RU2012142230A - Антитела против csf-1r человека и их применение - Google Patents
Антитела против csf-1r человека и их применение Download PDFInfo
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Abstract
1. Антитело, связывающееся с CSF-1R человека, отличающееся связыванием с тем же эпитопом, что и антитело, депонированное в коллекции под номером DSM ACC2921.2. Антитело по п.1, отличающееся включением в качестве области CDR3 вариабельного домена тяжелой цепи области CDR3 последовательности SEQ ID NO:1.3. Антитело по п.2, отличающееся тем, чтоа) вариабельный домен тяжелой цепи включает область CDR3 последовательности SEQ ID NO:1, область CDR2 последовательности SEQ ID NO:2, и область CDR1 последовательности SEQ ID NO:3, и вариабельный домен легкой цепи включает область CDR3 последовательности SEQ ID NO:4, область CDR2 последовательности SEQ ID NO:5, область CDR1 последовательности SEQ ID NO:6; илиб) вариант антител по пункту а) имеет пересаженную область CDR, является гуманизированным или у него ослаблен Т-клеточный эпитоп.4. Антитело по п.3, отличающееся тем, что содержита) аминокислотную последовательность вариабельного домена тяжелой цепи, которая имеет последовательность SEQ ID NO:7, и аминокислотную последовательность вариабельного домена легкой цепи, которая имеет последовательность SEQ ID NO:8; илиб) вариант антител по пункту а) имеет пересаженную область CDR, является гуманизированным или у него ослаблен Т-клеточный эпитоп.5. Антитело по пп.1-4, отличающееся тем, что указанное антитело относится к подклассу IgG4 человека или подклассу IgG1 человека.6. Фармацевтическая композиция, отличающаяся включением антитела или его фрагмента по пп.1-5.7. Антитело по п.п.1-5 для лечения рака.8. Антитело по пп.1-5 для лечения потери кости.9. Антитело по пп.1-5 для предупреждения или лечения метастазов.10. Антитело по пп.1-5 для лечения воспалительных заболеваний.11. Нуклеиновая кислота, кодирующая тяжелую цеп�
Claims (16)
1. Антитело, связывающееся с CSF-1R человека, отличающееся связыванием с тем же эпитопом, что и антитело, депонированное в коллекции под номером DSM ACC2921.
2. Антитело по п.1, отличающееся включением в качестве области CDR3 вариабельного домена тяжелой цепи области CDR3 последовательности SEQ ID NO:1.
3. Антитело по п.2, отличающееся тем, что
а) вариабельный домен тяжелой цепи включает область CDR3 последовательности SEQ ID NO:1, область CDR2 последовательности SEQ ID NO:2, и область CDR1 последовательности SEQ ID NO:3, и вариабельный домен легкой цепи включает область CDR3 последовательности SEQ ID NO:4, область CDR2 последовательности SEQ ID NO:5, область CDR1 последовательности SEQ ID NO:6; или
б) вариант антител по пункту а) имеет пересаженную область CDR, является гуманизированным или у него ослаблен Т-клеточный эпитоп.
4. Антитело по п.3, отличающееся тем, что содержит
а) аминокислотную последовательность вариабельного домена тяжелой цепи, которая имеет последовательность SEQ ID NO:7, и аминокислотную последовательность вариабельного домена легкой цепи, которая имеет последовательность SEQ ID NO:8; или
б) вариант антител по пункту а) имеет пересаженную область CDR, является гуманизированным или у него ослаблен Т-клеточный эпитоп.
5. Антитело по пп.1-4, отличающееся тем, что указанное антитело относится к подклассу IgG4 человека или подклассу IgG1 человека.
6. Фармацевтическая композиция, отличающаяся включением антитела или его фрагмента по пп.1-5.
7. Антитело по п.п.1-5 для лечения рака.
8. Антитело по пп.1-5 для лечения потери кости.
9. Антитело по пп.1-5 для предупреждения или лечения метастазов.
10. Антитело по пп.1-5 для лечения воспалительных заболеваний.
11. Нуклеиновая кислота, кодирующая тяжелую цепь антитела, связывающегося с CSF-1R, отличающаяся тем, что указанное антитело включает вариабельный домен по пп.2, 3 или 4.
