PT92368A - Processo para a preparacao de novas quinuclidinas e de composicoes farmaceuticas que as contem - Google Patents

Processo para a preparacao de novas quinuclidinas e de composicoes farmaceuticas que as contem

Info

Publication number
PT92368A
PT92368A PT92368A PT9236889A PT92368A PT 92368 A PT92368 A PT 92368A PT 92368 A PT92368 A PT 92368A PT 9236889 A PT9236889 A PT 9236889A PT 92368 A PT92368 A PT 92368A
Authority
PT
Portugal
Prior art keywords
quinuclidines
pharmaceutical compositions
compositions containing
preparing new
preparing
Prior art date
Application number
PT92368A
Other languages
English (en)
Other versions
PT92368B (pt
Inventor
Karl-Heinz Weber
Werner Stransky
Gerhard Walther
Helmut Ensinger
Franz Josef Kuhn
Enzio Muller
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of PT92368A publication Critical patent/PT92368A/pt
Publication of PT92368B publication Critical patent/PT92368B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT92368A 1988-11-22 1989-11-21 Processo para a preparacao de novas quinuclidinas e de composicoes farmaceuticas que as contem PT92368B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3839385A DE3839385A1 (de) 1988-11-22 1988-11-22 Neue quinuclidine, ihre herstellung als arzneimittel und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
PT92368A true PT92368A (pt) 1990-05-31
PT92368B PT92368B (pt) 1995-07-18

Family

ID=6367625

Family Applications (1)

Application Number Title Priority Date Filing Date
PT92368A PT92368B (pt) 1988-11-22 1989-11-21 Processo para a preparacao de novas quinuclidinas e de composicoes farmaceuticas que as contem

Country Status (18)

Country Link
US (2) US5451587A (pt)
EP (1) EP0370415B1 (pt)
JP (1) JPH0686449B2 (pt)
KR (1) KR0165667B1 (pt)
AU (1) AU628884B2 (pt)
BG (1) BG61859B2 (pt)
CA (1) CA2003422C (pt)
DE (3) DE3839385A1 (pt)
DK (1) DK170167B1 (pt)
ES (1) ES2054988T3 (pt)
FI (1) FI91637C (pt)
HU (1) HU202527B (pt)
IE (1) IE62328B1 (pt)
IL (1) IL92377A (pt)
NO (1) NO172801C (pt)
NZ (1) NZ231445A (pt)
PT (1) PT92368B (pt)
ZA (1) ZA898858B (pt)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1307790C (en) * 1987-08-04 1992-09-22 Ian Anthony Cliffe Ethers
YU84791A (sh) * 1990-05-19 1994-06-10 Boehringer Ingelheim Kg. Biciklicni 1-aza-cikloalkalni
EP0492904A1 (en) * 1990-12-21 1992-07-01 MERCK SHARP & DOHME LTD. Substituted benzene derivatives for use in the treatment of glaucoma
EP0492902A1 (en) * 1990-12-21 1992-07-01 MERCK SHARP & DOHME LTD. Substituted pyridine derivatives for use in the treatment of glaucoma
EP0492903A1 (en) * 1990-12-21 1992-07-01 MERCK SHARP & DOHME LTD. Substituted pyrazines, pyrimidines and pyridazines for use in the treatment of glaucoma
ZA92278B (en) * 1991-02-01 1992-10-28 Akzo Nv 3-quinuclidine derivatives
GB9122988D0 (en) * 1991-10-30 1991-12-18 Ici Plc Heterocyclic compounds
GB9127279D0 (en) * 1991-12-23 1992-02-19 Ici Plc Heterocyclic derivatives
JPH06508377A (ja) * 1992-04-10 1994-09-22 ゼネカ　リミテッド ヘテロ環式化合物
GB9211796D0 (en) * 1992-06-04 1992-07-15 Ici Plc Heterocyclic derivatives
GB9216721D0 (en) * 1992-08-06 1992-09-23 Ici Plc Therapeutic heterocyclic derivatives
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
DE4236331A1 (de) * 1992-10-28 1994-05-05 Boehringer Ingelheim Kg Synergistische Kombination
GB9226573D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
US5998404A (en) * 1994-10-24 1999-12-07 Eli Lilly And Company Heterocyclic compounds and their use
US5512574A (en) * 1994-12-21 1996-04-30 American Home Products Corporation Quinuclidine and azabicyclo 2.2.1! heptane pyrazinyl ethers as muscarinic agonists
EP0785198B1 (de) 1996-01-19 2000-07-05 Lonza Ag Verfahren zur Herstellung von optisch aktivem 3-Chinuclidinol
SE9600683D0 (sv) * 1996-02-23 1996-02-23 Astra Ab Azabicyclic esters of carbamic acids useful in therapy
CZ54498A3 (cs) * 1997-03-07 1998-11-11 Lonza Ag Katalyzátorová směs na bázi amorfního částečně dehydratovaného hydroxidu zirkoničitého a způsob její výroby a použití
WO1998046225A1 (en) * 1997-04-11 1998-10-22 Eli Lilly And Company Method for treating schizophrenia
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
DE10106971A1 (de) * 2001-02-15 2002-08-29 Boehringer Ingelheim Pharma Arzneimittelformulierung die einen muskarinischen Agonisten enthält
KR100448002B1 (ko) * 2002-02-01 2004-09-13 한국과학기술연구원 신규한 퀴누클리딘 화합물 및 그 제조방법
KR20030083289A (ko) * 2002-04-20 2003-10-30 한승호 다공질 화분
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
PE20060437A1 (es) 2004-06-18 2006-06-08 Novartis Ag COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1928437A2 (en) * 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2068872A1 (en) 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US20210251970A1 (en) 2018-10-10 2021-08-19 Presbyopia Therapies Inc Compositions and methods for storage stable ophthalmic drugs
WO2020117637A1 (en) * 2018-12-05 2020-06-11 Presbyopia Therapies Llc Prodrugs of quinuclidine ring-containing muscarinic agonists and compositions and methods thereof
US12180206B2 (en) 2021-11-17 2024-12-31 Lenz Therapeutics Operations, Inc. Aceclidine derivatives, compositions thereof and methods of use thereof
US12414942B1 (en) 2024-03-15 2025-09-16 Lenz Therapeutics Operations, Inc. Compositions, methods, and systems for treating presbyopia

