PT87193A - Semisynthetische rhodomycine verfahren zu ihrer herstellung und their verwendung als zytostatika - Google Patents

Semisynthetische rhodomycine verfahren zu ihrer herstellung und their verwendung als zytostatika

Info

Publication number: PT87193A
Authority: PT; Portugal
Prior art keywords: formula; hydrogen; alpha; rhodosaminyl; semisynthetische
Prior art date: 1987-04-11

Application number

PT87193A

Other languages

English (en)

Other versions

PT87193B (pt

Inventor

Manfred Gerken

Genek Kolar

Hans Peter Kraemer

Dieter Hoffmann

Peter Hermentin

Original Assignee

Behringwerke Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-11

Filing date

1988-04-08

Publication date

1988-05-01

1988-04-08 Application filed by Behringwerke Ag filed Critical Behringwerke Ag

1988-05-01 Publication of PT87193A publication Critical patent/PT87193A/pt

1992-07-31 Publication of PT87193B publication Critical patent/PT87193B/pt

Links

NOVZFMNCTCKLPF-UHFFFAOYSA-N 2,5-bis(aziridin-1-yl)-3,6-dipropoxycyclohexa-2,5-diene-1,4-dione Chemical compound O=C1C(OCCC)=C(N2CC2)C(=O)C(OCCC)=C1N1CC1 NOVZFMNCTCKLPF-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
150000002431 hydrogen Chemical class 0.000 abstract 5
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000005336 allyloxy group Chemical group 0.000 abstract 1
229940045799 anthracyclines and related substance Drugs 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
-1 hydroxymethylene Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Pyrane Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PT87193A 1987-04-11 1988-04-08 Processo para a preparacao de rodomicinas semi-sinteticas e de composicoes farmaceuticas de accao citostatica que as contem PT87193B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19873712350 DE3712350A1 (de)	1987-04-11	1987-04-11	Semisynthetische rhodomycine, verfahren zu ihrer herstellung und ihre verwendung als zytostatika

Publications (2)

Publication Number	Publication Date
PT87193A true PT87193A (pt)	1988-05-01
PT87193B PT87193B (pt)	1992-07-31

Family

ID=6325447

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT87193A PT87193B (pt)	1987-04-11	1988-04-08	Processo para a preparacao de rodomicinas semi-sinteticas e de composicoes farmaceuticas de accao citostatica que as contem

Country Status (12)

Country	Link
EP (1)	EP0286926B1 (pt)
JP (1)	JP2672965B2 (pt)
KR (1)	KR880012624A (pt)
AT (1)	ATE116991T1 (pt)
AU (1)	AU614954B2 (pt)
CA (1)	CA1340690C (pt)
DE (2)	DE3712350A1 (pt)
DK (1)	DK192388A (pt)
ES (1)	ES2067452T3 (pt)
FI (1)	FI90777C (pt)
GR (1)	GR3015231T3 (pt)
PT (1)	PT87193B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3722698A1 (de) *	1987-07-09	1989-01-19	Behringwerke Ag	Zytostatisch wirksame anthracyclinderivate
FR2630914A1 (fr) *	1988-05-04	1989-11-10	Hoechst Sa Laboratoires	Nouveaux analogues du l-fucose, leur procede de preparation, application de ces analogues a la preparation de nouveaux glycals, anthracyclines obtenues a l'aide de ces glycals et utilisation desdites anthracyclines en tant que medicaments
FR2630915A1 (fr) *	1988-05-04	1989-11-10	Hoechst Lab	Nouveaux glycals, anthracyclines obtenues a l'aide de ces glycals et utilisation desdites anthracyclines en tant que medicaments
DE3836122A1 (de) *	1988-10-22	1990-05-31	Behringwerke Ag	Verfahren zur herstellung von 4-0-alkyl-rhodomycinen
DE3842836A1 (de) *	1988-12-20	1990-06-21	Behringwerke Ag	Rhodomycine mit einer modifizierten kohlenhydrat-einheit
AU4752190A (en) *	1988-12-28	1990-08-01	Board Of Regents, The University Of Texas System	3'-deamino analogs of esorubicin and methods for their use
DE3920062A1 (de) *	1989-06-20	1991-01-10	Hoechst Ag	Neue anthracyclin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JP2021534196A (ja)	2018-08-23	2021-12-09	シージェンインコーポレイテッド	抗ｔｉｇｉｔ抗体

