RU2012116079A - Фармацевтическая композиция, включающая омега-3 жирную кислоту и гидроксипроизводное статина и способы ее применения - Google Patents

Фармацевтическая композиция, включающая омега-3 жирную кислоту и гидроксипроизводное статина и способы ее применения Download PDF

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RU2012116079A
RU2012116079A RU2012116079/15A RU2012116079A RU2012116079A RU 2012116079 A RU2012116079 A RU 2012116079A RU 2012116079/15 A RU2012116079/15 A RU 2012116079/15A RU 2012116079 A RU2012116079 A RU 2012116079A RU 2012116079 A RU2012116079 A RU 2012116079A
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hydroxyatorvastatin
pharmaceutical composition
statin
pharmaceutically acceptable
lactone
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Abstract

1. Фармацевтическая композиция, включающая (a) гидроксипроизводное статина или его фармацевтически приемлемой соли и (b) масло, включающее омега-3 жирные кислоты.2. Фармацевтическая композиция по п.1, где омега-3 жирная кислота включает этилэйкозапентаеноат.3. Фармацевтическая композиция по п.1, где масло включает, по меньшей мере, 95 масс.% этилэйкозапентаеноата.4. Фармацевтическая композиция по п.1, где масло включает, по меньшей мере, 95 масс.% этилдокозагексаеновой кислоты.5. Фармацевтическая композиция по п.3, где масло включает этилэйкозапентаеноат и этил докозагексаеновую кислоту.6. Фармацевтическая композиция по п.5, где масло включает этилэйкозапентаеноат и этил докозагексаеновую кислоту в молярном соотношении от около 1:1 до около 1,5:1.7. Фармацевтическая композиция по п.1, где гидроксипроизводное статина или его фармацевтически приемлемой соли выбирают из гидроксипроизводного аторвастатина, мевастатина, питавастатина, правастатина, розувастатина, флувастатина, симвастатина, ловастатина, церивастатина и их фармацевтически приемлемых солей.8. Фармацевтическая композиция по п.7, где гидроксипроизводное статина выбирают из орто или пара гидроксиаторвастатина и его фармацевтически приемлемых солей.9. Фармацевтическая композиция по п.8, где гидроксипроизводное статина или его фармацевтически приемлемой соли выбирают из o-гидроксиаторвастатина, п-гидроксиаторвастатина, п-гидроксиаторвастатина кальция, п-гидроксиаторвастатина динатрия, o-гидроксиаторвастатина кальция, o-гидроксиаторвастатина лактона, o-гидроксиаторвастатин-d5 кальция, o-гидроксиаторвастатин-d5 динатрия, o-гидроксиаторвастатин-d5 лактона, 2-гидрокс�

Claims (20)

1. Фармацевтическая композиция, включающая (a) гидроксипроизводное статина или его фармацевтически приемлемой соли и (b) масло, включающее омега-3 жирные кислоты.
2. Фармацевтическая композиция по п.1, где омега-3 жирная кислота включает этилэйкозапентаеноат.
3. Фармацевтическая композиция по п.1, где масло включает, по меньшей мере, 95 масс.% этилэйкозапентаеноата.
4. Фармацевтическая композиция по п.1, где масло включает, по меньшей мере, 95 масс.% этилдокозагексаеновой кислоты.
5. Фармацевтическая композиция по п.3, где масло включает этилэйкозапентаеноат и этил докозагексаеновую кислоту.
6. Фармацевтическая композиция по п.5, где масло включает этилэйкозапентаеноат и этил докозагексаеновую кислоту в молярном соотношении от около 1:1 до около 1,5:1.
7. Фармацевтическая композиция по п.1, где гидроксипроизводное статина или его фармацевтически приемлемой соли выбирают из гидроксипроизводного аторвастатина, мевастатина, питавастатина, правастатина, розувастатина, флувастатина, симвастатина, ловастатина, церивастатина и их фармацевтически приемлемых солей.
8. Фармацевтическая композиция по п.7, где гидроксипроизводное статина выбирают из орто или пара гидроксиаторвастатина и его фармацевтически приемлемых солей.
9. Фармацевтическая композиция по п.8, где гидроксипроизводное статина или его фармацевтически приемлемой соли выбирают из o-гидроксиаторвастатина, п-гидроксиаторвастатина, п-гидроксиаторвастатина кальция, п-гидроксиаторвастатина динатрия, o-гидроксиаторвастатина кальция, o-гидроксиаторвастатина лактона, o-гидроксиаторвастатин-d5 кальция, o-гидроксиаторвастатин-d5 динатрия, o-гидроксиаторвастатин-d5 лактона, 2-гидроксиаторвастатина бинатрия, п-гидроксиаторвастатина лактона, п-гидроксиаторвастатин-d5 кальция, п-гидроксиаторвастатин-d5 лактона, и 4-гидроксиаторвастатина бинатрия.
10. Фармацевтическая композиция по п.1, дополнительно включающая токоферол в количестве от около 0,1% до около 0,3% масс.
11. Фармацевтическая композиция по п.1, где от около 0,5 г до около 2 г указанной композиции присутствует в оболочке капсулы.
12. Способ лечения сердечнососудистого заболевания у пациента, нуждающегося в этом, включающий введение пациенту композиции, включающей (a) гидроксипроизводное статина или его фармацевтически приемлемой соли и (b) масло, включающее омега-3 жирные кислоты.
13. Способ по п.12, где омега-3 жирные кислоты включают этилэйкозапентаеноат.
14. Способ по п.13, где масло включает, по меньшей мере, 95 масс.% этилэйкозапентаеноата.
15. Способ по п.14, где масло включает этил эйкозапентаеноат и этилдокозагексаеновую кислоту в молярном соотношении от около 1,1 до 1 до около 1,5 до 1.
16. Способ по п.14, где масло включает этилдокозагексаеновую кислоту.
17. Способ по п.12, где гидроксипроизводное статина или его фармацевтически приемлемой соли выбирают из орто- или парагидроксиаторвастатина и его фармацевтически приемлемых солей.
18. Способ по п.12, где гидроксипроизводное статина или его фармацевтически приемлемую соль выбирают из o-гидрокси аторвастатина, п-гидроксиаторвастатина, п-гидроксиаторвастатина кальция, п-гидроксиаторвастатина динатрия, o-гидроксиаторвастатина кальция, o-гидроксиаторвастатина лактона, o-гидроксиаторвастатин-d5 кальция, o-гидроксиаторвастатин-d5 динатрия, o-гидроксиаторвастатин-d5 лактона, 2-гидроксиаторвастатина бинатрия, п-гидроксиаторвастатина лактона, п-гидроксиаторвастатин-d5 кальция, п-гидроксиаторвастатин-d5 лактона, и 4-гидроксиаторвастатина бинатрия.
19. Способ по п.12. где сердечнососудистое заболевание выбирают из гипертриглицеридемии, гиперхолестеринемии, смешанной дислипидемии, ишемической болезни сердца, сосудистых заболеваний, удара, атеросклероза, аритмии, гипертонии и инфаркта миокарда.
20. Способ по п.12, где сердечнососудистым заболеванием является атеросклероз.
RU2012116079/15A 2009-09-23 2010-09-23 Фармацевтическая композиция, включающая омега-3 жирную кислоту и гидроксипроизводное статина и способы ее применения RU2012116079A (ru)

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