RU2017131027A - Композиции и способы для улучшения внешнего вида кожи - Google Patents
Композиции и способы для улучшения внешнего вида кожи Download PDFInfo
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- RU2017131027A RU2017131027A RU2017131027A RU2017131027A RU2017131027A RU 2017131027 A RU2017131027 A RU 2017131027A RU 2017131027 A RU2017131027 A RU 2017131027A RU 2017131027 A RU2017131027 A RU 2017131027A RU 2017131027 A RU2017131027 A RU 2017131027A
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- 239000000203 mixture Substances 0.000 title claims 24
- 238000000034 method Methods 0.000 title claims 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 12
- 229920002674 hyaluronan Polymers 0.000 claims 12
- 229960003160 hyaluronic acid Drugs 0.000 claims 12
- 238000002347 injection Methods 0.000 claims 8
- 239000007924 injection Substances 0.000 claims 8
- 230000036571 hydration Effects 0.000 claims 5
- 238000006703 hydration reaction Methods 0.000 claims 5
- 238000002560 therapeutic procedure Methods 0.000 claims 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 3
- 229930195725 Mannitol Natural products 0.000 claims 3
- 230000007547 defect Effects 0.000 claims 3
- 235000010355 mannitol Nutrition 0.000 claims 3
- 239000000594 mannitol Substances 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical compound C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 claims 2
- 235000010323 ascorbic acid Nutrition 0.000 claims 2
- 239000011668 ascorbic acid Substances 0.000 claims 2
- 229960005070 ascorbic acid Drugs 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 150000003700 vitamin C derivatives Chemical class 0.000 claims 2
- PGMKGZOHRBZSSQ-UHFFFAOYSA-N 2-[2-(oxiran-2-ylmethoxy)ethenoxymethyl]oxirane Chemical group C1OC1COC=COCC1CO1 PGMKGZOHRBZSSQ-UHFFFAOYSA-N 0.000 claims 1
- -1 3-epoxypropyl Chemical group 0.000 claims 1
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical group OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 claims 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- 229960004194 lidocaine Drugs 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- A—HUMAN NECESSITIES
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/428—Vitamins, e.g. tocopherol, riboflavin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Dispersion Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Materials For Medical Uses (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Claims (15)
1. Инъекционная композиция для уменьшения появления поверхностных дефектов на коже, содержащая: гель гиалуроновой кислоты (ГК), содержащий поперечно-связанную матрицу ГК, полученную с помощью более чем 50 масс. %, по меньшей мере 70 масс. % или по меньшей мере 90 масс. % материала низкомолекулярной ГК, имеющей средневесовую молекулярную массу от 400000 Да до 800000 Да, относительно общей массы материала ГК; где концентрация ГК в композиции составляет от 10,0 мг/г до 12 мг/г; где поперечно-связанная матрица ГК поперечно связана с помощью поперечно-связывающего агента, выбранного из группы, состоящей из диглицидилового эфира 1,4-бутандиола (BDDE), 1,2-бис(2,3-эпоксипропокси)этилена и 1-(2,3-эпоксипропил)-2,3-эпоксициклогексана; и где композиция обеспечивает уменьшение появления поверхностных дефектов на коже в течение по меньшей мере 3 месяцев после введения в кожу.
2. Композиция по п. 1, обеспечивающая уменьшение появления поверхностных дефектов на коже в течение по меньшей мере 4 месяцев после введения в кожу, предпочтительно по меньшей мере 6 месяцев, 9 месяцев или 12 месяцев.
3. Композиция по п. 1 или 2, включающая не поперечно-связанную ГК, предпочтительно в количестве менее чем 10 масс. % или менее чем 5 масс. % относительно общей массы композиции.
4. Композиция по пп. 1-3, дополнительно содержащая по меньшей мере одно из маннита и производного витамина С, или дополнительно содержащая лидокаин, предпочтительно в количестве от 0,1 масс. % до 5 масс. % композиции, например 0,3 масс. %.
5. Композиция по п. 4, где маннит присутствует в количестве от 0,3 масс. % до 0,9 масс. % относительно общей массы композиции.
6. Композиция по п. 4, где производное витамина С представляет собой 2-глюкозид аскорбиновой кислоты.
