PT98800A - Processo para a preparacao de derivados de benzodioxano e de indolilo agonistas dos receptores 5ht1a para a serotonina e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de derivados de benzodioxano e de indolilo agonistas dos receptores 5ht1a para a serotonina e de composicoes farmaceuticas que os contem

Info

Publication number
PT98800A
PT98800A PT98800A PT9880091A PT98800A PT 98800 A PT98800 A PT 98800A PT 98800 A PT98800 A PT 98800A PT 9880091 A PT9880091 A PT 9880091A PT 98800 A PT98800 A PT 98800A
Authority
PT
Portugal
Prior art keywords
pharmaceutical compositions
serotonin
compositions containing
indolil
benzodioxan
Prior art date
Application number
PT98800A
Other languages
English (en)
Other versions
PT98800B (pt
Inventor
Mark William Dudley
Ian Alexander Mcdonald
Ronald Charles Bernotas
Jeffrey Scott Sprouse
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of PT98800A publication Critical patent/PT98800A/pt
Publication of PT98800B publication Critical patent/PT98800B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
PT98800A 1990-08-29 1991-08-28 Processo para a preparacao de derivados de benzodioxano e de indolilo agonistas dos receptores 5ht1a para a serotonina e de composicoes farmaceuticas que os contem PT98800B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57471090A 1990-08-29 1990-08-29
US07/735,700 US5189179A (en) 1990-08-29 1991-07-30 Serotonin 5ht1a agonists

Publications (2)

Publication Number Publication Date
PT98800A true PT98800A (pt) 1992-08-31
PT98800B PT98800B (pt) 1999-01-29

Family

ID=27076473

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98800A PT98800B (pt) 1990-08-29 1991-08-28 Processo para a preparacao de derivados de benzodioxano e de indolilo agonistas dos receptores 5ht1a para a serotonina e de composicoes farmaceuticas que os contem

Country Status (21)

