PT99073A - Processo para a preparacao de 4-amino-3-piridinois substituidos e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de 4-amino-3-piridinois substituidos e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT99073A PT99073A PT99073A PT9907391A PT99073A PT 99073 A PT99073 A PT 99073A PT 99073 A PT99073 A PT 99073A PT 9907391 A PT9907391 A PT 9907391A PT 99073 A PT99073 A PT 99073A
- Authority
- PT
- Portugal
- Prior art keywords
- loweralkyl
- chem
- hydrogen
- pyridinoises
- amino
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 230000001713 cholinergic effect Effects 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- -1 loweralkyl Chemical group 0.000 abstract 1
- 230000007074 memory dysfunction Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Surface Treatment Of Glass (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58911390A | 1990-09-27 | 1990-09-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT99073A true PT99073A (pt) | 1992-08-31 |
| PT99073B PT99073B (pt) | 1999-02-26 |
Family
ID=24356648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99073A PT99073B (pt) | 1990-09-27 | 1991-09-26 | Processo para a preparacao de 4-amino-3-piridinois substituidos e de composicoes farmaceuticas que os contem |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US5821239A (pt) |
| EP (1) | EP0477903B1 (pt) |
| JP (1) | JP3090511B2 (pt) |
| KR (1) | KR100215357B1 (pt) |
| AT (1) | ATE136297T1 (pt) |
| AU (1) | AU637720B2 (pt) |
| CA (1) | CA2052433C (pt) |
| CZ (1) | CZ282002B6 (pt) |
| DE (1) | DE69118470T2 (pt) |
| DK (1) | DK0477903T3 (pt) |
| ES (1) | ES2085940T3 (pt) |
| FI (1) | FI914504A7 (pt) |
| GR (1) | GR3019742T3 (pt) |
| HU (1) | HUT60247A (pt) |
| IE (1) | IE73874B1 (pt) |
| IL (1) | IL99581A (pt) |
| NO (1) | NO913778L (pt) |
| NZ (1) | NZ239935A (pt) |
| PT (1) | PT99073B (pt) |
| TW (1) | TW200462B (pt) |
| YU (1) | YU158591A (pt) |
| ZA (1) | ZA917692B (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
| FR2813891B1 (fr) * | 2000-09-14 | 2005-01-14 | Immunotech Sa | Reactif multifonctionnel pour erythrocytes mettant en jeu des carbamates et applications |
| DE10102791B4 (de) * | 2001-01-22 | 2004-04-15 | Ifm Electronic Gmbh | Elektrischer Meßumformer |
| BR0214967A (pt) * | 2001-12-14 | 2005-05-10 | Novo Nordisk As | Composto, sal famaceuticamente aceitável, processo para a preparação de um composto, composição farmacêutica, uso de um composto e método de tratar um distúrbio de um paciente |
| KR100443983B1 (ko) | 2002-01-15 | 2004-08-09 | 삼성전자주식회사 | 냉장고 |
| US8007826B2 (en) | 2003-12-11 | 2011-08-30 | Acorda Therapeutics, Inc. | Sustained release aminopyridine composition |
| US8354437B2 (en) | 2004-04-09 | 2013-01-15 | Acorda Therapeutics, Inc. | Method of using sustained release aminopyridine compositions |
| MX2007010076A (es) | 2005-02-17 | 2007-10-16 | Astellas Pharma Inc | Derivado de heterociclico-1-carboxilato que contiene nitrogeno no aromatico de piridilo. |
| CN101827522A (zh) * | 2008-09-10 | 2010-09-08 | 阿索尔达治疗股份有限公司 | 持续释放氨基吡啶组合物的使用方法 |
| EP2533645B1 (en) | 2010-02-09 | 2016-07-27 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| US9211288B2 (en) | 2012-12-13 | 2015-12-15 | H. Lundbeck A/S | Compositions comprising vortioxetine and donepezil |
| US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| CA2904767C (en) | 2013-03-15 | 2022-06-21 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
| EA034167B8 (ru) | 2015-05-22 | 2021-04-27 | Эйджинбайо, Инк. | Фармацевтические композиции леветирацетама пролонгированного высвобождения |
