PT86885A - Metodo para inibir a proliferacao de uma pluralidade de celulas neoplasticas - Google Patents

Metodo para inibir a proliferacao de uma pluralidade de celulas neoplasticas

Info

Publication number: PT86885A
Authority: PT; Portugal
Prior art keywords: neoplastic cells; proliferation; inhibiting; polypeptide; src
Prior art date: 1987-03-02

Application number

PT86885A

Other languages

English (en)

Other versions

PT86885B (pt

Inventor

Daniel R Twardzik

Anthony F Purchio

Shiu-Lok Hu

Hans Marquardt

Joseph P Brown

George J Todaro

A Gregory Bruce

Timothy M Rose

Suo Win Liu

Thomas J Franceschini

David Lee

Original Assignee

Oncogen

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-02

Filing date

1988-03-02

Publication date

1989-03-30

1988-03-02 Application filed by Oncogen filed Critical Oncogen

1989-03-30 Publication of PT86885A publication Critical patent/PT86885A/pt

1995-08-09 Publication of PT86885B publication Critical patent/PT86885B/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/73—Expression systems using phage (lambda) regulatory sequences
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Virology (AREA)
Plant Pathology (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT86885A 1987-03-02 1988-03-02 Processo de preparacao de compostos que inibem o crescimento de celulas neoplasticas para utilizacao no tratamento de doencas cancerigenas PT86885B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2060987A	1987-03-02	1987-03-02
US11513987A	1987-10-30	1987-10-30

Publications (2)

Publication Number	Publication Date
PT86885A true PT86885A (pt)	1989-03-30
PT86885B PT86885B (pt)	1995-08-09

Family

ID=26693642

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT86885A PT86885B (pt)	1987-03-02	1988-03-02	Processo de preparacao de compostos que inibem o crescimento de celulas neoplasticas para utilizacao no tratamento de doencas cancerigenas

Country Status (14)

Country	Link
EP (1)	EP0281363B1 (pt)
JP (1)	JPH01503513A (pt)
KR (1)	KR890700672A (pt)
AT (1)	ATE123061T1 (pt)
AU (1)	AU623589B2 (pt)
DE (1)	DE3853842T2 (pt)
ES (1)	ES2074049T3 (pt)
FI (1)	FI100336B (pt)
GR (1)	GR3017041T3 (pt)
IE (1)	IE69678B1 (pt)
IL (1)	IL85613A (pt)
NZ (1)	NZ223696A (pt)
PT (1)	PT86885B (pt)
WO (1)	WO1988006628A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4844895A (en) *	1985-11-01	1989-07-04	New York University	Composition containing a peptide fragment of platelet factor four and method for restoring suppressed immune responses
US5026639A (en) *	1988-01-14	1991-06-25	Nippon Mining Company, Limited	Method to improve mRNA translation and use thereof for production of platelet factor-4
GB2214508A (en) *	1988-01-27	1989-09-06	Bayer Ag	Plasmid vector for the efficient expression of foreign genes fused with newly conceived transcriptional and translational signal sequences.
US5800820A (en) *	1989-01-10	1998-09-01	Repligen Corporation	Methods and compositions for treatment of angiogenic diseases
US5086164A (en) *	1989-01-10	1992-02-04	Repligen Corporation	Novel methods and compositions for treatment of angiogenic diseases
US5187075A (en) *	1989-01-26	1993-02-16	Sri International	Cloning and expression of a variant gene of platelet factor 4 and compositions thereof to modulate immune responses
US5112946A (en) *	1989-07-06	1992-05-12	Repligen Corporation	Modified pf4 compositions and methods of use
JPH06509116A (ja) *	1991-07-15	1994-10-13	レプリゲン　コーポレーション	修正されたｐｆ４組成物及び使用方法
CA2106368A1 (en) *	1992-01-16	1993-07-17	Theodore E. Maione	Methods and compositions for treatment of angiogenic disease
WO1995012414A1 (en) *	1993-11-05	1995-05-11	Repligen Corporation	Novel modified pf4 compositions and methods of use
IL113561A0 (en) *	1994-05-09	1995-08-31	Lilly Co Eli	Expression of recombinant mpf-4, cpf-4, pf-4 and precursor compounds
US5985543A (en) *	1996-10-11	1999-11-16	The Trustees Of The University Of Pennsylvania	Compositions and methods for detection of antibody binding to cells
US6989435B2 (en)	1997-09-11	2006-01-24	Cambridge University Technical Services Ltd.	Compounds and methods to inhibit or augment an inflammatory response
US7067117B1 (en)	1997-09-11	2006-06-27	Cambridge University Technical Services, Ltd.	Compounds and methods to inhibit or augment an inflammatory response
US7238711B1 (en)	1999-03-17	2007-07-03	Cambridge University Technical Services Ltd.	Compounds and methods to inhibit or augment an inflammatory response
WO2007053952A1 (en) *	2005-11-10	2007-05-18	Chemokine Therapeutics Corporation	Platelet factor-4 (pf-4) analogs and their use
DK1368483T3 (da)	2001-03-09	2012-11-05	Genentech Inc	Fremgangsmåde til fremstilling af polypeptider
US8609621B2 (en)	2010-11-15	2013-12-17	E I Du Pont De Nemours And Company	Acid-cleavable linkers exhibiting altered rates of acid hydrolysis

