PT97720A - Processo para a preparacao de 3-{1-tiazolidinil-butil-4-piperazinil}-1h-indazois e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de 3-{1-tiazolidinil-butil-4-piperazinil}-1h-indazois e de composicoes farmaceuticas que os contem

Info

Publication number: PT97720A
Authority: PT; Portugal
Prior art keywords: loweralkyl; pyerazinyl; indazoes; thiazolidinyl; butyl
Prior art date: 1990-05-21

Application number

PT97720A

Other languages

English (en)

Other versions

PT97720B (pt

Inventor

Joseph Thomas Strupczewski

Nicholas J Hrib

John G Jurcak

Kenneth Bordean

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-21

Filing date

1991-05-20

Publication date

1992-02-28

1991-05-20 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1992-02-28 Publication of PT97720A publication Critical patent/PT97720A/pt

1998-09-30 Publication of PT97720B publication Critical patent/PT97720B/pt

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
150000001721 carbon Chemical group 0.000 abstract 2
125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 2
DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 abstract 2
VBZPHJDTCUOIGW-UHFFFAOYSA-N 2-[1-[4-(1h-indazol-3-yl)piperazin-1-yl]butyl]-1,3-thiazolidine Chemical class C1CN(C=2C3=CC=CC=C3NN=2)CCN1C(CCC)C1NCCS1 VBZPHJDTCUOIGW-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
239000000164 antipsychotic agent Substances 0.000 abstract 1
125000003435 aroyl group Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
-1 loweralkyl Chemical group 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)

PT97720A 1990-05-21 1991-05-20 Processo para a preparacao de 3-{1-tiazolidinil-butil-4-piperazinil}-1h-indazois e de composicoes farmaceuticas que os contem PT97720B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/526,089 US5041445A (en)	1990-05-21	1990-05-21	3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles

Publications (2)

Publication Number	Publication Date
PT97720A true PT97720A (pt)	1992-02-28
PT97720B PT97720B (pt)	1998-09-30

Family

ID=24095872

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97720A PT97720B (pt)	1990-05-21	1991-05-20	Processo para a preparacao de 3-{1-tiazolidinil-butil-4-piperazinil}-1h-indazois e de composicoes farmaceuticas que os contem

Country Status (23)

Country	Link
US (1)	US5041445A (pt)
EP (1)	EP0458234B1 (pt)
JP (1)	JP3161755B2 (pt)
KR (1)	KR100215616B1 (pt)
AT (1)	ATE178327T1 (pt)
AU (1)	AU642243B2 (pt)
CA (1)	CA2042982A1 (pt)
CZ (1)	CZ280005B6 (pt)
DE (1)	DE69131057T2 (pt)
DK (1)	DK0458234T3 (pt)
ES (1)	ES2130125T3 (pt)
FI (1)	FI94757C (pt)
GR (1)	GR3030233T3 (pt)
HU (1)	HU215845B (pt)
IE (1)	IE911708A1 (pt)
IL (1)	IL98184A (pt)
MX (1)	MX25858A (pt)
NO (1)	NO179749C (pt)
NZ (1)	NZ238184A (pt)
PL (1)	PL165731B1 (pt)
PT (1)	PT97720B (pt)
RU (2)	RU2038355C1 (pt)
ZA (1)	ZA913794B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3875073T2 (de) *	1987-11-20	1993-03-11	Hoechst Roussel Pharma	3-(4(1-substituierte-4-piperazinyl)butyl)-4-thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel.
US5801186A (en) *	1987-11-20	1998-09-01	Hoechst Marion Roussel, Inc.	3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
CA2157348A1 (en) *	1994-09-01	1996-03-02	Aventis Pharmaceuticals Inc.	3-¬4-(1-substituted-4-piperazinyl)butyl\|-4-thiazolidinone and related compounds
EP1984351A1 (en) *	2006-02-17	2008-10-29	Memory Pharmaceuticals Corporation	Compounds having 5-ht6 receptor affinity
WO2009023844A2 (en) *	2007-08-15	2009-02-19	Memory Pharmaceuticals Corporation	3' substituted compounds having 5-ht6 receptor affinity
US20100016297A1 (en) *	2008-06-24	2010-01-21	Memory Pharmaceuticals Corporation	Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
US20100029629A1 (en) *	2008-07-25	2010-02-04	Memory Pharmaceuticals Corporation	Acyclic compounds having 5-ht6 receptor affinity
US20100056531A1 (en) *	2008-08-22	2010-03-04	Memory Pharmaceuticals Corporation	Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
JP5760300B2 (ja)	2009-09-10	2015-08-05	株式会社リコー	インクジェット用インク組成物材料及びインクジェット用インク組成物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4100282A (en) *	1972-12-23	1978-07-11	Boehringer Ingelheim Gmbh	N-Aryl-N'-(phenyl- or phenoxy-alkyl)-piperazines and salts thereof
DE3132916A1 (de) *	1981-08-20	1983-03-03	Kali-Chemie Pharma Gmbh, 3000 Hannover	1-phenylindazol-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4775761A (en) *	1983-08-22	1988-10-04	Hoechst-Roussel Pharmaceuticals, Inc.	3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles
US4732984A (en) *	1985-10-17	1988-03-22	American Home Products Corporation	Piperazinoisothiazolones with psychotropic activity
EP0302423A3 (en) *	1987-08-07	1991-01-09	Hoechst-Roussel Pharmaceuticals Incorporated	1-phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments
DE3875073T2 (de) *	1987-11-20	1993-03-11	Hoechst Roussel Pharma	3-(4(1-substituierte-4-piperazinyl)butyl)-4-thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel.
NZ230045A (en) *	1988-08-05	1990-11-27	Janssen Pharmaceutica Nv	3-piperazinylbenzazole derivatives and pharmaceutical compositions
US4954503A (en) *	1989-09-11	1990-09-04	Hoechst-Roussel Pharmaceuticals, Inc.	3-(1-substituted-4-piperazinyl)-1H-indazoles

