RU2012117746A - Композиции, содержащие противовоспалительную смесь - Google Patents

Композиции, содержащие противовоспалительную смесь Download PDF

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RU2012117746A
RU2012117746A RU2012117746/15A RU2012117746A RU2012117746A RU 2012117746 A RU2012117746 A RU 2012117746A RU 2012117746/15 A RU2012117746/15 A RU 2012117746/15A RU 2012117746 A RU2012117746 A RU 2012117746A RU 2012117746 A RU2012117746 A RU 2012117746A
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extract
inhibitor
composition
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inflammatory compound
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Симарна КАУР
Майкл САУТХОЛЛ
Саманта Д. ТАКЕР-САМАРАС
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Кхалид МАХМУД
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Джонсон Энд Джонсон Конзьюмер Компаниз, Инк.
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Abstract

1. Композиция, содержащая:ингибитор NF-kB; ипротивовоспалительное соединение, которое не является ингибитором NF-kB и имеет концентрацию IC50 приблизительно 70 мкг/мл или менее.2. Композиция по п.1, в которой противовоспалительное соединение имеет концентрацию IC50 приблизительно 50 мкг/мл или менее.3. Композиция по п.1, в которой противовоспалительное соединение имеет концентрацию IC50 приблизительно 40 мкг/мл или менее.4. Композиция по п.1, в которой противовоспалительное соединение представляет собой экстракт, выбранный из группы, состоящей из экстракта луба амурского бархата (), пиретрума девичьего (), гинкго (), скумпии (), дерезы обыкновенной (), экстракта чертополоха морского (), масла амаранта (), гранатового дерева (), травы мате (экстракта листьев), экстракта цветов лилии белой (), экстракта листьев оливы (), флоретина (экстракта яблока), а также их комбинаций.5. Композиция по п.1, в которой противовоспалительное соединение представляет собой экстракт, выбранный из группы, состоящей из пиретрума девичьего (), дерезы обыкновенной (), экстракта чертополоха морского (), масла амаранта (), гранатового дерева (), травы мате (экстракта листьев), экстракта цветов лилии белой (), экстракта листьев оливы (), флоретина (экстракта яблока), а также их комбинаций.6. Композиция по п.1, в которой ингибитор NF-kB выбран из группы, состоящей из замещенных резорцинолов, (E)-3-(4-метилфенилсульфонил)-2-пропеннитрила, тетрагидрокуркуминоидов, экстрактов древесины павловнии войлочной, а также их комбинаций.7. Композиция по п.1, в которой ингибитор NF-kB выбран из группы, состоящей из замещенных резорцинолов, тетрагидрокуркуминоидов и их комбинаций.8. Композиция по п.4, в ко�

Claims (10)

1. Композиция, содержащая:
ингибитор NF-kB; и
противовоспалительное соединение, которое не является ингибитором NF-kB и имеет концентрацию IC50 приблизительно 70 мкг/мл или менее.
2. Композиция по п.1, в которой противовоспалительное соединение имеет концентрацию IC50 приблизительно 50 мкг/мл или менее.
3. Композиция по п.1, в которой противовоспалительное соединение имеет концентрацию IC50 приблизительно 40 мкг/мл или менее.
4. Композиция по п.1, в которой противовоспалительное соединение представляет собой экстракт, выбранный из группы, состоящей из экстракта луба амурского бархата (Phellodendron amurense), пиретрума девичьего (Tanacetum parthenium), гинкго (Ginkgo Biloba), скумпии (Cotinus coggygria), дерезы обыкновенной (Lycium barbarum), экстракта чертополоха морского (Silybum marianum), масла амаранта (Amaranthus cruentus), гранатового дерева (Punica granatum), травы мате (экстракта листьев Ilex paraguariensis), экстракта цветов лилии белой (Lilium Candidum), экстракта листьев оливы (Olea europaea), флоретина (экстракта яблока), а также их комбинаций.
5. Композиция по п.1, в которой противовоспалительное соединение представляет собой экстракт, выбранный из группы, состоящей из пиретрума девичьего (Tanacetum parthenium), дерезы обыкновенной (Lycium barbarum), экстракта чертополоха морского (Silybum marianum), масла амаранта (Amaranthus cruentus), гранатового дерева (Punica granatum), травы мате (экстракта листьев Ilex paraguariensis), экстракта цветов лилии белой (Lilium Candidum), экстракта листьев оливы (Olea europaea), флоретина (экстракта яблока), а также их комбинаций.
6. Композиция по п.1, в которой ингибитор NF-kB выбран из группы, состоящей из замещенных резорцинолов, (E)-3-(4-метилфенилсульфонил)-2-пропеннитрила, тетрагидрокуркуминоидов, экстрактов древесины павловнии войлочной, а также их комбинаций.
7. Композиция по п.1, в которой ингибитор NF-kB выбран из группы, состоящей из замещенных резорцинолов, тетрагидрокуркуминоидов и их комбинаций.
8. Композиция по п.4, в которой ингибитор NF-kB выбран из группы, состоящей из замещенных резорцинолов, тетрагидрокуркуминоидов и их комбинаций.
9. Композиция по п.5, в которой ингибитор NF-kB выбран из группы, состоящей из замещенных резорцинолов, тетрагидрокуркуминоидов и их комбинаций.
10. Композиция по п.1, в которой ингибитор NF-kB и противовоспалительное соединение присутствуют в весовом соотношении от приблизительно 1:10 до приблизительно 10:1.
RU2012117746/15A 2009-10-02 2010-10-01 Композиции, содержащие противовоспалительную смесь RU2554766C2 (ru)

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US61/247,992 2009-10-02
PCT/US2010/051080 WO2011041648A1 (en) 2009-10-02 2010-10-01 Compositions comprising an anti-inflammatory blend

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CN102573820B (zh) 2015-11-25
EP2482809A1 (en) 2012-08-08
ES2674569T3 (es) 2018-07-02
RU2554766C2 (ru) 2015-06-27
BR112012007512A2 (pt) 2016-11-22
US20110081433A1 (en) 2011-04-07
CN102573820A (zh) 2012-07-11
IN2012DN02441A (ru) 2015-08-21
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US8318217B2 (en) 2012-11-27
CA2774026A1 (en) 2011-04-07

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