PT1299729E - Diagnostico precoce de doencas conformacionais - Google Patents

Diagnostico precoce de doencas conformacionais

Info

Publication number
PT1299729E
PT1299729E PT01938411T PT01938411T PT1299729E PT 1299729 E PT1299729 E PT 1299729E PT 01938411 T PT01938411 T PT 01938411T PT 01938411 T PT01938411 T PT 01938411T PT 1299729 E PT1299729 E PT 1299729E
Authority
PT
Portugal
Prior art keywords
early diagnosis
conformational diseases
conformational
diseases
diagnosis
Prior art date
Application number
PT01938411T
Other languages
English (en)
Inventor
Soto Claudio
Saborio Gabriella
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of PT1299729E publication Critical patent/PT1299729E/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT01938411T 2000-07-07 2001-06-13 Diagnostico precoce de doencas conformacionais PT1299729E (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00114650 2000-07-07
EP00127892 2000-12-20
EP01102732 2001-02-07

Publications (1)

Publication Number Publication Date
PT1299729E true PT1299729E (pt) 2006-10-31

Family

ID=27223071

Family Applications (2)

Application Number Title Priority Date Filing Date
PT01938411T PT1299729E (pt) 2000-07-07 2001-06-13 Diagnostico precoce de doencas conformacionais
PT06015975T PT1712920E (pt) 2000-07-07 2001-06-13 Diagnóstico precoce de doenças conformacionais

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT06015975T PT1712920E (pt) 2000-07-07 2001-06-13 Diagnóstico precoce de doenças conformacionais

Country Status (30)