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4565785A (en) *	1978-06-08	1986-01-21	The President And Fellows Of Harvard College	Recombinant DNA molecule
IL60184A (en) *	1979-05-31	1984-05-31	Schering Ag	Process for the specific cleavage of protein sequences from proteins
US4530901A (en) *	1980-01-08	1985-07-23	Biogen N.V.	Recombinant DNA molecules and their use in producing human interferon-like polypeptides
US4582800A (en) *	1982-07-12	1986-04-15	Hoffmann-La Roche Inc.	Novel vectors and method for controlling interferon expression
SE8300693L (sv) *	1983-02-09	1984-08-10	Sven Lofdahl	Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta
EP0133123A1 (en) *	1983-07-25	1985-02-13	Mgi Pharma, Inc.	Immunogens of papilloma viruses
US4645828A (en) *	1984-03-23	1987-02-24	Oncogen	Platelet related growth regulator
WO1986001828A1 (fr) *	1984-09-18	1986-03-27	Sagami Chemical Research Center	Adn cyclique a double-toron, procede de preparation, microorganisme contenant ledit adn, et procede de preparation d'une proteine contenant un site de determinant d'antigene de la proteine du capside du virus de la poliomyelite vp1 utilisant le microorganisme
JPH0816063B2 (ja) *	1985-03-15	1996-02-21	オンコゲン	腫瘍細胞増殖阻害剤
EP0196864A3 (en) *	1985-03-25	1988-03-23	Cetus Corporation	Alkaline phosphatase-mediated processing and secretion of recombinant proteins, dna sequences for use therein and cells transformed using such sequences
JPS61280292A (ja) *	1985-06-04	1986-12-10	Wakunaga Pharmaceut Co Ltd	菌体外分泌による蛋白質の製造法

1988
- 1988-02-26 JP JP63502722A patent/JPH01503513A/ja active Pending
- 1988-02-26 AU AU14924/88A patent/AU623589B2/en not_active Ceased
- 1988-02-26 WO PCT/US1988/000634 patent/WO1988006628A1/en not_active Ceased
- 1988-03-01 EP EP88301774A patent/EP0281363B1/en not_active Expired - Lifetime
- 1988-03-01 ES ES88301774T patent/ES2074049T3/es not_active Expired - Lifetime
- 1988-03-01 NZ NZ223696A patent/NZ223696A/en unknown
- 1988-03-01 AT AT88301774T patent/ATE123061T1/de not_active IP Right Cessation
- 1988-03-01 DE DE3853842T patent/DE3853842T2/de not_active Expired - Fee Related
- 1988-03-02 IL IL8561388A patent/IL85613A/en not_active IP Right Cessation
- 1988-03-02 IE IE59188A patent/IE69678B1/en not_active IP Right Cessation
- 1988-03-02 PT PT86885A patent/PT86885B/pt not_active IP Right Cessation
- 1988-11-01 FI FI885031A patent/FI100336B/fi not_active IP Right Cessation
- 1988-11-02 KR KR1019880701398A patent/KR890700672A/ko not_active Withdrawn
1995
- 1995-08-08 GR GR950402158T patent/GR3017041T3/el unknown

