KR960010683A - 소마토스타틴 펩타이드, 이의 제법 및 이를 함유하는 약학적 조성물 - Google Patents

소마토스타틴 펩타이드, 이의 제법 및 이를 함유하는 약학적 조성물 Download PDF

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KR960010683A
KR960010683A KR1019950028905A KR19950028905A KR960010683A KR 960010683 A KR960010683 A KR 960010683A KR 1019950028905 A KR1019950028905 A KR 1019950028905A KR 19950028905 A KR19950028905 A KR 19950028905A KR 960010683 A KR960010683 A KR 960010683A
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compound
pharmaceutical composition
radionuclide
complex
pharmaceutically acceptable
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KR100364111B1 (ko
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알버트 라이너
브룬스 크리스티안
스미스-존즈 페터
스톨츠 바바라
베크베커 기스버트
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페. 래스·에이치. 알. 하우스
산도즈 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

유리 형태 또는 염 형태인 하기 일반식(Ⅰ)의 화합물은 α선-또는 β선-방출 방사성핵종 또는 오오제-전자-캐스캐이드를 가지는 핵종과 착화합물을 형성했을때 방사성 의약품으로서 유용하다.
상기 식에서, M은 양이온 등가물이고, A는 페닐알라닌 또는 타이로신이다.

Description

소마토스타딘 펩타이드, 이의 제법 및 이를 함유하는 약학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 유리 형태, 염 형태 또는 방사성 핵종과 착화합된 형태의 일반식(Ⅰ)의 화합물.
    상기 식에서, M은 양이온이고, A는 페닐알라닌 또는 타이로신이다.
  2. 제1항에 있어서, A가 타이로신인 화합물.
  3. 제1항에 또는 제2항에 있어서,90Y또는161Tb와 착화합물을 형성한 화합물.
  4. 제1항에 있어서,M이 H+인 화합물.
  5. 방사성핵종과 착화합물을 형성한 제1항의 일반식 (Ⅰ)의 화합, 또는 그 약학적 허용염을 포함하고, 하나 이상의 약학적 허용 담체 및 회석제를 포함하는 소마토스타틴 수용테 양성인 종양 및 그 전이부 치료용 약학조성물.
  6. 제5 항에 있어서, 부가적으로 안정화제를 포함하는 약학 조성물.
  7. 제6항에 있어서, 안정화제가 혈청 알부민, 아스코르빈산, 레티놀, 겐티신산 또는 그 유도체, 및 아미노산 용액으로 이루어진 그룹중에서 선택되는 특징으로 하는 약학 조성물.
  8. 60내지 120℃의 온도에서 방사성핵종-산출 화합물과 일ㄹ반식(Ⅰ)의 화합물을 반응시키는 단계로 구성되는 제1항의 일반식(Ⅰ)이 화합물과 방사성핵종을 착화합시키는 방법.
  9. 방사성핵종과 착화합물을 형성한 일반식(Ⅰ)의 화합물, 또는 그 약학적 허용염을 포함하는 약학 조성물을 함유하면서 추가로 세포증식 억제제를 포함하는 하나 이상의 약학 조성물을 함유하는 종양 침윤성 및 종양 성장과 관련된 증후군 치료용 조합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950028905A 1994-09-06 1995-09-05 소마토스타틴펩타이드,이의제법및이를함유하는약학적조성물 Expired - Lifetime KR100364111B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9417873.8 1994-09-06
GB9417873A GB9417873D0 (en) 1994-09-06 1994-09-06 Organic compounds

Publications (2)

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KR960010683A true KR960010683A (ko) 1996-04-20
KR100364111B1 KR100364111B1 (ko) 2003-02-05

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US (2) US6183721B1 (ko)
EP (1) EP0714911B1 (ko)
JP (1) JP3054346B2 (ko)
KR (1) KR100364111B1 (ko)
CN (1) CN1185252C (ko)
AT (1) ATE199561T1 (ko)
AU (1) AU703057B2 (ko)
BR (1) BR9503936A (ko)
CA (1) CA2157530C (ko)
CO (1) CO4410344A1 (ko)
CZ (1) CZ287012B6 (ko)
DE (1) DE69520256T2 (ko)
DK (1) DK0714911T3 (ko)
ES (1) ES2157309T3 (ko)
FI (1) FI117424B (ko)
GB (1) GB9417873D0 (ko)
GR (1) GR3035997T3 (ko)
HU (1) HU218284B (ko)
IL (1) IL115154A (ko)
NO (1) NO316569B1 (ko)
NZ (1) NZ272919A (ko)
PE (1) PE41496A1 (ko)
PL (1) PL182434B1 (ko)
PT (1) PT714911E (ko)
RU (1) RU2156774C2 (ko)
SG (1) SG50356A1 (ko)
SI (1) SI0714911T1 (ko)
SK (1) SK283774B6 (ko)
TR (1) TR199501094A2 (ko)
TW (1) TW387898B (ko)
ZA (1) ZA957475B (ko)

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LT4095130T (lt) * 2013-10-18 2024-04-25 Novartis Ag Žymėti prostatos specifinio membranos antigeno (psma) inhibitoriai, jų naudojimas kaip vizualizavimo medžiagų ir farmacinių medžiagų prostatos vėžiui gydyti
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NO953457D0 (no) 1995-09-04
CN1127259A (zh) 1996-07-24
RU2156774C2 (ru) 2000-09-27
SK108895A3 (en) 1996-06-05
CO4410344A1 (es) 1997-01-09
JP3054346B2 (ja) 2000-06-19
NO316569B1 (no) 2004-02-23
DE69520256D1 (de) 2001-04-12
PL182434B1 (pl) 2002-01-31
US6183721B1 (en) 2001-02-06
ES2157309T3 (es) 2001-08-16
CA2157530C (en) 2007-04-03
GR3035997T3 (en) 2001-09-28
BR9503936A (pt) 1996-09-24
US6277356B1 (en) 2001-08-21
IL115154A (en) 2000-08-13
EP0714911B1 (en) 2001-03-07
HU218284B (en) 2000-07-28
DK0714911T3 (da) 2001-07-09
CZ287012B6 (en) 2000-08-16
FI954147L (fi) 1996-03-07
FI954147A0 (fi) 1995-09-04
NZ272919A (en) 1996-12-20
EP0714911A2 (en) 1996-06-05
SI0714911T1 (en) 2001-08-31
CA2157530A1 (en) 1996-03-07
HUT72895A (en) 1996-06-28
GB9417873D0 (en) 1994-10-26
CN1185252C (zh) 2005-01-19
DE69520256T2 (de) 2001-08-09
HU9502577D0 (en) 1995-11-28
TW387898B (en) 2000-04-21
JPH0881498A (ja) 1996-03-26
IL115154A0 (en) 1995-12-31
FI117424B (fi) 2006-10-13
ZA957475B (en) 1997-03-06
EP0714911A3 (en) 1996-08-21
ATE199561T1 (de) 2001-03-15
AU703057B2 (en) 1999-03-11
AU3041495A (en) 1996-03-21
SG50356A1 (en) 2000-11-21
PL310274A1 (en) 1996-03-18
PE41496A1 (es) 1996-10-14
CZ226395A3 (en) 1996-03-13
NO953457L (no) 1996-03-07
SK283774B6 (sk) 2004-01-08
PT714911E (pt) 2001-08-30
KR100364111B1 (ko) 2003-02-05
TR199501094A2 (tr) 1996-06-21

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