PT96788A - Processo de preparacao de compostos de ureia substituida e de composicoes farmaceuticas - Google Patents

Processo de preparacao de compostos de ureia substituida e de composicoes farmaceuticas

Info

Publication number: PT96788A
Authority: PT; Portugal
Prior art keywords: chemical structure; compounds; substituted; ureia; preparation
Prior art date: 1990-02-16

Application number

PT96788A

Other languages

English (en)

Other versions

PT96788B (pt

Inventor

John Bondo Hansen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-16

Filing date

1991-02-15

Publication date

1991-10-31

1991-02-15 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1991-10-31 Publication of PT96788A publication Critical patent/PT96788A/pt

1998-07-31 Publication of PT96788B publication Critical patent/PT96788B/pt

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
239000000126 substance Substances 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
208000028017 Psychotic disease Diseases 0.000 abstract 1
206010047700 Vomiting Diseases 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical group C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
150000003672 ureas Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Treating Waste Gases (AREA)
Peptides Or Proteins (AREA)
Cephalosporin Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT96788A 1990-02-16 1991-02-15 Processo de preparacao de compostos de ureia substituida e de composicoes farmaceuticas PT96788B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK040890A DK40890D0 (da)	1990-02-16	1990-02-16	Substituerede urinstofforbindelser, deres fremstilling og anvendelse

Publications (2)

Publication Number	Publication Date
PT96788A true PT96788A (pt)	1991-10-31
PT96788B PT96788B (pt)	1998-07-31

Family

ID=8093190

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96788A PT96788B (pt)	1990-02-16	1991-02-15	Processo de preparacao de compostos de ureia substituida e de composicoes farmaceuticas

Country Status (15)

Country	Link
US (2)	US5187164A (pt)
EP (1)	EP0515537B1 (pt)
JP (1)	JPH05504358A (pt)
AT (1)	ATE156128T1 (pt)
AU (1)	AU648066B2 (pt)
CA (1)	CA2074803A1 (pt)
DE (1)	DE69127072T2 (pt)
DK (1)	DK40890D0 (pt)
FI (1)	FI923475A0 (pt)
IE (1)	IE910523A1 (pt)
IL (1)	IL97429A (pt)
NZ (1)	NZ237122A (pt)
PT (1)	PT96788B (pt)
WO (1)	WO1991012254A1 (pt)
ZA (1)	ZA911103B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5530008A (en) *	1989-04-21	1996-06-25	Sandoz Ltd.	Use of 5-HT3 receptor antagonists in treating panic disorders or obsessive compulsive disorders
DK443489D0 (da) *	1989-09-08	1989-09-08	Ferrosan As	Substituerede urinstofforbindelser, deres fremstilling og anvendelse
GB9214184D0 (en) *	1992-07-03	1992-08-12	Smithkline Beecham Plc	Pharmaceuticals
US5663182A (en) *	1993-08-19	1997-09-02	Bymaster; Franklin Porter	Antipsychotic method
US6953855B2 (en) *	1998-12-11	2005-10-11	Targacept, Inc.	3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
WO2001095903A1 (en) *	2000-06-15	2001-12-20	Respiratorius Ab	5-ht3 receptor antagonists for treatment of disorders involving airway constriction
AU2003303373B8 (en) *	2002-12-18	2010-06-10	Cytovia, Inc.	3,5-disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
DK1663978T3 (da)	2003-07-23	2008-04-07	Bayer Pharmaceuticals Corp	Fluorsubstitueret omega-carboxyaryl-diphenylurinstof til behandling og forebyggelse af sygdomme og lidelser
SA08290475B1 (ar)	2007-08-02	2013-06-22	Targacept Inc	(2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
TW201031664A (en)	2009-01-26	2010-09-01	Targacept Inc	Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
WO2014051055A1 (ja) *	2012-09-28	2014-04-03	東レ株式会社	キヌクリジンウレア誘導体及びその医薬用途
US9724340B2 (en)	2015-07-31	2017-08-08	Attenua, Inc.	Antitussive compositions and methods

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3917615A (en) *	1974-04-01	1975-11-04	Searle & Co	1,1-Diaryl-1-oxadiazol-alkylamines
US4003904A (en) *	1974-04-01	1977-01-18	G. D. Searle & Co.	Anti-diarrheal oxadiazoles
CH614709A5 (pt) *	1975-09-25	1979-12-14	Ciba Geigy Ag
US4012393A (en) *	1976-03-22	1977-03-15	G. D. Searle & Co.	2-[5-(CYCLIC AMINO) ETHYL-10,11-DIHYDRO-5H-dibenzo[a,d]-cyclohepten-5- yl]-5
EP0235878A3 (en) *	1986-01-16	1989-06-14	Beecham Group Plc	Novel compounds
DE3785507T2 (de) *	1986-07-31	1993-07-29	Beecham Group Plc	Azabicyclische verbindungen, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.
IE63906B1 (en) *	1987-11-13	1995-06-14	Novo Nordisk As	Azabicyclic compounds and their preparation and use
IE62231B1 (en) *	1987-12-24	1995-01-11	Wyeth John & Brother Ltd	Heterocyclic compounds
US4863921A (en) *	1988-04-27	1989-09-05	Rorer Pharmaceutical Corporation	Dibenzofurancarboxamides and their pharmaceutical compositions and methods
DK443489D0 (da) *	1989-09-08	1989-09-08	Ferrosan As	Substituerede urinstofforbindelser, deres fremstilling og anvendelse

