RU92004362A - Производные таксола и водорастворимые производные таксола - Google Patents

Производные таксола и водорастворимые производные таксола

Info

Publication number
RU92004362A
RU92004362A RU92004362/04A RU92004362A RU92004362A RU 92004362 A RU92004362 A RU 92004362A RU 92004362/04 A RU92004362/04 A RU 92004362/04A RU 92004362 A RU92004362 A RU 92004362A RU 92004362 A RU92004362 A RU 92004362A
Authority
RU
Russia
Prior art keywords
taxol
synthesized
taxol derivatives
water
oxy
Prior art date
Application number
RU92004362/04A
Other languages
English (en)
Other versions
RU2043346C1 (ru
Inventor
Дж.Ай Кингстон Дэвид
Зао Зи-Янг
Original Assignee
Вирджиния Тек Интеллекчуал Пропертиз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/573,731 external-priority patent/US5059699A/en
Application filed by Вирджиния Тек Интеллекчуал Пропертиз, Инк. filed Critical Вирджиния Тек Интеллекчуал Пропертиз, Инк.
Application granted granted Critical
Publication of RU2043346C1 publication Critical patent/RU2043346C1/ru
Publication of RU92004362A publication Critical patent/RU92004362A/ru

Links

Claims (1)

  1. Синтезированы производные сульфированного 2'-акрилоилтаксола и сульфированного 2'-О-ацилкислого таксола, обладающие улучшенной растворимостью в воде и стабильностью с одновременным сохранением биоактивности. В частности, синтезирована натриевая соль 2'-[(3-сульфо-1-оксопропил)окси] таксола при взаимодействии таксола с акриловой кислотой и с последующей реакцией 2'-акрилоилтаксола с бисульфитом согласно реакции Михаэлиса. При взаимодействии 2'-сукцинилтаксола с солями тетрабутиламмония и таурина и 3-аминопропилсульфокислотой соответственно с последующим обменом аммония на натрий были синтезированы натриевые соли 2'-{[4-((2-сульфоэтил)амино)-1,4-диоксобутил] окси} таксола и 2'-{[4-((3-сульфопропил)амино)-1,4-диоксобутил]окси}таксола. При взаимодействии гликоля с 2-O-ацилкислым таксолом были синтезированы гликолевые производные 2'-O-ацилкислых таксолов, обладающие улучшенной растворимостью в воде.
RU9292004362A 1990-08-28 1992-10-14 Производные таксола и водорастворимые производные таксола RU2043346C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US573731 1990-08-28
US07/573,731 US5059699A (en) 1990-08-28 1990-08-28 Water soluble derivatives of taxol

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU5001413 Division

Publications (2)

Publication Number Publication Date
RU2043346C1 RU2043346C1 (ru) 1995-09-10
RU92004362A true RU92004362A (ru) 1996-12-20

Family

ID=24293168

Family Applications (2)

Application Number Title Priority Date Filing Date
SU915001413A RU2059630C1 (ru) 1990-08-28 1991-08-27 Акрилоилпроизводные таксола и способ их получения, водорастворимые производные таксола и способ их получения (варианты)
RU9292004362A RU2043346C1 (ru) 1990-08-28 1992-10-14 Производные таксола и водорастворимые производные таксола

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SU915001413A RU2059630C1 (ru) 1990-08-28 1991-08-27 Акрилоилпроизводные таксола и способ их получения, водорастворимые производные таксола и способ их получения (варианты)

Country Status (24)

Country Link
US (2) US5059699A (ru)
EP (1) EP0473326A1 (ru)
JP (1) JPH0699410B2 (ru)
KR (1) KR0132157B1 (ru)
CN (1) CN1059337A (ru)
AU (2) AU645340B2 (ru)
CA (1) CA2049160C (ru)
CS (1) CS263291A3 (ru)
EG (1) EG19914A (ru)
FI (1) FI913651A7 (ru)
HU (1) HU210326B (ru)
IE (1) IE913015A1 (ru)
IL (1) IL99183A0 (ru)
MX (2) MX9100832A (ru)
MY (1) MY107794A (ru)
NO (1) NO913007L (ru)
NZ (1) NZ239377A (ru)
OA (1) OA10035A (ru)
PL (4) PL166242B1 (ru)
PT (1) PT98787A (ru)
RU (2) RU2059630C1 (ru)
TW (1) TW209214B (ru)
YU (1) YU144891A (ru)
ZA (1) ZA916450B (ru)

