PT98114A - Processo para a prparacao de 1-indolilalquil-4-(alcoxipirimidinil)piperazinas e de composicoes farmaceuticas que as contem - Google Patents

Processo para a prparacao de 1-indolilalquil-4-(alcoxipirimidinil)piperazinas e de composicoes farmaceuticas que as contem

Info

Publication number: PT98114A
Authority: PT; Portugal
Prior art keywords: piperazines; lower alkyl; indolilalquil; alcoxypyrimidinyl; pharmaceutical compositions
Prior art date: 1990-06-29

Application number

PT98114A

Other languages

English (en)

Other versions

PT98114B (pt

Inventor

Ronald J Mattson

David W Smith

Frank D Yocca

Joseph P Yevich

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-29

Filing date

1991-06-27

Publication date

1992-03-31

1991-06-27 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1992-03-31 Publication of PT98114A publication Critical patent/PT98114A/pt

1998-12-31 Publication of PT98114B publication Critical patent/PT98114B/pt

Links

150000004885 piperazines Chemical class 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03B—APPARATUS OR ARRANGEMENTS FOR TAKING PHOTOGRAPHS OR FOR PROJECTING OR VIEWING THEM; APPARATUS OR ARRANGEMENTS EMPLOYING ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ACCESSORIES THEREFOR
- G03B7/00—Control of exposure by setting shutters, diaphragms or filters, separately or conjointly
- G03B7/08—Control effected solely on the basis of the response, to the intensity of the light received by the camera, of a built-in light-sensitive device
- G03B7/099—Arrangement of photoelectric elements in or on the camera
- G03B7/0993—Arrangement of photoelectric elements in or on the camera in the camera
- G03B7/0997—Through the lens [TTL] measuring
- G03B7/09971—Through the lens [TTL] measuring in mirror-reflex cameras
- G03B7/09976—Through the lens [TTL] measuring in mirror-reflex cameras the sensor being mounted in, before, or behind the porro-prism

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Physics & Mathematics (AREA)
General Physics & Mathematics (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)

PT98114A 1990-06-29 1991-06-27 Processo para a prparacao de 1-indolilalquil-4-(alcoxipirimidinil)piperazinas e de composicoes farmaceuticas que as contem PT98114B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/546,121 US5077293A (en)	1990-06-29	1990-06-29	1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines

Publications (2)

Publication Number	Publication Date
PT98114A true PT98114A (pt)	1992-03-31
PT98114B PT98114B (pt)	1998-12-31

Family

ID=24178969

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT98114A PT98114B (pt)	1990-06-29	1991-06-27	Processo para a prparacao de 1-indolilalquil-4-(alcoxipirimidinil)piperazinas e de composicoes farmaceuticas que as contem

Country Status (19)

