-03-29
HRP990394A2 (en)	2000-08-31
PT1013639E (pt)	2004-02-27
IL133578A0 (en)	2001-04-30
YU69699A (sh)	2001-12-26
EP1013639B1 (fr)	2003-10-01
CA2292921C (fr)	2004-08-17
IL133578A (en)	2004-07-25
DE69911726D1 (de)	2003-11-06
HUP9904659A2 (hu)	2000-11-28
RU2179969C2 (ru)	2002-02-27
NZ501891A (en)	2001-10-26
PE20001368A1 (es)	2000-12-14
AU735640B2 (en)	2001-07-12
KR20000048322A (ko)	2000-07-25
ID25983A (id)	2000-11-16
UY25876A1 (es)	2001-07-31
TR199903310A3 (tr)	2000-10-23
US6335459B1 (en)	2002-01-01
TWI221834B (en)	2004-10-11
AR029320A1 (es)	2003-06-25

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MA26451A1 (fr)	2004-12-20	Amides inhibiteurs de secretion de apo b/mtp, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA26713A1 (fr)	2004-12-20	Modulateurs de recepteurs de la prostaglandine i2 (ip), procede pour leur preparation, composition pharmaceutique les contenant et leur utilisation
MA26687A1 (fr)	2004-12-20	4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinoleines, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26424A1 (fr)	2004-12-20	Derives de 6-phenylpyridyl-2-amine, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2718136B1 (fr)	1996-06-21	Composés aromatiques aminés, procédé pour leur obtention et compositions pharmaceutiques les contenant.
MA26479A1 (fr)	2004-12-20	Derives de nicotinamide, procede pour leur preparation et compositions pharmaceutiques les contenant
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MA26508A1 (fr)	2004-12-20	Formulations pharmaceutiques contenant du variconazole, et procede pour leur preparation.
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