12. Векторы экспрессии, отличающиеся тем, что содержат нуклеиновую кислоту по п.11 для экспрессии антитела, связывающегося с CSF-1R, в прокариотических или эукариотических клетках-хозяевах.
13. Прокариотические или эукариотические клетки-хозяева, включающие вектор по п.12.
14. Способ получения рекомбинантного антитела по пп.1-5, отличающийся экспрессией нуклеиновой кислоты по п.11 в прокариотических или эукариотических клетках-хозяевах и выделением указанного антитела из указанных клеток или супернатанта культур клеток.
15. Антитело, связывающееся с CSF-1R человека, отличающееся тем, что
а) вариабельный домен тяжелой цепи включает область CDR3 последовательности SEQ ID NO:1, область CDR2 последовательности SEQ ID NO:2 и область CDR1 последовательности SEQ ID NO:3, и вариабельный домен легкой цепи включает область CDR3 последовательности SEQ ID NO:4, область CDR2 последовательности SEQ ID NO:5 и область CDR1 последовательности SEQ ID NO:6; или
б) вариант антител по пункту а) имеет пересаженную область CDR, является гуманизированным или у него ослаблен Т-клеточный эпитоп.
16. Антитело по п.15, отличающееся включением
а) аминокислотной последовательностью вариабельного домена тяжелой цепи, имеющей последовательность SEQ ID NO:7, и аминокислотной последовательностью вариабельного домена легкой цепи, имеющей последовательность SEQ ID NO:8; или
б) вариант антител по пункту а) имеет пересаженную область CDR, является гуманизированным или у него ослаблен Т-клеточный эпитоп.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10002269 | 2010-03-05 | ||
| EP10002269.8 | 2010-03-05 | ||
| PCT/EP2011/053213 WO2011131407A1 (en) | 2010-03-05 | 2011-03-03 | Antibodies against human csf-1r and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2012142230A true RU2012142230A (ru) | 2014-04-10 |
| RU2617966C2 RU2617966C2 (ru) | 2017-04-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012142230A RU2617966C2 (ru) | 2010-03-05 | 2011-03-03 | Антитела против csf-1r человека и их применение |
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| Country | Link |
|---|---|
| US (3) | US9221910B2 (ru) |
| EP (1) | EP2542588A1 (ru) |
| JP (1) | JP5989547B2 (ru) |
| KR (1) | KR101647871B1 (ru) |
| CN (1) | CN102918061B (ru) |
| BR (1) | BR112012022046A2 (ru) |
| CA (1) | CA2789071C (ru) |
| MX (1) | MX336682B (ru) |
| RU (1) | RU2617966C2 (ru) |
| WO (1) | WO2011131407A1 (ru) |
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- 2011-03-03 MX MX2012010019A patent/MX336682B/es unknown
- 2011-03-03 JP JP2012555429A patent/JP5989547B2/ja not_active Expired - Fee Related
- 2011-03-03 BR BR112012022046A patent/BR112012022046A2/pt not_active Application Discontinuation
-
2015
- 2015-10-29 US US14/927,373 patent/US9624302B2/en not_active Expired - Fee Related
-
2017
- 2017-03-03 US US15/448,986 patent/US20170275368A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RU2617966C2 (ru) | 2017-04-28 |
| EP2542588A1 (en) | 2013-01-09 |
| US9221910B2 (en) | 2015-12-29 |
| JP2013520978A (ja) | 2013-06-10 |
| JP5989547B2 (ja) | 2016-09-07 |
| MX336682B (es) | 2016-01-27 |
| US20170275368A1 (en) | 2017-09-28 |
| CN102918061B (zh) | 2016-06-08 |
| WO2011131407A1 (en) | 2011-10-27 |
| US20160053015A1 (en) | 2016-02-25 |
| US20130005949A1 (en) | 2013-01-03 |
| CA2789071C (en) | 2018-03-27 |
| US9624302B2 (en) | 2017-04-18 |
| KR101647871B1 (ko) | 2016-08-11 |
| CN102918061A (zh) | 2013-02-06 |
| BR112012022046A2 (pt) | 2017-02-14 |
| CA2789071A1 (en) | 2011-10-27 |
| KR20120134138A (ko) | 2012-12-11 |
| MX2012010019A (es) | 2012-11-29 |
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| Date | Code | Title | Description |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20190304 |