PT90175A - Processo para preparacao de derivados de gem-difosfonato substituidos por fenol e de composicoes farmaceuticas que os contem - Google Patents

Processo para preparacao de derivados de gem-difosfonato substituidos por fenol e de composicoes farmaceuticas que os contem

Info

Publication number: PT90175A
Authority: PT; Portugal
Prior art keywords: phenol; contain; pharmaceutical compositions; derivatives substituted; diphosphonate derivatives
Prior art date: 1988-03-31

Application number

PT90175A

Other languages

English (en)

Other versions

PT90175B (pt

Inventor

Lan Nguyen

Eric Niesor

Hieu Phan

Pierre Maechler

Craig Bentzen

Original Assignee

Symphar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-31

Filing date

1989-03-30

Publication date

1989-11-10

1989-03-30 Application filed by Symphar Sa filed Critical Symphar Sa

1989-11-10 Publication of PT90175A publication Critical patent/PT90175A/pt

1994-06-30 Publication of PT90175B publication Critical patent/PT90175B/pt

Links

ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical group OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
239000008194 pharmaceutical composition Chemical group 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3865—Polyphosphonic acids containing sulfur substituents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
- C07F9/404—Esters of poly(thio)phosphonic acids containing hydroxy substituents in the hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
- C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4423—Amides of poly (thio)phosphonic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Obesity (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT90175A 1988-03-31 1989-03-30 Processo para preparacao de derivados de gem-difosfonato substituidos por fenol e de composicoes farmaceuticas que os contem PT90175B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH1239/88A CH675422A5 (pt)	1988-03-31	1988-03-31

Publications (2)

Publication Number	Publication Date
PT90175A true PT90175A (pt)	1989-11-10
PT90175B PT90175B (pt)	1994-06-30

Family

ID=4205733

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT90175A PT90175B (pt)	1988-03-31	1989-03-30	Processo para preparacao de derivados de gem-difosfonato substituidos por fenol e de composicoes farmaceuticas que os contem

Country Status (25)