Families Citing this family (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469868A (en) * 1982-05-24 1984-09-04 Warner-Lambert Company Alkylimidazo[1,2-c]pyrazolo[3,4-e]pyrimidines
US5278324A (en) * 1990-08-28 1994-01-11 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
US5380916A (en) * 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
US5475120A (en) * 1990-11-02 1995-12-12 University Of Florida Method for the isolation and purification of taxol and its natural analogues
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US7074945B2 (en) * 1991-09-23 2006-07-11 Florida State University Metal alkoxide taxane derivatives
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US6011056A (en) * 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5284865A (en) * 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5728725A (en) * 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
WO1993014787A1 (en) * 1992-01-31 1993-08-05 The Trustees Of Columbia University In The City Of New York Taxol as a radiation sensitizer
US6080777A (en) * 1992-01-31 2000-06-27 The Trustees Of Columbia University In The City Of New York Taxol as a radiation sensitizer
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
IT1254515B (it) * 1992-03-06 1995-09-25 Indena Spa Tassani di interesse oncologico, loro metodo di preparazione ed uso
JPH069600A (ja) * 1992-05-06 1994-01-18 Bristol Myers Squibb Co タクソールのベンゾエート誘導体
AU4406793A (en) * 1992-06-04 1993-12-30 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
US5364947A (en) * 1992-07-02 1994-11-15 Hauser Chemical Research, Inc. Process for separating cephalomannine from taxol using ozone and water-soluble hydrazines or hydrazides
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
US5470866A (en) * 1992-08-18 1995-11-28 Virginia Polytechnic Institute And State University Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol
US5614549A (en) * 1992-08-21 1997-03-25 Enzon, Inc. High molecular weight polymer-based prodrugs
US5789189A (en) * 1993-09-24 1998-08-04 The Regents Of The University Of California Inhibition of cyst formation by cytoskeletal specific drugs
FR2697019B1 (fr) * 1992-10-15 1994-11-25 Rhone Poulenc Rorer Sa Nouveaux dérivés du taxane, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5411984A (en) * 1992-10-16 1995-05-02 Virginia Tech Intellectual Properties, Inc. Water soluble analogs and prodrugs of taxol
US5356927A (en) * 1992-12-02 1994-10-18 Thomas Jefferson University Methods of treating plasmodium and babesia parasitic infections
US5631278A (en) * 1992-12-02 1997-05-20 Thomas Jefferson University Methods of killing protozoal parasites
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co 7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CZ292993B6 (cs) * 1992-12-23 2004-01-14 Bristol-Myers Squibb Company Způsob přípravy taxanu nesoucího oxazolinový postranní řetězec a taxan tímto způsobem připravený
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
MX9308012A (es) * 1992-12-24 1994-08-31 Bristol Myers Squibb Co Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen.
RU2136673C1 (ru) * 1992-12-24 1999-09-10 Бристоль-Мейерз Сквибб Компани Фосфонооксиметиловые эфиры таксановых производных, промежуточные соединения, противоопухолевая фармацевтическая композиция, способ ингибирования роста опухоли у млекопитающих
US6537579B1 (en) 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US20030068362A1 (en) * 1993-02-22 2003-04-10 American Bioscience, Inc. Methods and formulations for the delivery of pharmacologically active agents
US6753006B1 (en) 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
US5439686A (en) * 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US5665382A (en) * 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of pharmaceutically active agents for in vivo delivery
NZ262679A (en) * 1993-02-22 1997-08-22 Vivorx Pharmaceuticals Inc Compositions for in vivo delivery of pharmaceutical agents where the agents are contained in a polymeric shell
US5916596A (en) 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US20030133955A1 (en) * 1993-02-22 2003-07-17 American Bioscience, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US5650156A (en) * 1993-02-22 1997-07-22 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of nutriceuticals and compositions useful therefor
US6710191B2 (en) 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
US6066747A (en) * 1993-03-05 2000-05-23 Florida State University Process for the preparation of 9-desoxotaxanes
WO1994020089A1 (en) * 1993-03-09 1994-09-15 Enzon, Inc. Taxol-based compositions with enhanced bioactivity
