PT92594A - Processo para a preparacao de derivados de ergolina - Google Patents

Processo para a preparacao de derivados de ergolina

Info

Publication number: PT92594A
Authority: PT; Portugal
Prior art keywords: preparation; ergoline derivatives; ergoline; derivatives
Prior art date: 1988-12-19

Application number

PT92594A

Other languages

English (en)

Other versions

PT92594B (pt

Inventor

David Wayne Robertson

Marlene Lois Cohen

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-19

Filing date

1989-12-15

Publication date

1990-06-29

1989-12-15 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1990-06-29 Publication of PT92594A publication Critical patent/PT92594A/pt

1995-08-09 Publication of PT92594B publication Critical patent/PT92594B/pt

Links

AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PT92594A 1988-12-19 1989-12-15 Processo para a preparacao de derivados de ergolina PT92594B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/286,192 US4902691A (en)	1988-12-19	1988-12-19	Heteroalkylamides of (8-β)-1-alkyl-6-(substituted)ergolines useful for blocking 5HT2 receptors

Publications (2)

Publication Number	Publication Date
PT92594A true PT92594A (pt)	1990-06-29
PT92594B PT92594B (pt)	1995-08-09

Family

ID=23097493

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT92594A PT92594B (pt)	1988-12-19	1989-12-15	Processo para a preparacao de derivados de ergolina

Country Status (15)

Country	Link
US (1)	US4902691A (pt)
EP (1)	EP0375297A3 (pt)
JP (1)	JPH02218682A (pt)
KR (1)	KR900009661A (pt)
CN (1)	CN1023014C (pt)
AU (1)	AU621432B2 (pt)
CA (1)	CA2005506A1 (pt)
DK (1)	DK632189A (pt)
HU (1)	HU203345B (pt)
IL (1)	IL92706A0 (pt)
MX (1)	MX164891B (pt)
NZ (1)	NZ231774A (pt)
PH (1)	PH26522A (pt)
PT (1)	PT92594B (pt)
ZA (1)	ZA899580B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5141944A (en) *	1990-04-11	1992-08-25	Eli Lilly And Company	N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides
US5441961A (en) *	1992-08-27	1995-08-15	Eli Lilly And Company	Substituted cyclo or bicycloalkylamides of (8β)-6-(substituted) ergolines
PT628042E (pt) *	1992-12-24	2002-01-30	Pharmacia & Upjohn Spa	Derivados de ergolina serotoninergicos
US5688807A (en) *	1994-03-11	1997-11-18	Eli Lilly And Company	Method for treating 5HT2B receptor related conditions
EP0796619A1 (en)	1996-03-21	1997-09-24	Merrell Pharmaceuticals Inc.	Use of (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethanol in treating depressive disorders and bipolar disorders
US5886003A (en) *	1996-03-25	1999-03-23	Eli Lilly And Company	Methods of treating or ameliorating the symptoms of venomous bites and stings
AUPO588297A0 (en) *	1997-03-26	1997-04-24	Luminis Pty Limited	Mediation in melatonin production
GB0306604D0 (en) *	2003-03-21	2003-04-30	Curidium Ltd	Second medical use
EP1720861A2 (en) *	2004-02-25	2006-11-15	Eli Lilly And Company	Histamine h3 receptor antagonists, preparation and therapeutic uses
WO2025080608A1 (en) *	2023-10-09	2025-04-17	The Regents Of The University Of California	Desamide isotryptamine tetracycles for treating brain disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3228944A (en) *		1966-01-11		Lumiergoline derivatives
CH196549A (de) *	1936-06-20	1938-03-15	Chem Fab Vormals Sandoz	Verfahren zur Darstellung von rac. Lysergsäure-iso-propanolamid.
US2997470A (en) *	1956-03-05	1961-08-22	Lilly Co Eli	Lysergic acid amides
GB982737A (en) *	1961-05-08	1965-02-10	Westminster Bank Ltd	Improvements in or relating to lysergic acid compounds
SE396753B (sv) *	1970-05-18	1977-10-03	Richter Gedeon Vegyeszet	Analogiforfarande for framstellning av en forening tillhorande dihydrolysergsyraserien
DE2108502A1 (en) *	1971-02-23	1972-11-02	Sharon, Wilfred J., Euclid, Ohio (V.StA.)	Metal cold forging for producing hollow - articles
US3904633A (en) *	1973-02-05	1975-09-09	Richter Gedeon Vegyeszet	Lysergic amides
HU172649B (hu) *	1975-04-24	1978-11-28	Gyogyszerkutato Intezet	Sposob poluchenija novykh biologicheski aktivnykh lizergamidov
CH653333A5 (de) *	1981-11-04	1985-12-31	Sandoz Ag	N-substituierte ergolin- und 9,10-didehydroergolinderivate, ihre herstellung und sie enthaltende arzneimittel.
IL86725A (en) *	1987-06-15	1993-01-14	Lilly Co Eli	1-alkyl-n-cycloalkyl- 6-methyl-ergoline-8'- carboxamides, their preparation and pharmaceutical compositions containing them

1988
- 1988-12-19 US US07/286,192 patent/US4902691A/en not_active Expired - Fee Related
1989
- 1989-12-13 HU HU896527A patent/HU203345B/hu not_active IP Right Cessation
- 1989-12-14 IL IL92706A patent/IL92706A0/xx not_active IP Right Cessation
- 1989-12-14 JP JP1325747A patent/JPH02218682A/ja active Pending
- 1989-12-14 KR KR1019890018514A patent/KR900009661A/ko not_active Ceased
- 1989-12-14 DK DK632189A patent/DK632189A/da not_active Application Discontinuation
- 1989-12-14 CA CA002005506A patent/CA2005506A1/en not_active Abandoned
- 1989-12-14 PH PH39700A patent/PH26522A/en unknown
- 1989-12-14 NZ NZ231774A patent/NZ231774A/en unknown
- 1989-12-14 AU AU46751/89A patent/AU621432B2/en not_active Ceased
- 1989-12-14 ZA ZA899580A patent/ZA899580B/xx unknown
- 1989-12-15 EP EP19890313149 patent/EP0375297A3/en not_active Ceased
- 1989-12-15 MX MX18737A patent/MX164891B/es unknown
- 1989-12-15 CN CN89109366A patent/CN1023014C/zh not_active Expired - Fee Related
- 1989-12-15 PT PT92594A patent/PT92594B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU621432B2 (en)	1992-03-12
ZA899580B (en)	1991-08-28
US4902691A (en)	1990-02-20
KR900009661A (ko)	1990-07-05
HUT52499A (en)	1990-07-28
AU4675189A (en)	1990-06-21
HU203345B (en)	1991-07-29
NZ231774A (en)	1991-04-26
MX164891B (es)	1992-09-30
PT92594B (pt)	1995-08-09
DK632189A (da)	1990-06-20
CA2005506A1 (en)	1990-06-19
CN1023014C (zh)	1993-12-08
DK632189D0 (da)	1989-12-14
IL92706A0 (en)	1990-09-17
PH26522A (en)	1992-08-07
JPH02218682A (ja)	1990-08-31
EP0375297A3 (en)	1991-10-23
EP0375297A2 (en)	1990-06-27
CN1043715A (zh)	1990-07-11
HU896527D0 (en)	1990-02-28

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Legal Events

Date

Code

Title

Description

1995-08-09

FG3A

Patent granted, date of granting

Effective date: 19950412

1997-02-28

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19961031