1990
- 1990-02-16 DK DK040890A patent/DK40890D0/da not_active Application Discontinuation
1991
- 1991-02-04 US US07/650,143 patent/US5187164A/en not_active Expired - Fee Related
- 1991-02-14 ZA ZA911103A patent/ZA911103B/xx unknown
- 1991-02-14 NZ NZ237122A patent/NZ237122A/xx unknown
- 1991-02-15 CA CA002074803A patent/CA2074803A1/en not_active Abandoned
- 1991-02-15 JP JP3504586A patent/JPH05504358A/ja active Pending
- 1991-02-15 WO PCT/DK1991/000044 patent/WO1991012254A1/en not_active Ceased
- 1991-02-15 AU AU73409/91A patent/AU648066B2/en not_active Ceased
- 1991-02-15 FI FI923475A patent/FI923475A0/fi not_active Application Discontinuation
- 1991-02-15 PT PT96788A patent/PT96788B/pt not_active IP Right Cessation
- 1991-02-15 IE IE052391A patent/IE910523A1/en unknown
- 1991-02-15 AT AT91905032T patent/ATE156128T1/de not_active IP Right Cessation
- 1991-02-15 EP EP91905032A patent/EP0515537B1/en not_active Expired - Lifetime
- 1991-02-15 DE DE69127072T patent/DE69127072T2/de not_active Expired - Fee Related
- 1991-03-05 IL IL9742991A patent/IL97429A/en not_active IP Right Cessation
1992
- 1992-08-17 US US07/931,229 patent/US5290795A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5187164A (en)	1993-02-16
EP0515537B1 (en)	1997-07-30
US5290795A (en)	1994-03-01
DK40890D0 (da)	1990-02-16
AU648066B2 (en)	1994-04-14
CA2074803A1 (en)	1991-08-17
IE910523A1 (en)	1991-08-28
FI923475L (fi)	1992-07-31
PT96788B (pt)	1998-07-31
IL97429A0 (en)	1992-06-21
AU7340991A (en)	1991-09-03
NZ237122A (en)	1993-02-25
ZA911103B (en)	1991-11-27
ATE156128T1 (de)	1997-08-15
DE69127072D1 (de)	1997-09-04
IL97429A (en)	1996-01-31
FI923475A7 (fi)	1992-07-31
WO1991012254A1 (en)	1991-08-22
DE69127072T2 (de)	1998-01-22
FI923475A0 (fi)	1992-07-31
JPH05504358A (ja)	1993-07-08
EP0515537A1 (en)	1992-12-02

Legal Events

Date

Code

Title

Description

1991-10-31

BB1A

Laying open of patent application

Effective date: 19910702

1998-07-31

FG3A

Patent granted, date of granting

Effective date: 19980407

2000-02-29

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19991031

Publication	Publication Date	Title
NO920833D0 (no)	1992-03-03	Substituerte ureaforbindelser og bearbeiding og bruk av disse
YU115688A (en)	1988-10-31	Process for obtaining derivatives of imidazole as calcium independent camp inhibtors of phosphodiestheraze
FI96857B (fi)	1996-05-31	Menetelmä valmistaa farmakologisesti käyttökelpoista tiatsoliyhdistettä
NO942452D0 (no)	1994-06-29	Amid- og ureaderivater med antihyperkolesteremisk aktivitet, deres fremstilling og terapeutiske anvendelser
NO891471D0 (no)	1989-04-10	Fremgangsmaate for fremstilling av spirocykliske forbindelser innbefattende fem-leddede ringer med to heteroatomer.
FI925871A0 (fi)	1992-12-23	Menetelmä terapeuttisesti aktiivisten fenyyliguanidiinijohdannaisten valmistamiseksi
IL97429A0 (en)	1992-06-21	Substituted urea compounds,their preparation and pharmaceutical compositions comprising them
CS743389A3 (en)	1992-03-18	Amino(methyl)phenyl derivatives, process for their preparation and use
DK492288D0 (da)	1988-09-05	Amidforbindelser, farmaceutisk praeparat indeholdende samme samt fremgangsmaade til fremstilling af forbindelserne
TW238304B (en)	1995-01-11	A process for the preparation of 1-substituted-5(4H)-tetrazolinones
DE68927554D1 (de)	1997-01-30	Cephalosporinverbindungen und Verfahren zu ihrer Herstellung
AR247737A1 (es)	1995-03-31	Un procedimiento para la fabricacion de compuestos.
NO923194L (no)	1992-08-14	Substituerte urea-forbindelser, deres fremstilling og anvendelse
NZ328482A (en)	2000-12-22	Using an H2 or H3 agonist to treat sexual dysfunction