7. Композиция по п. 6, где 2-глюкозид аскорбиновой кислоты присутствует в количестве от 0,3 масс. % до 0,6 масс. % относительно общей массы композиции.
8. Композиция по пп. 1-4, дополнительно содержащая 0,9 масс. % маннита и 0,6 масс. % 2-глюкозида аскорбиновой кислоты относительно общей массы композиции.
9. Композиция по пп. 1-8, где матрица ГК получена с помощью комбинации высокомолекулярной и низкомолекулярной ГК, причем 90 масс. % ГК представляет собой низкомолекулярную ГК.
10. Композиция по п. 1 для применения в способе улучшения по меньшей мере одного из текстуры, степени увлажнения и эластичности кожи, включающем: обработку участка кожи путем введения в участок кожи в ходе однократной процедуры многократных пространственно разнесенных инъекций указанной композиции, где инъекции разнесены на расстояние от 5 мм до 20 мм, например 5 мм или 10 мм; где обработанная кожа в результате лечения сохраняет по меньшей мере одно из улучшенной текстуры, степени увлажнения и эластичности в течение по меньшей мере 3 месяцев.
11. Нетерапевтический способ улучшения по меньшей мере одного из текстуры, степени увлажнения и эластичности кожи, включающий обработку участка кожи путем введения в участок кожи в ходе однократной процедуры многократных пространственно разнесенных инъекций композиции по п. 1, где инъекции разнесены на расстояние от 5 мм до 20 мм, например 5 мм или 10 мм; и где обработанная кожа в результате лечения сохраняет по меньшей мере одно из улучшенной текстуры, степени увлажнения и эластичности в течение по меньшей мере 3 месяцев.
12. Композиция для применения по п. 10 или нетерапевтический способ по п. 11, где обработанная кожа в результате лечения сохраняет по меньшей мере одно из улучшенной текстуры, степени увлажнения и эластичности в течение по меньшей мере 6 месяцев, по меньшей мере 9 месяцев или по меньшей мере 12 месяцев.
13. Композиция для применения по п. 10 или 12 или нетерапевтический способ по п. 11 или 12, где инъекции вводят в количестве от 5 мкл до 100 мкл на инъекцию.
14. Композиция для применения по п. 10 или 12 или нетерапевтический способ по пп. 11-13, где обработка занимает не более чем 45 минут.
15. Композиция для применения по п. 10 и пп. 12-14 или нетерапевтический способ по пп. 11-14, где инъекции доставляют через иглу калибра от 28 G до 33 G.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2015/000347 WO2016128783A1 (en) | 2015-02-09 | 2015-02-09 | Compositions and methods for improving skin appearance |
| IBPCT/IB2015/000347 | 2015-02-09 | ||
| PCT/EP2016/052682 WO2016128374A1 (en) | 2015-02-09 | 2016-02-09 | Compositions and methods for improving skin appearance |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020112214A Division RU2020112214A (ru) | 2015-02-09 | 2016-02-09 | Композиции и способы для улучшения внешнего вида кожи |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017131027A true RU2017131027A (ru) | 2019-03-12 |
| RU2017131027A3 RU2017131027A3 (ru) | 2019-08-01 |
| RU2718873C2 RU2718873C2 (ru) | 2020-04-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017131027A RU2718873C2 (ru) | 2015-02-09 | 2016-02-09 | Композиции и способы для улучшения внешнего вида кожи |
| RU2020112214A RU2020112214A (ru) | 2015-02-09 | 2016-02-09 | Композиции и способы для улучшения внешнего вида кожи |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2020112214A RU2020112214A (ru) | 2015-02-09 | 2016-02-09 | Композиции и способы для улучшения внешнего вида кожи |
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| Country | Link |
|---|---|
| US (3) | US11260015B2 (ru) |
| EP (2) | EP3256097B1 (ru) |
| JP (4) | JP2018504448A (ru) |
| KR (2) | KR20240027881A (ru) |
| CN (2) | CN107205911A (ru) |
| AU (4) | AU2016217963B2 (ru) |
| BR (1) | BR112017017043B1 (ru) |
| CA (1) | CA2972561A1 (ru) |
| ES (1) | ES2910249T3 (ru) |
| HK (1) | HK1244443A1 (ru) |
| RU (2) | RU2718873C2 (ru) |
| WO (2) | WO2016128783A1 (ru) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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