1990
- 1990-05-21 US US07/526,089 patent/US5041445A/en not_active Expired - Fee Related
1991
- 1991-04-29 AU AU76181/91A patent/AU642243B2/en not_active Ceased
- 1991-05-16 NO NO911921A patent/NO179749C/no not_active IP Right Cessation
- 1991-05-17 FI FI912401A patent/FI94757C/fi active
- 1991-05-17 NZ NZ238184A patent/NZ238184A/en unknown
- 1991-05-17 IL IL9818491A patent/IL98184A/en unknown
- 1991-05-20 IE IE170891A patent/IE911708A1/en not_active IP Right Cessation
- 1991-05-20 PL PL91290327A patent/PL165731B1/pl unknown
- 1991-05-20 MX MX2585891A patent/MX25858A/es unknown
- 1991-05-20 KR KR1019910008144A patent/KR100215616B1/ko not_active Expired - Fee Related
- 1991-05-20 ZA ZA913794A patent/ZA913794B/xx unknown
- 1991-05-20 PT PT97720A patent/PT97720B/pt not_active IP Right Cessation
- 1991-05-20 RU SU914895498A patent/RU2038355C1/ru active
- 1991-05-20 CZ CS911480A patent/CZ280005B6/cs not_active IP Right Cessation
- 1991-05-20 JP JP14277791A patent/JP3161755B2/ja not_active Expired - Fee Related
- 1991-05-21 CA CA002042982A patent/CA2042982A1/en not_active Abandoned
- 1991-05-21 HU HU1697/91A patent/HU215845B/hu not_active IP Right Cessation
- 1991-05-21 EP EP91108124A patent/EP0458234B1/en not_active Expired - Lifetime
- 1991-05-21 DE DE69131057T patent/DE69131057T2/de not_active Expired - Fee Related
- 1991-05-21 AT AT91108124T patent/ATE178327T1/de not_active IP Right Cessation
- 1991-05-21 ES ES91108124T patent/ES2130125T3/es not_active Expired - Lifetime
- 1991-05-21 DK DK91108124T patent/DK0458234T3/da active
1993
- 1993-05-18 RU RU93005087A patent/RU2105765C1/ru active
1999
- 1999-05-14 GR GR990401320T patent/GR3030233T3/el unknown