Country Link
US (1) US7351526B2 (pt)
EP (2) EP1299729B1 (pt)
JP (1) JP4790966B2 (pt)
KR (1) KR100764981B1 (pt)
CN (1) CN1221807C (pt)
AR (1) AR029583A1 (pt)
AT (2) ATE426816T1 (pt)
AU (2) AU6408901A (pt)
BG (1) BG66272B1 (pt)
BR (1) BRPI0112262B8 (pt)
CA (1) CA2413078C (pt)
CY (1) CY1109106T1 (pt)
CZ (1) CZ304365B6 (pt)
DE (2) DE60138146D1 (pt)
DK (2) DK1712920T3 (pt)
EA (1) EA007391B1 (pt)
EE (1) EE05675B1 (pt)
ES (2) ES2322660T3 (pt)
HR (1) HRP20030033B1 (pt)
HU (1) HU228813B1 (pt)
IL (2) IL153824A0 (pt)
MX (1) MXPA03000226A (pt)
NO (1) NO331624B1 (pt)
NZ (1) NZ523213A (pt)
PL (1) PL211154B1 (pt)
PT (2) PT1299729E (pt)
RS (1) RS51523B (pt)
SI (2) SI1712920T1 (pt)
SK (1) SK287768B6 (pt)
WO (1) WO2002004954A2 (pt)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002073210A1 (de) * 2001-03-13 2002-09-19 Manfred Eigen Verfahren zur verstärkung der bildung von aggregaten aus proteinuntereinheiten
EP1395833B1 (en) 2001-05-31 2013-02-27 Adlyfe, Inc. Misfolded protein sensor method
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
AU2004248302B2 (en) * 2003-06-19 2009-07-30 Merck Serono Sa Use of prion conversion modulating agents
DE10328125A1 (de) * 2003-06-23 2005-01-13 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach spontaner Transformationsreaktion
DE10328830A1 (de) * 2003-06-26 2005-01-20 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach asymmetrischer Interaktion
US20070054322A1 (en) * 2003-07-31 2007-03-08 Hadasit Medical Research Services & Development Lt Methods and kits for the detection of prion diseases
NZ580256A (en) 2003-08-13 2011-07-29 Novartis Vaccines & Diagnostic Prion-specific peptide reagents comprising the sequence KKRPKPGG
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
JP4568840B2 (ja) * 2004-12-28 2010-10-27 国立大学法人金沢大学 アルツハイマー病の検査方法
US8372593B2 (en) * 2005-02-15 2013-02-12 Adlyfe, Inc. Method for detecting misfolded proteins and prions
EP1882188A2 (en) * 2005-04-20 2008-01-30 Board of Regents, The University of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification
EP1731911A1 (fr) * 2005-06-07 2006-12-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Procédé utile pour la détection d'encéphalopathies
DE102005031429A1 (de) * 2005-07-04 2007-01-11 Heinrich-Heine-Universität Düsseldorf Verfahren zur selektiven Bestimmung pathologischer Proteinablagerungen
EP1931695B1 (en) 2005-09-09 2013-04-10 Novartis AG Prion-specific peptoid reagents
US20070281367A1 (en) 2006-05-03 2007-12-06 Applera Corporation Methods, Compositions, and Kits for Quantitating Antibodies
JP5097206B2 (ja) 2006-07-28 2012-12-12 エイディーライフ インコーポレイティッド 診断および治療のためのペプチドプローブ
CA2662863A1 (en) * 2006-09-06 2008-03-13 The Board Of Regents Of The University Of Texas System Methods and compositions for the detection of protein folding disorders
WO2009015091A1 (en) * 2007-07-20 2009-01-29 The Government of the United States of America as represented by the Secretary of the Detection of infectious prion protein by seeded conversion of recombinant prion protein
FR2929290B1 (fr) * 2008-03-27 2010-05-07 Lfb Biotechnologies Methode de detection et/ou de titrage in vitro d'un agent transmissible non conventionnel
WO2009145194A1 (ja) 2008-05-28 2009-12-03 独立行政法人農業・食品産業技術総合研究機構 羊スクレイピー由来異常プリオン蛋白質の効率的増幅方法
EP2280029A4 (en) 2008-05-28 2014-10-01 Inc Admin Agency Naro METHOD FOR THE EFFICIENT REINFORCEMENT OF BSE DERIVED ABNORMAL PRION PROTEINS
ITMI20081052A1 (it) * 2008-06-10 2009-12-11 Univ Milano Bicocca Liposomi in grado di legare efficacemente il peptide beta-amiloide
FR2935711A1 (fr) * 2008-09-05 2010-03-12 Lfb Biotechnologies Clone cellulaire stable exprimant un prion
JP2013510297A (ja) * 2009-11-04 2013-03-21 ノバルティス アーゲー モノマーからのタンパク質凝集体の分離における結合試薬としての正に荷電した種
US10215763B2 (en) * 2010-05-18 2019-02-26 Board Of Regents Of The University Of Texas System Methods for estimating prion concentration in fluids and tissue by quantitative PMCA
IT1405762B1 (it) 2010-11-25 2014-01-24 Icgeb Proteine ricombinanti con attivita' di inattivazione selettiva di proteine bersaglio
CN103460049B (zh) * 2011-01-18 2016-08-17 美国政府(由卫生和人类服务部的部长所代表) 扩增和检测朊病毒的方法
FR2973114A1 (fr) 2011-03-21 2012-09-28 Ets Francais Du Sang Nanobilles recouvertes de plasminogene comme support direct d'amplification cyclique de la proteine prion prpsc
WO2013056841A1 (en) 2011-10-19 2013-04-25 Inra (Institut National De La Recherche Agronomique) A method for diagnosing tse
KR101483438B1 (ko) * 2014-04-17 2015-01-16 한림대학교 산학협력단 극미량 병원성 프리온 단백질 검출방법 및 장치
WO2016040903A1 (en) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of misfolded amyloid beta protein
EP3191599B1 (en) 2014-09-11 2023-08-02 Board Of Regents Of the University Of Texas System Detection of misfolded proteins
WO2016040905A1 (en) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of misfolded alpha synuclein protein
US10359434B2 (en) 2014-10-22 2019-07-23 Colorado State University Research Foundation In vitro detection of prions in blood
WO2016149537A1 (en) 2015-03-17 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains
TW201901153A (zh) 2017-05-16 2019-01-01 美商安培恩股份有限公司 折疊錯誤之ｔａｕ蛋白的檢測及檢測折疊錯誤之ｔａｕ蛋白的套組
WO2019222554A2 (en) * 2018-05-16 2019-11-21 Amprion, Inc. Detection of brain injury or neurological disease using tau protein
CN119264211A (zh) 2018-08-27 2025-01-07 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
US11598783B1 (en) 2019-10-23 2023-03-07 Colorado State University Research Foundation In vitro detection of prions
WO2021198098A1 (en) * 2020-04-03 2021-10-07 Universität Zürich Improved method of detecting biomarkers in a biological sample
CN120367833B (zh) * 2025-04-26 2026-02-24 浙江青霄科技股份有限公司 一种潜水泵