Country	Link
US (2)	US5043330A (pt)
EP (1)	EP0339237B1 (pt)
JP (1)	JPH0822865B2 (pt)
KR (1)	KR0147830B1 (pt)
CN (2)	CN1086820A (pt)
AR (1)	AR247569A1 (pt)
AT (1)	ATE84040T1 (pt)
AU (1)	AU612475B2 (pt)
CA (1)	CA1338495C (pt)
CH (1)	CH675422A5 (pt)
DE (2)	DE339237T1 (pt)
DK (1)	DK173936B1 (pt)
ES (1)	ES2011210T3 (pt)
FI (1)	FI92933C (pt)
GR (2)	GR900300002T1 (pt)
HU (1)	HU203556B (pt)
IE (1)	IE62692B1 (pt)
IL (1)	IL89649A (pt)
MY (1)	MY103850A (pt)
NO (1)	NO891317L (pt)
NZ (1)	NZ228516A (pt)
PH (1)	PH27603A (pt)
PT (1)	PT90175B (pt)
ZA (1)	ZA892126B (pt)
ZW (1)	ZW3789A1 (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0377894A (ja) *	1989-08-18	1991-04-03	Toray Ind Inc	メチレンジホスホン酸化合物
US5157027A (en) *	1991-05-13	1992-10-20	E. R. Squibb & Sons, Inc.	Bisphosphonate squalene synthetase inhibitors and method
JPH05163150A (ja) *	1991-05-13	1993-06-29	E R Squibb & Sons Inc	アテローム性動脈硬化症の抑制・治療剤
CA2067974A1 (en) *	1991-05-13	1992-11-14	Scott A. Biller	Method for lowering cholesterol employing a phosphonomethylphosphinate squalene synthetase inhibitor
DK0594857T3 (da) *	1991-09-05	1998-10-07	Toray Industries	Methandiphosphonsyrederivat, fremstilling deraf ogmedicinsk anvendelse deraf
EP0541037A3 (en) *	1991-11-06	1997-02-26	Takeda Chemical Industries Ltd	Squalene synthetase inhibitory composition and use thereof
JPH06172372A (ja) *	1991-11-06	1994-06-21	Takeda Chem Ind Ltd	スクアレン合成酵素阻害剤およびその用途
FR2683529B1 (fr) *	1991-11-12	1994-02-04	Bretagne Occidentale Universite	Composes pharmaceutiques gem-diphosphonates analogues du cis-platine.
CH683996A5 (fr) *	1992-03-05	1994-06-30	Symphar Sa	Dérivés aminophosphonates substitués, leur procédé de préparation et compositions pharmaceutiques les contenant.
EP0603401B1 (en) *	1992-07-10	2001-04-11	Toray Industries, Inc.	Methanediphosphonate derivative, production thereof, and pharmaceutical use thereof
US5332728A (en) *	1992-11-23	1994-07-26	Bristol-Myers Squibb Company	Method for treating a fungal infection
US5434288A (en) *	1992-12-01	1995-07-18	Monsanto Company	PLA2 inhibitors
ZA941088B (en) *	1993-02-19	1995-09-27	Symphar Sa	Substituted ketophosphonates the processes for their preparation and pharmaceutical compositions containing them
WO1994019359A1 (en) *	1993-02-25	1994-09-01	Toray Industries, Inc.	Process for producing methanediphosphonate compound
US5419845A (en) *	1994-03-15	1995-05-30	Basf Corporation	Perfluorinated gemdiphosphonates as corrosion inhibitors for antifreeze coolants and other functional fluids
DE69530064T2 (de) *	1994-08-24	2003-12-18	Toray Industries, Inc.	Verfahren zur herstellung einer methanphosphonsäureverbindung
CH690163A5 (fr) *	1995-07-28	2000-05-31	Symphar Sa	Dérivés gem-diphosphonates substitués utiles en tant qu'agents anti-cancers.
GB9603637D0 (en) *	1996-02-21	1996-04-17	Smithkline Beecham Plc	Process
WO1997043437A2 (en) *	1996-05-15	1997-11-20	The University Of Sheffield	Isopentenyl pyrophosphate isomerase (ipi) and/or prenyl transferase inhibitors
US6670398B2 (en) *	1997-05-14	2003-12-30	Atherogenics, Inc.	Compounds and methods for treating transplant rejection
IL164568A0 (en) *	1997-05-14	2005-12-18	Atherogenics Inc	Compounds and methods for the inhibition of the expression of vcam-1
IL125336A0 (en) *	1998-07-14	1999-03-12	Yissum Res Dev Co	Compositions for inhibition and treatment of restinosis
US7008645B2 (en)	1998-07-14	2006-03-07	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Method of inhibiting restenosis using bisphosphonates
US6984400B2 (en)	1998-07-14	2006-01-10	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Method of treating restenosis using bisphosphonate nanoparticles
AUPQ872800A0 (en) *	2000-07-12	2000-08-03	Heart Research Institute, The	Compositions and methods for treating cardiovascular disorders
GB0019272D0 (en) *	2000-08-04	2000-09-27	Symphar Sa	Pharmaceutical compounds
WO2002087556A2 (en) *	2001-04-11	2002-11-07	Atherogenics, Inc.	Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
WO2003032909A2 (en) *	2001-10-18	2003-04-24	Ilex Products, Inc.	Methods of treating skin with diphosphonate derivatives
EP1485106A2 (en) *	2002-02-19	2004-12-15	Ilex Products, Inc.	Phosphonate-phosphate and diphosphonate apolipoprotein e modulators
EP1506208A4 (en) *	2002-05-11	2006-05-24	Ilex Products Inc	1,1- AND 1,2-BISPHOSPHONATES AS MODULATORS OF APOLIPOPROTEIN E
US7479507B2 (en) *	2003-01-14	2009-01-20	Adam Heller	Anti-inflammatory substituted phenols and elastomeric compositions for oral delivery of drugs
US10517883B2 (en)	2003-06-27	2019-12-31	Zuli Holdings Ltd.	Method of treating acute myocardial infarction
US7687482B2 (en) *	2006-03-17	2010-03-30	The Board Of Trustees Of The University Of Illinois	Bisphosphonate compounds and methods
WO2008118948A1 (en) *	2007-03-26	2008-10-02	Atherogenics, Inc.	Methods and compositions of derivatives of probucol for the treatment of diabetes
WO2008118946A1 (en) *	2007-03-27	2008-10-02	Atherogenics, Inc.	Methods and compositions using certain phenolic derivatives for the treatment of diabetes
US9993427B2 (en)	2013-03-14	2018-06-12	Biorest Ltd.	Liposome formulation and manufacture
WO2016063297A1 (en) *	2014-10-21	2016-04-28	Council Of Scientific & Industrial Research	Alkylidene phosphonate esters as p-glycoprotein inducers
WO2018236221A2 (en) *	2017-06-03	2018-12-27	Can Holding B.V.	Neurodegenerative peptide deposit dissolution

