PT94034A - Processo para a preparacao de eteres (tio) morfolinilo e piperazinilo-alquilfenolico anti-rinovirais - Google Patents
Processo para a preparacao de eteres (tio) morfolinilo e piperazinilo-alquilfenolico anti-rinoviraisInfo
- Publication number
- PT94034A PT94034A PT94034A PT9403490A PT94034A PT 94034 A PT94034 A PT 94034A PT 94034 A PT94034 A PT 94034A PT 9403490 A PT9403490 A PT 9403490A PT 94034 A PT94034 A PT 94034A
- Authority
- PT
- Portugal
- Prior art keywords
- 4alkyl
- morpholinyl
- piperazinyl
- hydrogen
- compounds
- Prior art date
Links
- -1 MORPHOLINYL Chemical class 0.000 title 1
- 125000001495 ethyl group Chemical class [H]C([H])([H])C([H])([H])* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- SCVJRXQHFJXZFZ-KVQBGUIXSA-N 2-amino-9-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purine-6-thione Chemical compound C1=2NC(N)=NC(=S)C=2N=CN1[C@H]1C[C@H](O)[C@@H](CO)O1 SCVJRXQHFJXZFZ-KVQBGUIXSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000002128 anti-rhinoviral effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35169989A | 1989-05-15 | 1989-05-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT94034A true PT94034A (pt) | 1991-01-08 |
| PT94034B PT94034B (pt) | 1996-11-29 |
Family
ID=23381997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT94034A PT94034B (pt) | 1989-05-15 | 1990-05-14 | Processo para a preparacao de eteres (tio) morfolinilo e piperazinilo-alquilfenolico anti-rinovirais |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0398426B1 (pt) |
| JP (1) | JPH0347181A (pt) |
| KR (1) | KR900018089A (pt) |
| CN (1) | CN1026489C (pt) |
| AT (1) | ATE102621T1 (pt) |
| AU (1) | AU619111B2 (pt) |
| CA (1) | CA2016741A1 (pt) |
| DE (1) | DE69007164T2 (pt) |
| DK (1) | DK0398426T3 (pt) |
| ES (1) | ES2053078T3 (pt) |
| FI (1) | FI96948C (pt) |
| HU (1) | HUT58311A (pt) |
| IE (1) | IE63537B1 (pt) |
| IL (1) | IL94383A (pt) |
| NO (1) | NO179553C (pt) |
| NZ (1) | NZ233503A (pt) |
| PT (1) | PT94034B (pt) |
| RU (1) | RU2057130C1 (pt) |
| ZA (1) | ZA903663B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5364866A (en) | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
| US5561128A (en) * | 1989-05-19 | 1996-10-01 | Hoechst-Roussel Pharmaceuticals, Inc. | N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility |
| US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
| JO1645B1 (en) * | 1989-12-26 | 1991-11-27 | شركة جانسين فارماسوتيكا ان. في | Pyridazine compounds are antibacterial viruses |
| DE4136900C1 (pt) * | 1991-11-09 | 1993-07-29 | Schaper & Bruemmer Gmbh & Co Kg, 3320 Salzgitter, De | |
| JPH05255089A (ja) * | 1991-12-18 | 1993-10-05 | Sanwa Kagaku Kenkyusho Co Ltd | 抗ウイルス剤 |
| DK0690850T3 (da) * | 1993-03-26 | 1998-02-09 | Schering Corp | 2-Substituerede morpholin- og thiomorpholinderivater som GABAB-antagonister |
| US5453433A (en) * | 1994-05-13 | 1995-09-26 | Sterling Winthrop Inc. | Thiadiazoles and antipicornaviral compositions |
| DE19743435A1 (de) * | 1997-10-01 | 1999-04-08 | Merck Patent Gmbh | Benzamidinderivate |
| SE9801287D0 (sv) * | 1998-04-14 | 1998-04-14 | Astra Ab | Incorporation of active substances in carrier matrixes |
| RU2242977C1 (ru) * | 2003-09-30 | 2004-12-27 | Плотников Евгений Владимирович | Антивирусная и бактерицидная композиция |
