PT1284977E - Compostos de tienodibenzoazuleno como inibidores do factor de necrose tumoral - Google Patents

Compostos de tienodibenzoazuleno como inibidores do factor de necrose tumoral Download PDF

Info

Publication number: PT1284977E
Authority: PT; Portugal
Prior art keywords: compounds; necrosis factor; tumor necrosis; thienodibenzoazulene; factor inhibitors
Prior art date: 2000-05-17

Application number

PT01929882T

Other languages

English (en)

Inventor

Mladen Mercep

Milan Mesic

Dijana Pesic

Zeljko Zupanovic

Boska Hrvacic

Original Assignee

Glaxosmithkline Zagreb

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-17

Filing date

2001-05-16

Publication date

2009-09-09

2001-05-16 Application filed by Glaxosmithkline Zagreb filed Critical Glaxosmithkline Zagreb

2009-09-09 Publication of PT1284977E publication Critical patent/PT1284977E/pt

Links

150000001875 compounds Chemical class 0.000 title abstract 3
229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 title 1
239000002451 tumor necrosis factor inhibitor Substances 0.000 title 1
108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 2
102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

PT01929882T 2000-05-17 2001-05-16 Compostos de tienodibenzoazuleno como inibidores do factor de necrose tumoral PT1284977E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HR20000310A HRP20000310A2 (en)	2000-05-17	2000-05-17	New dibenzoazulene compounds as tumor necrosis factor inhibitors

Publications (1)

Publication Number	Publication Date
PT1284977E true PT1284977E (pt)	2009-09-09

Family

ID=10947110

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT01929882T PT1284977E (pt)	2000-05-17	2001-05-16	Compostos de tienodibenzoazuleno como inibidores do factor de necrose tumoral

Country Status (36)

Country	Link
US (2)	US6897211B2 (pt)
EP (1)	EP1284977B1 (pt)
JP (1)	JP2003533528A (pt)
KR (1)	KR100823064B1 (pt)
CN (1)	CN1194976C (pt)
AR (1)	AR030562A1 (pt)
AT (1)	ATE434619T1 (pt)
AU (2)	AU2001256560B2 (pt)
BG (1)	BG65967B1 (pt)
BR (1)	BR0111202A (pt)
CA (1)	CA2409090C (pt)
CR (1)	CR6860A (pt)
CY (1)	CY1109328T1 (pt)
CZ (1)	CZ301770B6 (pt)
DE (1)	DE60139070D1 (pt)
DK (1)	DK1284977T3 (pt)
DZ (1)	DZ3357A1 (pt)
EA (1)	EA006069B1 (pt)
EE (1)	EE200200636A (pt)
ES (1)	ES2328335T3 (pt)
GE (1)	GEP20043304B (pt)
HR (1)	HRP20000310A2 (pt)
HU (1)	HUP0302295A3 (pt)
IL (1)	IL152809A0 (pt)
IS (1)	IS6621A (pt)
MA (1)	MA27125A1 (pt)
MX (1)	MXPA02011269A (pt)
NO (1)	NO20025510L (pt)
NZ (1)	NZ522553A (pt)
PL (1)	PL204849B1 (pt)
PT (1)	PT1284977E (pt)
RS (1)	RS50893B (pt)
SI (1)	SI1284977T1 (pt)
SK (1)	SK17702002A3 (pt)
WO (1)	WO2001087890A1 (pt)
ZA (1)	ZA200209180B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20020303A8 (en)	2002-04-10	2009-03-31	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	Benzonaphthoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020305A8 (en) *	2002-04-10	2009-03-31	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020304B1 (en) *	2002-04-10	2008-04-30	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof
HRP20020440B1 (en)	2002-05-21	2008-02-29	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
HRP20020441A2 (en) *	2002-05-21	2003-12-31	Pliva D D	1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20020453A2 (en)	2002-05-23	2003-12-31	Pliva D D	1,3-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20020452A2 (en)	2002-05-23	2004-02-29	Pliva D D	1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof
HRP20020451A2 (en) *	2002-05-23	2003-12-31	Pliva D D	1-tia-3-aza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof
HRP20030160A2 (en) *	2003-03-06	2005-04-30	Pliva-Istra�iva�ki institut d.o.o.	1-thiadibenzoazulene derivatives and biological action thereof
HRP20030324A2 (en)	2003-04-24	2005-02-28	Pliva-Istra�iva�ki institut d.o.o.	Compounds of antiinflammatory effect
CA2575975A1 (en) *	2003-11-12	2005-05-26	Dr. Reddy's Laboratories, Inc.	Preparation of escitalopram
HRP20030955A2 (en) *	2003-11-21	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030954A2 (en) *	2003-11-21	2005-08-31	Pliva D.D.	USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20040104A2 (en) *	2004-01-30	2005-10-31	Pliva-Istra�iva�ki institut d.o.o.	Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
US20090048221A1 (en)	2004-10-27	2009-02-19	Mladen Mercep	Conjugates with Anti-Inflammatory Activity
RU2401257C2 (ru) *	2004-12-07	2010-10-10	Янссен Фармацевтика Н.В.	Новые замещенные тетрациклические производные тетрагидрофурана, пирролидина и тетрагидротиофена
JP2008532927A (ja) *	2005-01-13	2008-08-21	グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ	抗炎症マクロライド接合体
DK2026651T3 (da)	2006-03-08	2013-07-08	Cortria Corp	Kombinationsterapi med ikke-selektive COX-inhibitorer til forebyggelse af COX-relaterede maveskader
EP2114427B1 (en)	2007-01-30	2014-06-25	New York University	Peptides for treatment of conditions associated with nitric oxide
WO2008096755A1 (ja) *	2007-02-07	2008-08-14	Nippon Suisan Kaisha, Ltd.	バニロイド受容体（ｖｒ１）阻害剤及びその用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3711489A (en) *	1971-03-31	1973-01-16	Pfizer	Certain 8,9-dihydro(3,4,7,8)cycloocta(1,2-d)imidazoles
JPS53116385A (en) *	1977-03-19	1978-10-11	Hokuriku Pharmaceutical	Pyrazin derivative and method for its production
US4198421A (en) *	1978-11-30	1980-04-15	E. I. Du Pont De Nemours And Company	Antiinflammatory 2-substituted-dibenzo[2,3:6,7]oxepino[4,5-d]imidazoles
DE69720709T2 (de) *	1996-04-12	2004-03-11	Janssen Pharmaceutica N.V.	Substituierte tetracyclische tetrahydrofuranderivate
GB9713368D0 (en) *	1997-06-25	1997-08-27	Weston Medical Ltd	Flame control
EP0887339A1 (de) *	1997-06-27	1998-12-30	Boehringer Mannheim Gmbh	Neue Azulenderivate und diese enthaltende Arzneimittel