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2014831A1 (en) * 1968-08-01 1970-04-24 Sogeras Quinuclidinyl and quinuclidinylalkyl ethers with cholino - lytic, antihistaminic and neurosedative activity
IL88156A (en) * 1987-11-13 1997-02-18 Novo Nordisk As Azacyclic compounds their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
KR900007837A (ko) 1990-06-02
FI91637B (fi) 1994-04-15
IL92377A0 (en) 1990-07-26
CA2003422A1 (en) 1990-05-22
JPH02243688A (ja) 1990-09-27
HU202527B (en) 1991-03-28
NO172801C (no) 1993-09-08
FI91637C (fi) 1994-07-25
ES2054988T3 (es) 1994-08-16
IE893712L (en) 1990-05-22
NZ231445A (en) 1991-08-27
CA2003422C (en) 1999-12-21
IE62328B1 (en) 1995-01-25
HUT53102A (en) 1990-09-28
HU896032D0 (en) 1990-02-28
EP0370415A1 (de) 1990-05-30
NO894630D0 (no) 1989-11-21
DK170167B1 (da) 1995-06-06
PT92368B (pt) 1995-07-18
DE3839385A1 (de) 1990-05-23
EP0370415B1 (de) 1993-06-02
JPH0686449B2 (ja) 1994-11-02
ZA898858B (en) 1991-07-31
IL92377A (en) 1995-01-24
NO894630L (no) 1990-05-23
DE8817121U1 (de) 1993-02-04
AU4540389A (en) 1990-05-31
DE58904567D1 (de) 1993-07-08
KR0165667B1 (ko) 1999-01-15
BG61859B2 (bg) 1998-07-31
DK584089A (da) 1990-05-23
US5451587A (en) 1995-09-19
US5508405A (en) 1996-04-16
DK584089D0 (da) 1989-11-21
FI895531A0 (fi) 1989-11-21
NO172801B (no) 1993-06-01
AU628884B2 (en) 1992-09-24

Similar Documents

Publication Publication Date Title
PT92368A (pt) Processo para a preparacao de novas quinuclidinas e de composicoes farmaceuticas que as contem
PT89009A (pt) Processo para a preparacao de novos derivados de fluorocitidina e composicoes farmaceuticas que os contem
PT84149B (pt) Processo para a preparacao de novas tieno-1,4-diazepinas e de composicoes farmaceuticas que as contem
PT87913A (pt) Processo para a preparacao de derivados de benzopirano e de composicoes farmaceuticas que os contem
PT81746B (pt) Processo para a preparacao de peptido-aldeidos e de composicoes farmaceuticas que os contem
PT89328A (pt) Processo para a preparacao de novos derivados da adenosina e de composicoes farmaceuticas que os contem
PT84569B (pt) Processo para a preparacao de tiazepinas e de composicoes farmaceuticas que os contem
PT78732A (pt) Processo para a preparacao de 13 alpha-alquilgonanos e de composicoes farmaceuticas que os contem
PT93079A (pt) Processo para a preparacao de composicoes farmaceuticas que contem ciclosporinas
PT87201A (pt) Processo para a preparacao de novos derivados de cefalosporina 3,7-substituida e de composicoes farmaceuticas que os contem
PT81650B (pt) Processo para a preparacao de novas pteridinas e de composicoes farmaceuticas que as contem
PT88203A (pt) Processo para a preparacao de quinolonas e de composicoes farmaceuticas que as contem
PT88914A (pt) Processo para a preparacao de polipeptidos e de composicoes farmaceuticas que os contem
PT89655A (pt) Processo para a preparacao de novas lactamas substituidas e de composicoes farmaceuticas que as contem
PT93060A (pt) Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem
PT80246B (pt) Processo para a preparacao de novos derivados de cefalosporina e de composicoes farmaceuticas que os contem
PT91870A (pt) Processo para apreparacao de novas quinoliloxazol-2-onas e de composicoes farmaceuticas que as contem
PT81659B (pt) Processo para a preparacao de aminoacil-labdanos e de composicoes farmaceuticas que os contem
PT80794B (pt) Processo para a preparacao de novas isoindolinil-alquilpiperazinas e de composicoes farmaceuticas que as contem
PT82984B (pt) Processo para a preparacao de derivados de poli-4-aminopirrole-2-carboxamido e de composicoes farmaceuticas que os contem
PT84358B (pt) Processo para a preparacao de naftotiazepinonas e de composicoes farmaceuticas que as contem
PT94902A (pt) Processo para a preparacao de novos derivados de cromano e de composicoes farmaceuticas que os contem
PT93138A (pt) Processo para a preparacao de novos compostos derivados da acetamina e de composicoes farmaceuticas que os contem
PT87115A (pt) Processo para a preparacao de derivados da dihidropiridazinona e de composicoes farmaceuticas que os contem
PT98697A (pt) Processo para a preparacao de compostos macrociclicos e de composicoes farmaceuticas que os contem

Legal Events

Date Code Title Description
MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20100303