TW467896B (en) 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
US5336684A (en) * 1993-04-26 1994-08-09 Hauser Chemical Research, Inc. Oxidation products of cephalomannine
HU213200B (en) * 1993-05-12 1997-03-28 Chinoin Gyogyszer Es Vegyeszet The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production
ES2205663T3 (es) * 1993-06-11 2004-05-01 PHARMACIA & UPJOHN COMPANY Uso antineoplasico de delta 6,7-taxoles y composiciones farmaceuticas que los contienen.
US6005120A (en) 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
CA2129288C (en) * 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
AU8052194A (en) * 1993-10-20 1995-05-08 Enzon, Inc. 2'- and/or 7- substituted taxoids
US5965566A (en) * 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US5880131A (en) * 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5605976A (en) * 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
DE69527346T2 (de) 1994-01-11 2003-02-13 The Scripps Research Institute, La Jolla Sich selbst bildende taxo-diterpenoid nanostrukturen
AU697626B2 (en) * 1994-01-11 1998-10-15 Scripps Research Institute, The Water soluble onium salt of taxo-diterpenoid
US5731334A (en) * 1994-01-11 1998-03-24 The Scripps Research Institute Method for treating cancer using taxoid onium salt prodrugs
AU698382B2 (en) * 1994-01-11 1998-10-29 Scripps Research Institute, The Chemical switching of taxo-diterpenoids between low solubility active forms and high solubility inactive forms
IL127598A (en) * 1994-01-28 2003-04-10 Upjohn Co Process for preparing isotaxol analogs
GB9405400D0 (en) * 1994-03-18 1994-05-04 Erba Carlo Spa Taxane derivatives
US5508447A (en) * 1994-05-24 1996-04-16 Board Of Regents, The University Of Texas System Short synthetic route to taxol and taxol derivatives
US5677470A (en) 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
US6458976B1 (en) 1994-10-28 2002-10-01 The Research Foundation Of State University Of New York Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods
US6500858B2 (en) 1994-10-28 2002-12-31 The Research Foundation Of The State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
EP0788493A1 (en) * 1994-10-28 1997-08-13 The Research Foundation Of State University Of New York Taxoid derivatives, their preparation and their use as antitumor agents
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
US5489589A (en) * 1994-12-07 1996-02-06 Bristol-Myers Squibb Company Amino acid derivatives of paclitaxel
AU716005B2 (en) 1995-06-07 2000-02-17 Cook Medical Technologies Llc Implantable medical device
ATE309235T1 (de) * 1995-09-12 2005-11-15 Zeneus Pharma Ltd Hydrolyse-einleitende hydrophobe taxane derivate
US6107332A (en) 1995-09-12 2000-08-22 The Liposome Company, Inc. Hydrolysis-promoting hydrophobic taxane derivatives
EP1229030B1 (en) * 1995-09-12 2005-11-09 Zeneus Pharma Limited Hydrolysis-promoting taxane hydrophobic derivates
US6051600A (en) * 1995-09-12 2000-04-18 Mayhew; Eric Liposomal hydrolysis-promoting hydrophobic taxane derivatives
US6177456B1 (en) 1995-10-02 2001-01-23 Xechem International, Inc. Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor
US5854278A (en) * 1995-12-13 1998-12-29 Xechem International, Inc. Preparation of chlorinated paclitaxel analogues and use thereof as antitumor agents
US5840748A (en) * 1995-10-02 1998-11-24 Xechem International, Inc. Dihalocephalomannine and methods of use therefor
US5654448A (en) * 1995-10-02 1997-08-05 Xechem International, Inc. Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
US5807888A (en) * 1995-12-13 1998-09-15 Xechem International, Inc. Preparation of brominated paclitaxel analogues and their use as effective antitumor agents
FR2742751B1 (fr) * 1995-12-22 1998-01-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US6441025B2 (en) * 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
CN1304058C (zh) 1996-03-12 2007-03-14 Pg-Txl有限公司 水溶性紫杉醇产品
AU724499B2 (en) 1996-05-06 2000-09-21 Florida State University 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
US5696152A (en) * 1996-05-07 1997-12-09 Wisconsin Alumni Research Foundation Taxol composition for use as organ preservation and cardioplegic agents
IT1283633B1 (it) * 1996-05-10 1998-04-23 Indena Spa Derivati tassanici loro sintesi e formulazioni che li contengono
US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
GB9705903D0 (en) 1997-03-21 1997-05-07 Elliott Gillian D VP22 Proteins and uses thereof
US8853260B2 (en) 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
EP2272504A3 (en) 1997-06-27 2014-02-26 Abraxis BioScience, LLC Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