| JP6899120B2 (ja) * | 2016-10-12 | 2021-07-07 | 株式会社ナノエッグ | アセチルコリンエステラーゼ（ＡＣｈＥ）阻害剤 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179563A (en) * | 1978-05-19 | 1979-12-18 | Warner-Lambert Company | 3-Aryloxy-substituted-aminopyridines and methods for their production |
| US4734275A (en) * | 1983-08-19 | 1988-03-29 | Research Corporation | Anti-curare agents |
| DE3514073A1 (de) * | 1985-04-18 | 1986-10-23 | Hoechst Ag, 6230 Frankfurt | Mehrfach substituierte pyridin-1-oxide, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
| US4735958A (en) * | 1986-12-22 | 1988-04-05 | Warner-Lambert Company | Trans-6-[2-[2-(substituted-phenyl)-3- (or 4-) heteroaryl-5-substituted-1H-pyrrol-1-yl]-ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one inhibitors of cholesterol biosynthesis |
| US4831044A (en) * | 1987-10-29 | 1989-05-16 | Ici Americas Inc. | Fungicidal pyridyl cyclopropane carboxamidines |
| US4994473A (en) * | 1987-11-17 | 1991-02-19 | Ici Americas Inc. | Pyridyl containing insecticides |
| EP0361489A3 (en) * | 1988-09-30 | 1991-06-12 | Chugai Seiyaku Kabushiki Kaisha | Novel 3,4-diaminoquinoline and pyridine compounds |
| ATE89553T1 (de) * | 1988-11-16 | 1993-06-15 | Hoechst Roussel Pharma | Hydroxy-1,2,3,4-tetrahydroaminoacridine, verfahren fuer ihre herstellung und ihre verwendung als arzneimittel. |
| US4931457B1 (en) * | 1989-06-28 | 1993-11-16 | Hoechst-Roussel Pharmaceuticals Incorporated | Naphthylamino-and naphthyloxy-pyridineamin compounds useful as topical antiinflammatory agents for the treatment of skin disorders |
-
1991
- 1991-08-31 TW TW080106907A patent/TW200462B/zh active
- 1991-09-25 DK DK91116336.8T patent/DK0477903T3/da active
- 1991-09-25 EP EP91116336A patent/EP0477903B1/en not_active Expired - Lifetime
- 1991-09-25 FI FI914504A patent/FI914504A7/fi not_active Application Discontinuation
- 1991-09-25 DE DE69118470T patent/DE69118470T2/de not_active Expired - Fee Related
- 1991-09-25 CZ CS912936A patent/CZ282002B6/cs not_active IP Right Cessation
- 1991-09-25 NZ NZ239935A patent/NZ239935A/en unknown
- 1991-09-25 ES ES91116336T patent/ES2085940T3/es not_active Expired - Lifetime
- 1991-09-25 AT AT91116336T patent/ATE136297T1/de not_active IP Right Cessation
- 1991-09-26 IL IL9958191A patent/IL99581A/en not_active IP Right Cessation
- 1991-09-26 HU HU913075A patent/HUT60247A/hu unknown
- 1991-09-26 NO NO91913778A patent/NO913778L/no unknown
- 1991-09-26 ZA ZA917692A patent/ZA917692B/xx unknown
- 1991-09-26 YU YU158591A patent/YU158591A/sh unknown
- 1991-09-26 IE IE338991A patent/IE73874B1/en not_active IP Right Cessation
- 1991-09-26 AU AU84756/91A patent/AU637720B2/en not_active Expired - Fee Related
- 1991-09-26 CA CA002052433A patent/CA2052433C/en not_active Expired - Fee Related
- 1991-09-26 JP JP03273439A patent/JP3090511B2/ja not_active Expired - Fee Related
- 1991-09-26 PT PT99073A patent/PT99073B/pt not_active IP Right Cessation
- 1991-09-27 KR KR1019910016850A patent/KR100215357B1/ko not_active Expired - Fee Related
-
1996
- 1996-02-16 US US08/602,693 patent/US5821239A/en not_active Expired - Fee Related
- 1996-04-24 GR GR960401135T patent/GR3019742T3/el unknown
-
1998
- 1998-06-02 US US09/088,928 patent/US5869480A/en not_active Expired - Fee Related
- 1998-06-02 US US09/088,926 patent/US5866565A/en not_active Expired - Fee Related
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19920408 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19981119 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20040531 |