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262332A (en) 1989-04-05 1993-11-16 Brigham And Women's Hospital Diagnostic method for Alzheimer's disease: examination of non-neural tissue
US5616871A (en) * 1995-09-28 1997-04-01 Drummond Scientific Company Pipet gun assembly
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
CA2268904A1 (en) * 1996-10-15 1998-04-23 Imperial College Of Science, Technology And Medicine Diagnosis of spongiform encephalopathy
WO2001000235A1 (en) * 1999-06-29 2001-01-04 Mcgill University Prion protein binding proteins and uses thereof
EP1238290A1 (en) 1999-12-10 2002-09-11 Misonix Incorporated Ultrasonic horn assembly
EP1882188A2 (en) * 2005-04-20 2008-01-30 Board of Regents, The University of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification

Also Published As

Publication number Publication date
CZ304365B6 (cs) 2014-04-02
HRP20030033A2 (en) 2004-02-29
EP1712920B1 (en) 2009-03-25
SI1299729T1 (sl) 2006-10-31
NO331624B1 (no) 2012-02-06
YU101202A (sh) 2006-01-16
SK18582002A3 (sk) 2003-05-02
EP1712920A1 (en) 2006-10-18
EP1299729A2 (en) 2003-04-09
DE60138146D1 (de) 2009-05-07
EA200300126A1 (ru) 2003-06-26
IL153824A (en) 2010-02-17
RS51523B (sr) 2011-06-30
MXPA03000226A (es) 2004-05-21
EA007391B1 (ru) 2006-10-27
HUP0301020A2 (hu) 2003-07-28
SI1712920T1 (sl) 2009-10-31
JP4790966B2 (ja) 2011-10-12
WO2002004954A3 (en) 2002-10-24
PT1712920E (pt) 2009-04-09
CN1221807C (zh) 2005-10-05
PL360397A1 (en) 2004-09-06
BRPI0112262B1 (pt) 2016-08-09
CA2413078C (en) 2010-08-03
DE60121958D1 (de) 2006-09-14
ATE426816T1 (de) 2009-04-15
NO20030059L (no) 2003-03-07
DE60121958T2 (de) 2007-02-01
NO20030059D0 (no) 2003-01-06
KR100764981B1 (ko) 2007-10-09
CY1109106T1 (el) 2014-07-02
WO2002004954A2 (en) 2002-01-17
US20050064505A1 (en) 2005-03-24
BRPI0112262B8 (pt) 2021-07-27
EP1299729B1 (en) 2006-08-02
EE200300005A (et) 2004-08-16
HK1058065A1 (en) 2004-04-30
CA2413078A1 (en) 2002-01-17
US7351526B2 (en) 2008-04-01
KR20030036257A (ko) 2003-05-09
HUP0301020A3 (en) 2010-03-29
AU2001264089B2 (en) 2006-03-30
BG107498A (bg) 2003-11-28
ES2322660T3 (es) 2009-06-24
SK287768B6 (sk) 2011-09-05
BR0112262A (pt) 2003-05-20
EE05675B1 (et) 2013-08-15
CZ200336A3 (cs) 2003-06-18
AR029583A1 (es) 2003-07-02
HU228813B1 (en) 2013-05-28
PL211154B1 (pl) 2012-04-30
ATE335204T1 (de) 2006-08-15
IL153824A0 (en) 2003-07-31
CN1449497A (zh) 2003-10-15
DK1712920T3 (da) 2009-05-11
HRP20030033B1 (hr) 2008-04-30
NZ523213A (en) 2005-01-28
JP2004503748A (ja) 2004-02-05
DK1299729T3 (da) 2006-12-04
ES2264691T3 (es) 2007-01-16
AU6408901A (en) 2002-01-21
BG66272B1 (bg) 2012-11-30

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