PT1054892E - Peptidomimeticos de azol como antagonistas do receptor de trombina - Google Patents

Peptidomimeticos de azol como antagonistas do receptor de trombina

Info

Publication number
PT1054892E
PT1054892E PT99905837T PT99905837T PT1054892E PT 1054892 E PT1054892 E PT 1054892E PT 99905837 T PT99905837 T PT 99905837T PT 99905837 T PT99905837 T PT 99905837T PT 1054892 E PT1054892 E PT 1054892E
Authority
PT
Portugal
Prior art keywords
trombine
azolic
peptidomimetics
receptor antagonists
useful
Prior art date
Application number
PT99905837T
Other languages
English (en)
Inventor
William Hoekstra
Becky L Hulshizer
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of PT1054892E publication Critical patent/PT1054892E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT99905837T 1998-02-19 1999-02-08 Peptidomimeticos de azol como antagonistas do receptor de trombina PT1054892E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7517198P 1998-02-19 1998-02-19

Publications (1)

Publication Number Publication Date
PT1054892E true PT1054892E (pt) 2002-12-31

Family

ID=22124023

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99905837T PT1054892E (pt) 1998-02-19 1999-02-08 Peptidomimeticos de azol como antagonistas do receptor de trombina

Country Status (10)

Country Link
EP (1) EP1054892B1 (pt)
JP (1) JP2002504490A (pt)
AT (1) ATE223928T1 (pt)
AU (1) AU2590799A (pt)
CA (1) CA2321104A1 (pt)
DE (1) DE69902887T2 (pt)
DK (1) DK1054892T3 (pt)
ES (1) ES2183515T3 (pt)
PT (1) PT1054892E (pt)
WO (1) WO1999042475A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU42401A (sh) 1998-12-14 2003-12-31 Ortho-Mcneil Pharmaceuticals Inc. Supstituisani heterociklični acil-tripeptidi korisni kao modulatori receptora trombina
WO2001000656A2 (en) 1999-06-29 2001-01-04 Ortho-Mcneil Pharmaceutical, Inc. Novel indazole peptidomimetics as thrombin receptor antagonists
US6365617B1 (en) 1999-06-29 2002-04-02 Ortho-Mcneil Pharmaceutical, Inc. Indole and indazole urea-peptoids as thrombin receptor antagonists
US6858577B1 (en) 1999-06-29 2005-02-22 Ortho-Mcneil Pharmaceutical, Inc. Indole peptidomimetics as thrombin receptor antagonists
US6630451B1 (en) 1999-06-29 2003-10-07 Orthomcneil Pharmaceutical, Inc. Benzimidazolone peptidometics as thrombin receptor antagonist
US7622593B2 (en) 2006-06-27 2009-11-24 The Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
EP2982756A1 (en) * 2014-08-04 2016-02-10 Berlin Cures Holding AG Aptamers for use against autoantibody-associated diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL106197A (en) * 1992-07-30 1999-11-30 Cor Therapeutics Inc Agagonists for the rhombin receptors and pharmaceutical preparations containing them
JPH07285952A (ja) * 1994-04-08 1995-10-31 Fujisawa Pharmaceut Co Ltd 新規複素環誘導体

Also Published As

Publication number Publication date
EP1054892A1 (en) 2000-11-29
DE69902887D1 (de) 2002-10-17
CA2321104A1 (en) 1999-08-26
DK1054892T3 (da) 2003-01-20
WO1999042475A1 (en) 1999-08-26
EP1054892B1 (en) 2002-09-11
AU2590799A (en) 1999-09-06
DE69902887T2 (de) 2003-08-07
ATE223928T1 (de) 2002-09-15
JP2002504490A (ja) 2002-02-12
HK1031388A1 (en) 2001-06-15
ES2183515T3 (es) 2003-03-16

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