Also Published As

Publication number	Publication date
GR3030233T3 (en)	1999-08-31
EP0458234A2 (en)	1991-11-27
HU911697D0 (en)	1991-11-28
RU2038355C1 (ru)	1995-06-27
HUT61018A (en)	1992-11-30
ES2130125T3 (es)	1999-07-01
US5041445A (en)	1991-08-20
IL98184A0 (en)	1992-06-21
DE69131057D1 (de)	1999-05-06
CZ280005B6 (cs)	1995-09-13
AU642243B2 (en)	1993-10-14
CZ148091A3 (en)	1993-08-11
PT97720B (pt)	1998-09-30
FI94757C (fi)	1995-10-25
DE69131057T2 (de)	1999-09-09
IL98184A (en)	1995-03-15
PL165731B1 (pl)	1995-02-28
RU2105765C1 (ru)	1998-02-27
IE911708A1 (en)	1991-12-04
DK0458234T3 (da)	1999-10-11
NO179749C (no)	1996-12-11
ATE178327T1 (de)	1999-04-15
EP0458234A3 (en)	1992-09-30
JPH04226979A (ja)	1992-08-17
NO911921D0 (no)	1991-05-16
ZA913794B (en)	1992-02-26
AU7618191A (en)	1991-11-21
NO179749B (no)	1996-09-02
PL290327A1 (en)	1992-05-04
EP0458234B1 (en)	1999-03-31
MX25858A (es)	1993-09-01
JP3161755B2 (ja)	2001-04-25
FI912401A0 (fi)	1991-05-17
KR910020007A (ko)	1991-12-19
HU215845B (hu)	1999-04-28
NZ238184A (en)	1993-01-27
FI912401L (fi)	1991-11-22
KR100215616B1 (ko)	1999-08-16
FI94757B (fi)	1995-07-14
NO911921L (no)	1991-11-22
CA2042982A1 (en)	1991-11-22

Legal Events

Date

Code

Title

Description

1992-02-28

BB1A

Laying open of patent application

Effective date: 19911028

1998-09-30

FG3A

Patent granted, date of granting

Effective date: 19980616

2005-02-28

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20041216

Publication	Publication Date	Title
PT89020A (pt)	1988-12-01	Processo para a preparacao de 3-(4(1-substituidas-4-piperazinil)butil)-4-tiazolidinonas e de composicoes farmaceuticas que as contem
PT95202A (pt)	1991-05-22	Processo para a preparacao de n-substituidas-4-pirimidinaminas e de composicoes farmaceuticas que os contem
PT98114A (pt)	1992-03-31	Processo para a prparacao de 1-indolilalquil-4-(alcoxipirimidinil)piperazinas e de composicoes farmaceuticas que as contem
ES2145743T3 (es)	2000-07-16	Compuesto de anillo condensado benzoxa, su produccion y composicion farmaceutica que lo contiene.
EP0957080A4 (en)	2004-10-20	NEW ETHYLAMINE DERIVATIVES
PT94297A (pt)	1991-02-08	Processo para a preparacao de n-hetero-aril-purin-6-aminas e de composicoes farmaceuticas que as contem
PT96030A (pt)	1991-09-13	Processo para a preparacao de aminocarbonilcarbamatos relacionados com fisoestigmina e de composicoes farmaceuticas que os contem
MX25858A (es)	1993-09-01	3-[1-tiazolidinilbutil-4-piperazinil]-1h-indazolesun procedimiento para su preparacion y su uso comomedicamentos.
PT93218A (pt)	1990-08-31	Processo para a preparacao de 2-amino-1,2,3,4-tetra-idronaftalenos e 3-aminocromanos substituidos no anel
RU93005087A (ru)	1996-01-27	3-(тиазолидинилбутил-4-пиперазинил)-ih-индазолы
PT92591A (pt)	1990-06-29	Processo para a preparacao de aciloxipropanolaminas com accao bloqueadora beta--adrenergica e de composicoes farmaceuticas que as contem
ES2163036T3 (es)	2002-01-16	Nueva sintesis asimetrica de r y s warfarina y sus analogos.
ATE267182T1 (de)	2004-06-15	Oxazolidinverbindungen und verfahren zu ihrer herstellung