PT1023050E (pt) * 1997-06-27 2013-12-04 Abraxis Bioscience Llc Novas formulações de agentes farmacológicos, métodos para a sua preparação e métodos para a sua utilização
DE69805860T2 (de) 1998-08-21 2003-01-02 Pharmachemie B.V., Haarlem Wasserlösliche ähnliche verbindungen und medicament-vorstufe von paclitaxel
US7235583B1 (en) 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
CN1088703C (zh) * 1999-09-17 2002-08-07 漆又毛 水溶性紫杉醇衍生物
US20030054977A1 (en) * 1999-10-12 2003-03-20 Cell Therapeutics, Inc. Manufacture of polyglutamate-therapeutic agent conjugates
US20040009229A1 (en) * 2000-01-05 2004-01-15 Unger Evan Charles Stabilized nanoparticle formulations of camptotheca derivatives
US20020077290A1 (en) * 2000-03-17 2002-06-20 Rama Bhatt Polyglutamic acid-camptothecin conjugates and methods of preparation
CN1098846C (zh) * 2000-04-20 2003-01-15 复旦大学 紫杉醇的多羟基水溶性衍生物及其制备方法
US6395771B1 (en) * 2000-05-31 2002-05-28 Dabur Research Foundation Paclitaxel derivatives for the treatment of cancer
CZ2003837A3 (cs) * 2000-09-22 2004-12-15 Bristol-Myers Squibb Company Způsob pro snížení toxicity při kombinovaných chemoterapiích
US20030157170A1 (en) * 2001-03-13 2003-08-21 Richard Liggins Micellar drug delivery vehicles and precursors thereto and uses thereof
CA2440935A1 (en) 2001-03-13 2002-09-19 Richard Liggins Micellar drug delivery vehicles and precursors thereto and uses thereof
ES2387562T3 (es) * 2001-03-23 2012-09-26 Luitpold Pharmaceuticals, Inc. Conjugados alcohol graso-medicamento
EP1427407A4 (en) * 2001-03-23 2005-05-11 Luitpold Pharm Inc FAT AMIN DRUG CONJUGATES
DE60220519T2 (de) * 2001-04-20 2007-09-27 The University Of British Columbia, Vancouver Mizellares arzneistoffverabreichungssystem für hydrophobe arzneistoffe
US20030054042A1 (en) * 2001-09-14 2003-03-20 Elaine Liversidge Stabilization of chemical compounds using nanoparticulate formulations
PL368945A1 (en) * 2001-11-30 2005-04-04 Bristol-Myers Squibb Company Paclitaxel solvates
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US7989490B2 (en) 2004-06-02 2011-08-02 Cordis Corporation Injectable formulations of taxanes for cad treatment
US7846940B2 (en) 2004-03-31 2010-12-07 Cordis Corporation Solution formulations of sirolimus and its analogs for CAD treatment
US8003122B2 (en) * 2004-03-31 2011-08-23 Cordis Corporation Device for local and/or regional delivery employing liquid formulations of therapeutic agents
US20070073385A1 (en) * 2005-09-20 2007-03-29 Cook Incorporated Eluting, implantable medical device
WO2008005284A2 (en) 2006-06-30 2008-01-10 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20080241215A1 (en) * 2007-03-28 2008-10-02 Robert Falotico Local vascular delivery of probucol alone or in combination with sirolimus to treat restenosis, vulnerable plaque, aaa and stroke
US8409601B2 (en) 2008-03-31 2013-04-02 Cordis Corporation Rapamycin coated expandable devices
US8420110B2 (en) 2008-03-31 2013-04-16 Cordis Corporation Drug coated expandable devices
MX2010011165A (es) * 2008-04-10 2011-02-22 Abraxis Bioscience Llc Composiciones de derivados de taxano hidrofobos y sus usos.
US8273404B2 (en) * 2008-05-19 2012-09-25 Cordis Corporation Extraction of solvents from drug containing polymer reservoirs
US8642063B2 (en) 2008-08-22 2014-02-04 Cook Medical Technologies Llc Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
US9198968B2 (en) 2008-09-15 2015-12-01 The Spectranetics Corporation Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
JP2013530993A (ja) 2010-07-02 2013-08-01 アンジオケム インコーポレーテッド 治療用コンジュゲートのための短く且つd−アミノ酸を含有するポリペプチドおよびその使用
US20120302954A1 (en) 2011-05-25 2012-11-29 Zhao Jonathon Z Expandable devices coated with a paclitaxel composition
US20120303115A1 (en) 2011-05-25 2012-11-29 Dadino Ronald C Expandable devices coated with a rapamycin composition
CN108686203A (zh) 2012-04-04 2018-10-23 哈洛齐梅公司 使用抗透明质酸剂和肿瘤靶向紫杉烷的组合疗法
CN103044363B (zh) * 2012-04-17 2015-04-22 湘北威尔曼制药股份有限公司 紫杉醇衍生物及其制备与应用
US9956385B2 (en) 2012-06-28 2018-05-01 The Spectranetics Corporation Post-processing of a medical device to control morphology and mechanical properties
WO2015018380A2 (en) 2014-07-03 2015-02-12 Cspc Zhongqi Pharmaceutical Technology(Shijiazhuang)Co., Ltd. Therapeutic nanoparticles and the preparation methods thereof
AU2016326747A1 (en) 2015-09-25 2018-03-01 Zy Therapeutics Inc. Drug formulation based on particulates comprising polysaccharide-vitamin conjugate
CN106800542A (zh) * 2016-12-31 2017-06-06 辰欣药业股份有限公司 一种亲水性紫杉醇类化合物及其制备方法
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
CN115385875B (zh) * 2022-07-18 2023-06-13 中国药科大学 一类紫杉醇衍生物及其制备方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof

