PT1147103E - Fenantridina-n-oxidos com actividade inibitoria de pde-iv - Google Patents

Fenantridina-n-oxidos com actividade inibitoria de pde-iv

Info

Publication number
PT1147103E
PT1147103E PT00901539T PT00901539T PT1147103E PT 1147103 E PT1147103 E PT 1147103E PT 00901539 T PT00901539 T PT 00901539T PT 00901539 T PT00901539 T PT 00901539T PT 1147103 E PT1147103 E PT 1147103E
Authority
PT
Portugal
Prior art keywords
oxides
fenantridine
pde
inhibitors activity
inhibitors
Prior art date
Application number
PT00901539T
Other languages
English (en)
Inventor
Rolf Beume
Hildegard Boss
Dieter Flockerzi
Beate Schmidt
Armin Hatzelmann
Hermann Amschler
Kley Hans-Peter
Bundschuh Daniela
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of PT1147103E publication Critical patent/PT1147103E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Junction Field-Effect Transistors (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT00901539T 1999-01-15 2000-01-13 Fenantridina-n-oxidos com actividade inibitoria de pde-iv PT1147103E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99100693 1999-01-15

Publications (1)

Publication Number Publication Date
PT1147103E true PT1147103E (pt) 2005-08-31

Family

ID=8237350

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00901539T PT1147103E (pt) 1999-01-15 2000-01-13 Fenantridina-n-oxidos com actividade inibitoria de pde-iv

Country Status (12)

Country Link
US (1) US6534519B1 (pt)
EP (1) EP1147103B1 (pt)
JP (1) JP2003502278A (pt)
AT (1) ATE294793T1 (pt)
AU (1) AU2290000A (pt)
CA (1) CA2359449A1 (pt)
DE (1) DE60019894T2 (pt)
DK (1) DK1147103T3 (pt)
ES (1) ES2241571T3 (pt)
PT (1) PT1147103E (pt)
SI (1) SI1147103T1 (pt)
WO (1) WO2000042034A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60024581T2 (de) * 1999-01-15 2006-08-10 Altana Pharma Ag 6-phenylphenanthridine mit pde-iv hemmender wirkung
EP1250325B1 (en) 2000-01-11 2008-05-07 Nycomed GmbH Phenanthridine-n-oxides
ATE288430T1 (de) 2000-07-14 2005-02-15 Altana Pharma Ag 6-heteroarylphenanthridine
US7423046B2 (en) 2002-08-29 2008-09-09 Nycomed Gmbh 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
AU2003255493B8 (en) * 2002-08-29 2009-03-26 Takeda Gmbh 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors
WO2005012252A1 (en) * 2003-07-31 2005-02-10 Altana Pharma Ag Novel 6-phenylphenantridines
US20060189641A1 (en) * 2003-07-31 2006-08-24 Beate Schmidt Novel 6-phenlyphenanthridines
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
WO2005023253A1 (en) * 2003-09-05 2005-03-17 Altana Pharma Ag Use of pde4 inhibitors for the treatment of diabetes mellitus
WO2005077906A1 (en) 2004-02-18 2005-08-25 Altana Pharma Ag Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
SG182194A1 (en) 2004-03-03 2012-07-30 Nycomed Gmbh Novel hydroxy-6-heteroarylphenanthridines and their use as pde4 inhibitors
NZ549254A (en) * 2004-03-10 2010-06-25 Nycomed Gmbh Amido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors
SI1856093T1 (sl) * 2005-03-02 2010-03-31 Nycomed Gmbh Hidrokloridna sol R aR bR dimetoksipiridin il etoksi metoksi a b heksahidrofenantridin ola
AU2006222060B2 (en) 2005-03-08 2011-09-01 Takeda Gmbh Roflumilast for the treatment of diabetes mellitus
WO2009043784A1 (en) 2007-10-04 2009-04-09 F. Hoffmann-La Roche Ag Cyclopropyl aryl amide derivatives and uses thereof
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455252A (en) * 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
US5475003A (en) * 1994-03-03 1995-12-12 Syntex (U.S.A.) Inc. 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
US5466697A (en) * 1994-07-13 1995-11-14 Syntex (U.S.A.) Inc. 8-phenyl-1,6-naphthyridin-5-ones
BR9707233A (pt) 1996-01-31 1999-07-20 Byk Gulden Lomberg Chem Fab Fenantridinas
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
EP0889886B1 (de) * 1996-03-26 2002-09-18 ALTANA Pharma AG Neue in 6-position substituierte phenanthridine
GB9622386D0 (en) * 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
GEP20012390B (en) 1996-11-11 2001-03-25 Byk Gulden Lomberg Chem Fab Benzonaphthyridines as Bronchial Therapeutics
GB9626643D0 (en) 1996-12-21 1997-02-12 Astra Pharma Prod Compounds
US6143759A (en) 1997-03-07 2000-11-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrazoles
AU8106598A (en) 1997-06-03 1998-12-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine
PL190685B1 (pl) * 1997-07-25 2005-12-30 Altana Pharma Ag Nowe pochodne tetrazolu, środek farmaceutyczny oraz zastosowanie
JP2002523505A (ja) 1998-08-31 2002-07-30 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング Ｐｄｅ３−及びｐｄｅ−４抑制作用を有するベンゾナフチリデン−ｎ−オキシド

Also Published As

Publication number Publication date
EP1147103A1 (en) 2001-10-24
EP1147103B1 (en) 2005-05-04
ES2241571T3 (es) 2005-11-01
SI1147103T1 (en) 2005-10-31
US6534519B1 (en) 2003-03-18
DE60019894D1 (de) 2005-06-09
WO2000042034A1 (en) 2000-07-20
CA2359449A1 (en) 2000-07-20
JP2003502278A (ja) 2003-01-21
AU2290000A (en) 2000-08-01
DK1147103T3 (da) 2005-08-29
ATE294793T1 (de) 2005-05-15
DE60019894T2 (de) 2006-01-12

Similar Documents

Publication Publication Date Title
NO20013341L (no) Fenylfenantridiner med PDE-IV inhiberende aktivitet
BR9707233A (pt) Fenantridinas
EE200000033A (et) Uudsed tetrasoolderivaadid
DK1147103T3 (da) Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet
PT937074E (pt) Benzonaftiridinas como terapeutica bronquica
AU2904300A (en) Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity
DK1109810T3 (da) Benzonaphthydin-N-oxider med PDE3- og PDE4-inhiberende aktivitet
PT1147088E (pt) 6-arilfenantridinas com actividade inibitoria da pde-iv
PT1147087E (pt) Feantridina-n-oxidos com actividade de inibicao de pde-iv
ATE258930T1 (de) Dihydrobenzifurane