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2056443B (en) *	1979-08-20	1984-01-18	Hoffmann La Roche	Cyclic compounds
US4302449A (en) *	1980-09-02	1981-11-24	Board Of Control Of Michigan Technological University	Carminomycin analogue
GB2120667B (en) *	1982-05-24	1985-06-05	Erba Farmitalia	Anthracycline glycosides
DE3323025A1 (de) *	1983-06-25	1985-01-10	Hoechst Ag, 6230 Frankfurt	Anthracyclin-derivate, ein mikrobiologisches verfahren zu ihrer herstellung und ihre verwendung als cytostatika
DE3425357A1 (de) *	1984-07-10	1986-01-23	Hoechst Ag, 6230 Frankfurt	1-hydroxy-cytorhodine, ein mikrobiologisches verfahren zu ihrer herstellung und ihre verwendung als cytostatika
JPS6133194A (ja) *	1984-07-25	1986-02-17	Sanraku Inc	新規アントラサイクリン抗生物質
JPS61236792A (ja)	1985-04-12	1986-10-22	Sanraku Inc	新規アントラサイクリン抗生物質
JPS62238298A (ja) *	1986-04-08	1987-10-19	Sanraku Inc	新規アントラサイクリン抗生物質ｄｃｐ−１及び２
JPS6391395A (ja) *	1986-10-03	1988-04-22	Kirin Brewery Co Ltd	アンスラサイクリン化合物、その製造法およびその用途
DE3641833A1 (de) *	1986-12-08	1988-06-09	Behringwerke Ag	Zytostatisch wirksame anthracyclinderivate
DE3641835A1 (de) *	1986-12-08	1988-06-16	Behringwerke Ag	Zytostatisch wirksame anthracyclinderivate
JPS63227599A (ja) *	1987-03-14	1988-09-21	Kirin Brewery Co Ltd	アンスラサイクリン化合物およびその用途
DE3722698A1 (de) *	1987-07-09	1989-01-19	Behringwerke Ag	Zytostatisch wirksame anthracyclinderivate

1987
- 1987-04-11 DE DE19873712350 patent/DE3712350A1/de not_active Ceased
1988
- 1988-04-01 DE DE3852711T patent/DE3852711D1/de not_active Expired - Fee Related
- 1988-04-01 AT AT88105330T patent/ATE116991T1/de not_active IP Right Cessation
- 1988-04-01 ES ES88105330T patent/ES2067452T3/es not_active Expired - Lifetime
- 1988-04-01 EP EP88105330A patent/EP0286926B1/de not_active Expired - Lifetime
- 1988-04-07 FI FI881610A patent/FI90777C/fi not_active IP Right Cessation
- 1988-04-08 DK DK192388A patent/DK192388A/da not_active Application Discontinuation
- 1988-04-08 JP JP63085542A patent/JP2672965B2/ja not_active Expired - Fee Related
- 1988-04-08 PT PT87193A patent/PT87193B/pt not_active IP Right Cessation
- 1988-04-08 CA CA000563694A patent/CA1340690C/en not_active Expired - Fee Related
- 1988-04-09 KR KR1019880004037A patent/KR880012624A/ko not_active Ceased
- 1988-04-11 AU AU14468/88A patent/AU614954B2/en not_active Ceased
1995
- 1995-02-28 GR GR950400437T patent/GR3015231T3/el unknown

Also Published As

Publication number	Publication date
AU614954B2 (en)	1991-09-19
EP0286926A3 (en)	1990-09-19
KR880012624A (ko)	1988-11-28
DE3852711D1 (de)	1995-02-23
FI881610A7 (fi)	1988-10-12
DK192388A (da)	1988-10-12
JP2672965B2 (ja)	1997-11-05
PT87193B (pt)	1992-07-31
FI90777B (fi)	1993-12-15
EP0286926B1 (de)	1995-01-11
JPS63267775A (ja)	1988-11-04
FI881610A0 (fi)	1988-04-07
CA1340690C (en)	1999-08-03
GR3015231T3 (en)	1995-05-31
DE3712350A1 (de)	1988-10-20
AU1446888A (en)	1988-10-13
FI90777C (fi)	1994-03-25
EP0286926A2 (de)	1988-10-19
ATE116991T1 (de)	1995-01-15
ES2067452T3 (es)	1995-04-01
DK192388D0 (da)	1988-04-08

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Legal Events

Date

Code

Title

Description

1992-07-31

FG3A

Patent granted, date of granting

Effective date: 19920116

2004-10-29

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20040716