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA777769A (en) *	1963-03-18	1968-02-06	H. Roy Clarence	Substituted methylene diphosphonic acid compounds and detergent compositions
DE1302557B (pt) *	1963-04-09	1971-08-26
GB2043072B (en) *	1979-02-13	1983-11-23	Symphar Sa	Diphosphonate compounds
US4416877A (en) *	1979-02-13	1983-11-22	Symphar S.A.	Anti-atherosclerotic pharmaceutical compositions containing diphosphonate compounds
FR2531088B1 (fr) *	1982-07-29	1987-08-28	Sanofi Sa	Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
CH664158A5 (fr) *	1984-07-18	1988-02-15	Symphar Sa	Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant.
US6259935B1 (en) *	1997-06-24	2001-07-10	Matsushita Electrical Industrial Co., Ltd.	Electro-mechanical-acoustic transducing device

1988
- 1988-03-31 CH CH1239/88A patent/CH675422A5/fr not_active IP Right Cessation
1989
- 1989-03-13 IE IE80289A patent/IE62692B1/en not_active IP Right Cessation
- 1989-03-14 US US07/323,334 patent/US5043330A/en not_active Expired - Lifetime
- 1989-03-15 ZW ZW37/89A patent/ZW3789A1/xx unknown
- 1989-03-16 AT AT89104656T patent/ATE84040T1/de not_active IP Right Cessation
- 1989-03-16 DE DE198989104656T patent/DE339237T1/de active Pending
- 1989-03-16 EP EP89104656A patent/EP0339237B1/en not_active Expired - Lifetime
- 1989-03-16 DE DE8989104656T patent/DE68904104T2/de not_active Expired - Fee Related
- 1989-03-16 ES ES89104656T patent/ES2011210T3/es not_active Expired - Lifetime
- 1989-03-16 MY MYPI89000332A patent/MY103850A/en unknown
- 1989-03-17 IL IL8964989A patent/IL89649A/en not_active IP Right Cessation
- 1989-03-21 ZA ZA892126A patent/ZA892126B/xx unknown
- 1989-03-22 CA CA000594468A patent/CA1338495C/en not_active Expired - Fee Related
- 1989-03-28 DK DK198901481A patent/DK173936B1/da not_active IP Right Cessation
- 1989-03-29 NO NO89891317A patent/NO891317L/no unknown
- 1989-03-29 NZ NZ228516A patent/NZ228516A/en unknown
- 1989-03-29 AR AR89313527A patent/AR247569A1/es active
- 1989-03-30 AU AU32243/89A patent/AU612475B2/en not_active Ceased
- 1989-03-30 CN CN93116289A patent/CN1086820A/zh active Pending
- 1989-03-30 CN CN89101830A patent/CN1024555C/zh not_active Expired - Fee Related
- 1989-03-30 KR KR1019890004076A patent/KR0147830B1/ko not_active Expired - Fee Related
- 1989-03-30 PT PT90175A patent/PT90175B/pt not_active IP Right Cessation
- 1989-03-30 FI FI891538A patent/FI92933C/fi not_active IP Right Cessation
- 1989-03-30 HU HU891595A patent/HU203556B/hu not_active IP Right Cessation
- 1989-03-31 PH PH38417A patent/PH27603A/en unknown
- 1989-03-31 JP JP1083855A patent/JPH0822865B2/ja not_active Expired - Fee Related
1991
- 1991-06-07 GR GR90300002T patent/GR900300002T1/el unknown
- 1991-07-31 US US07/738,430 patent/US5128331A/en not_active Expired - Lifetime
1993
- 1993-03-23 GR GR930400629T patent/GR3007442T3/el unknown

Also Published As

Publication number	Publication date
FI891538L (fi)	1989-10-01
ES2011210T3 (es)	1994-01-01
CH675422A5 (pt)	1990-09-28
NZ228516A (en)	1990-12-21
DK148189A (da)	1989-10-17
CN1086820A (zh)	1994-05-18
IE890802L (en)	1989-09-30
CN1036772A (zh)	1989-11-01
ZW3789A1 (en)	1989-08-23
DK173936B1 (da)	2002-02-25
DE68904104D1 (de)	1993-02-11
EP0339237A2 (en)	1989-11-02
IE62692B1 (en)	1995-02-22
MY103850A (en)	1993-09-30
CA1338495C (en)	1996-07-30
DK148189D0 (da)	1989-03-28
HUT50482A (en)	1990-02-28
IL89649A0 (en)	1989-09-28
JPH0822865B2 (ja)	1996-03-06
NO891317D0 (no)	1989-03-29
AU612475B2 (en)	1991-07-11
FI891538A0 (fi)	1989-03-30
FI92933B (fi)	1994-10-14
PH27603A (en)	1993-08-31
KR0147830B1 (ko)	1998-08-17
NO891317L (no)	1989-10-02
AR247569A1 (es)	1995-01-31
ZA892126B (en)	1989-11-29
PT90175B (pt)	1994-06-30
IL89649A (en)	1995-07-31
DE339237T1 (de)	1990-02-08
DE68904104T2 (de)	1993-06-17
ATE84040T1 (de)	1993-01-15
FI92933C (fi)	1995-01-25
HU203556B (en)	1991-08-28
US5128331A (en)	1992-07-07
EP0339237B1 (en)	1992-12-30
KR890014569A (ko)	1989-10-24
CN1024555C (zh)	1994-05-18
JPH0222285A (ja)	1990-01-25
AU3224389A (en)	1989-10-05
GR3007442T3 (pt)	1993-07-30
ES2011210A4 (es)	1990-01-01
GR900300002T1 (en)	1991-06-07
US5043330A (en)	1991-08-27
EP0339237A3 (en)	1991-01-09

