PT96455A - Processo para a preparacao de novos derivados ureidicos de compostos poli-4-amino-2-carboxi-1-metilicos e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de novos derivados ureidicos de compostos poli-4-amino-2-carboxi-1-metilicos e de composicoes farmaceuticas que os contem

Info

Publication number
PT96455A
PT96455A PT96455A PT9645591A PT96455A PT 96455 A PT96455 A PT 96455A PT 96455 A PT96455 A PT 96455A PT 9645591 A PT9645591 A PT 9645591A PT 96455 A PT96455 A PT 96455A
Authority
PT
Portugal
Prior art keywords
derivatives
substituted
ureidic
methylic
carboxy
Prior art date
Application number
PT96455A
Other languages
English (en)
Other versions
PT96455B (pt
Inventor
Marina Ciomei
Maria Grandi
Nicola Mongelli
Giovanni Biasoli
Alfredo Paio
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of PT96455A publication Critical patent/PT96455A/pt
Publication of PT96455B publication Critical patent/PT96455B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyamides (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT96455A 1990-01-11 1991-01-10 Processo para a preparacao de novos derivados ureidicos de compostos poli-4-amino-2-carboxi-1-metilicos e de composicoes farmaceuticas que os contem PT96455B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909000644A GB9000644D0 (en) 1990-01-11 1990-01-11 New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds

Publications (2)

Publication Number Publication Date
PT96455A true PT96455A (pt) 1991-10-15
PT96455B PT96455B (pt) 1998-06-30

Family

ID=10669147

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96455A PT96455B (pt) 1990-01-11 1991-01-10 Processo para a preparacao de novos derivados ureidicos de compostos poli-4-amino-2-carboxi-1-metilicos e de composicoes farmaceuticas que os contem

Country Status (33)