Similar Documents

Publication Publication Date Title
RU92004362A (ru) Производные таксола и водорастворимые производные таксола
CA2049160A1 (en) Water soluble derivatives of taxol
ATE135002T1 (de) Wasserlösliche derivate von taxol mit antineoplastischer aktivität
RU96105706A (ru) Соль нимесулида, растворимая в воде, способ ее приготовления и фармацевтическая композиция для лечения воспалительных заболеваний
KR960010683A (ko) 소마토스타틴 펩타이드, 이의 제법 및 이를 함유하는 약학적 조성물
SE8304045L (sv) Derivat av morfolinyl-daunorubicin och morfolinyl-doxorubicin, och analoger derav samt forfarande for framstellning derav
ATE63739T1 (de) Verfahren zur aufarbeitung von niedrigmolekularen alkoholen von waessrigen fermentationsmedium.
BG95531A (bg) Включени комплекси на n-етоксикарбонил-3-морфолино-сиднонимин или негови соли,образувани с циклодекстринови производни, получаването им и фармацевтични състави,съдържащи ги
SE8504786L (sv) Metallkomplex av bis-indol-foreningar och vattenhaltiga farmaceutiska kompositioner innehallande desamma
ES461389A1 (es) Un procedimiento para preparar una sal por adicion de acido metanosulfonico.
IT1188176B (it) Sali della carnitina particolarmente idonei per uso orale
JPS5681557A (en) Preparation of optically active alpha-methyl-beta- mercaptopropionic acid derivative
ES8400238A1 (es) "un procedimiento para la preparacion de soluciones acuosas de sulfonamidas potenciales".
KR860001815A (ko) 옥타하이드로-옥사졸로[4,5-g]퀴놀린의 제조방법
DK1369122T3 (da) Anticancermiddel
SE9002508D0 (sv) Asymmetric synthesis of furo (3,4-c) pyridine derivatives
JPS56147704A (en) Dermatological composition
ES2147606T3 (es) Sal onio soluble en agua de taxo-diterpenoide.
TH15242A (th) อนุพันธุ์ที่ละลายน้ำได้ของทาซอล
KR930016415A (ko) 퀴놀론-카복실산의 염 및 그 함유조성물
JPS55151536A (en) New optically active tert-leucine d-10-camphasulfonic acid salt and its preparation
JPS5545608A (en) Preparation of organosilver compound
DK0738148T3 (da) Selv-samlede taxo-diterpenoid-nanostrukturer
RU99126871A (ru) Гликоконъюгаты 20(s)-камптотецина
KR920000787A (ko) 결정성 폴리펩티드