Country Link
US (3) US5189179A (pt)
EP (1) EP0478954B1 (pt)
JP (1) JPH04270264A (pt)
KR (1) KR920004345A (pt)
CN (1) CN1030766C (pt)
AT (1) ATE197040T1 (pt)
AU (1) AU641535B2 (pt)
CA (1) CA2049803A1 (pt)
DE (1) DE69132450T2 (pt)
DK (1) DK0478954T3 (pt)
ES (1) ES2153346T3 (pt)
FI (1) FI914065A7 (pt)
GR (1) GR3035062T3 (pt)
HU (1) HU208955B (pt)
IE (1) IE913036A1 (pt)
IL (1) IL99306A (pt)
NO (1) NO175430C (pt)
NZ (1) NZ239521A (pt)
PH (1) PH30242A (pt)
PT (1) PT98800B (pt)
TW (1) TW200457B (pt)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189179A (en) * 1990-08-29 1993-02-23 Merrell Dow Pharmaceuticals Inc. Serotonin 5ht1a agonists
US5892112A (en) * 1990-11-21 1999-04-06 Glycomed Incorporated Process for preparing synthetic matrix metalloprotease inhibitors
USRE38506E1 (en) 1991-10-04 2004-04-20 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
US6406859B1 (en) * 1992-01-08 2002-06-18 Synaptic Pharmaceutical Corporation DNA encoding a 5-HT 1F receptor and uses thereof
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
GB9304632D0 (en) * 1993-03-06 1993-04-21 Wyeth John & Brother Ltd Amide derivatives
FR2707294B1 (fr) * 1993-07-06 1995-09-29 Pf Medicament Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine.
US5478572A (en) * 1994-09-06 1995-12-26 Bristol-Myers Squibb Co. Gepirone dosage form
HUP9902160A3 (en) 1996-03-29 2001-02-28 Pfizer Benzyl(idene)-lactam derivatives, their use as selective (ant)agonists of 5-ht1a-and/or 5-ht1d receptors, pharmaceutical compositions containing these compounds
US8022095B2 (en) * 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US5872145A (en) * 1996-08-16 1999-02-16 Pozen, Inc. Formulation of 5-HT agonist and NSAID for treatment of migraine
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
EP1070050A1 (en) * 1998-04-08 2001-01-24 American Home Products Corporation N-aryloxyethyl-indoly-alkylamines for the treatment of depression (5-ht1a receptor active agents)
US6150533A (en) * 1998-04-08 2000-11-21 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
US6121307A (en) 1998-04-08 2000-09-19 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
CN1304409A (zh) * 1998-04-08 2001-07-18 美国家用产品公司 用于治疗抑郁症的吲哚－3－基－环己胺衍生物(5－ht1受体拮抗剂)
DK1068199T3 (da) * 1998-04-08 2003-03-03 Wyeth Corp N-Aryloxyethyl-indolyl-alkylaminer til behandling af depression
US7588029B2 (en) * 2000-03-21 2009-09-15 Fisher & Paykel Healthcare Limited Humidified gases delivery apparatus
EP1423509A2 (en) * 2001-08-30 2004-06-02 Stem Cell Therapeutics Inc. Differentiation of neural stem cells and therapeutic use thereof
EP1430114B1 (en) 2001-09-14 2012-01-18 Stem Cell Therapeutics Inc. Prolactin induced increase in neural stem cell numbers and therapeutical use thereof
AR036402A1 (es) * 2001-09-18 2004-09-08 Stem Cell Therapeutics Inc Efecto de la hormona de crecimiento y de igf-1 sobre celulas madre neuronales.
WO2004011497A1 (en) * 2002-07-31 2004-02-05 Stem Cell Therapeutics Inc. Method of enhancing neural stem cell proliferation, differentiation, and survival using pituitary adenylate cyclase activating polypeptide (pacap)
ES2380827T3 (es) * 2002-12-26 2012-05-18 Pozen, Inc. Formas de dosificación con múltiples capas que contienen naproxeno y triptanes
BRPI0410807A (pt) * 2003-06-06 2006-06-27 Glaxo Group Ltd composição farmacêutica, e, método pata tratar um mamìfero sofrendo de ou susceptìvel a condições associadas com dor cefálica
WO2005018541A2 (en) * 2003-07-11 2005-03-03 Pharmacia Corporation Cox-2 inhibitor and serotonin modulator for treating cns damage
US20070111932A1 (en) * 2003-07-31 2007-05-17 Stem Cell Therapeutics Inc. Method of enhancing and/or inducing neuronal migration using erythropoietin
BRPI0413679A (pt) * 2003-08-22 2006-10-24 Pharmacia Corp formulações de um inibidor seletivo da ciclooxigenase-2 e de um agente de modulação da serotonina para o tratamento da neoplasia
CN1325673C (zh) * 2003-12-30 2007-07-11 上海交通大学 利用废旧紫铜生产无氧铜的装置
ES2392282T3 (es) * 2004-02-13 2012-12-07 Stem Cell Therapeutics Corp. Uso de la hormona luteinizante (LH) y de la gonadotropina coriónica (hCG) para la proliferación de células precursoras neurales y la neurogénesis
MY147767A (en) 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
CA2609185A1 (en) 2005-05-20 2006-11-30 Ahmed F. Abdel-Magid Process for preparation of sulfamide derivatives
KR20080074108A (ko) 2005-09-27 2008-08-12 스템 셀 테라퓨틱스 코포레이션 프로락틴에 의해 조절되는 올리고덴드로사이트 전구체 세포증식
US8937096B2 (en) 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US8716231B2 (en) 2005-12-19 2014-05-06 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
US8691867B2 (en) 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US8497298B2 (en) 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US8492431B2 (en) 2005-12-19 2013-07-23 Janssen Pharmaceutica, N.V. Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity
US20070191474A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-fused heterocyle sulfamide derivatives for the treatment of migraine
WO2007106986A1 (en) * 2006-03-17 2007-09-27 Stem Cell Therapeutics Corp. Dosing regimes for lh or hcg and epo for treatment of neurological disorders
AU2007253814A1 (en) 2006-05-19 2007-11-29 Janssen Pharmaceutica N.V. Co-therapy for the treatment of epilepsy
WO2010008776A2 (en) 2008-06-23 2010-01-21 Janssen Pharmaceutica Nv Disposable patch and reusable sensor assembly for use in medical device localization and mapping systems
US8815939B2 (en) 2008-07-22 2014-08-26 Janssen Pharmaceutica Nv Substituted sulfamide derivatives
CN111116451A (zh) * 2020-01-16 2020-05-08 宁波大学 一种多取代色胺基苯甲酰胺类化合物及其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2725386A (en) * 1953-02-13 1955-11-29 Fond Emanuele Paterno 2-(1, 4-benzodioxan) methyl derivatives of amino-lower fatty acid amides and preparation thereof
FR2463765A1 (fr) * 1979-08-17 1981-02-27 Clin Midy Nouveaux derives de l'indole actifs sur le systeme cardiovasculaire
US4684739A (en) * 1980-12-15 1987-08-04 Mitsubishi Chemical Industries Limited Alkylenedioxybenzene derivatives and acid addition salts thereof
US4614807A (en) * 1984-10-04 1986-09-30 Eli Lilly And Company 6,7-dihalomelatonins
ATE65084T1 (de) * 1986-06-26 1991-07-15 Ciba Geigy Ag Hydrierte 1-benzooxacycloalkylpyridincarbons|ureverbindungen.
DE3642497A1 (de) * 1986-12-12 1988-06-23 Hoechst Ag Substituierte aminopropionsaeureamide, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte
US4956382A (en) * 1987-02-07 1990-09-11 Pfizer Inc. Sulfonamide anti-arrhythmic agents
US5189179A (en) * 1990-08-29 1993-02-23 Merrell Dow Pharmaceuticals Inc. Serotonin 5ht1a agonists
US5120758A (en) * 1991-02-08 1992-06-09 Ciba-Geigy Corporation Certain benzodioxole, benzodioxane and benzodioxepin derivatives useful as 5-lipoxygenase inhibitors

