PT96871A - Processo para a preparacao de compostos 3-arilcarbonil-1h-indol uteis como agentes terapeuticos - Google Patents

Processo para a preparacao de compostos 3-arilcarbonil-1h-indol uteis como agentes terapeuticos

Info

Publication number
PT96871A
PT96871A PT96871A PT9687191A PT96871A PT 96871 A PT96871 A PT 96871A PT 96871 A PT96871 A PT 96871A PT 9687191 A PT9687191 A PT 9687191A PT 96871 A PT96871 A PT 96871A
Authority
PT
Portugal
Prior art keywords
uteis
arylcarbonyl
indol
compounds
preparation
Prior art date
Application number
PT96871A
Other languages
English (en)
Other versions
PT96871B (pt
Inventor
Thomas Edward D Ambra
Edward Richard Bacon
Malcolm Rice Bell
Philip Michael Carabateas
Michael Allen Eissenstat
Virendra Kumar
John Peter Mallamo
Susan Jean Ward
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of PT96871A publication Critical patent/PT96871A/pt
Publication of PT96871B publication Critical patent/PT96871B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
PT96871A 1990-02-26 1991-02-25 Processo para a preparacao de compostos 3-arilcarbonil-1h-indol uteis como agentes terapeuticos PT96871B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/484,759 US5068234A (en) 1990-02-26 1990-02-26 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles

Publications (2)

Publication Number Publication Date
PT96871A true PT96871A (pt) 1991-10-31
PT96871B PT96871B (pt) 1998-07-31

Family

ID=23925489

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96871A PT96871B (pt) 1990-02-26 1991-02-25 Processo para a preparacao de compostos 3-arilcarbonil-1h-indol uteis como agentes terapeuticos

Country Status (17)

Country Link
US (4) US5068234A (pt)
EP (1) EP0444451A3 (pt)
JP (1) JPH0741475A (pt)
KR (1) KR100191258B1 (pt)
AU (1) AU638795B2 (pt)
CA (1) CA2035711A1 (pt)
FI (1) FI910851A7 (pt)
HU (1) HU208132B (pt)
IE (1) IE910492A1 (pt)
IL (1) IL97313A (pt)
MX (1) MX24568A (pt)
MY (1) MY107158A (pt)
NO (1) NO177006C (pt)
NZ (1) NZ237041A (pt)
PT (1) PT96871B (pt)
RU (1) RU2052457C1 (pt)
SG (1) SG55090A1 (pt)