Country Link
US (3) US5260329A (pt)
EP (1) EP0462258B1 (pt)
JP (1) JP3121343B2 (pt)
KR (1) KR0176258B1 (pt)
CN (1) CN1032750C (pt)
AT (1) ATE131810T1 (pt)
AU (1) AU647446B2 (pt)
BG (1) BG60534B2 (pt)
CA (1) CA2050331C (pt)
CZ (1) CZ285251B6 (pt)
DE (1) DE69115570T2 (pt)
DK (1) DK0462258T3 (pt)
ES (1) ES2084153T3 (pt)
FI (1) FI99011C (pt)
GB (1) GB9000644D0 (pt)
GR (1) GR3018767T3 (pt)
HK (1) HK1006455A1 (pt)
HR (1) HRP930311B1 (pt)
HU (2) HUT61280A (pt)
IE (1) IE69462B1 (pt)
IL (1) IL96875A (pt)
MX (1) MX9203119A (pt)
MY (1) MY107890A (pt)
NO (1) NO176274C (pt)
NZ (1) NZ236707A (pt)
PT (1) PT96455B (pt)
RU (1) RU2078079C1 (pt)
SI (1) SI9110025B (pt)
SK (1) SK280190B6 (pt)
UA (1) UA32513A (pt)
WO (1) WO1991010649A1 (pt)
YU (1) YU48548B (pt)
ZA (1) ZA91177B (pt)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9000644D0 (en) * 1990-01-11 1990-03-14 Erba Carlo Spa New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
WO1992013838A1 (en) * 1991-02-06 1992-08-20 Synphar Laboratories, Inc. Oligopeptide antiretroviral agents
GB2261661A (en) * 1991-11-21 1993-05-26 Erba Carlo Spa Derivatives of poly-4-amino-2-carboxy-1-methyl pyrroles
GB9216962D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives
GB9225475D0 (en) * 1992-12-05 1993-01-27 Imp Cancer Res Tech Compounds to combat angiogenesis
US6114355A (en) * 1993-03-01 2000-09-05 D'amato; Robert Methods and compositions for inhibition of angiogenesis
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US8143283B1 (en) 1993-03-01 2012-03-27 The Children's Medical Center Corporation Methods for treating blood-born tumors with thalidomide
GB9304589D0 (en) * 1993-03-05 1993-04-21 Erba Carlo Spa Biologically active ureido derivatives useful as antimetastic agents
GB9307948D0 (en) * 1993-04-16 1993-06-02 Erba Carlo Spa Biologically active ureido derivatives useful in the treatment of lentivirus-induced disease
DE4320157A1 (de) * 1993-06-18 1994-12-22 Bayer Ag Verwendung von 1,2,4-Dithiazolium-Salzen als Chemotherapeutica
US5463063A (en) * 1993-07-02 1995-10-31 Celgene Corporation Ring closure of N-phthaloylglutamines
GB9403909D0 (en) * 1994-03-01 1994-04-20 Erba Carlo Spa Ureido derivatives of naphthalenephosphonic acids and process for their preparation
GB9504065D0 (en) * 1995-03-01 1995-04-19 Pharmacia Spa Poly-pyrrolecarboxamidonaphthalenic acid derivatives
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
GB2310207A (en) * 1996-02-15 1997-08-20 Pharmacia Spa Antiviral ureido derivatives of substituted heterocyclic compounds
ATE493983T1 (de) * 1996-11-05 2011-01-15 Childrens Medical Center Thalidomide und dexamethason für die behandlung von tumors
GB9713732D0 (en) * 1997-06-27 1997-09-03 Pharmacia & Upjohn Spa Substituted triazinic compounds
GB9713733D0 (en) * 1997-06-27 1997-09-03 Pharmacia & Upjohn Spa Poly-branched polycarboxamido compounds
US6562859B1 (en) 1997-12-04 2003-05-13 The United States Of America As Represented By The Department Of Health And Human Services Ureido derivatives of poly-4-amino-2-carboxy-1-methyl pyrrole compounds for inhibition of inflammation
DE69831013T2 (de) * 1997-12-22 2006-04-20 Bayer Pharmaceuticals Corp., West Haven Inhibierung der raf-kinase durch substituierte heterocyclische harnstoffverbindungen
GB9727524D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
US7378400B2 (en) * 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
US6232297B1 (en) * 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
US7427606B2 (en) * 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
GB0015447D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
ATE374609T1 (de) 2000-11-30 2007-10-15 Childrens Medical Center Synthese von 4-aminothalidomid enantiomeren
DK1382604T3 (da) * 2001-04-27 2006-04-18 Kirin Brewery Quinolinderivater med en azolylgruppe og quinazolinderivater
EP1470119A4 (en) * 2001-06-13 2005-10-19 Genesoft Pharmaceuticals Inc BENZOTHIOPHENE COMPOUNDS WITH ANTI-INFECTIOUS ACTIVITY
NZ531294A (en) * 2001-08-06 2005-11-25 Childrens Medical Center Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs
NZ556354A (en) * 2001-10-01 2008-10-31 Univ Virginia 2-Propynyl adenosine analogs having A2A agonist activity and compositions thereof
DK1471054T3 (da) * 2002-01-11 2009-11-09 Daiichi Sankyo Co Ltd Aminoalkohol-derivat eller phosphonsyre-derivat og medicinsk sammensætning, der indeholder disse
NZ549162A (en) 2004-02-24 2009-12-24 Sankyo Co Amino-pyrrol alcohol compounds
WO2006023272A1 (en) * 2004-08-02 2006-03-02 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having a2a agonist activity
AU2005267706B2 (en) * 2004-08-02 2011-12-08 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity
US7576069B2 (en) * 2004-08-02 2009-08-18 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having A2A agonist activity
US8178509B2 (en) * 2006-02-10 2012-05-15 University Of Virginia Patent Foundation Method to treat sickle cell disease
US8188063B2 (en) * 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
US8058259B2 (en) * 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
EP3381897A1 (en) 2017-03-27 2018-10-03 Leadiant Biosciences SA Derivatives of the disodium 2,2'-{carbonylbis[imino-3,1-phenylenecarbonylimino(1-methyl-1h-pyrrole-4,2-diyl)carbonylimino]}dinaphthalene-1,5-disulfonate salt and related compounds as heparanase inhibitors for the treatment of cancer
US12152106B2 (en) 2020-06-15 2024-11-26 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Electrically conducting polyamides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2785183A (en) * 1954-04-19 1957-03-12 American Cyanamid Co N [4-aminopyrrolyl-2-carbonyl] amino acids
US2785182A (en) * 1954-04-19 1957-03-12 American Cyanamid Co Substituted pyrrolecarboxamidopyroles
CA1308516C (en) * 1987-07-06 1992-10-06 The Governors Of The University Of Alberta Oligopeptide anticancer and antiviral agents
GB9000644D0 (en) * 1990-01-11 1990-03-14 Erba Carlo Spa New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
GB9028123D0 (en) * 1990-12-28 1991-02-13 Erba Carlo Spa Monoclonal antibodies against human tumor necrosis factor alpha