Also Published As

Publication number	Publication date
EP0281363A2 (en)	1988-09-07
ES2074049T3 (es)	1995-09-01
FI885031A0 (fi)	1988-11-01
IE69678B1 (en)	1996-10-02
NZ223696A (en)	1991-06-25
GR3017041T3 (en)	1995-11-30
ATE123061T1 (de)	1995-06-15
DE3853842T2 (de)	1995-12-07
JPH01503513A (ja)	1989-11-30
WO1988006628A1 (en)	1988-09-07
KR890700672A (ko)	1989-04-26
AU1492488A (en)	1988-09-26
AU623589B2 (en)	1992-05-21
FI100336B (fi)	1997-11-14
IL85613A0 (en)	1988-08-31
IL85613A (en)	1994-10-07
PT86885B (pt)	1995-08-09
FI885031L (fi)	1988-11-01
EP0281363A3 (en)	1988-11-17
EP0281363B1 (en)	1995-05-24
DE3853842D1 (de)	1995-06-29
IE880591L (en)	1988-09-02

Legal Events

Date

Code

Title

Description

1995-08-09

FG3A

Patent granted, date of granting

Effective date: 19950404

1999-02-26

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19981031

Publication	Publication Date	Title
ATE107662T1 (de)	1994-07-15	Mit thrombozyten verwandter wachstumregulator.
FI885031A0 (fi)	1988-11-01	Vaextregulator av blodplaettetyp.
ES2054676T3 (es)	1994-08-16	Regulacion de transcripcion especifica de semillas.
DE3888642D1 (de)	1994-04-28	Rollflasche zur Züchtung von Zellengewebekulturen.
EP0267155A3 (en)	1988-07-20	Bicyclic compounds
IL197686A0 (en)	2011-07-31	Pharmaceutical compositions containing alpha-4 integrin antagonists and uses thereof in the treatment of multiple myeloma and diseases associated therewith
DK46687D0 (da)	1987-01-29	N6-substituerede adenosiner, fremgangsmaade til deres fremstilling og farmaceutisk komposition indeholdende forbindelserne
DK11391A (da)	1991-01-23	Alkoxy-4(1h)-pyridonderivater og farmakologisk acceptable salte deraf, deres fremstilling og anvendelse
EP0061138A3 (en)	1983-09-07	Angiotropins of leukocytes and inflamed tissue: a new class of natural chemotropic protein mitogens for specific induction of directional growth of blood vessels, neovascularization of tissues and morphogenesis of blood vessel patterns, process for their biotechnical preparation and pharmaceutical compositions
GR3000944T3 (en)	1991-12-10	Pharmaceutical composition containing thymus extract fractions
ES2054612T3 (es)	1994-08-16	Secuencias de adn que codifican para proteinas con actividad biologica de los inhibidores husi tipo-i y procedimientos tecnologicos geneticos para la preparacion de estas proteinas.
KR970706838A (ko)	1997-12-01	조혈 단백질을 사용한 적혈구생성을 자극하는 방법(methods for stimulating erythropoiesis using hematopoietic proteins)
DK87190A (da)	1990-04-06	Fremgangsmaade til at regulere plantevaekst under anvendelse af svovlholdige organiske syrer
ATE74761T1 (de)	1992-05-15	Verwendung von pflanzenpollenextrakten zur herstellung von das wachstum von tumorzellen hemmenden pharmazeutischen praeparaten und verfahren zu ihrer herstellung.
DK410887D0 (da)	1987-08-06	Protein isoleret fra pattedyrhjernevaev
NO871137D0 (no)	1987-03-19	Ikke-betennelsesfremkallende hyaluronsyrefraksjon og fremgangsmaate for fremstilling av denne.
ES2003180A6 (es)	1988-10-16	Un metodo para preparar un polipeptido capaz de modular la actividad del crecimiento.
ES2070934T3 (es)	1995-06-16	Derivados de oxotremorina 3- o 4-sustituidos.
EP0136093A3 (en)	1986-07-30	Anti-cancer factors
DE68911305D1 (de)	1994-01-20	Das lungenwachstum stimulierende und hemmende faktoren für krebstumorzellen.
DK197091A (da)	1991-12-06	Fremgangsmaade til fremstilling af proteiner med fviii aktivitet og/eller fviii derivater
DE69012624D1 (de)	1994-10-27	Reines Histon H1 zur therapeutischen Verwendung.
IT8848237A0 (it)	1988-07-27	Procedimento per la produzione difosfati cristallini di titanio, di zirconio e misti di zirconio e titanio
IT8423876A0 (it)	1984-12-04	Procedimento per la preparazione di esteri.
ATE100137T1 (de)	1994-01-15	Serumfreies medium zur proliferation von lymphokin-aktivierten toeterzellen.