2000
- 2000-05-17 HR HR20000310A patent/HRP20000310A2/hr not_active Application Discontinuation
2001
- 2001-05-16 RS YUP-841/02A patent/RS50893B/sr unknown
- 2001-05-16 GE GE5019A patent/GEP20043304B/en unknown
- 2001-05-16 EP EP01929882A patent/EP1284977B1/en not_active Expired - Lifetime
- 2001-05-16 CA CA2409090A patent/CA2409090C/en not_active Expired - Fee Related
- 2001-05-16 WO PCT/HR2001/000027 patent/WO2001087890A1/en not_active Ceased
- 2001-05-16 HU HU0302295A patent/HUP0302295A3/hu unknown
- 2001-05-16 SK SK1770-2002A patent/SK17702002A3/sk unknown
- 2001-05-16 NZ NZ522553A patent/NZ522553A/en unknown
- 2001-05-16 DE DE60139070T patent/DE60139070D1/de not_active Expired - Lifetime
- 2001-05-16 KR KR1020027015567A patent/KR100823064B1/ko not_active Expired - Fee Related
- 2001-05-16 AU AU2001256560A patent/AU2001256560B2/en not_active Ceased
- 2001-05-16 CZ CZ20024090A patent/CZ301770B6/cs not_active IP Right Cessation
- 2001-05-16 JP JP2001584284A patent/JP2003533528A/ja active Pending
- 2001-05-16 EE EEP200200636A patent/EE200200636A/xx unknown
- 2001-05-16 AT AT01929882T patent/ATE434619T1/de not_active IP Right Cessation
- 2001-05-16 PL PL365054A patent/PL204849B1/pl not_active IP Right Cessation
- 2001-05-16 EA EA200201223A patent/EA006069B1/ru not_active IP Right Cessation
- 2001-05-16 CN CNB018115896A patent/CN1194976C/zh not_active Expired - Fee Related
- 2001-05-16 ES ES01929882T patent/ES2328335T3/es not_active Expired - Lifetime
- 2001-05-16 MX MXPA02011269A patent/MXPA02011269A/es active IP Right Grant
- 2001-05-16 IL IL15280901A patent/IL152809A0/xx unknown
- 2001-05-16 AU AU5656001A patent/AU5656001A/xx active Pending
- 2001-05-16 PT PT01929882T patent/PT1284977E/pt unknown
- 2001-05-16 DZ DZ013357A patent/DZ3357A1/fr active
- 2001-05-16 DK DK01929882T patent/DK1284977T3/da active
- 2001-05-16 BR BR0111202-3A patent/BR0111202A/pt not_active Application Discontinuation
- 2001-05-16 SI SI200130930T patent/SI1284977T1/sl unknown
- 2001-05-17 AR ARP010102339A patent/AR030562A1/es active IP Right Grant
2002
- 2002-11-11 MA MA26901A patent/MA27125A1/fr unknown
- 2002-11-12 ZA ZA200209180A patent/ZA200209180B/en unknown
- 2002-11-14 IS IS6621A patent/IS6621A/is unknown
- 2002-11-15 NO NO20025510A patent/NO20025510L/no not_active Application Discontinuation
- 2002-11-18 US US10/298,217 patent/US6897211B2/en not_active Expired - Fee Related
- 2002-12-17 BG BG107399A patent/BG65967B1/bg unknown
- 2002-12-17 CR CR6860A patent/CR6860A/es not_active Application Discontinuation
2005
- 2005-03-25 US US11/090,743 patent/US20050171091A1/en not_active Abandoned
2009
- 2009-08-20 CY CY20091100888T patent/CY1109328T1/el unknown