Country	Link
US (1)	US5077293A (pt)
EP (1)	EP0464604B1 (pt)
JP (1)	JPH0819123B2 (pt)
KR (1)	KR920000749A (pt)
AT (1)	ATE120462T1 (pt)
AU (1)	AU643765B2 (pt)
CA (1)	CA2045359C (pt)
CY (1)	CY1857A (pt)
DE (1)	DE69108461T2 (pt)
DK (1)	DK0464604T3 (pt)
ES (1)	ES2071169T3 (pt)
FI (1)	FI100241B (pt)
GR (1)	GR3015585T3 (pt)
HK (1)	HK109695A (pt)
IE (1)	IE67288B1 (pt)
MX (1)	MX9202844A (pt)
PT (1)	PT98114B (pt)
TW (1)	TW198030B (pt)
ZA (1)	ZA915036B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2043709C (en) *	1990-06-29	2002-01-22	David W. Smith	Antimigraine alkoxypyrimidine derivatives
FR2673628B1 (fr) *	1991-03-07	1993-07-09	Esteve Labor Dr	Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.
CA2084531A1 (en) *	1991-12-19	1993-06-20	David W. Smith	Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
CA2130078A1 (en) *	1993-09-16	1995-03-17	Jonas A. Gylys	Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
US5521188A (en) *	1993-09-16	1996-05-28	Bristol-Myers Squibb Company	Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
HUT76923A (hu) *	1994-07-27	1998-01-28	Sankyo Company Limited	Muszkarinreceptorokra alloszterikus hatást kifejtő heterociklusos vegyületek
GB9423682D0 (en) *	1994-11-23	1995-01-11	Merck Sharp & Dohme	Therapeutic agents
GB9501865D0 (en) *	1995-01-31	1995-03-22	Merck Sharp & Dohme	Therapeutic agents
US5618816A (en) *	1995-03-02	1997-04-08	Bristol-Myers Squibb Company	Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines
JPH09124643A (ja) *	1995-08-14	1997-05-13	Bristol Myers Squibb Co	抗うつ作用を有する１−アリールアルキル−４−（アルコキシピリジニル）−又は４−（アルコキシピリミジニル）ピペラジン誘導体
EP0937715B1 (en) *	1996-06-28	2005-06-01	Meiji Seika Kaisha Ltd.	Tetrahydrobenzindole compounds
SE9603283D0 (sv) *	1996-09-10	1996-09-10	Astra Ab	New compounds
TW472045B (en) *	1996-09-25	2002-01-11	Astra Ab	Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation
AR017200A1 (es)	1997-12-23	2001-08-22	Astrazeneca Ab	Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos
SE9800835D0 (sv)	1998-03-13	1998-03-13	Astra Ab	New Compounds
US6492406B1 (en)	1999-05-21	2002-12-10	Astrazeneca Ab	Pharmaceutically active compounds
US6346625B1 (en)	1999-06-23	2002-02-12	Astrazeneca Ab	Protein kinase inhibitors
GB0119797D0 (en) *	2001-08-14	2001-10-03	Glaxo Group Ltd	Chemical compounds
US20040023977A1 (en) *	2002-07-15	2004-02-05	Larsen Robert D.	Process for making substituted thiazolyl-amino pyrimidinyl
DE10252102A1 (de) *	2002-11-08	2004-05-27	Merck Patent Gmbh	Indolderivate
WO2010075273A1 (en)	2008-12-23	2010-07-01	Schering Corporation	Bicyclic heterocycle derivatives and methods of use thereof
WO2015014256A1 (en) *	2013-07-29	2015-02-05	Sunshine Lake Pharma Co., Ltd.	Substituted heteroaryl compounds and methods of use thereof
US10316025B2 (en)	2015-06-03	2019-06-11	Sunshine Lake Pharma Co., Ltd.	Substituted piperazine compounds and methods of use and use thereof
ES2974248T3 (es)	2017-09-29	2024-06-26	Sunshine Lake Pharma Co Ltd	Compuesto de pirimidin-piperazina sustituido y uso del mismo
CN108658871B (zh) *	2018-06-19	2020-10-30	舞阳威森生物医药有限公司	周效磺胺中间体4,6-二氯-5-甲氧基嘧啶的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB944443A (pt) *	1959-09-25	1900-01-01
GB1189064A (en) *	1967-05-01	1970-04-22	Sterling Drug Inc	Indole Derivatives
IT1170387B (it) *	1982-06-07	1987-06-03	Glaxo Group Ltd	Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono
DE3321969A1 (de) *	1983-06-18	1984-12-20	Troponwerke GmbH & Co KG, 5000 Köln	2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
GB2162522B (en) *	1984-08-01	1988-02-24	Glaxo Group Ltd	An indole derivative
US4954502A (en) *	1988-06-10	1990-09-04	Bristol-Myers Squibb Company	1-indolyalkyl-4-(substituted-pyridinyl)piperazines
FR2635104B1 (fr) *	1988-08-03	1992-04-30	Synthelabo	Derives d'indolone, leur preparation et leur application en therapeutique
CA2043709C (en) *	1990-06-29	2002-01-22	David W. Smith	Antimigraine alkoxypyrimidine derivatives

1990
- 1990-06-29 US US07/546,121 patent/US5077293A/en not_active Expired - Lifetime
1991
- 1991-04-03 AU AU74037/91A patent/AU643765B2/en not_active Expired
- 1991-06-25 DK DK91110485.9T patent/DK0464604T3/da active
- 1991-06-25 DE DE69108461T patent/DE69108461T2/de not_active Expired - Lifetime
- 1991-06-25 EP EP91110485A patent/EP0464604B1/en not_active Expired - Lifetime
- 1991-06-25 AT AT91110485T patent/ATE120462T1/de not_active IP Right Cessation
- 1991-06-25 CA CA002045359A patent/CA2045359C/en not_active Expired - Lifetime
- 1991-06-25 ES ES91110485T patent/ES2071169T3/es not_active Expired - Lifetime
- 1991-06-26 TW TW080104979A patent/TW198030B/zh active
- 1991-06-26 FI FI913117A patent/FI100241B/fi active
- 1991-06-27 PT PT98114A patent/PT98114B/pt not_active IP Right Cessation
- 1991-06-27 KR KR1019910010810A patent/KR920000749A/ko not_active Abandoned
- 1991-06-28 ZA ZA915036A patent/ZA915036B/xx unknown
- 1991-06-28 IE IE227991A patent/IE67288B1/en not_active IP Right Cessation
- 1991-06-28 JP JP3183889A patent/JPH0819123B2/ja not_active Expired - Lifetime
1992
- 1992-06-12 MX MX9202844A patent/MX9202844A/es unknown
1995
- 1995-03-31 GR GR940404162T patent/GR3015585T3/el unknown
- 1995-07-06 HK HK109695A patent/HK109695A/en not_active IP Right Cessation
1996
- 1996-04-05 CY CY185796A patent/CY1857A/xx unknown