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US5486525A (en) * 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles
US5532237A (en) * 1995-02-15 1996-07-02 Merck Frosst Canada, Inc. Indole derivatives with affinity for the cannabinoid receptor
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GB2308362A (en) * 1995-12-19 1997-06-25 Lilly Industries Ltd Pharmaceutical indole derivatives
DE69717148T2 (de) * 1996-12-10 2003-10-02 Abbott Laboratories, Abbott Park 3-pyridylenantiomere und ihre verwendung als analgetika
US6132762A (en) * 1997-05-05 2000-10-17 Cristobal; Walter Transcutaneous application of marijuana
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CA2340445A1 (en) * 1998-05-04 1999-11-11 The University Of Connecticut Novel analgesic and immunomodulatory cannabinoids
US6166069A (en) * 1998-05-12 2000-12-26 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6479535B1 (en) 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
US7897598B2 (en) * 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
US7589220B2 (en) * 1998-06-09 2009-09-15 University Of Connecticut Inhibitors of the anandamide transporter
US7276613B1 (en) 1998-11-24 2007-10-02 University Of Connecticut Retro-anandamides, high affinity and stability cannabinoid receptor ligands
US7161016B1 (en) 1998-11-24 2007-01-09 University Of Connecticut Cannabimimetic lipid amides as useful medications
US6566560B2 (en) 1999-03-22 2003-05-20 Immugen Pharmaceuticals, Inc. Resorcinolic compounds
US6943266B1 (en) * 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
US7741365B2 (en) * 1999-10-18 2010-06-22 University Of Connecticut Peripheral cannabinoid receptor (CB2) selective ligands
US8084467B2 (en) * 1999-10-18 2011-12-27 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
EP1702617A1 (en) * 1999-10-18 2006-09-20 The University Of Connecticut Cannabimimetic indole derivatives
US6900236B1 (en) 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
US7393842B2 (en) * 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
CA2387764A1 (en) 1999-10-18 2001-04-26 University Of Connecticut Peripheral cannabinoid receptor (cb2) selective ligands
US7119108B1 (en) 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
AU2042301A (en) * 1999-12-03 2001-06-12 Alcon Universal Limited 1-aminoalkyl-1H-indoles for treating glaucoma
WO2002026224A2 (en) * 2000-09-28 2002-04-04 Immugen Pharmaceuticals, Inc. Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation
US6541510B2 (en) * 2000-09-28 2003-04-01 Immugen Pharmaceuticals, Inc. Antiviral methods and compounds
AUPR118000A0 (en) * 2000-11-02 2000-11-23 Amrad Operations Pty. Limited Therapeutic molecules and methods
EP1361876A4 (en) * 2001-01-26 2004-03-31 Univ Connecticut NEW CANNABIMIMETIC LIGANDS
DE60237431D1 (de) 2001-01-29 2010-10-07 Univ Connecticut Rezeptor-selektive cannabimimetische aminoalkylindole
TW200600497A (en) * 2001-02-02 2006-01-01 Sankyo Co Preparation of indoline derivative
JP4312594B2 (ja) * 2001-07-13 2009-08-12 ユニバーシティ オブ コネチカット 新規な二環式及び三環式カンナビノイド
JP2003040866A (ja) * 2001-07-31 2003-02-13 Nippon Kayaku Co Ltd Ｎ置換インドール誘導体、その製造法及びそれを有効成分とする害虫防除剤
PL373115A1 (en) * 2001-08-30 2005-08-08 F.Hoffmann-La Roche Ag Aminopyrrole compounds as antiinflammatory agents
US7666867B2 (en) * 2001-10-26 2010-02-23 University Of Connecticut Heteroindanes: a new class of potent cannabimimetic ligands
WO2003080043A1 (en) * 2002-03-18 2003-10-02 Immugen Pharmaceuticals, Inc. Topical formulations of resorcinols and cannibinoids and methods of use
DE60320784D1 (de) 2002-06-06 2008-06-19 Yissum Res Dev Co Stände zur modulierung des knochenwachstums
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WO2005007628A1 (en) 2003-07-11 2005-01-27 Bristol-Myers Squibb Company Tetrahydroquinoline derivatives as cannabinoid receptor modulators
US7326706B2 (en) 2003-08-15 2008-02-05 Bristol-Myers Squibb Company Pyrazine modulators of cannabinoid receptors
IL160420A0 (en) 2004-02-16 2004-07-25 Yissum Res Dev Co Treating or preventing diabetes with cannabidiol
ES2346900T3 (es) * 2005-03-12 2010-10-21 Unilever N.V. Composiciones para el cuidado del cabello y/o el cuero cabelludo que incorporan compuestos amino-oxo-indol-ilideno.
JP4901853B2 (ja) * 2005-03-12 2012-03-21 ユニリーバー・ナームローゼ・ベンノートシヤープ テルペノイド化合物を含む頭髪および／または頭皮ケア組成物
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DE102009056426A1 (de) 2009-09-03 2011-03-10 Liebherr-Hausgeräte Ochsenhausen GmbH Unterbaugruppenelement für ein Kühl- und/oder Gefriergerät, Kühl- und/oder Gefriergerät sowie Verfahren zur Montage eines Kühl- und/oder Gefriergerätes
CN102838525A (zh) * 2012-09-04 2012-12-26 江苏昊华精细化工有限公司 1-戊基-3-(1萘甲酰基)吲哚的合成方法
EP3519816A4 (en) 2016-09-29 2020-05-06 The Regents of the University of California CONNECTIONS FOR INCREASING NEURONAL PLASTICITY
MX2021010198A (es) * 2019-02-27 2021-09-21 Univ California Indoles n-sustituidos y otros heterociclos para el tratamiento de trastornos cerebrales.
KR102946120B1 (ko) 2019-02-27 2026-03-30 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 뇌 장애를 치료하기 위한 아제피노-인돌 및 다른 헤테로사이클
IL313455A (en) 2021-12-15 2024-08-01 Delix Therapeutics Inc Phenoxy and benzyloxy modified psychroplastogens and their uses

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BR6570394D0 (pt) * 1964-07-02 1973-08-14 Merck & Co Inc Processo para a preparacao de compostos da serie indolica
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Also Published As

Publication number Publication date
US5607933A (en) 1997-03-04
IL97313A (en) 1995-07-31
HU208132B (en) 1993-08-30
AU7122291A (en) 1991-08-29
JPH0741475A (ja) 1995-02-10
EP0444451A3 (en) 1992-04-08
MY107158A (en) 1995-09-30
NO910731D0 (no) 1991-02-25
AU638795B2 (en) 1993-07-08
RU2052457C1 (ru) 1996-01-20
IL97313A0 (en) 1992-05-25
NZ237041A (en) 1992-11-25
NO177006B (no) 1995-03-27
MX24568A (es) 1993-09-01
US5324737A (en) 1994-06-28
US5068234A (en) 1991-11-26
CA2035711A1 (en) 1991-08-27
HU910400D0 (en) 1991-08-28
KR100191258B1 (ko) 1999-06-15
IE910492A1 (en) 1991-08-28
KR910021399A (ko) 1991-12-20
FI910851A0 (fi) 1991-02-22
FI910851A7 (fi) 1991-08-27
NO910731L (no) 1991-08-27
HUT56565A (en) 1991-09-30
SG55090A1 (en) 1998-12-21
US5817651A (en) 1998-10-06
PT96871B (pt) 1998-07-31
EP0444451A2 (en) 1991-09-04
NO177006C (no) 1995-07-05

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Effective date: 19910704

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Effective date: 19980408

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