Also Published As

Publication number	Publication date
HRP20000310A2 (en)	2002-02-28
HK1056719A1 (en)	2004-02-27
DK1284977T3 (da)	2009-09-14
WO2001087890A1 (en)	2001-11-22
RS50893B (sr)	2010-08-31
US20050171091A1 (en)	2005-08-04
AU2001256560B2 (en)	2005-10-06
EP1284977B1 (en)	2009-06-24
MXPA02011269A (es)	2003-06-06
DE60139070D1 (de)	2009-08-06
KR20030010625A (ko)	2003-02-05
ATE434619T1 (de)	2009-07-15
US20030153750A1 (en)	2003-08-14
SK17702002A3 (sk)	2003-10-07
ZA200209180B (en)	2003-11-12
US6897211B2 (en)	2005-05-24
AU5656001A (en)	2001-11-26
BG65967B1 (bg)	2010-07-30
IS6621A (is)	2002-11-14
SI1284977T1 (sl)	2009-10-31
HUP0302295A2 (hu)	2003-10-28
CN1194976C (zh)	2005-03-30
NO20025510D0 (no)	2002-11-15
NO20025510L (no)	2003-01-14
PL204849B1 (pl)	2010-02-26
YU84102A (sh)	2006-01-16
BR0111202A (pt)	2003-04-01
KR100823064B1 (ko)	2008-04-18
BG107399A (bg)	2003-09-30
PL365054A1 (en)	2004-12-27
CN1437605A (zh)	2003-08-20
CA2409090A1 (en)	2001-11-22
IL152809A0 (en)	2003-06-24
CA2409090C (en)	2010-06-29
EE200200636A (et)	2004-04-15
AR030562A1 (es)	2003-08-27
CR6860A (es)	2008-06-02
GEP20043304B (en)	2004-02-10
MA27125A1 (fr)	2005-01-03
HUP0302295A3 (en)	2007-03-28
EP1284977A1 (en)	2003-02-26
CZ301770B6 (cs)	2010-06-16
DZ3357A1 (fr)	2001-11-22
JP2003533528A (ja)	2003-11-11
CZ20024090A3 (cs)	2003-05-14
ES2328335T3 (es)	2009-11-12
EA200201223A1 (ru)	2003-06-26
EA006069B1 (ru)	2005-08-25
CY1109328T1 (el)	2012-05-23
NZ522553A (en)	2005-04-29

Publication	Publication Date	Title
PL365054A1 (en)	2004-12-27	Thienodibenzoazulene compounds as tumor necrosis factor inhibitors
PL360495A1 (en)	2004-09-06	Arylmethylamine derivatives for use as tryptase inhibitors
NO20050851L (no)	2005-03-29	Kaspase-inhibitorer og anvendelser derav
MXPA05010958A (es)	2006-01-30	Derivados indazol como inhibidores jnk.
BG105653A (bg)	2002-01-31	Ароматни хетероциклени съединения като противовъзпалителни средства
MX9803851A (es)	1998-09-30	Compuestos macrociclicos novedosos como inhibidores de metaloproteasas.
HU9602664D0 (en)	1996-11-28	Pyrimidinyl derivatives as interleukin inhibitors
GB0112348D0 (en)	2001-07-11	Compounds
IS9037A (is)	2014-01-28	P38 kínasatálmar að stofni til úr 5 hluta heteróhring
EA200201276A1 (ru)	2003-06-26	Производные арилметиламина для использования в качестве ингибиторов триптазы
WO1999009000A3 (en)	1999-09-10	Novel inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis
AU2003224923A1 (en)	2003-10-27	Heterocyclic amide derivatives as cytokine inhibitors
AU2001266289A1 (en)	2002-01-02	2-arachidonylglycerol (2-ag) - an inhibitor of tumor necrosis factor -alfa and neuroprotector of brain in closed head injury
AU7385398A (en)	1998-12-08	Novel macrocyclic compounds as metalloprotease inhibitors
DE60230155D1 (de)	2009-01-15	Verwendung von verzweigtkettigen fettsäuren und ihrer derivate zur schmerzbehandlung
ITMI20042475A1 (it)	2005-03-23	Uso di derivati tiazolidinonici come agenti terapeutici
FI974444A0 (fi)	1997-12-05	N-hydroksiureayhdisteitä anti-inflammatorisina aineina
ATE320797T1 (de)	2006-04-15	Verwendung von 6-dimethylaminomethyl-1-phenyl- cyclohexanverbindungen zur therapie der harninkontinenz
SE0004827D0 (sv)	2000-12-22	Therapeutic compounds
NO972906D0 (no)	1997-06-20	4,4-(Disubstituerte)cykloheksan-1-ol-monomerer og beslektede forbindelser
EA199800372A1 (ru)	1998-10-29	Новые макроциклические соединения-ингибиторы