Legal Events

Date

Code

Title

Description

1994-06-30

FG3A

Patent granted, date of granting

Effective date: 19931213

1996-10-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19960630

Publication	Publication Date	Title
PT90175A (pt)	1989-11-10	Processo para preparacao de derivados de gem-difosfonato substituidos por fenol e de composicoes farmaceuticas que os contem
PT84569B (pt)	1989-11-30	Processo para a preparacao de tiazepinas e de composicoes farmaceuticas que os contem
PT93094A (pt)	1990-08-31	Processo para a preparacao de 1,3-oxatiolanos substituidos e de composicoes farmaceuticas que os contem
PT89009A (pt)	1988-12-01	Processo para a preparacao de novos derivados de fluorocitidina e composicoes farmaceuticas que os contem
PT87913A (pt)	1989-06-30	Processo para a preparacao de derivados de benzopirano e de composicoes farmaceuticas que os contem
PT98369A (pt)	1992-05-29	Processo para a preparacao de azois substituidos e de composicoes farmaceuticas que os contem
PT99671A (pt)	1992-10-30	Processo para a preparacao de heparosanos-n,o-sulfatados e de composicoes farmaceuticas que os contem
PT87880A (pt)	1989-06-30	Processo para a preparacao de composicoes farmaceuticas anti-virais que contem ciclo-dextrinas
PT89094A (pt)	1988-12-01	Processo para a preparacao de 1-aril-3-quinolina-e 1-aril-3-isoquinolina-carboxamidas e de composicoes farmaceuticas que as contem
PT87201A (pt)	1989-05-12	Processo para a preparacao de novos derivados de cefalosporina 3,7-substituida e de composicoes farmaceuticas que os contem
PT88914A (pt)	1988-12-01	Processo para a preparacao de polipeptidos e de composicoes farmaceuticas que os contem
PT89497A (pt)	1989-10-04	Processo para a preparacao de compostos piperidinilicos 1,4-dissubstituidos e de composicoes farmaceuticas que os contem
PT98943A (pt)	1992-07-31	Processo para a preparacao de novos analogos carbociclicos de adenosina e de composicoes farmaceuticas que os contem.
PT80363B (pt)	1987-10-20	Processo para a preparacao de derivados de fenol e de composicoes farmaceuticas que os contem
PT93060A (pt)	1990-08-31	Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem
PT93067A (pt)	1990-08-31	Processo para a preparacao de derivados de 2-hidroxiacidos alifaticos e de eteres de 1-benzil-3-hidroximetilindazol, e de composicoes farmaceuticas que os contem
PT84828B (pt)	1989-12-29	Processo para a preparacao de compostos heterociclicos triciclicos fundidos e de composicoes farmaceuticas que os contem
PT84358B (pt)	1989-11-10	Processo para a preparacao de naftotiazepinonas e de composicoes farmaceuticas que as contem
PT89234A (pt)	1989-12-29	Processo para a preparacao de novos compostos de amonio e de composicoes farmaceuticas que os contem
PT95522A (pt)	1991-08-14	Processo para a preparacao de novos compostos tetraciclicos com accao anti-alergica e anti-asmatica e de composicoes farmaceuticas que os contem
PT88351A (pt)	1989-06-30	Processo para a preparacao de derivados de isoxazol-beta-carbolina e de composicoes farmaceuticas que os contem
PT87115A (pt)	1989-09-14	Processo para a preparacao de derivados da dihidropiridazinona e de composicoes farmaceuticas que os contem
PT96154A (pt)	1991-09-30	Processo para a preparacao de derivados de carbamoilo e de composicoes farmaceuticas que os contem
PT92264A (pt)	1990-05-31	Processo para a preparacao de 14alfa, 17alfa-etano-estratrienos e de composicoes farmaceuticas que os contem
PT87090A (pt)	1988-04-01	Processo para a preparacao de derivados de imidazopiridinas e de composicoes farmaceuticas que os contem