| GB0502046D0 (en) * | 2005-02-01 | 2005-03-09 | Sinclair Pharmaceuticals Ltd | Method |
| CN1887875B (zh) * | 2005-06-30 | 2011-04-06 | 深圳市东阳光实业发展有限公司 | 哒嗪胺衍生物及其用于制备小rna病毒抑制剂的用途 |
| EP2736905A4 (en) * | 2011-07-28 | 2015-07-29 | Mapi Pharma Ltd | INTERMEDIATE COMPOUNDS AND PROCESS FOR THE PREPARATION OF LURASIDONE AND SALTS THEREOF |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1243991A (en) * | 1968-06-10 | 1971-08-25 | Ici Ltd | Piperidine, morpholine and piperazine derivatives |
| US4089965A (en) * | 1976-03-26 | 1978-05-16 | American Cyanamid Company | Thiazolylphenylguanidines as antirhinovirus agents |
| US4140785A (en) * | 1978-05-08 | 1979-02-20 | E. I. Du Pont De Nemours And Company | N-(benzothienopyrazol)amide antirhinoviral agents |
| US5001125A (en) * | 1984-03-26 | 1991-03-19 | Janssen Pharmaceutica N.V. | Anti-virally active pyridazinamines |
-
1990
- 1990-04-30 NZ NZ233503A patent/NZ233503A/en unknown
- 1990-05-10 AT AT90201185T patent/ATE102621T1/de not_active IP Right Cessation
- 1990-05-10 EP EP90201185A patent/EP0398426B1/en not_active Expired - Lifetime
- 1990-05-10 DE DE69007164T patent/DE69007164T2/de not_active Expired - Fee Related
- 1990-05-10 AU AU54943/90A patent/AU619111B2/en not_active Ceased
- 1990-05-10 DK DK90201185.7T patent/DK0398426T3/da active
- 1990-05-10 ES ES90201185T patent/ES2053078T3/es not_active Expired - Lifetime
- 1990-05-14 FI FI902388A patent/FI96948C/fi not_active IP Right Cessation
- 1990-05-14 RU SU904743852A patent/RU2057130C1/ru active
- 1990-05-14 NO NO902136A patent/NO179553C/no unknown
- 1990-05-14 CA CA002016741A patent/CA2016741A1/en not_active Abandoned
- 1990-05-14 IE IE172890A patent/IE63537B1/en not_active IP Right Cessation
- 1990-05-14 HU HU903028A patent/HUT58311A/hu unknown
- 1990-05-14 PT PT94034A patent/PT94034B/pt not_active IP Right Cessation
- 1990-05-14 IL IL9438390A patent/IL94383A/en not_active IP Right Cessation
- 1990-05-14 ZA ZA903663A patent/ZA903663B/xx unknown
- 1990-05-15 CN CN90103653A patent/CN1026489C/zh not_active Expired - Fee Related
- 1990-05-15 KR KR1019900006909A patent/KR900018089A/ko not_active Ceased
- 1990-05-15 JP JP2125261A patent/JPH0347181A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69007164D1 (de) | 1994-04-14 |
| FI96948C (fi) | 1996-09-25 |
| IE63537B1 (en) | 1995-05-17 |
| FI902388A0 (fi) | 1990-05-14 |
| PT94034B (pt) | 1996-11-29 |
| FI96948B (fi) | 1996-06-14 |
| KR900018089A (ko) | 1990-12-20 |
| EP0398426B1 (en) | 1994-03-09 |
| NO902136D0 (no) | 1990-05-14 |
| ES2053078T3 (es) | 1994-07-16 |
| ZA903663B (en) | 1992-01-29 |
| CN1026489C (zh) | 1994-11-09 |
| IL94383A (en) | 1994-07-31 |
| NO902136L (no) | 1990-11-16 |
| NO179553C (no) | 1996-10-30 |
| JPH0347181A (ja) | 1991-02-28 |
| AU5494390A (en) | 1990-11-15 |
| RU2057130C1 (ru) | 1996-03-27 |
| DK0398426T3 (da) | 1994-04-05 |
| CN1047289A (zh) | 1990-11-28 |
| IL94383A0 (en) | 1991-03-10 |
| DE69007164T2 (de) | 1994-07-07 |
| NO179553B (no) | 1996-07-22 |
| AU619111B2 (en) | 1992-01-16 |
| IE901728L (en) | 1990-11-15 |
| HUT58311A (en) | 1992-02-28 |
| HU903028D0 (en) | 1990-09-28 |
| NZ233503A (en) | 1991-06-25 |
| CA2016741A1 (en) | 1990-11-15 |
| ATE102621T1 (de) | 1994-03-15 |
| EP0398426A1 (en) | 1990-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19960829 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19990228 |