Also Published As

Publication number Publication date
CA2049803A1 (en) 1992-03-01
US5189179A (en) 1993-02-23
AU641535B2 (en) 1993-09-23
ES2153346T3 (es) 2001-03-01
AU8266491A (en) 1992-03-05
CN1030766C (zh) 1996-01-24
NO913384D0 (no) 1991-08-28
GR3035062T3 (en) 2001-03-30
FI914065A0 (fi) 1991-08-28
TW200457B (pt) 1993-02-21
IL99306A (en) 1995-03-30
EP0478954B1 (en) 2000-10-18
DE69132450D1 (de) 2000-11-23
JPH04270264A (ja) 1992-09-25
NO175430C (no) 1994-10-12
PT98800B (pt) 1999-01-29
PH30242A (en) 1997-02-05
NZ239521A (en) 1993-07-27
IL99306A0 (en) 1992-07-15
US5387604A (en) 1995-02-07
KR920004345A (ko) 1992-03-27
DE69132450T2 (de) 2001-05-03
HUT59092A (en) 1992-04-28
HU208955B (en) 1994-02-28
NO913384L (no) 1992-03-02
FI914065L (fi) 1992-03-01
IE913036A1 (en) 1992-03-11
NO175430B (no) 1994-07-04
US5559143A (en) 1996-09-24
ATE197040T1 (de) 2000-11-15
CN1059717A (zh) 1992-03-25
DK0478954T3 (da) 2001-01-08
EP0478954A1 (en) 1992-04-08
FI914065A7 (fi) 1992-03-01

Similar Documents

Publication Publication Date Title
PT99267A (pt) Processo para a preparacao de novos derivados de mercaptoacetilamida e de composicoes farmaceuticas que os contem
PT89793A (pt) Processo de preparacao de derivados de quinolina substituidos e de composicoes farmaceuticas que os contem
PT88013A (pt) Processo para a preparacao de isomeros opticos de derivados imidazolicos e de composicoes farmaceuticas que os contem
NO913384D0 (no) Fremgangsmaate for fremstilling av serotonin 5ht1a-agonister.
PT87913A (pt) Processo para a preparacao de derivados de benzopirano e de composicoes farmaceuticas que os contem
PT89009A (pt) Processo para a preparacao de novos derivados de fluorocitidina e composicoes farmaceuticas que os contem
PT92880A (pt) Processo para a preparacao de derivados alquilados de polietilenoimina e de composicoes farmaceuticas que os contem
PT93241A (pt) Processo de preparacao de derivados de piperidina e de composicoes farmaceuticas que os contem
PT90175A (pt) Processo para preparacao de derivados de gem-difosfonato substituidos por fenol e de composicoes farmaceuticas que os contem
PT92502A (pt) Processo para a preparacao de compostos de pirimidina e de composicoes farmaceuticas que os contem
PT87201A (pt) Processo para a preparacao de novos derivados de cefalosporina 3,7-substituida e de composicoes farmaceuticas que os contem
PT80836B (pt) Processo para a preparacao de novos derivados dos acidos naftiridinoquinolina, benzoxazina-carboxilicos e de composicoes farmaceuticas que os contem
PT84319B (pt) Processo para a preparacao de derivados substituidos de tienoimidazol e de composicoes farmaceuticas que os contem
PT98529A (pt) Processo para a preparacao de derivados de acetamida e de composicoes farmaceuticas que os contem
PT98365A (pt) Processo para a preparacao de novos derivados de oxalilo e de composicoes farmaceuticas que os contem
PT97114A (pt) Processo para a preparacao de derivados de hidantoina e de composicoes farmaceuticas que os contem
PT82985B (pt) Processo para a preparacao de derivados de distamicina e de composicoes farmaceuticas que os contem
PT84460B (pt) Processo para a preparacao de derivados de ciclopropano 1,1-dissubstituidos e de composicoes farmaceuticas que os contem
PT99795A (pt) Processo para a preparacao e novos derivados de piperidinil-benzimidazol e de composicoes farmaceuticas que os contem
PT83559B (pt) Processo para a preparacao de novos derivados de indol e indazol-ceto-sulfona e de composicoes farmaceuticas que os contem
PT90864A (pt) Processo para a preparacao de derivados de cromano e de composicoes farmaceuticas que os contem
PT90563A (pt) Processo para a preparacao de 3-(n-meterociclil)-2,6-diaminopiridinas e de -n-oxidos substituidos e de composicoes farmaceuticas que os contem
PT94902A (pt) Processo para a preparacao de novos derivados de cromano e de composicoes farmaceuticas que os contem
PT88351A (pt) Processo para a preparacao de derivados de isoxazol-beta-carbolina e de composicoes farmaceuticas que os contem
PT89792A (pt) Processo de preparacao de derivados da quinolina substituidos e de composicoes farmaceuticas que os contem

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19920317

FG3A Patent granted, date of granting

Effective date: 19981029

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20020430

NF3A Restitutio in integrum

Free format text: RESTITUTIO IN INTEGRUMO

Effective date: 20021014

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20040430