Also Published As

Publication number	Publication date
HK109695A (en)	1995-07-14
IE67288B1 (en)	1996-03-20
ZA915036B (en)	1993-02-24
CA2045359C (en)	2001-09-04
GR3015585T3 (en)	1995-06-30
AU7403791A (en)	1992-01-02
JPH0819123B2 (ja)	1996-02-28
EP0464604A2 (en)	1992-01-08
FI913117L (fi)	1991-12-30
DE69108461T2 (de)	1995-07-27
AU643765B2 (en)	1993-11-25
FI913117A0 (fi)	1991-06-26
ATE120462T1 (de)	1995-04-15
EP0464604B1 (en)	1995-03-29
JPH04230377A (ja)	1992-08-19
MX9202844A (es)	1992-06-30
US5077293A (en)	1991-12-31
IE912279A1 (en)	1992-01-01
DE69108461D1 (de)	1995-05-04
TW198030B (pt)	1993-01-11
DK0464604T3 (da)	1995-06-12
KR920000749A (ko)	1992-01-29
FI100241B (fi)	1997-10-31
CY1857A (en)	1996-04-05
ES2071169T3 (es)	1995-06-16
PT98114B (pt)	1998-12-31
EP0464604A3 (en)	1992-02-26
CA2045359A1 (en)	1991-12-30

Legal Events

Date

Code

Title

Description

1992-03-31

BB1A

Laying open of patent application

Effective date: 19911126

1998-12-31

FG3A

Patent granted, date of granting

Effective date: 19980903

2000-07-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20000331

Publication	Publication Date	Title
PT98114A (pt)	1992-03-31	Processo para a prparacao de 1-indolilalquil-4-(alcoxipirimidinil)piperazinas e de composicoes farmaceuticas que as contem
PT90805A (pt)	1989-12-29	Processo para a preparacao de 1-indolilalquil-4-(piridinil substituido)-piperazinas e de composicoes farmaceuticas que as contem
MX9204746A (es)	1994-04-29	Nuevos derivados de tiazolilbenzofuranos, procedimientos para la preparacion de los mismos y las composiciones farmaceuticas que los contienen.
DK0842661T3 (da)	2001-09-24	Anvendelse af estrogenagonister og -antagonister til fremstilling af et lægemiddel til behandling af atherosclerose, uafhængigt af lipidsænkning
DE69431974D1 (de)	2003-02-13	Benzamid-Derivate und ihre Verwendung als Vasopressin-Antagonisten
BR8704582A (pt)	1988-04-26	Processo para preparar derivados de piridinacarboxamida
DE69215694D1 (de)	1997-01-16	Benzamid-derivate
PT94297A (pt)	1991-02-08	Processo para a preparacao de n-hetero-aril-purin-6-aminas e de composicoes farmaceuticas que as contem
EA200400806A1 (ru)	2004-12-30	Способ получения эхинокандиновых соединений
ES2155655T3 (es)	2001-05-16	Compuestos de benzotiofeno, usos y formulaciones de los mismos.
EA199900460A1 (ru)	2000-02-28	Производные бензолсульфоамида и лекарственные средства, содержащие упомянутые производные
PT99674A (pt)	1992-10-30	Processo para a preparacao de 5-amino-5,6,7,8-tetra-hidroquinolinas e de composicoes farmaceuticas que as contem
ATE56967T1 (de)	1990-10-15	Amidderivate.
ES8301480A1 (es)	1982-12-01	Un procedimiento para la produccion de derivados de 11-piperazinil-5h--pirrolo 1,2-b, 1,2,5 benzotriazepina.
ES2044883T3 (es)	1994-01-16	Procedimiento para preparar quinoxalinas sustituidas.
TW275629B (pt)	1996-05-11
DE3778088D1 (de)	1992-05-14	Substituierte pyrimidochinoxaline.
DE69112095D1 (de)	1995-09-21	1-Phenoxycarbonyl-2-Pyrrolidon-Derivate und nootrope Wirkstoffe.