Also Published As

Publication number Publication date
CA2050331C (en) 2002-03-19
CN1032750C (zh) 1996-09-11
CA2050331A1 (en) 1991-07-12
DK0462258T3 (da) 1996-01-29
HRP930311A2 (en) 1994-12-31
YU48548B (sh) 1998-11-05
SI9110025A (en) 1996-10-31
AU7059991A (en) 1991-08-05
MX9203119A (es) 1992-07-01
EP0462258B1 (en) 1995-12-20
HUT61280A (en) 1992-12-28
KR0176258B1 (ko) 1999-03-20
GB9000644D0 (en) 1990-03-14
ATE131810T1 (de) 1996-01-15
CN1053230A (zh) 1991-07-24
EP0462258A1 (en) 1991-12-27
HU912923D0 (en) 1992-01-28
PT96455B (pt) 1998-06-30
IE69462B1 (en) 1996-09-18
HK1006455A1 (en) 1999-02-26
DE69115570T2 (de) 1996-05-02
NO913572D0 (no) 1991-09-10
MY107890A (en) 1996-06-29
RU2078079C1 (ru) 1997-04-27
HRP930311B1 (en) 2000-04-30
CS9100056A2 (en) 1991-10-15
WO1991010649A1 (en) 1991-07-25
FI914251A0 (fi) 1991-09-09
BG60534B2 (bg) 1995-07-28
FI99011B (fi) 1997-06-13
ES2084153T3 (es) 1996-05-01
DE69115570D1 (de) 1996-02-01
KR920701150A (ko) 1992-08-11
JP3121343B2 (ja) 2000-12-25
NO913572L (no) 1991-09-10
HU211237A9 (en) 1995-11-28
SK280190B6 (sk) 1999-09-10
YU2591A (sh) 1994-05-10
IL96875A (en) 1995-03-30
CZ285251B6 (cs) 1999-06-16
US5260329A (en) 1993-11-09
IE910074A1 (en) 1991-07-17
JPH04504426A (ja) 1992-08-06
NZ236707A (en) 1992-10-28
US5420296A (en) 1995-05-30
ZA91177B (en) 1991-10-30
SI9110025B (sl) 1998-06-30
UA32513A (uk) 2001-02-15
US5593976A (en) 1997-01-14
FI99011C (fi) 1997-09-25
IL96875A0 (en) 1992-03-29
NO176274B (no) 1994-11-28
NO176274C (no) 1995-03-08
GR3018767T3 (en) 1996-04-30
AU647446B2 (en) 1994-03-24

Similar Documents

Publication Publication Date Title
PT96455A (pt) Processo para a preparacao de novos derivados ureidicos de compostos poli-4-amino-2-carboxi-1-metilicos e de composicoes farmaceuticas que os contem
LU91362I2 (fr) Palipéridone et ses dérivés pharmaceutiquement acceptables (INVEGA)
FI921030A0 (fi) Cykliska ureaderivat, dessa foereningar innehaollande laekemedel och foerfarande foer deras framstaellning.
CZ284872B6 (cs) Cyklické močoviny a jejich analogy a farmaceutické přípravky na jejich bázi
FI803264L (fi) 2-hydroxialkyl-3,4,5-trihydroxipiperidiner foerfarande foer framstaellning av dem och anvaendning av dem som laekemedel
MX163528B (es) Productos de reaccion de poli(oxialquileno)de acido succinico hidrocarbilo-substituido y/o terminados de anhidrido amina y sistemas acuosos conteniendo los mismos
FI875596A0 (fi) Foerfarande foer framstaellning av tienyletylaminer och aeven ditienyletylaminer.
RU94040382A (ru) Серотонинэргические производные эрголина, способы их получения, фармацевтическая композиция
ES2125963T3 (es) Nuevos derivados espiranicos del 3-amino-cromano, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen.
ES2075180T3 (es) Nuevos derivados de la piridona, su procedimiento de preparacion, los nuevos productos intermedios obtenidos, su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.
SE8501988L (sv) Iminotiazolidinderivat
BG96487A (bg) Р-заместени производни на 4-оксибутанамина,методи за получаването им и тяхното приложение
ATE56436T1 (de) Diselenobisbenzoesaeureamide primaerer heterocyclischer amine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
MX9307874A (es) Compuestos de amida ciclica, procedimiento para supreparacion y su uso como herbicidas.
SE8801964L (sv) Nya 5-(w-ammoniumacyloximetylen)tetrahydrofuraner och -tetrahydrotiofener
SE8801945L (sv) Nya 5-metoxi- aklylammonium- tetrahydrofuraner och -tetrahydrotiofener
MA21913A1 (fr) Procede de preparation de derives amino-oligohydroxy inhibiteurs de la renine .
NZ220294A (en) Heteropolycyclic aromatic amines and pharmaceutical compositions thereof
KR960014106A (ko) 신규한 항바이러스성 1-알킬-2,4-피리미딘디온 유도체 및 그의 제조방법
IL61253A (en) Nb-quaternary derivatives of 10-bromoajmaline and 10-bromoisoajmaline,their preparation and pharmaceutical compositions containing them
ATE9228T1 (de) N(b)-quartaere derivate von 10-bromsandwicin und 10-bromisosandwicin, verfahren und zwischenprodukte zur herstellung der derivate und diese derivate enthaltende arzneimittel.
SE8802162D0 (sv) Nya aminoacylater av glycerolacetal
NO974458L (no) Fremstilling av cis-4-O-beskyttede-2-cyklopentenolderivater
JPS5283453A (en) Preparation of intermediate for synthesizing prostaglandin

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19910531

FG3A Patent granted, date of granting

Effective date: 19980331

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20020930